@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : JAK3_HUMAN: (2013-07-21 )
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
Atome Classification :
(76 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530......-.540...-....550--.......560.......570.......580.......590..-.-....600.......610..-.....620.......630.......640.......650.......--660.......670.......680.......690....-...700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820....--...830.......840.-......850.....-.---.-860.........870.......880.......890.......900.......910......---.920.......930.......940.......950.......960.......970....-...980.......990.......1000......1010......1020......--1030......1040.....-.1050......1060......1070......1080......1090......1100......1110......1120.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRG-CRHEVVD-GEARKTE--VLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG-D-STMVQEFVHLGAIDMYLRK-RGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREG--ADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECL-REAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYIS--QLGKGNFGSVELCRYDP-LGDNTGALVAVKQL-Q---H-S--GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHR---ARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPL-DKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCS--PSAEFLRMMGCERDVPALC-RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
7
PsiBlast_PDB
87.37
99%
-107
- C1 -
4HVI
1
A:
[5-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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I
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-----------------------
2
PsiBlast_PDB
86.97
99%
-104
- C1 -
3LXL
1
A:
[17-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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T
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--------------------------
6
PsiBlast_PDB
86.93
99%
-107
- C1 -
4HVH
1
A:
[4-292]
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P
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----------------------
5
PsiBlast_PDB
86.78
99%
-103
- C1 -
4HVG
1
A:
[4-293]
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4
PsiBlast_PDB
86.66
99%
-105
- C1 -
4HVD
2
A:
[5-291]
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1
PsiBlast_PDB
84.76
99%
-103
- C1 -
3LXK
1
A:
[18-301]
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9
PsiBlast_PDB
79.78
61%
-103
- C1 -
4BBF
2
JAK2_HUMAN
A:
[5-290]
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I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
-
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
21
PsiBlast_CBE
79.43
61%
-102
- C1 -
4BBF
1
D:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
--
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-
Q
---
H
-
S
--
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
---
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
-
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
8
PsiBlast_PDB
76.91
61%
-102
- C1 -
4BBE
2
JAK2_HUMAN
A:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
--
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-
Q
---
H
-
S
--
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
---
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
-
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
23
PsiBlast_CBE
75.97
61%
-101
- C1 -
4BBF
2
JAK2_HUMAN
B:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
--
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-
Q
---
H
-
S
--
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
---
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
-
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
24
PsiBlast_CBE
75.30
61%
-101
- C1 -
4BBE
1
D:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
--
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-
Q
---
H
-
S
--
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
---
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
-
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
22
PsiBlast_CBE
73.96
61%
-99
- C1 -
4BBF
1
JAK2_HUMAN
C:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
--
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-
Q
---
H
-
S
--
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
---
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
-
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
26
PsiBlast_CBE
73.49
61%
-97
- C1 -
4BBE
2
JAK2_HUMAN
B:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
--
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-
Q
---
H
-
S
--
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
---
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
-
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
10
PsiBlast_PDB
73.35
61%
-99
- C1 -
3UGC
1
A:
[6-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
--
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-
Q
---
H
-
S
--
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
---
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
--------------
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
25
PsiBlast_CBE
73.19
61%
-96
- C1 -
4BBE
1
JAK2_HUMAN
C:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
--
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
-
Q
---
H
-
S
--
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
K
H
K
---
E
R
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
-
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
--
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
--------------------------
18
PsiBlast_PDB
69.95
50%
-105
- C1 -
3NYX
3
A:
[8-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
--
G
E
M
V
A
V
K
A
L
-
K
A
--
D
-
C
--
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
-
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
---
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
--
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
28
PsiBlast_CBE
69.15
51%
-102
- C1 -
4E20
1
A:
[1-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-
K
---
E
-
G
C-
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
----
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
C
---
V
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
--
P
H
T
K
F
T
E
L
I
G
----
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
-----------------------------
20
PsiBlast_PDB
68.08
50%
-99
- C1 -
3NZ0
1
A:
[7-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-
K
A--
D
-
C
--
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
---
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
--
P
P
T
K
F
L
E
L
I
G
------
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
19
PsiBlast_PDB
67.89
50%
-104
- C1 -
4GFO
4
?
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-----------------
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
------
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
---
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
--
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
14
PsiBlast_PDB
67.50
50%
-91
- C1 -
4GII
1
?
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-
K
A--
D
-
A
--
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
---
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
--
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
16
PsiBlast_PDB
67.25
50%
-92
- C1 -
4GJ3
1
?
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-
K
A--
D
-
A
--
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
---
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
--
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
15
PsiBlast_PDB
66.84
50%
-91
- C1 -
4GJ2
1
?
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-
K
A--
D
-
A
--
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
---
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
--
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
12
PsiBlast_PDB
66.04
56%
-89
- C1 -
4FVP
2
A:
[1-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
H
K
I
R
N
E
D
L
I
F
N
E
S
L
G
Q
G
T
F
T
K
I
F
K
G
-
V
R
R
E
V
G
D
Y
G
Q
L
H
E
T
E
--
V
L
L
K
V
L
D
K
A
H
R
N
Y
S
E
S
F
F
E
A
A
S
M
M
S
K
L
S
H
K
H
L
V
L
N
Y
G
V
C
V
C
G
-
D
E
N
I
L
V
Q
E
F
V
K
F
G
S
L
D
T
Y
L
K
K
-
N
K
N
C
I
N
I
L
W
K
L
E
V
A
K
Q
L
A
A
A
M
H
F
L
E
E
N
T
L
I
H
G
N
V
C
A
K
N
I
L
L
I
R
E
E
DR
K
T
G
N
P
P
F
I
K
L
S
D
P
G
I
S
I
T
V
L
P
K
D
I
L
Q
E
R
I
P
W
V
P
P
E
C
I
-
E
N
P
K
N
L
N
L
A
T
D
K
W
S
F
G
T
T
L
W
E
I
C
S
G
G
D
K
P
L
S
A
L
D
S
Q
R
K
L
Q
F
Y
E
D
R
H
Q
L
P
A
P
K
A
A
E
L
A
N
L
I
N
N
C
M
D
Y
E
P
D
H
R
P
S
F
R
A
I
I
R
D
L
N
S
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.00
50%
-90
- C1 -
4GIH
1
?
A:
[9-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-
K
A--
D
-
A
--
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
---
I
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
--
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
---------------------
27
PsiBlast_CBE
65.39
51%
-96
- C1 -
4E1Z
1
A:
[2-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
--
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-
K
---
E
-
G
C-
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
---
K
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
C
---
V
G
L
--
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
-
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
--
P
H
T
K
F
T
E
L
I
G
H
T
Q
G
Q
M
T
V
L
-
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
-----------------------------
130
HHSearch
62.07
37%
-95
- C1 -
4FL3
1
KSYK_HUMAN
A:
[375-632]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
-
K
--
K
V
V
K
T
V
A
V
K
I
L
-
K
---
N
-
E
AN
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
---
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
----
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
--------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
----------------
R
G
M
K
G
S
-
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
-----------------------
76
PsiBlast_CBE
59.55
36%
-103
- C1 -
3POZ
1
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-----
V
K
I
P
V
A
I
K
E
L
-------------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
---------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
86
PsiBlast_CBE
59.18
36%
-104
- C1 -
1XKK
1
A:
[36-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-----
V
K
I
P
V
A
I
K
E
L
-
R
---
E
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
120
HHSearch
59.14
37%
-97
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[33-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
--
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
---
K
M
L
V
A
V
K
A
L
-
K
---
E
-
A
--
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
--
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
PDP
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
----------------
Y
Q
L
S
N
T
-
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
-----------------------
85
PsiBlast_CBE
58.80
36%
-103
- C1 -
2RGP
1
A:
[5-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-----
V
K
I
P
V
A
I
K
E
L
-
R
----------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
41
PsiBlast_CBE
58.39
37%
-102
- C1 -
4I24
1
EGFR_HUMAN
A:
[13-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-------------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
68
PsiBlast_CBE
57.56
36%
-104
- C1 -
3W33
1
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
----------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
40
PsiBlast_CBE
56.44
37%
-96
- C1 -
4I24
1
B:
[13-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
32
PsiBlast_CBE
56.28
38%
-87
- C1 -
3BCE
2
C:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
L
K
R
V
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
-
N
---
E
-
T
T-
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
---
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
---
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
--
D
E
K
E
Y
N
A
-
D
G
-
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
GI
P
T
----------
R
E
I
P
-------
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
-----------------------------
69
PsiBlast_CBE
56.19
36%
-93
- C1 -
3W32
1
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
30
PsiBlast_CBE
56.18
37%
-88
- C1 -
2R4B
1
B:
[16-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
-----
N
Q
A
Q
L
------
R
I
L
K
E
T
E
L
K
R
V
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
-------------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
---
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
---
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
-
D
E
K
E
Y
N
A
-
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
--
G
I
P
--------
T
R
E
I
P
-------
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
-----------------------------
29
PsiBlast_CBE
56.00
44%
-87
- C1 -
3ZON
1
A:
[39-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
L
S
F
H
R
V
D
Q
K
E
I
T
Q
L
S
H
L
G
Q
G
T
R
T
N
V
Y
E
G
R
L
R
V
-----------
E
LR
V
V
L
K
V
L
D
P
S
H
H
D
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
V
S
H
T
H
L
A
F
V
H
G
V
C
V
R
G
P
E
-
N
I
M
V
T
E
Y
V
E
H
G
P
L
D
V
W
L
R
R
E
R
G
H
-
V
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
L
E
N
K
N
L
V
H
G
N
V
C
G
R
N
I
L
L
A
R
L
G
L-
A
E
G
T
S
P
F
I
K
L
S
D
P
G
V
G
L
G
A
L
S
R
E
E
R
V
E
R
I
P
W
L
A
P
E
C
L
P-----
L
S
T
A
M
D
K
W
G
F
G
A
T
L
L
E
I
C
F
D
G
E
A
P
L
Q
S
R
S
P
S
E
K
E
H
F
Y
Q
R
Q
H
R
L
P
E
P
---
Q
L
A
T
L
T
S
Q
C
L
T
Y
E
P
T
Q
R
P
S
F
R
T
I
L
R
D
L
T
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
55.62
36%
-95
- C1 -
3W2Q
2
A:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
57
PsiBlast_CBE
55.44
36%
-96
- C1 -
3GT8
1
EGFR_HUMAN
B:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
-----------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
42
PsiBlast_CBE
55.27
37%
-94
- C1 -
2JIU
1
EGFR_HUMAN
A:
[12-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
74
PsiBlast_CBE
55.21
36%
-96
- C1 -
3UG2
2
A:
[18-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
-----------
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
70
PsiBlast_CBE
55.18
36%
-100
- C1 -
3W2S
1
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
35
PsiBlast_CBE
55.10
38%
-93
- C1 -
3BBT
1
ERBB4_HUMAN
B:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
L
K
R
V
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
-
N
---
E
----
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
---
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
---
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
----------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
----------
R
E
I
P
-------
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
-----------------------------
71
PsiBlast_CBE
54.98
36%
-92
- C1 -
2GS6
1
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-------
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
73
PsiBlast_CBE
54.91
36%
-96
- C1 -
3VJN
1
A:
[18-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-----
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
31
PsiBlast_CBE
54.81
37%
-86
- C1 -
2R4B
1
ERBB4_HUMAN
A:
[16-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
-----
N
Q
A
Q
L
------
R
I
L
K
E
T
E
L
K
R
V
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
-
N
-----------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
---
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
---
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
-
D
E
K
E
Y
N
A
-
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
--
G
I
P
--------
T
R
E
I
P
-------
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
-----------------------------
55
PsiBlast_CBE
54.76
36%
-97
- C1 -
3GT8
1
D:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
-----------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
87
PsiBlast_CBE
54.59
36%
-92
- C1 -
4JRV
1
?
A:
[13-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-------
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
45
PsiBlast_CBE
54.44
36%
-95
- C1 -
3LZB
1
EGFR_HUMAN
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
56
PsiBlast_CBE
53.88
36%
-98
- C1 -
3GT8
1
EGFR_HUMAN
C:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
89
PsiBlast_CBE
53.46
36%
-94
- C1 -
4JQ8
1
?
A:
[13-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
72
PsiBlast_CBE
53.40
36%
-95
- C1 -
3VJO
1
A:
[18-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
--
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
-------
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
75
PsiBlast_CBE
53.30
36%
-93
- C1 -
3UG1
1
A:
[18-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
-----------
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
44
PsiBlast_CBE
53.28
36%
-92
- C1 -
3LZB
1
EGFR_HUMAN
B:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
79
PsiBlast_CBE
53.13
36%
-94
- C1 -
2ITY
1
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
58
PsiBlast_CBE
52.81
36%
-95
- C1 -
3GT8
1
EGFR_HUMAN
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
-----------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
59
PsiBlast_CBE
52.59
36%
-93
- C1 -
2GS7
1
B:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
-----
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
100
PsiBlast_CBE
52.19
36%
-97
- C1 -
2ITN
1
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
-----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
63
PsiBlast_CBE
52.13
37%
-90
- C1 -
3RCD
1
ERBB2_HUMAN
C:
[13-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
L
R
K
V
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R----------
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
---
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
-------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
--
G
I
P
--------
A
R
E
I
P
-------
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
---------------------------------
60
PsiBlast_CBE
52.12
36%
-92
- C1 -
2GS7
1
EGFR_HUMAN
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
97
PsiBlast_CBE
52.07
36%
-90
- C1 -
2ITQ
1
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
81
PsiBlast_CBE
52.02
36%
-88
- C1 -
2ITW
1
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
64
PsiBlast_CBE
51.94
37%
-90
- C1 -
3RCD
1
ERBB2_HUMAN
A:
[13-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
L
R
K
V
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R----------
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
---
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
-------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
--
G
I
P
--------
A
R
E
I
P
-------
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
---------------------------------
80
PsiBlast_CBE
51.82
36%
-90
- C1 -
2ITX
1
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----
E
K
E
Y
H
A
--
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
102
PsiBlast_CBE
51.69
36%
-92
- C1 -
2ITV
1
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
-----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
34
PsiBlast_CBE
50.52
38%
-90
- C1 -
3BBT
1
D:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
L
K
R
V
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
---
E
T
V
K
I
P
V
A
I
K
I
L
-
N
---
E
-----
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
---
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
---
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
GI
P
T
----------
R
E
I
P
-------
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
-----------------------------
103
PsiBlast_CBE
50.43
36%
-94
- C1 -
2ITU
1
A:
[11-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
E
T
E
F
K
K
I
K
--
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
R
---
E
A
T
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
---
T
S
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
---
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
---------------
G
I
P
A
-
S
-
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
---------------------------------
50
PsiBlast_CBE
49.47
38%
-85
- C1 -
4ID7
1
ACK1_HUMAN
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
L
E
--
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
G
K
T
V
S
-
V
A
V
K
C
L
-
K
P--------
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
---
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
---
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
--------
W
I
G
L
N
G
S
Q
--------
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
---------------------------------
54
PsiBlast_CBE
49.08
38%
-84
- C1 -
3EQP
1
ACK1_HUMAN
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
L
E
--
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
G
K
T
V
S
-
V
A
V
K
C
L
----------
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
---
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
---
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
--------
W
I
G
L
N
G
S
Q
--------
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
---------------------------------
51
PsiBlast_CBE
47.62
38%
-84
- C1 -
3EQR
1
ACK1_HUMAN
B:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
L
E
--
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
G
K
T
V
S
-
V
A
V
K
C
L
-
K
P
DV
L
-
S
--
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
---
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
---
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
D
H
Y
V
M
---
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
--------
W
I
G
L
N
G
S
Q
--------
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
---------------------------------
48
PsiBlast_CBE
47.06
38%
-86
- C1 -
1U4D
1
ACK1_HUMAN
A:
[17-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
L
E
--
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
G
K
T
V
S
-
V
A
V
K
C
------------
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
---
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
---
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
---
D
H
Y
V
M
-----
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
--------
W
I
G
L
N
G
S
Q
--------
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
---------------------------------
46
PsiBlast_CBE
46.60
38%
-84
- C1 -
1U54
1
ACK1_HUMAN
B:
[17-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
L
E
--
K
L
G
D
G
---
V
V
R
R
G
E
W
D
A
-
P
S
G
K
T
V
S
-
V
A
V
K
C
L
------------
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
---
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
---
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
--------
W
I
G
L
N
G
S
Q
--------
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
---------------------------------
122
HHSearch
46.40
37%
-86
- C1 -
4FYO
1
A:
[11-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
DK
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
---
K
K
V
V
K
T
V
A
V
K
I
L
-----------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
---
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
----
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
-
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
----------------
G
M
K
G
S
-
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
----------------------
53
PsiBlast_CBE
46.08
38%
-82
- C1 -
3EQP
1
ACK1_HUMAN
B:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
L
E
--
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
G
K
T
V
S
-
V
A
V
K
C
L
----------
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
---
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
---
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
--------
W
I
G
L
N
G
S
Q
--------
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
---------------------------------
52
PsiBlast_CBE
44.60
38%
-81
- C1 -
3EQR
1
ACK1_HUMAN
A:
[7-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
L
E
--
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
G
K
T
V
S
-
V
A
V
K
C
L
-
K
P---------
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
---
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
---
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
--------
W
I
G
L
N
G
S
Q
--------
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
---------------------------------
47
PsiBlast_CBE
41.49
38%
-81
- C1 -
1U4D
1
ACK1_HUMAN
B:
[17-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
L
E
--
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
G
K
T
V
S
-
V
A
V
K
C
L
-------------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
---
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
------
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
D
H
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
--------
W
I
G
L
N
G
S
Q
--------
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
---------------------------------
Add PDB User Result:
(19 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
136
-
100%
-105
- C1 -
U136
1
A:
[813-1095]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
---
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
--
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
C
E
R
D
V
P
A
L
C
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
-----------------------------
137
-
100%
-105
- C1 -
U137
1
A:
[813-1095]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
---
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
--
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
C
E
R
D
V
P
A
L
C
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
-----------------------------
138
-
100%
-105
- C1 -
U138
1
A:
[813-1095]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
---
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
--
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
C
E
R
D
V
P
A
L
C
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
-----------------------------
139
-
100%
-105
- C1 -
U139
1
A:
[813-1095]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
---
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
R
L
--
S
R
L
L
L
Y
S
S
Q
I
C
K
G
M
E
Y
L
G
S
R
R
C
V
H
R
D
L
A
A
R
N
I
L
V
E
S
E
A
H
V
K
I
A
D
F
G
L
A
K
L
L
P
L
D
K
D
Y
Y
V
V
R
E
P
G
Q
S
P
I
F
W
Y
A
P
E
S
L
S
D
N
I
F
S
R
Q
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
C
D
K
S
C
S
P
S
A
E
F
L
R
M
M
G
C
E
R
D
V
P
A
L
C
R
L
L
E
L
L
E
E
G
Q
R
L
P
A
P
P
A
C
P
A
E
V
H
E
L
M
K
L
C
W
A
P
S
P
Q
D
R
P
S
F
S
A
L
G
P
Q
L
-----------------------------
140
-
100%
-105
- C1 -
U140
1
A:
[813-1095]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
I
F
E
E
R
H
L
K
Y
I
S
Q
L
G
K
G
N
F
G
S
V
E
L
C
R
Y
D
P
L
G
D
N
T
G
A
L
V
A
V
K
Q
L
Q
H
S
G
P
D
Q
Q
R
D
F
Q
R
E
I
Q
I
L
K
A
L
H
S
D
F
I
V
K
Y
R
G
V
S
Y
G
---
Q
S
L
R
L
V
M
E
Y
L
P
S
G
C
L
R
D
F
L
Q
R
H
R
A
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A
L
G
P
Q
L
-----------------------------
141
-
100%
-101
- C1 -
U141
1
A:
[815-1103]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
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L
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S
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---------------------
142
-
100%
-111
- C1 -
U142
1
A:
[813-1095]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
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A
L
G
P
Q
L
-----------------------------
143
-
100%
-107
- C1 -
U143
1
A:
[814-1098]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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--------------------------
144
-
100%
-101
- C1 -
U144
1
A:
[815-1103]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
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L
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S
R
---------------------
145
-
100%
-107
- C1 -
U145
1
A:
[814-1098]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
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--------------------------
146
-
100%
-107
- C1 -
U146
1
A:
[815-1101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
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-----------------------
147
-
100%
-101
- C1 -
U147
1
A:
[815-1103]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
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S
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---------------------
148
-
100%
-111
- C1 -
U148
1
A:
[813-1095]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
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A
L
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Q
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-----------------------------
149
-
100%
-105
- C1 -
U149
1
A:
[815-1101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
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D
F
G
L
A
K
L
L
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L
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K
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Y
Y
V
V
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P
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A
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L
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V
L
Y
E
L
F
T
Y
C
D
K
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C
S
P
S
A
E
F
L
R
M
M
-----
V
P
A
L
C
R
L
L
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L
L
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G
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L
P
A
P
P
A
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P
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D
R
P
S
F
S
A
L
G
P
Q
L
D
M
L
W
S
G
-----------------------
150
-
100%
-109
- C1 -
U150
1
A:
[812-1101]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
P
T
I
F
E
E
R
H
L
K
Y
I
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Q
L
G
K
G
N
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D
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---
G
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--
L
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A
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F
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-----------------
G
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L
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V
V
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F
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Y
C
D
K
S
C
--------------
D
V
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A
L
C
R
L
L
E
L
L
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A
L
G
P
Q
L
D
M
L
W
S
G
-----------------------
151
-
100%
-107
- C1 -
U151
1
A:
[815-1101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
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R
H
L
K
Y
I
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------
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A
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F
L
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M
M
-----
V
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A
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L
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A
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P
Q
L
D
M
L
W
S
G
-----------------------
152
-
100%
-101
- C1 -
U152
1
A:
[815-1103]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
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R
H
L
K
Y
I
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L
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F
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--
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F
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A
L
G
P
Q
L
D
M
L
W
S
G
S
R
---------------------
153
-
100%
-101
- C1 -
U153
1
A:
[815-1103]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
F
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R
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L
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Y
I
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L
G
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G
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F
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A
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--
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L
W
S
G
S
R
---------------------
154
-
100%
-105
- C1 -
U154
1
D:
[814-1098]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
F
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E
R
H
L
K
Y
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G
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A
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P
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L
D
M
L
--------------------------