@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC1D_HUMAN: (2013-07-21 )
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK
Atome Classification :
(80 SA)
.........10........20........30........40..---......50........60--.--.-----.---.--....70........80........90........100.......110.......120.......130....-...140.......150....-..-.160.......-170........180.......190.---......200.......210.......220..-...-..230.......240.......250.......260.......-----270---.........-280..--..-----....290---....--..-...-300........310.......320.......330.......340.......350.......360.......370.......380...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEK---ATGKLFAVKCIPKKALKG--K--E-----S---S--IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLH-RMGIVHRDLKPENLLYYSQD-EE-SKIMISDFGLS-KM-EGKGDVMSTACGTPGYVAPEVL---AQKPYSKAVDCWSIGVIAYILLCGYPPFYDE-NDS-KLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYT-----C-----EQAARHPWI-AG-DT--AL-----NKNIH-----ESVS--AQ-IRK-NF-AKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK
4
PsiBlast_PDB
87.38
84%
-137
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[11-299]
-------------
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
-------------------
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
-
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
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D
S
A
K
D
F
I
R
H
L
M
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K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
-
A
G
-
D
T
--
A
L
-----
D
K
N
I
H
-----
Q
S
V
S
--
E
Q
-
I
K
K
-
N
F
-
A
-----------------------------------------------------------------------------------
116
HHSearch
86.21
82%
-139
* C1 *
4FG7
1
KCC1A_HUMAN
A:
[9-277]
----------
R
W
K
-
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
---------------------
S
--
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
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Y
L
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Q
L
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E
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Y
T
E
R
D
A
S
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F
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D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
G
L
S
-
K
M
-
E
D
P
G
--------
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
-
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
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D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
-
A
---------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.40
84%
-123
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[11-314]
-------------
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-----------------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
--------------------
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
-
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
-
A
G
-
D
T
--
A
L
-----
D
K
N
I
H
-----
Q
S
V
S
--
E
Q
-
I
K
K
-
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------------------
22
PsiBlast_CBE
83.93
84%
-134
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-299]
----------------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
G
---------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
-
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
-
A
G
-
D
T
--
A
L
-----
D
K
N
I
H
-----
Q
S
V
S
--
E
Q
-
I
K
K
-
N
F
-
A
-----------------------------------------------------------------------------------
21
PsiBlast_CBE
83.81
84%
-126
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-314]
----------------
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
-
S
K
I
M
I
S
D
F
------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
-
K
L
F
E
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I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
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A
K
D
F
I
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H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
-
A
G
-
D
T
--
A
L
-----
D
K
N
I
H
-----
Q
S
V
S
--
E
Q
-
I
K
K
-
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------------------
126
HHSearch
78.63
74%
-120
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
-----------------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-------------------
S
--
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
-
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
-
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
-
D
G
-
N
T
--
A
L
-----
H
R
D
I
Y
-----
P
S
V
S
--
L
Q
-
I
Q
K
-
N
F
-
A
K
S
---------------------------------------------------------------------------------
23
PsiBlast_CBE
77.81
74%
-118
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[4-289]
---------------
T
T
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
I
-
K
K
S
------------------
S
--
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
-
S
K
I
M
I
T
D
F
G
L
S
-
K
M
-
E
Q
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
-
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
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H
P
W
I
-
D
G
-
N
T
--
A
L
-----
H
R
D
I
Y
-----
P
S
V
S
--
L
Q
-
I
Q
K
-
N
F
-
A
K
----------------------------------------------------------------------------------
90
PsiBlast_CBE
65.69
39%
-116
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
65.38
39%
-112
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
65.04
35%
-106
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[6-302]
--------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
--
S
--
R
R
G
V
S
R
E
---
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
N
--
Q
Q
-----
A
M
V
R
R
-----
E
S
V
V
N
L
E
N
-
F
R
K
-
Q
Y
-
V
-----------------------------------------------------------------------------------
69
PsiBlast_CBE
64.87
39%
-115
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
64.58
35%
-109
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[6-302]
--------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
--
S
--
R
R
G
V
S
R
E
---
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
N
--
Q
Q
-----
A
M
V
R
R
-----
E
S
V
V
N
L
E
N
-
F
R
K
-
Q
Y
-
V
-----------------------------------------------------------------------------------
11
PsiBlast_PDB
64.51
41%
-114
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[6-301]
----------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
--
R
--
D
H
----
Q
---
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
-
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
-
C
Q
-
R
-----------
S
M
M
H
-----
R
Q
E
T
--
V
D
-
C
L
K
-
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------
62
PsiBlast_CBE
64.41
35%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[6-302]
--------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
--
S
--
R
RGVSR
E
---
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
N
--
Q
Q
-----
A
M
V
R
R
-----
E
S
V
V
NL
E
N
-
F
R
K
-
Q
Y
-
V
-----------------------------------------------------------------------------------
26
PsiBlast_CBE
64.13
41%
-106
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-286]
----------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
--
R
--
D
H----
Q
---
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
-
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
-
C
Q
-
R
S
--
T
V
-----
A
S
M
M
H
-----
R
Q
E
T
--
V
E
-
C
L
K
-
K
F
-------------------------------------------------------------------------------------
29
PsiBlast_CBE
64.02
35%
-104
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-302]
----------
T
F
K
Q
Q
K
--
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
--
S
--
R
RGVC
R
E
---
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
T
--
Q
Q
-----
A
M
V
R
R
-----
E
S
V
V
N
L
E
N
-
F
K
K
-
Q
Y
-
V
-----------------------------------------------------------------------------------
15
PsiBlast_PDB
63.82
41%
-99
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[33-321]
----------------------
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
---
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
--
R
--
D
H
----
Q
---
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
-
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
-
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
D
Q
A
L
K
H
P
W
V
-
C
Q
-
R
S
--
T
V
-----
A
S
M
M
H
-----
R
Q
E
T
--
V
E
C
L
R
K
-
F
N
-
A
R
R
K
L
K
G
-----------------------------------------------------------------------------
40
PsiBlast_CBE
63.69
36%
-101
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[5-302]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
K
P
K
-
D
T
Q
Q
A
L
-----
S
R
K
A
S
-----
A
V
N
M
--
E
K
-
F
K
K
-
F
A
-
A
R
----------------------------------------------------------------------------------
13
PsiBlast_PDB
63.42
41%
-105
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-286]
----------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
--
R
--
D
H
----
Q
---
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
-
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
-
C
Q
-
R
S
--
T
V
-----
A
S
M
M
H
-----
R
Q
E
T
--
V
E
-
C
L
K
-
K
F
-------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.41
41%
-97
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[6-301]
----------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
--
R
--
D
H
----
Q
---
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
-
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
-
C
Q
-
R
S
--
T
V
-----
A
S
M
M
H
-----
R
Q
E
T
--
V
D
-
C
L
K
-
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------
25
PsiBlast_CBE
63.27
41%
-96
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[6-301]
----------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
--
R
--
D
H----
Q
---
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
-
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
-
C
Q
-
R
S
--
T
V
-----
A
S
M
M
H
-----
R
Q
E
T
--
V
D
-
C
L
K
-
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------
16
PsiBlast_PDB
63.16
43%
-125
- C1 -
3LIJ
1
?
A:
[35-295]
------------------
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
---
V
T
H
V
E
R
A
I
K
I
I
R
K
----
S
--
S
--
N
-----
S
---
K
--
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
-
K
D
-
A
L
I
K
I
V
D
F
G
L
S
-
A
V
-
F
E
N
Q
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
----
R
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
-
T
D
Q
-
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
-----
Q
Q
A
L
E
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.86
35%
-107
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[4-302]
----------
T
F
K
Q
Q
K
--
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
--
S
--
R
RGVC
R
E
---
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
T
--
Q
Q
-----
A
M
V
R
R
-----
E
S
V
V
N
L
E
N
-
F
K
K
-
Q
Y
-
V
-----------------------------------------------------------------------------------
81
PsiBlast_CBE
62.76
39%
-106
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[4-274]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
62.58
35%
-107
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[6-302]
--------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
--
S
--
R
RGVSR
E
---
E
--
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
N
--
Q
Q
-----
A
M
V
R
R
-----
E
S
V
V
NL
E
N
-
F
R
K
-
Q
Y
-
V
-----------------------------------------------------------------------------------
85
PsiBlast_CBE
62.49
39%
-107
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVSR
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
62.27
39%
-112
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
62.16
39%
-106
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[4-274]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
62.09
39%
-104
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[4-274]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
61.83
39%
-109
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[4-274]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
61.69
39%
-107
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.47
41%
-96
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[13-303]
----------------------
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
---
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
S
A
--
R
--
D
H
----
Q
---
K
--
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
-
K
G
-
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
-
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
-----
A
-----
A
E
A
L
K
H
P
W
I
-
S
H
-
R
S
--
T
V
-----
A
S
C
M
H
-----
R
Q
E
T
--
V
D
-
C
L
K
-
K
F
N
A
R
R
K
L
K
G
A
I
---------------------------------------------------------------------------
79
PsiBlast_CBE
61.29
39%
-106
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[4-274]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
GVS
R
-
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
135
HHSearch
60.87
39%
-107
- C1 -
3MWU
1
?
A:
[14-316]
-----------
L
Y
F
Q
-
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K-
D
--
T
-----
S
---
T
--
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
-
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
Q
N
----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
---
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
-
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
-
Q
K
-
Y
S
--
S
E
T
P
T
IS
D
L
P
S
L
-----
E
S
A
M
--
T
N
-
I
R
Q
-
F
Q
-
A
E
K
K
L
A
Q
A
A
---------------------------------------------------------------------------
75
PsiBlast_CBE
60.58
39%
-104
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
60.44
39%
-102
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
60.34
39%
-106
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
60.31
39%
-128
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-275]
----------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
-------------VS
R
--
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
----------
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
60.10
39%
-105
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
60.01
38%
-99
- C1 -
3UPZ
1
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
-------------------------
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
83
PsiBlast_CBE
60.00
39%
-103
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[4-274]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
-------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
---
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
59.99
38%
-100
- C1 -
3SX9
1
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
-----------------------
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
74
PsiBlast_CBE
59.91
39%
-106
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
59.88
39%
-118
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-----------
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.75
43%
-121
- C1 -
3HZT
9
?
A:
[12-264]
----------------------------
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
---
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
T
--
T
--
S
-----
N
---
S
G
A
L
L
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
R
D
-
A
L
I
K
I
V
D
F
G
L
S
-
A
H
-
F
E
V
G
--------
T
A
Y
Y
I
A
P
E
V
L
----
R
K
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
-
T
D
Q
-
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
-----
E
E
A
L
N
H
P
W
I
-
V
---------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
59.67
38%
-99
- C1 -
3UPX
1
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
-------------------------
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
76
PsiBlast_CBE
59.58
39%
-103
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
59.43
39%
-102
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[5-275]
--------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
--
S
--
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.35
41%
-109
- C1 -
3IGO
8
?
A:
[30-315]
----------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
--
K
--------
T
---
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
-
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
Q
N
T
-------
T
A
Y
Y
I
A
P
E
V
L
----
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
-
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
-
Q
K
-
Y
S
--
S
E
-----
T
P
T
I
S
D
L
P
S
L
E
S
A
M
--
T
N
-
I
R
Q
-
F
Q
-
A
E
K
K
L
A
Q
A
----------------------------------------------------------------------------
124
HHSearch
59.20
39%
-123
- C1 -
4GV1
5
AKT1_HUMAN
A:
[9-270]
---------------------
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
--
K
--
D
E
V
---
A
---
H
--
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
-
K
D
-
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
---
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
-
D
H
E
-
K
L
F
E
L
I
L
M
E
E
I
R
F
----
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
-----
K
E
I
M
Q
H
R
F
F
-
A
G
--------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
58.66
41%
-114
- C1 -
3MA6
1
?
A:
[34-291]
----------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
-
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
58.61
38%
-98
- C1 -
3V5P
1
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
-------------------------
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
7
PsiBlast_PDB
58.39
46%
-109
- C1 -
2W4O
1
KCC4_HUMAN
A:
[51-343]
------------------
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
---
G
T
Q
K
P
Y
A
L
K
V
L
K
K
---------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
-
A
P
L
K
I
A
D
F
------------------
G
T
P
G
Y
C
A
P
E
I
L
---
R
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
-
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
-----
F
Q
A
L
Q
H
P
W
V
-
T
G
-
K
A
--
A
-------
N
F
V
H
-----
M
D
T
A
--
Q
K
-
K
L
Q
-
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
-----------------------------------------------------------------------
54
PsiBlast_CBE
58.26
38%
-97
- C1 -
3T3V
2
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
-----------------------
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
51
PsiBlast_CBE
58.21
38%
-96
- C1 -
3V51
1
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
-----------------------
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
134
HHSearch
58.16
38%
-103
- C1 -
3NYV
1
?
A:
[19-322]
-------------
H
S
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
KT
D
--
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
---
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
------
D
V
P
S
L
-----
D
N
A
I
--
L
N
-
I
R
Q
-
F
Q
-
G
T
Q
K
L
A
Q
A
A
L
L
-------------------------------------------------------------------------
137
HHSearch
58.03
39%
-110
- C1 -
3Q5I
1
?
A:
[29-341]
-------------
K
K
E
G
K
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
---
N
G
H
S
E
K
A
I
K
V
I
K
K
-----K-
F
--
H
-----
E
---
E
--
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
-
S
L
-
L
N
I
K
I
V
D
F
G
L
S
-
S
F
-
F
S
K
D
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
---
K
-
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
-
N
D
Q
-
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
-----
E
E
A
L
N
S
R
W
I
-
K
K
-
Y
A
--
N
N
INKS-
D
Q
K
T
L
-----
C
G
A
L
--
S
N
-
M
R
K
-
F
E
-
G
S
Q
K
L
A
Q
A
A
I
--------------------------------------------------------------------------
48
PsiBlast_CBE
57.73
38%
-108
- C1 -
3HX4
3
?
A:
[52-358]
----------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
--------D-
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
----------------
E
Q
I
S
--
V
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
49
PsiBlast_CBE
57.44
38%
-95
- C1 -
3V5T
1
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
-----------------------
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
88
PsiBlast_CBE
56.07
39%
-112
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[7-275]
----------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-----
R
RGVS
R
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
----------
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
55.46
39%
-118
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-275]
----------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
--------R----
E
---
D
--
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-V
P
K
-
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
------------
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
55.10
42%
-125
- C1 -
2YCR
1
CHK2_HUMAN
A:
[16-278]
--------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
55.01
41%
-113
- C1 -
3MA6
1
?
B:
[34-291]
----------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
---TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
54.76
41%
-112
- C1 -
3NCG
1
?
A:
[30-315]
----------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
--
K
--
D
-----
T
---
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
-
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
Q
N
T
-----
I
G
T
A
Y
Y
I
A
P
E
V
L
----
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
-
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
-
Q
K
-
Y
S
--
S
E
-----
T
P
T
I
S
D
L
P
S
L
E
S
A
M
--
T
N
-
I
R
Q
-
F
Q
-
A
E
K
K
L
A
Q
A
----------------------------------------------------------------------------
35
PsiBlast_CBE
54.58
42%
-125
- C1 -
2YIT
1
CHK2_HUMAN
A:
[16-278]
--------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------L--
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
54.46
38%
-90
- C1 -
3SXF
3
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
T
D
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
----------------
E
Q
I
S
--
V
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
55
PsiBlast_CBE
54.32
38%
-94
- C1 -
3T3U
5
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
----------------
E
Q
I
S
--
V
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
36
PsiBlast_CBE
54.15
42%
-124
- C1 -
2YIR
1
CHK2_HUMAN
A:
[16-278]
--------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------L--
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
53.86
42%
-122
- C1 -
2YCS
1
CHK2_HUMAN
A:
[16-278]
--------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
53.71
43%
-114
- C1 -
2WEI
1
?
A:
[30-280]
----------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
--
K
--
D
-----
T
---
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
-
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
Q
N
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
----
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
-
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
53.44
42%
-125
- C1 -
2W0J
1
CHK2_HUMAN
A:
[16-278]
--------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
53.04
38%
-92
- C1 -
3I7B
4
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
----------------
E
Q
I
S
--
V
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
44
PsiBlast_CBE
53.00
42%
-121
- C1 -
2CN5
1
CHK2_HUMAN
A:
[22-284]
--------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
R
-------------------
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
52.47
42%
-124
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[16-278]
--------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
52.37
42%
-123
- C1 -
4BDG
2
?
A:
[22-284]
--------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
52.08
42%
-115
- C1 -
2XM9
1
CHK2_HUMAN
A:
[22-284]
--------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------P
A
L
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
51.74
38%
-93
- C1 -
3N51
3
?
A:
[31-334]
-------------------------
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
K
TD
K
-----
E
---
S
--
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
-
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-
Q
T
-
Y
T
--
K
----------------
E
Q
I
S
--
V
D
-
V
P
S
L
D
N
-
A
I
L
N
I
R
Q
-
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
---------------------------------------------------
42
PsiBlast_CBE
51.59
42%
-116
- C1 -
4A9T
4
CHK2_HUMAN
A:
[22-284]
--------------------------
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------P
A
L
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
50.28
42%
-116
- C1 -
2YCF
1
CHK2_HUMAN
A:
[16-278]
--------------------------
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------
N
--
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
-
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------
125
HHSearch
41.64
33%
-108
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-287]
--------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
--
R
--
D
R
----
V
-----------
D
I
L
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
-
E
E
-
G
H
I
K
L
T
D
F
G
L
S
-
K
-----
E
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
---
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
-
D
R
K
-
E
T
M
T
M
I
L
K
A
K
L
G
----
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-----
A
GPD
G
V
E
E
I
K
R
H
S
F
F
-
S
T
--------------------------------------------------------------------------------------------------------------------------