@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC1A_HUMAN: (2013-07-21 )
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGTELSPTLPHQL
Atome Classification :
(92 SA)
.........10........20........30........40--.........50------...-....--..--60.----.-----.......70...-.....80........90........100.......110.......120.......130.-......140.......150...---....160....-..-.170........180.......190----..---.......200.......210.......220.-.......230.......240.......250.......260....-----.-----..270.....-.-.280.-----.----.....-..290-.......-.300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDK---RTQKLVAIKC-------IAK-EALE--GK--E-G----S-----MENEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH-DLGIVHRDLKPENLLYYSLDED---SKIMISDFGLS-KM-ED-PGSVLSTACGTPGYVAPEVL------AQ---KPYSKAVDCWSIGVIAYILLCGYPPFYD-EN-DAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFT-----C-----EQALQHPWIA-G-DT--A-----L----DKNIH-QSVS--EQIKKNF-AKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGTELSPTLPHQL
4
PsiBlast_PDB
87.71
100%
-145
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-299]
---------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
-------
I
A
K
-
E
------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
---
S
K
I
M
I
S
D
F
--------------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
--
A
-----
L
----
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
-----------------------------------------------------------------------
2
PsiBlast_PDB
86.49
100%
-129
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-314]
---------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
-------
I
A
K
-
E
-----------------------
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
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V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
---
S
K
I
M
I
S
D
F
---------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
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D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
--
A
-----
L
----
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------
6
PsiBlast_PDB
86.46
84%
-136
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[15-314]
----------
K
Q
A
E
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
---
A
T
G
K
L
F
A
V
K
C
-------
I
P
K
-
K
A
----------
S
----
S
-----
I
E
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
-
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
E
E
---
S
K
I
M
I
S
-----------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
-----
C
-----
E
Q
A
A
R
H
P
W
I
A
-
G
-
D
T
--
A
-----
L
----
N
K
N
I
H
-
E
S
V
S
--
A
Q
I
R
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
A
T
------------------------------------------------------------
23
PsiBlast_CBE
86.25
84%
-137
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[15-314]
----------
K
Q
A
E
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
---
A
T
G
K
L
F
A
V
K
C
-------
I
P
K
-
K
A
---------------
S
-----
I
E
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
-
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
E
E
---
S
K
I
M
I
S
-----------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
-----
C
-----
E
Q
A
A
R
H
P
W
I
A
-
G
-
D
T
--
A
-----
L
----
N
K
N
I
H
-
E
S
V
S
--
A
Q
I
R
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
A
T
------------------------------------------------------------
115
HHSearch
85.93
100%
-147
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-277]
--------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
-------
I
A
-------------------
S
-----
M
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
---
S
K
I
M
I
S
D
F
G
L
S
-
K
M
-
E
D
-
P
G
--------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A
--------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.58
100%
-133
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-314]
-------------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
-------
I
A
K
---------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
---
S
K
I
M
I
S
D
F
-------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
--
A
-----
L
----
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------
22
PsiBlast_CBE
81.64
100%
-140
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-299]
-------------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
-------
I
A
K
--------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
---
S
K
I
M
I
S
D
F
G
----------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
-
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
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E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A
-
G
-
D
T
--
A
-----
L
----
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
-
A
-----------------------------------------------------------------------
125
HHSearch
73.72
71%
-125
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
--------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
-------
I
K
K
-
S
----------------
S
-----
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
---
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
-
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
-
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
D
-
G
-
N
T
--
A
-----
L
----
H
R
D
I
Y
-
P
S
V
S
--
L
Q
I
Q
K
N
F
-
A
K
S
---------------------------------------------------------------------
24
PsiBlast_CBE
73.35
70%
-123
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[4-289]
------------
T
T
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
-------
I
-
K
-
K
S
---------------
S
-----
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
---
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
-
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
-
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
D
-
G
-
N
T
--
A
-----
L
----
H
R
D
I
Y
-
P
S
V
S
--
L
Q
I
Q
K
N
F
-
A
K
----------------------------------------------------------------------
14
PsiBlast_PDB
65.33
41%
-122
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[2-301]
---------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
--
A
R
--
D
H
Q
----
K
-----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
---------------
S
M
M
H
R
Q
E
T
V
--
D
C
L
K
K
F
N
-
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------
18
PsiBlast_PDB
63.78
41%
-112
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[2-293]
---------------
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
--
A
R
--
D
-
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
C
-
Q
-
R
S
--
T
-----
V
----
A
S
M
M
H
R
Q
E
T
V
--
E
C
L
K
K
F
N
-
A
R
R
K
L
K
------------------------------------------------------------------
134
HHSearch
63.49
39%
-113
- C1 -
3MWU
1
?
A:
[14-317]
---------
L
Y
F
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
-------
I
N
K
-
A
S
A
K
--
N
K
D-
T
-
S
----
T
-----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
---
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
-
Q
N
----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
----
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
Q
-
K
-
Y
S
--
S
E
T
P
T
I
S
----
D
L
P
S
L
-
E
S
A
M
--
T
N
I
R
Q
F
Q
-
A
E
K
K
L
A
Q
A
A
L
--------------------------------------------------------------
79
PsiBlast_CBE
62.59
37%
-111
* C1 *
2YAA
1
DAPK2_MOUSE
B:
[6-302]
-----------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
-------
I
K
K
R
Q
S
R
A
--
S
R
--
R
-
G
VC
R
E
E
-----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
T
--
Q
-----
Q
----
A
M
V
R
R
-
E
S
V
V
N
L
E
N
F
K
K
Q
Y
-
V
-----------------------------------------------------------------------
80
PsiBlast_CBE
62.03
37%
-113
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[6-302]
-----------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
-------
I
K
K
R
Q
S
R
A
--
S
R
--
R
-
G
VC
R
E
E
-----
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
T
--
Q
-----
Q
----
A
M
V
R
R
-
E
S
V
V
N
L
E
N
F
K
K
Q
Y
-
V
-----------------------------------------------------------------------
11
PsiBlast_PDB
61.77
41%
-109
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[31-321]
-----------------
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
---
T
P
T
Q
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
--
A
R
--
D
-
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
-
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
-
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
D
Q
A
L
K
H
P
W
V
C
-
Q
-
R
S
--
T
-----
V
----
A
S
M
M
H
R
Q
E
T
V
--
E
C
L
R
K
F
N
-
A
R
R
K
L
K
G
-----------------------------------------------------------------
29
PsiBlast_CBE
61.02
41%
-112
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-293]
---------------
M
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
--
A
R
--
D
-
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
C
-
Q
-
R
S
--
T
-----
V
----
A
S
M
M
H
R
Q
E
T
V
--
E
C
L
K
K
F
N
-
A
R
R
K
L
K
------------------------------------------------------------------
60
PsiBlast_CBE
60.82
43%
-124
- C1 -
3IGO
8
?
A:
[24-280]
-------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
-------
I
N
K
-
A
S
A
K
--
N
K
----
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
---
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
-
Q
N
T
-------
T
A
Y
Y
I
A
P
E
V
L
-------
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
---------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.32
41%
-106
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[2-301]
---------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
--
A
R
--
D
-
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
S
--
T
-----
V
----
A
S
M
M
H
R
Q
E
T
V
--
D
C
L
K
K
F
N
-
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------
26
PsiBlast_CBE
59.78
41%
-105
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[2-301]
---------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
-------
I
N
T
-
K
K
L
S
--
A
R
--
D
-
H
----
Q
K----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
-
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
C
-
Q
-
R
S
--
T
-----
V
----
A
S
M
M
H
R
Q
E
T
V
--
D
C
L
K
K
F
N
-
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------
13
PsiBlast_PDB
59.74
44%
-135
- C1 -
3LIJ
1
?
A:
[35-295]
---------------
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
---
V
T
H
V
E
R
A
I
K
I
-------
I
R
K
--------
S
--
S
-
N
----
S
K
----
L
L
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
K
D
---
A
L
I
K
I
V
D
F
G
L
S
-
A
V
-
F
E
-
N
Q
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
---
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
-
Q
T
-
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
-----
Q
Q
A
L
E
H
P
W
I
---------------------------------------------------------------------------------------------------------------
123
HHSearch
58.52
38%
-128
- C1 -
4GV1
5
AKT1_HUMAN
A:
[9-270]
------------------
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
-------
L
K
K
-
E
V
I
V
--
A
K
DE
V
-
A
----
H
-----
T
L
T
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
K
D
---
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
I
K
-
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
------
E
D
---
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
-
Q
D
-
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
-----
K
E
I
M
Q
H
R
F
F
A
-
G
------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
58.45
40%
-123
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[3-275]
--------
V
F
R
Q
-
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.54
43%
-126
- C1 -
3HZT
9
?
A:
[3-264]
----------------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
---
L
T
G
A
E
R
A
I
K
I
-------
I
K
K
-
S
S
V
T
TT
S
N
--
S
-
G
----
A
-----
L
L
D
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
R
D
---
A
L
I
K
I
V
D
F
G
L
S
-
A
H
-
F
E
-
V
G
--------
T
A
Y
Y
I
A
P
E
V
L
-------
R
---
K
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
-
Q
T
-
D
Q
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
-----
E
E
A
L
N
H
P
W
I
V
--------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.25
43%
-129
- C1 -
3NCG
1
?
A:
[24-280]
-------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
-------
I
N
K
-
A
S
A
K
--
N
K
--
D
-
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
---
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
-
Q
N
T
-----
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
-
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
---------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.24
40%
-119
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[82-363]
-----
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
MEVTAER
L
S
P
-
E
Q
L
E
--
E
V
--
R
-
E
----
A
-----
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
N
---
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
-
L
E
-
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
---
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
-
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
---------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
57.10
40%
-117
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[4-274]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
57.02
41%
-120
- C1 -
2YIT
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------L---
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
96
PsiBlast_CBE
56.88
40%
-118
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[5-275]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VSRED
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VPK
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
56.67
41%
-120
- C1 -
4A9R
2
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
38
PsiBlast_CBE
56.30
41%
-123
- C1 -
4BDC
2
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
100
PsiBlast_CBE
56.23
40%
-117
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[4-274]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
------
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
56.05
41%
-119
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
19
PsiBlast_PDB
55.99
41%
-118
- C1 -
2YCR
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
92
PsiBlast_CBE
55.98
40%
-116
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[5-275]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
55.89
40%
-116
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[4-274]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
55.87
41%
-120
- C1 -
4BDK
4
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------A
L
--
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
101
PsiBlast_CBE
55.85
40%
-118
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[4-274]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.79
47%
-118
- C1 -
2W4O
1
KCC4_HUMAN
A:
[51-343]
---------------
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
---
G
T
Q
K
P
Y
A
L
K
V
-------
L
K
K
----------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
P
D
---
A
P
L
K
I
A
D
F
-------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
G
---
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
-----
F
Q
A
L
Q
H
P
W
V
T
-
G
-
K
A
--
A
-----------
N
F
V
H
-
M
D
T
A
--
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
-----------------------------------------------------------
43
PsiBlast_CBE
55.63
41%
-121
- C1 -
4A9S
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
32
PsiBlast_CBE
55.63
41%
-118
- C1 -
4BDI
6
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------A
L
--
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
62
PsiBlast_CBE
55.62
42%
-130
- C1 -
3HX4
3
?
A:
[50-309]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
---------D-
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
55.60
38%
-109
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[5-302]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
Q
Q
A
-----
L
----
S
R
K
A
S
-
A
V
N
M
--
E
K
F
K
K
F
A
-
A
R
----------------------------------------------------------------------
48
PsiBlast_CBE
55.47
41%
-121
- C1 -
2WTD
4
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
86
PsiBlast_CBE
55.41
40%
-121
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-363]
-----
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
M
EVTA
E
R
L
S
P
-
E
Q
L
E
--
E
V
--
R
-
E
----
A
-----
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
N
---
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
-
L
E
-
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
---
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
-
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
---------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
55.04
40%
-118
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[4-274]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
54.93
41%
-119
- C1 -
4BDG
2
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
94
PsiBlast_CBE
54.88
40%
-113
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[5-275]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
54.79
41%
-119
- C1 -
2YIR
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------L---
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
91
PsiBlast_CBE
54.76
40%
-116
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[5-275]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
54.72
40%
-137
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-275]
-------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
---------------------VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VPK
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-----------
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
54.70
41%
-120
- C1 -
2W0J
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
93
PsiBlast_CBE
54.60
40%
-115
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[5-275]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
54.51
41%
-124
- C1 -
4BDD
3
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
33
PsiBlast_CBE
54.48
41%
-126
- C1 -
4BDH
4
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
55
PsiBlast_CBE
54.29
41%
-120
- C1 -
2YCS
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
50
PsiBlast_CBE
54.29
41%
-122
- C1 -
2CN8
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
------
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
133
HHSearch
54.12
40%
-107
- C1 -
3NYV
1
?
A:
[20-322]
-----------
S
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
----
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
Q
-
T
-
Y
T
--
K
----------
D
V
P
S
L
-
D
N
A
I
--
L
N
I
R
Q
F
Q
-
G
T
Q
K
L
A
Q
A
A
L
L
-------------------------------------------------------------
31
PsiBlast_CBE
54.11
41%
-122
- C1 -
4BDJ
1
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
47
PsiBlast_CBE
54.08
41%
-118
- C1 -
2WTI
3
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
39
PsiBlast_CBE
53.92
41%
-123
- C1 -
4BDB
10
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------L---
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
72
PsiBlast_CBE
53.89
42%
-125
- C1 -
3SX9
1
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
53.86
41%
-121
- C1 -
4A9U
10
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------DP
A
L
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
89
PsiBlast_CBE
53.73
39%
-106
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[5-302]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
Q
Q
A
-----
L
----
S
R
K
A
S
-
A
V
N
M
--
E
K
F
K
K
F
A
-
A
R
----------------------------------------------------------------------
54
PsiBlast_CBE
53.69
41%
-118
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------------
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
68
PsiBlast_CBE
53.53
42%
-122
- C1 -
3UPX
1
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
53.46
40%
-115
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[82-363]
-----
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
MEVR---
L
S
P
-
E
Q
L
E
--
E
V
--
R
-
E
----
A
-----
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
N
---
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
-
L
E
-
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
---
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
-
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
---------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
53.43
41%
-111
- C1 -
4A9T
4
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
97
PsiBlast_CBE
53.37
40%
-114
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[4-274]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
-------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP--
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
53.24
41%
-122
- C1 -
4BDE
5
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------A
L
--
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
20
PsiBlast_PDB
53.21
41%
-112
- C1 -
2YCF
1
CHK2_HUMAN
A:
[8-294]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
40
PsiBlast_CBE
53.12
41%
-122
- C1 -
4BDA
8
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
95
PsiBlast_CBE
52.94
40%
-110
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[5-275]
-----------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
-------
I
K
K
-
R
R
T
K
--
S
S
--
R
-
R
----
G
VS
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
D
T
-
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
52.90
42%
-118
- C1 -
3MA6
1
?
A:
[32-295]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
--
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
Q
-
T
-
Y
T
---------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
52.88
41%
-119
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
71
PsiBlast_CBE
52.76
42%
-117
- C1 -
3SXF
3
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
T
D
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
52.59
41%
-118
- C1 -
2CN5
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
-
R
----------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
35
PsiBlast_CBE
52.45
41%
-120
- C1 -
4BDF
3
?
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
------------------
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
45
PsiBlast_CBE
52.42
41%
-112
- C1 -
2XM9
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
121
HHSearch
52.28
41%
-96
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-306]
-------------
T
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
---
L
A
G
Q
E
Y
A
A
M
I
-------
I
N
T
-
K
K
L
S
--
A
R
D
-
H
-
Q
----
K
-----
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
K
G
---
A
A
V
K
L
A
D
F
G
L
A
-
I
E
-
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
---
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
-
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
-----
A
-----
A
E
A
L
K
H
P
W
I
S
-
H
-
R
S
--
T
-----
V
----
A
S
C
M
H
R
Q
E
T
V
--
D
C
L
K
K
F
N
-
A
R
R
K
L
K
G
A
I
L
T
V
------------------------------------------------------------
67
PsiBlast_CBE
52.21
42%
-120
- C1 -
3UPZ
1
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
51.95
42%
-120
- C1 -
3T3V
2
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
51.74
41%
-118
- C1 -
2WTC
1
CHK2_HUMAN
A:
[14-300]
---------------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
-------
I
S
K
--------------P
A
L
-
N
-----
V
E
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
---
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
-
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
Q
---
D
E
--
D
-----
M
----
K
R
K
F
Q
-
D
L
L
S
--
E
E
------------------------------------------------------------------------------
136
HHSearch
51.56
38%
-114
- C1 -
3Q5I
1
?
A:
[28-342]
---------
R
K
K
E
G
K
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
---
N
G
H
S
E
K
A
I
K
V
-------
I
K
K
-------
K
F
--
H
-
E
----
E
-----
I
Y
N
E
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
S
L
---
L
N
I
K
I
V
D
F
G
L
S
-
S
F
-
F
S
-
K
D
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
------
K
----
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
-
Q
N
-
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
-----
E
E
A
L
N
S
R
W
I
K
-
K
-
Y
A
--
N
-----
N
INKS
D
Q
K
T
L
-
C
G
A
L
--
S
N
M
R
K
F
E
-
G
S
Q
K
L
A
Q
A
A
I
L
-------------------------------------------------------------
70
PsiBlast_CBE
51.27
42%
-121
- C1 -
3T3U
5
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
51.23
42%
-118
- C1 -
3V5T
1
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
51.13
42%
-119
- C1 -
3V51
1
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
50.18
42%
-118
- C1 -
3I7B
4
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
50.04
42%
-120
- C1 -
3V5P
1
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
49.77
42%
-118
- C1 -
3N51
3
?
A:
[26-285]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
49.65
42%
-124
- C1 -
3KU2
1
?
A:
[49-308]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
K
TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
49.38
42%
-117
- C1 -
3MA6
1
?
B:
[32-295]
-----------------
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
-
R
Q
V
K
--
Q
-TD
K
-
E
----
S
-----
L
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
---
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
-
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
Q
-
T
-
Y
T
---------------------------------------------------------------------------------------------------------
124
HHSearch
38.75
34%
-112
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-287]
-----------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
-------
L
K
K
-
A
T
L
K
--
V
R
D
-
R
-
V
---------------
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
E
---
G
H
I
K
L
T
D
F
G
L
S
-
K
------
E
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
---
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
-
K
D
-
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
----
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-----
A
GPD
G
V
E
E
I
K
R
H
S
F
F
S
-
T
------------------------------------------------------------------------------------------------------------