@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC2A_HUMAN: (2013-07-21 )
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Atome Classification :
(61 SA)
.........10........20........30..---......40..--....---..-50..----..----.-...----.60.......-.70........80........90........100...----.----...110.......120.....-..130.......140....-...150.......160....-.....170..-.....180....------...-190.......200.......210....--...-------220.......230.......240.......250.......260----.-----.......270---....----.----...280.......---------290-....---.....300-----.........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKV---LAGQEYAAKI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVARE----Y----YSEADASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASK-LKGAAVKLADFGLA--IEVE-GEQQAWFGFA-GTPGYLSPEVLR------KDP-YGKPVDLWACGVILYILLVGYPPFWDE--DQH-------RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRIT-----A-----AEALKHPWI----SHRS----T----VASCMHRQETVDC---------L---KKFN---ARRKLK-------GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
138
HHSearch
84.65
100%
-102
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-444]
------
T
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
---
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
H
----
Q
-
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
L
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
E
V
E
-
G
E
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
-
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
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E
--
D
Q
H
-------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
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P
E
A
K
D
L
I
N
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M
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T
I
N
P
S
K
R
I
T
-----
A
-----
A
E
A
L
K
H
P
W
I
----
S
H
R
S
----
T
----
V
A
S
C
M
H
R
Q
E
T
V
D
C
---------
L
---
K
K
F
N
---
A
R
R
K
L
K
-------
G
A
I
L
T
V
M
L
A
T
R
N
F
S
------------------------------
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
S
----
5
PsiBlast_PDB
75.39
92%
-116
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[2-301]
--------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
H
----
Q
-
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
-
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
-------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
----
C
Q
R
S
----
T
----
V
A
S
M
M
H
R
Q
E
T
V
D
C
---------
L
---
K
K
F
N
---
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.66
90%
-118
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-293]
--------
M
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
H
----
Q
-
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
-
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
E
A
-
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
-------
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
----
C
Q
R
S
----
T
----
V
A
S
M
M
H
R
Q
E
T
V
E
C
---------
L
---
K
K
F
N
---
A
R
R
K
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.61
90%
-118
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[2-293]
--------
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
H
----
Q
-
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
-
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
E
A
-
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
-------
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
----
C
Q
R
S
----
T
----
V
A
S
M
M
H
R
Q
E
T
V
E
C
---------
L
---
K
K
F
N
---
A
R
R
K
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.48
90%
-125
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[2-308]
--------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
H
----
Q
-
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
-
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
-------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
----
C
Q
R
------------
S
M
M
H
R
Q
E
T
V
D
C
---------
L
---
K
K
F
N
---
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.15
89%
-112
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[25-321]
----
T
C
T
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
---
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
H
----
Q
-
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
-
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
-
G
E
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
-
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
-------
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
D
Q
A
L
K
H
P
W
V
----
C
Q
R
S
----
T
----
V
A
S
M
M
H
R
Q
E
T
V
E
C
---------
L
---
R
K
F
N
---
A
R
R
K
L
K
-------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.24
92%
-115
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[2-301]
--------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
H
----
Q
-
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
-
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--
D
Q
H
-------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
----
C
Q
R
S
----
T
----
V
A
S
M
M
H
R
Q
E
T
V
D
C
---------
L
---
K
K
F
N
---
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.91
46%
-107
- C1 -
3C0H
1
CSKP_HUMAN
A:
[22-318]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
T
----
E
-
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
-------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
---------
L
---
R
K
F
N
---
A
R
R
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
62.85
47%
-106
- C1 -
3MFS
1
CSKP_HUMAN
A:
[22-320]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
T
----
E
-
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
-------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
---------
L
---
R
K
F
N
---
A
R
R
K
L
K
-------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
62.53
40%
-122
- C1 -
3LIJ
1
?
A:
[35-335]
--------
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
---
V
T
H
V
E
R
A
I
K
I
--
I
R
K
----------
S
----
S
N
----
S
-
K
L
L
----
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
----
K
----
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
E
K
D
A
L
I
K
I
V
D
F
G
L
S
--
A
V
F
E
-
N
-
Q
K
K
M
K
E
R
L
-
G
T
A
Y
Y
I
A
P
E
V
L
R
------
K
-
K
-
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
--
T
D
Q
-------
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
-----
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
E
----
S
-------
L
P
S
L
A
N
A
I
E
N
---------
M
---
R
K
F
Q
---
N
S
Q
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.41
47%
-104
- C1 -
3MFU
1
CSKP_HUMAN
A:
[22-320]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
T
----
E
-
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
-------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
---------
L
---
R
K
F
N
---
A
R
R
K
L
K
-------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.36
47%
-103
- C1 -
3MFR
1
CSKP_HUMAN
A:
[22-320]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
T
----
E
-
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
-------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
---------
L
---
R
K
F
N
---
A
R
R
K
L
K
-------
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
HHSearch
62.15
46%
-103
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-317]
------
V
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
T
----
E
-
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
----
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
--
K
-
E
-------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
---------
L
---
R
K
F
N
---
A
R
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
61.55
46%
-107
- C1 -
3C0H
1
CSKP_HUMAN
B:
[22-318]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
T
----
E
-
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
DAGF
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
-------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
---------
L
---
R
K
F
N
---
A
R
R
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
61.25
40%
-114
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-289]
--------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
---
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
-
S
-
A
E
----
E
V
----
Q
-
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
N
---
I
K
L
T
D
F
G
F
S
--
C
Q
L
D
P
G
E
K
L
R
--
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D-
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
--
K
Q
M
-------
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
-----
E
E
A
L
A
H
P
F
F
----
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
61.22
40%
-115
- C1 -
1QL6
1
PHKG1_RABIT
A:
[15-289]
--------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
---
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
-
S
-
A
E
----
E
V
----
Q
-
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
N
---
I
K
L
T
D
F
G
F
S
--
C
Q
L
D
P
G
E
K
L
R
--
S
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
-
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
--
K
Q
M
-------
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
-----
E
E
A
L
A
H
P
F
F
----
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
60.37
40%
-116
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[92-363]
--------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
---
R
L
-
S
-
P
E
----
Q
L
----
E
-
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
----
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
Q
---
I
R
L
S
D
F
G
F
S
--
C
H
L
E
P
G
E
K
L
R
--
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
ET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
-------
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
60.26
40%
-116
- C1 -
2PHK
2
PHKG1_RABIT
A:
[2-276]
--------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
---
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
-
S
-
A
E
----
E
V
----
Q
-
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
N
---
I
K
L
T
D
F
G
F
S
--
C
Q
L
D
P
G
E
K
L
R
--
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D-
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
--
K
Q
M
-------
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
-----
E
E
A
L
A
H
P
F
F
----
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
60.21
43%
-119
* C1 *
4FG7
1
KCC1A_HUMAN
A:
[13-277]
-----
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
--
I
A
------------------------
S
M
E
----
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
S
K
I
M
I
S
D
F
G
L
S
--
K
M
E
D
-
P
----------
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
-------
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
59.72
40%
-114
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[92-363]
--------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
---
R
L
-
S
-
P
E
----
Q
L
----
E
-
E
V
R
EATR
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
----
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
Q
---
I
R
L
S
D
F
G
F
S
--
C
H
L
E
P
G
E
K
L
R
--
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
-------
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
59.69
39%
-114
- C1 -
3UPX
1
?
A:
[24-324]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
K
----
E
-
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
--------------
T
Y
T
K
------
V
PSL
D
N
A
I
L
N
I
---
R
Q
F
Q
---
G
T
Q
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
59.60
46%
-103
- C1 -
3C0G
1
CSKP_HUMAN
A:
[22-326]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
T
----
E
-
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
-------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
---------
L
---
R
K
F
N
---
A
R
R
K
L
K
---------
V
L
A
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
PsiBlast_CBE
58.76
36%
-125
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[13-276]
------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
--
I
-------------V---
S
R
----
E
-
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
58.25
40%
-116
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[92-363]
--------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
ME
V
------
R
L
-
S
-
P
E
----
Q
L
----
E
-
E
V
R
EATR
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
----
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
Q
---
I
R
L
S
D
F
G
F
S
--
C
H
L
E
P
G
E
K
L
R
--
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
-------
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
58.01
37%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[14-302]
------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
R
R
G
V
S
R
----
E
-
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
--
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
N
-----
Q
Q
A
M
V
R
R
E
S
V
V
N
---------
L
---
E
N
F
R
K
Q
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
58.01
46%
-103
- C1 -
3C0G
1
CSKP_HUMAN
B:
[22-326]
--------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
T
----
E
-
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
-
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
---
K
E
-------
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
---------
L
---
R
K
F
N
---
A
R
R
K
L
K
-------
G
A
V
L
A
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
57.99
42%
-116
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[20-299]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
-----------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
S
K
I
M
I
S
D
F
----------------------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
-------
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
G
D
T
----
A
----
L
D
K
N
I
H
-
Q
S
V
S
E
Q
---------
I
---
K
K
N
F
---
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
57.69
39%
-110
- C1 -
3UPZ
1
?
A:
[24-324]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
K
----
E
-
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
--------------
T
Y
T
K
------
V
PSL
D
N
A
I
L
N
I
---
R
Q
F
Q
---
G
T
Q
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
57.31
39%
-109
- C1 -
3HZT
9
?
A:
[3-317]
---------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
---
L
T
G
A
E
R
A
I
K
I
--
I
K
K
S
---
S
V
-
T
-
T
T
----
S
N
----
S
G
A
L
L
----
D
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
----
K
----
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
R
D
A
L
I
K
I
V
D
F
G
L
S
AH
F
E
V
G
-------------
T
A
Y
Y
I
A
P
E
V
L
R
------
K
-
K
-
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
--
T
D
Q
-------
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
-----
E
E
A
L
N
H
P
W
I
V
K
F
C
S
Q
------------
V
G
K
H
A
L
T
G
A
L
G
N
---------
M
---
K
K
F
Q
---
S
S
Q
K
L
A
Q
A
A
M
L
F
M
G
S
K
L
T
T
L
E
E
T
K
E
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
PsiBlast_CBE
56.75
36%
-124
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[13-276]
------------
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
-
S
R
RGV-
S
R
----
E
-
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
----------------
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
56.54
37%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[14-302]
------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
R
R
G
V
S
R
----
E
-
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
--
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
N
-----
Q
Q
A
M
V
R
R
E
S
V
V
N
---------
L
---
E
N
F
R
K
Q
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
56.48
39%
-110
- C1 -
3V5P
1
?
A:
[24-324]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
K
----
E
-
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
--------------
T
Y
T
K
------
V
PSL
D
N
A
I
L
N
I
---
R
Q
F
Q
---
G
T
Q
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
PsiBlast_CBE
56.16
36%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[13-276]
------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
R
RGV-
S
R
----
E
-
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
56.00
39%
-106
- C1 -
3I7B
4
?
A:
[24-324]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
K
----
E
-
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
--------------
T
Y
T
K
E
Q
I
S
V
D
V
PSL
D
N
A
I
L
N
I
---
R
Q
F
Q
---
G
T
Q
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
55.94
39%
-107
- C1 -
3T3U
5
?
A:
[24-324]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
K
----
E
-
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
--------------
T
Y
T
K
E
Q
I
S
V
D
V
PSL
D
N
A
I
L
N
I
---
R
Q
F
Q
---
G
T
Q
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
PsiBlast_CBE
55.90
37%
-114
- C1 -
3KN5
1
B:
[19-282]
------------------
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
---
K
S
N
Q
A
F
A
V
K
I
--
I
-
S
K
---
R
M
-
E
-
A
-----
N
T
----
Q
-
K
E
I
----
T
A
L
K
L
C
E
--
G
-
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
K
----
H
----
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
-
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-----
L
E
I
K
I
I
D
F
G
F
A
--
R
L
K
P
-
P
-----------------------------
N
G
-
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
H
--
D
R
S
LTCTS
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
-----
S
G
L
R
Y
N
E
W
L
----
Q
D
G
S
----
Q
----
L
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
HHSearch
55.57
40%
-102
- C1 -
3MWU
1
?
A:
[19-323]
-------
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
-
K
-
N
K
----
D
T
----
S
-
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
-
Q
N
-----
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
R
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
--
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
----
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
---------
I
---
R
Q
F
Q
---
A
E
K
K
L
A
-------
Q
A
A
L
L
Y
M
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
55.56
37%
-105
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[14-302]
------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
RRGV
S
R
----
E
-
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
--
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
N
-----
Q
Q
A
M
V
R
R
E
S
V
V
N
---------
L
---
E
N
F
R
KQY
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
55.53
39%
-121
- C1 -
3HX4
3
?
A:
[48-348]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
---------------
D
K
----
E
-
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
-------
G
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
--------------
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
---
R
Q
F
Q
---
G
T
Q
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
55.14
37%
-106
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-302]
--
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
----
R
R
GVC
R
E
-
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
-
D
G
V
E
-
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
T
----
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
-------
F
---
K
K
Q
Y
---
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
55.11
37%
-107
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[3-302]
-
E
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
----
R
R
GVC
R
E
-
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
-
D
G
V
E
-
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
T
----
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
-------
F
---
K
K
Q
Y
---
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
55.09
37%
-105
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[14-302]
------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
RRGV
S
R
----
E
-
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
--
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
N
-----
Q
Q
A
M
V
R
R
E
S
V
V
N
---------
L
---
E
N
F
R
KQY
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
HHSearch
54.96
39%
-104
- C1 -
3NYV
1
?
A:
[21-325]
-----
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
Q
K
T
----
D
K
----
E
-
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
A
S
K
-
K
M
K
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
T
Y
T
----
K
------
D
V
P
S
L
D
N
A
I
L
N
---------
I
---
R
Q
F
Q
---
G
T
Q
K
L
A
-------
Q
A
A
L
L
Y
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
54.89
39%
-106
- C1 -
3N51
3
?
A:
[24-324]
--------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
K
----
E
-
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
--------------
T
Y
T
K
E
Q
I
S
V
D
V
P
SL
D
N
A
I
L
N
I
---
R
Q
F
Q
---
G
T
Q
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
54.53
42%
-112
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[20-299]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
------------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
S
K
I
M
I
S
D
F
G
-----------
G
S
V
L
S
T
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
-------
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
G
D
T
----
A
----
L
D
K
N
I
H
-
Q
S
V
S
E
Q
---------
I
---
K
K
N
F
---
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
54.40
39%
-103
- C1 -
3IGO
8
?
A:
[20-320]
--------
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
-
K
-
N
K
-----
T
----
S
-
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
--
Q
N
T
--------
T
A
Y
Y
I
A
P
E
V
L
R
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
--
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
S
E
T
P
T
----
I
S
D
L
P
S
L
E
S
A
M
T
N
---------
I
---
R
Q
F
Q
---
A
E
K
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
PsiBlast_CBE
54.30
36%
-119
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[13-276]
------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
----------
R
----
E
-
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-----------------
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
53.79
39%
-102
- C1 -
3NCG
1
?
A:
[20-320]
--------
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
-
K
-
N
K
----
D
T
----
S
-
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
--
Q
N
T
-----
I
-
G
T
A
Y
Y
I
A
P
E
V
L
R
------
G
-
T
-
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
--
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
S
E
T
P
T
----
I
S
D
L
P
S
L
E
S
A
M
T
N
---------
I
---
R
Q
F
Q
---
A
E
K
K
L
A
-------
Q
A
A
L
L
Y
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
53.64
42%
-106
- C1 -
2W4O
1
KCC4_HUMAN
A:
[51-346]
--------
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
---
G
T
Q
K
P
Y
A
L
K
V
--
L
K
--------
K
------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
----
Y
----
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
-
A
P
D
A
P
L
K
I
A
D
F
---------------------
G
T
P
G
Y
C
A
P
E
I
L
R
------
G
C
A
-
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
RG
D
Q
F
--------
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
-----
F
Q
A
L
Q
H
P
W
V
----
T
G
K
A
----------
A
N
F
V
H
M
D
T
A
Q
K
K
---------
L
---
Q
E
F
N
---
A
R
R
K
L
K
-------
A
A
V
K
A
V
V
A
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
PsiBlast_CBE
53.62
37%
-116
- C1 -
3KN5
1
KS6A5_HUMAN
A:
[19-282]
------------------
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
---
K
S
N
Q
A
F
A
V
K
I
--
I
-
S
K
---
R
M
-
E
-
A
-----
N
T
----
Q
-
K
E
I
----
T
A
L
K
L
C
E
--
G
-
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
K
----
H
----
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
-
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-----
L
E
I
K
I
I
D
F
G
F
A
--
R
L
K
P
-
P
-----------------------------
N
G
-
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
-------CTS
A
V
--
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
-----
S
G
L
R
Y
N
E
W
L
----
Q
D
G
S
----
Q
----
L
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
PsiBlast_CBE
53.05
34%
-106
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[13-293]
------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
-
S
R
RGV-
S
R
----
E
-
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
HK
I
D
F
G
-
N
E
F
K
N
I
F
G
----
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
P
K
D
----
T
----
Q
Q
A
L
S
R
K
A
S
A
V
N
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
PsiBlast_CBE
52.79
35%
-103
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[13-302]
------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
-
S
R
RGV-
S
R
----
E
-
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
HK
I
D
F
G
-
N
E
F
K
N
I
F
G
----
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
P
K
D
----
T
----
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
-------
F
---
K
K
F
A
---
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
52.70
42%
-107
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[20-313]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
------------------------
E
----
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
S
K
I
M
I
S
D
F
-----------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
-------
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
G
D
T
----
A
----
L
D
K
N
I
H
-
Q
S
V
S
E
Q
---------
I
---
K
K
N
F
---
A
K
S
K
W
K
-------
Q
A
F
N
A
T
A
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
HHSearch
52.45
33%
-112
- C1 -
4GV1
5
AKT1_HUMAN
A:
[7-270]
---------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
--
L
K
K
E
---
V
I
-
V
-
A
K
D---
E
V
----
A
-
H
T
L
----
T
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
----
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
----
D
G
H
I
K
I
T
D
F
G
L
C
--
K
E
G
I
-
K
D
G
A
T
M
K
T
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
--
D
H
E
-------
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
-----
K
E
I
M
Q
H
R
F
F
----
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
51.05
41%
-100
- C1 -
2WEI
1
?
A:
[20-285]
--------
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
-
K
-
N
K
----
D
T
----
S
-
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
--
Q
N
T
K
M
K
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
R
-------
G
T
-
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
--
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
50.80
42%
-107
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[20-313]
------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
-------------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
S
K
I
M
I
S
D
F
--------------
V
L
S
T
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
--
N
D
A
-------
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
G
D
T
----
A
----
L
D
K
N
I
H
-
Q
S
V
S
E
Q
---------
I
---
K
K
N
F
---
A
K
S
K
W
K
-------
Q
A
F
N
A
T
A
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
50.80
42%
-96
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
-------
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
--
I
--
K
---
K
S
-----------------
S
L
E
----
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
E
N
S
K
I
M
I
T
D
F
G
L
S
-----
K
-
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
--
T
E
S
-------
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
----
D
G
N
T
----
A
----
L
H
R
D
I
Y
P
S
V
S
L
Q
I
---------
Q
---
K
N
F
----
A
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
50.40
42%
-97
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[4-289]
-----
T
T
N
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
--
I
--
K
---
K
S
-----------------
S
L
E
----
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
E
N
S
K
I
M
I
T
D
F
G
L
S
-----
K
-
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
K
P
-
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
--
T
E
S
-------
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
----
D
G
N
T
----
A
----
L
H
R
D
I
Y
P
S
V
S
L
Q
I
---------
Q
---
K
N
F
----
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
PsiBlast_CBE
49.38
34%
-101
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[13-293]
------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
-
S
R
RGV-
S
R
----
E
-
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
HK
I
D
F
G
-
N
E
F
K
N
I
F
G
----
T
P
A
F
V
A
P
E
I
V
N
------
Y
E
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
P
K
D
----
T
----
Q
Q
A
L
S
R
K
A
S
A
V
N
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
PsiBlast_CBE
47.39
32%
-90
- C1 -
3Q5I
1
?
A:
[33-376]
-------
K
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
---
N
G
H
S
E
K
A
I
K
V
--
I
K
K
----------
K
----
F
H
----
E
-
E
I
Y
----
N
E
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
----
K
----
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
-
N
S
L
L
N
I
K
I
V
D
F
G
L
S
--
S
F
F
S
-
K
D
Y
K
L
R
-
D
R
L
-
G
T
A
Y
Y
I
A
P
E
V
L
K
------
K
-
K
-
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
--
N
D
Q
-------
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
-----
E
E
A
L
N
S
R
W
I
----
K
K
Y
A
----
N
----
N
I
N
K
S
D
Q
K
T
L
C
G
A
---------
L
S
N
M
R
K
F
E
---
G
S
Q
K
L
A
Q
A
A
I
L
F
I
G
S
K
L
T
T
L
E
E
R
K
E
L
T
D
I
F
K
K
L
D
K
N
G
D
G
Q
L
D
K
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------
147
HHSearch
42.42
33%
-101
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-287]
----------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
--
L
K
K
A
---
T
L
-
K
-
V
R
----
D
R
----
V
-----------
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
----
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
----
G
H
I
K
L
T
D
F
G
L
S
--
K
------
E
K
K
A
Y
S
F
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
------
R
R
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
--
D
R
K
-------
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-----
A
GPD
G
V
E
E
I
K
R
H
S
F
F
----
S
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------