@TOME V2.3
(Nov 2016)

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3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : KCC2A_HUMAN: (2013-07-21 )
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH

Atome Classification :

(61 SA) .........10........20........30..---......40..--....---..-50..----..----.-...----.60.......-.70........80........90........100...----.----...110.......120.....-..130.......140....-...150.......160....-.....170..-.....180....------...-190.......200.......210....--...-------220.......230.......240.......250.......260----.-----.......270---....----.----...280.......---------290-....---.....300-----.........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470......
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MATITCTRFTEEYQLFEELGKGAFSVVRRCVKV---LAGQEYAAKI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVARE----Y----YSEADASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASK-LKGAAVKLADFGLA--IEVE-GEQQAWFGFA-GTPGYLSPEVLR------KDP-YGKPVDLWACGVILYILLVGYPPFWDE--DQH-------RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRIT-----A-----AEALKHPWI----SHRS----T----VASCMHRQETVDC---------L---KKFN---ARRKLK-------GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
138 HHSearch 84.65100%-102 - C1 -3SOA KCC2A_HUMAN A:[7-444] ------TRFTEEYQLFEELGKG--SVVRRCVKV---LAGQEYAAMI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVARE----Y----YSEADASHCIQQILEAVLHCH-QMGVVHRNLKPENLLLASK-LKGAAVKLADFGLA--IEVE-GEQQAWFGFA-GTPGYLSPEVLR------KDP-YGKPVDLWACGVILYILLVGYPPFWDE--DQH-------RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRIT-----A-----AEALKHPWI----SHRS----T----VASCMHRQETVDC---------L---KKFN---ARRKLK-------GAILTVMLATRNFS------------------------------VRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPS----
5 PsiBlast_PDB 75.3992%-116 - C1 -2VN9 KCC2D_HUMAN A:[2-301] --------MTDEYQLFEELGKGAFSVVRRCMKI---PTGQEYAAKI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----Y----YSEADASHCIQQILESVNHCH-LNGIVHRDLKPENLLLASK-SKGAAVKLADFGLA--IEVQ-GDQQAWFGFA-GTPGYLSPEVLR------KDP-YGKPVDMWACGVILYILLVGYPPFWDE--DQH-------RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRIT-----A-----SEALKHPWI----CQRS----T----VASMMHRQETVDC---------L---KKFN---ARRKLK-------GAILTTML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23 PsiBlast_CBE 73.6690%-118 - C1 -3BHH KCC2B_HUMAN B:[2-293] --------MTDEYQLYEDIGK---SVVRRCVKL---CTGHEYAAKI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----Y----YSEADASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASK-CKGAAVKLADFGLA--IEVQ-GDQQAWFGFA-GTPGYLSPEVLR------KEA-YGKPVDIWACGVILYILLVGYPPFWDE--DQH-------KLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRIT-----A-----HEALKHPWV----CQRS----T----VASMMHRQETVEC---------L---KKFN---ARRKLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 73.6190%-118 - C1 -3BHH KCC2B_HUMAN A:[2-293] --------MTDEYQLYEDIG----SVVRRCVKL---CTGHEYAAKI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----Y----YSEADASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASK-CKGAAVKLADFGLA--IEVQ-GDQQAWFGFA-GTPGYLSPEVLR------KEA-YGKPVDIWACGVILYILLVGYPPFWDE--DQH-------KLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRIT-----A-----HEALKHPWV----CQRS----T----VASMMHRQETVEC---------L---KKFN---ARRKLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2 PsiBlast_PDB 73.4890%-125 - C1 -2WEL KCC2D_HUMAN A:[2-308] --------MTDEYQLFEELGKGAFSVVRRCMKI---PTGQEYAAKI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----Y----YSEADASHCIQQILESVNHCH-LNGIVHRDLKPENLLLASK-SKGAAVKLADFGLA--IEVQ-GDQQAWFGFA-GTPGYLSPEVLR------KDP-YGKPVDMWACGVILYILLVGYPPFWDE--DQH-------RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRIT-----A-----SEALKHPWI----CQR------------SMMHRQETVDC---------L---KKFN---ARRKLK-------GAILTTMLATRNFSA-------------------------------------------------------------------------------------------------------------------------------------------------------------------
4 PsiBlast_PDB 73.1589%-112 - C1 -2V7O KCC2G_HUMAN A:[25-321] ----TCTRFTDDYQLFEELGKG-FSVVRRCVKK---TPTQEYAAKI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----Y----YSEADASHCIHQILESVNHIH-QHDIVHRDLKPENLLLASK-CKGAAVKLADFGLA--IEVQ-GEQQAWFGFA-GTPGYLSPEVLR------KDP-YGKPVDIWACGVILYILLVGYPPFWDE--DQH-------KLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRIT-----A-----DQALKHPWV----CQRS----T----VASMMHRQETVEC---------L---RKFN---ARRKLK-------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22 PsiBlast_CBE 72.2492%-115 - C1 -2VN9 KCC2D_HUMAN B:[2-301] --------MTDEYQLFEELGKGAFSVVRRCMKI---PTGQEYAAKI--INTK---KL-S-AR----DH----Q-KLE----REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----Y----YSEADASHCIQQILESVNHCH-LNGIVHRDLKPENLLLASK-SKGAAVKLADFGLA--IEVQ-GDQQAWFGFA-GTPGYLSPEVLR------KDP-YGKPVDMWACGVILYILLVGYPPFWDE--DQH-------RLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRIT-----A-----SEALKHPWI----CQRS----T----VASMMHRQETVDC---------L---KKFN---ARRKLK-------GAILTTML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17 PsiBlast_PDB 62.9146%-107 - C1 -3C0H CSKP_HUMAN A:[22-318] --------FEDVYELCEVIGKGPFSVVRRCINR---ETGQQFAVKI--VDVA---KF-T-SSPGL-ST----E-DLK----REASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFV----YSEAVASHYMRQILEALRYCH-DNNIIHRDVKPHCVLLASK-ENSAPVKLGGFGVA--IQLG-ESGLVAGGRV-GTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT---KE-------RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----V-----YEALNHPWL----KERD----R----YAYKIHLPETVEQ---------L---RKFN---ARRKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12 PsiBlast_PDB 62.8547%-106 - C1 -3MFS CSKP_HUMAN A:[22-320] --------FEDVYELCEVIGKGAFSVVRRCINR---ETGQQFAVKI--VDVA---KF-T-SSPGL-ST----E-DLK----REASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFV----YSEAVASHYMRQILEALRYCH-DNNIIHRDVKPENVLLASK-ENSAPVKLGDFGVA--IQLG-ESGLVAGGRV-GTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT---KE-------RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----V-----YEALNHPWL----KERD----R----YAYKIHLPETVEQ---------L---RKFN---ARRKLK-------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67 PsiBlast_CBE 62.5340%-122 - C1 -3LIJ ? A:[35-335] --------LSEMYQRVKKLGS---GEVLLCRDK---VTHVERAIKI--IRK----------S----SN----S-KLL----EEVAVLKLLD-HPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRM----K----FNEVDAAVIIKQVLSGVTYLH-KHNIVHRDLKPENLLLESK-EKDALIKIVDFGLS--AVFE-N-QKKMKERL-GTAYYIAPEVLR------K-K-YDEKCDVWSIGVILFILLAGYPPFGGQ--TDQ-------EILRKVEKGKYTFDSPEWKNVSEGAKDLIKQMLQFDSQRRIS-----A-----QQALEHPWIKEMCSKKE----S-------LPSLANAIEN---------M---RKFQ---NSQKLA-------QAALLYM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14 PsiBlast_PDB 62.4147%-104 - C1 -3MFU CSKP_HUMAN A:[22-320] --------FEDVYELCEVIGKGAFSVVRRCINR---ETGQQFAVKI--VDVA---KF-T-SSPGL-ST----E-DLK----REASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFV----YSEAVASHYMRQILEALRYCH-DNNIIHRDVKPENVLLASK-ENSAPVKLGDFGVA--IQLG-ESGLVAGGRV-GTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT---KE-------RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----V-----YEALNHPWL----KERD----R----YAYKIHLPETVEQ---------L---RKFN---ARRKLK-------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11 PsiBlast_PDB 62.3647%-103 - C1 -3MFR CSKP_HUMAN A:[22-320] --------FEDVYELCEVIGKGAFSVVRRCINR---ETGQQFAVKI--VDVA---KF-T-SSPGL-ST----E-DLK----REASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFV----YSEAVASHYMRQILEALRYCH-DNNIIHRDVKPENVLLASK-ENSAPVKLGDFGVA--IQLG-ESGLVAGGRV-GTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT---KE-------RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----V-----YEALNHPWL----KERD----R----YAYKIHLPETVEQ---------L---RKFN---ARRKLK-------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150 HHSearch 62.1546%-103 - C1 -3C0I CSKP_HUMAN A:[20-317] ------VLFEDVYELCEVIGKGPFSVVRRCINR---ETGQQFAVKI--VDVA---KF-T-SSPGL-ST----E-DLK----REASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRA----DAGFVYSEAVASHYMRQILEALRYCH-DNNIIHRDVKPHCVLLASK-ENSAPVKLGGFGVA--IQLG-ESGLVAGGRV-GTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT--K-E-------RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----V-----YEALNHPWL----KERD----R----YAYKIHLPETVEQ---------L---RKFN---ARRK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39 PsiBlast_CBE 61.5546%-107 - C1 -3C0H CSKP_HUMAN B:[22-318] --------FEDVYELCEVIGKGPFSVVRRCINR---ETGQQFAVKI--VDVA---KF-T-SSPGL-ST----E-DLK----REASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFV----YSEAVASHYMRQILEALRYCH-DNNIIHRDVKPHCVLLASK-ENSAPVKLGGFGVA--IQLG-ESGLVAGGRV-GTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT---KE-------RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----V-----YEALNHPWL----KERD----R----YAYKIHLPETVEQ---------L---RKFN---ARRKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96 PsiBlast_CBE 61.2540%-114 - C1 -1PHK PHKG1_RABIT A:[15-289] --------FYENYEPKEILGRGVSSVVRRCIHK---PTCKEYAVKI--IDVTGGGSF-S-AE----EV----Q-ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKV----T----LSEKETRKIMRALLEVICALH-KLNIVHRDLKPENILLDDD-MN---IKLTDFGFS--CQLDPGEKLR--EVC-GTPSYLAPEIIECSMND-NHPGYGKEVDMWSTGVIMYTLLAGSPPFWHR--KQM-------LMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYT-----A-----EEALAHPFF----QQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95 PsiBlast_CBE 61.2240%-115 - C1 -1QL6 PHKG1_RABIT A:[15-289] --------FYENYEPKEILGRGVSSVVRRCIHK---PTCKEYAVKI--IDVTGGGSF-S-AE----EV----Q-ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKV----T----LSEKETRKIMRALLEVICALH-KLNIVHRDLKPENILLDDD-MN---IKLTDFGFS--CQLDPGEKLR--SVC-GTPSYLAPEIIECSMND-NHPGYGKEVDMWSTGVIMYTLLAGSPPFWHR--KQM-------LMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYT-----A-----EEALAHPFF----QQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89 PsiBlast_CBE 60.3740%-116 - C1 -2Y7J PHKG2_HUMAN A:[92-363] --------FYQKYDPKDVIGRGVSSVVRRCVHR---ATGHEFAVKIMEVTAE---RL-S-PE----QL----E-EVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV----A----LSEKETRSIMRSLLEAVSFLH-ANNIVHRDLKPENILLDDN-MQ---IRLSDFGFS--CHLEPGEKLR--ELC-GTPGYLAPEILKCSMDETHPG-YGKEVDLWACGVILFTLLAGSPPFWHR--RQI-------LMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLT-----A-----EQALQHPFF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97 PsiBlast_CBE 60.2640%-116 - C1 -2PHK PHKG1_RABIT A:[2-276] --------FYENYEPKEILGRGVSSVVRRCIHK---PTCKEYAVKI--IDVTGGGSF-S-AE----EV----Q-ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKV----T----LSEKETRKIMRALLEVICALH-KLNIVHRDLKPENILLDDD-MN---IKLTDFGFS--CQLDPGEKLR--EVC-GTPSYLAPEIIECSMND-NHPGYGKEVDMWSTGVIMYTLLAGSPPFWHR--KQM-------LMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYT-----A-----EEALAHPFF----QQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140 HHSearch 60.2143%-119 * C1 *4FG7 KCC1A_HUMAN A:[13-277] -----AEDIRDIYDFRDVLGTGAFSEVILAEDK---RTQKLVAIKC--IA------------------------SME----NEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKG----F----YTERDASRLIFQVLDAVKYLH-DLGIVHRDLKPENLLYYSL-DEDSKIMISDFGLS--KMED-P----------GTPGYVAPEVLA------QK---SKAVDCWSIGVIAYILLCGYPPFYDE--NDA-------KLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFT-----C-----EQALQHPWI----A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88 PsiBlast_CBE 59.7240%-114 - C1 -2Y7J PHKG2_HUMAN C:[92-363] --------FYQKYDPKDVIGRGVSSVVRRCVHR---ATGHEFAVKIMEVTAE---RL-S-PE----QL----E-EVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV----A----LSEKETRSIMRSLLEAVSFLH-ANNIVHRDLKPENILLDDN-MQ---IRLSDFGFS--CHLEPGEKLR--ELC-GTPGYLAPEILKCSMDETHPG-YGKEVDLWACGVILFTLLAGSPPFWHR--RQI-------LMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLT-----A-----EQALQHPFF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75 PsiBlast_CBE 59.6939%-114 - C1 -3UPX ? A:[24-324] --------FSDRYKGQRVLGKGSFGEVILCKDK---ITGQECAVKV--ISKR---QV-K-QKT---DK----E-SLL----REVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK----R----FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLLLESK-SKDANIRIIDFGLS--THFE-ASKKMKDKI--GTAYYIAPEVLH------G-T-YDEKCDVWSTGVILYILLSGCPPFNGA--NEY-------DILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRIS-----A-----RDALDHEWI----Q--------------TYTK------VPSLDNAILNI---RQFQ---GTQKLA-------QAALLYM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16 PsiBlast_PDB 59.6046%-103 - C1 -3C0G CSKP_HUMAN A:[22-326] --------FEDVYELCEVIGKGPFSVVRRCINR---ETGQQFAVKI--VDVA---KF-T-SSPGL-ST----E-DLK----REASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFV----YSEAVASHYMRQILEALRYCH-DNNIIHRDVKPHCVLLASK-ENSAPVKLGGFGVA--IQLG-ESGLVAGGRV-GTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT---KE-------RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----V-----YEALNHPWL----KERD----R----YAYKIHLPETVEQ---------L---RKFN---ARRKLK---------VLAAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124 PsiBlast_CBE 58.7636%-125 - C1 -3ZXT DAPK1_HUMAN D:[13-276] ------------YDTGEELGSGQFAVVKKCREK---STGLQYAAKF--I-------------V---SR----E-DIE----REVSILKEIQ-HPNVITLHEVYENKTDVILILELVAGGELFDFLAE------------TEEEATEFLKQILNGVYYLH-SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKID---------------TPEFVAPEIVN------YEP-LGLEADMWSIGVITYILLSGASPFLGD--TKQ-------ETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMT-----I-----QDSLQHPWI----K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87 PsiBlast_CBE 58.2540%-116 - C1 -2Y7J PHKG2_HUMAN D:[92-363] --------FYQKYDPKDVIGRGVSSVVRRCVHR---ATGHEFAVKIMEV------RL-S-PE----QL----E-EVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV----A----LSEKETRSIMRSLLEAVSFLH-ANNIVHRDLKPENILLDDN-MQ---IRLSDFGFS--CHLEPGEKLR--ELC-GTPGYLAPEILKCSMDETHPG-YGKEVDLWACGVILFTLLAGSPPFWHR--RQI-------LMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLT-----A-----EQALQHPFF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109 PsiBlast_CBE 58.0137%-108 - C1 -2CKE DAPK2_HUMAN A:[14-302] ------------YDIGEELGSGQFAIVKKCREK---STGLEYAAKF--IKKR---QS-R-ASRRGVSR----E-EIE----REVSILRQVL-HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKE----S----LSEEEATSFIKQILDGVNYLH-TKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA--HEIE--DGVEFKNIF-GTPEFVAPEIVN------YEP-LGLEADMWSIGVITYILLSGASPFLGD--TKQ-------ETLANITSVSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLT-----I-----QEALRHPWI----TPVD----N-----QQAMVRRESVVN---------L---ENFRKQYV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40 PsiBlast_CBE 58.0146%-103 - C1 -3C0G CSKP_HUMAN B:[22-326] --------FEDVYELCEVIGKGPFSVVRRCINR---ETGQQFAVKI--VDVA---KF-T-SSPGL-ST----E-DLK----REASICHMLK-HPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFV----YSEAVASHYMRQILEALRYCH-DNNIIHRDVKPHCVLLASK-ENSAPVKLGGFGVA--IQLG-ESGLVAGGRV-GTPHFMAPEVVK------REP-YGKPVDVWGCGVILFILLSGCLPFYGT---KE-------RLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERIT-----V-----YEALNHPWL----KERD----R----YAYKIHLPETVEQ---------L---RKFN---ARRKLK-------GAVLAAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64 PsiBlast_CBE 57.9942%-116 - C1 -4FG8 KCC1A_HUMAN A:[20-299] ------------YDFRDVLGTGAFSEVILAEDK---RTQKLVAIKC--IAKE-----------------------------NEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKG----F----YTERDASRLIFQVLDAVKYLH-DLGIVHRDLKPENLLYYSL-DEDSKIMISDF----------------------TPGYVAPEVLA------QKP-YSKAVDCWSIGVIAYILLCGYPPFYDE--NDA-------KLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFT-----C-----EQALQHPWI----AGDT----A----LDKNIH-QSVSEQ---------I---KKNF---A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74 PsiBlast_CBE 57.6939%-110 - C1 -3UPZ ? A:[24-324] --------FSDRYKGQRVLGKGSFGEVILCKDK---ITGQECAVKV--ISKR---QV-K-QKT---DK----E-SLL----REVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK----R----FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLLLESK-SKDANIRIIDFGLS--THFE-ASKKMKDKI--GTAYYIAPEVLH------G-T-YDEKCDVWSTGVILYILLSGCPPFNGA--NEY-------DILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRIS-----A-----RDALDHEWI----Q--------------TYTK------VPSLDNAILNI---RQFQ---GTQKLA-------QAALLYM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69 PsiBlast_CBE 57.3139%-109 - C1 -3HZT ? A:[3-317] ---------SDRYQRVKKLGSGAYGEVLLCKDK---LTGAERAIKI--IKKS---SV-T-TT----SN----SGALL----DEVAVLKQLD-HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQ----K----FSEVDAAVIMKQVLSGTTYLH-KHNIVHRDLKPENLLLESK-SRDALIKIVDFGLSAHFEVG-------------TAYYIAPEVLR------K-K-YDEKCDVWSCGVILYILLCGYPPFGGQ--TDQ-------EILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRIS-----A-----EEALNHPWIVKFCSQ------------VGKHALTGALGN---------M---KKFQ---SSQKLAQAAMLFMGSKLTTLEETKELT--------------------------------------------------------------------------------------------------------------------------------------------------------------------
125 PsiBlast_CBE 56.7536%-124 - C1 -3ZXT DAPK1_HUMAN C:[13-276] ------------YDTGEELG--QFAVVKKCREK---STGLQYAAKF--IKKR---RTKS-SRRGV-SR----E-DIE----REVSILKEIQ-HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE----S----LTEEEATEFLKQILNGVYYLH-SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKID----------------PEFVAPEIVN------YEP-LGLEADMWSIGVITYILLSGASPFLGD--TKQ-------ETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMT-----I-----QDSLQHPWI----K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108 PsiBlast_CBE 56.5437%-108 - C1 -2CKE DAPK2_HUMAN B:[14-302] ------------YDIGEELGSGQFAIVKKCREK---STGLEYAAKF--IKKR---QS-R-ASRRGVSR----E-EIE----REVSILRQVL-HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKE----S----LSEEEATSFIKQILDGVNYLH-TKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA--HEIE--DGVEFKNIF-GTPEFVAPEIVN------YEP-LGLEADMWSIGVITYILLSGASPFLGD--TKQ-------ETLANITSVSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLT-----I-----QEALRHPWI----TPVD----N-----QQAMVRRESVVN---------L---ENFRKQYV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72 PsiBlast_CBE 56.4839%-110 - C1 -3V5P ? A:[24-324] --------FSDRYKGQRVLGKGSFGEVILCKDK---ITGQECAVKV--ISKR---QV-K-QKT---DK----E-SLL----REVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK----R----FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLLLESK-SKDANIRIIDFGLS--THFE-ASKKMKDKI--GTAYYIAPEVLH------G-T-YDEKCDVWSTGVILYILLSGCPPFNGA--NEY-------DILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRIS-----A-----RDALDHEWI----Q--------------TYTK------VPSLDNAILNI---RQFQ---GTQKLA-------QAALLYM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126 PsiBlast_CBE 56.1636%-116 - C1 -3ZXT DAPK1_HUMAN B:[13-276] ------------YDTGEELGSGQFAVVKKCREK---STGLQYAAKF--IKKR---RTKS--RRGV-SR----E-DIE----REVSILKEIQ-HPNVITLHEVYENKTDVILILELVAGGELFDFLAEK----------LTEEEATEFLKQILNGVYYLH-SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKID---------------TPEFVAPEIVN------YEP-LGLEADMWSIGVITYIL-SGASPFLGD--TKQ-------ETLANVSAVNYEFEDEYFS---ALAKDFIRRLLVKDPKKRMT-----I-----QDSLQHPWI----K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81 PsiBlast_CBE 56.0039%-106 - C1 -3I7B ? A:[24-324] --------FSDRYKGQRVLGKGSFGEVILCKDK---ITGQECAVKV--ISKR---QV-K-QKT---DK----E-SLL----REVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK----R----FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLLLESK-SKDANIRIIDFGLS--THFE-ASKKMKDKI--GTAYYIAPEVLH------G-T-YDEKCDVWSTGVILYILLSGCPPFNGA--NEY-------DILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRIS-----A-----RDALDHEWI----Q--------------TYTKEQISVDVPSLDNAILNI---RQFQ---GTQKLA-------QAALLYM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77 PsiBlast_CBE 55.9439%-107 - C1 -3T3U ? A:[24-324] --------FSDRYKGQRVLGKGSFGEVILCKDK---ITGQECAVKV--ISKR---QV-K-QKT---DK----E-SLL----REVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK----R----FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLLLESK-SKDANIRIIDFGLS--THFE-ASKKMKDKI--GTAYYIAPEVLH------G-T-YDEKCDVWSTGVILYILLSGCPPFNGA--NEY-------DILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRIS-----A-----RDALDHEWI----Q--------------TYTKEQISVDVPSLDNAILNI---RQFQ---GTQKLA-------QAALLYM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117 PsiBlast_CBE 55.9037%-114 - C1 -3KN5 B:[19-282] ------------------LGEGSFSICRKCVHK---KSNQAFAVKI--I-SK---RM-E-A-----NT----Q-KEI----TALKLCE--G-HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKK----H----FSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPENLLFTD-----LEIKIIDFGFA--RLKP-P-----------------------------NG-YDESCDLWSLGVILYTMLSGQVPFQSH--DRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLK-----M-----SGLRYNEWL----QDGS----Q----LSS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153 HHSearch 55.5740%-102 - C1 -3MWU ? A:[19-323] -------TFAERYNIVCMLGKGSFGEVLKCKDR---ITQQEYAVKV--INKA---SA-K-NK----DT----S-TIL----REVELLKKLD-HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRK----R----FSEHDAARIIKQVFSGITYMH-KHNIVHRDLKPENILLESK-EKDCDIKIIDFGLS--TCFQ-QN-----DRI-GTAYYIAPEVLR------G-T-YDEKCDVWSAGVILYILLSGTPPFYGK--NEY-------DILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRIT-----A-----TQCLEHPWI----QKYS----SETPTISDLPSLESAMTN---------I---RQFQ---AEKKLA-------QAALLYMASK------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107 PsiBlast_CBE 55.5637%-105 - C1 -2CKE DAPK2_HUMAN C:[14-302] ------------YDIGEELGSGQFAIVKKCREK---STGLEYAAKF--IKKR---QS-R-ASRRGVSR----E-EIE----REVSILRQVL-HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKE----S----LSEEEATSFIKQILDGVNYLH-TKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA--HEIE--DGVEFKNIF-GTPEFVAPEIVN------YEP-LGLEADMWSIGVITYILLSGASPFLGD--TKQ-------ETLANITSVSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLT-----I-----QEALRHPWI----TPVD----N-----QQAMVRRESVVN---------L---ENFRKQYV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83 PsiBlast_CBE 55.5339%-121 - C1 -3HX4 ? A:[48-348] --------FSDRYKGQRVLGKGSFGEVILCKDK---ITGQECAVKV--ISK---------------DK----E-SLL----REVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK----R----FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLLLESK-SKDANIRIIDFGLS--THFE-ASKKMKDKI--GTAYYIAPEVLH-------GT-YDEKCDVWSTGVILYILLSGCPPFNGA--NEY-------DILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRIS-----A-----RDALDHEWI----Q--------------TYTKEQISVDVPSLDNAILNI---RQFQ---GTQKLA-------QAALLYM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91 PsiBlast_CBE 55.1437%-106 - C1 -2YAA DAPK2_MOUSE B:[4-302] --TFKQQKVEDFYDIGEELGSGQFAIVKKCREK---STGLEYAAKF--IKKR---QS-R-AS----RRGVCRE-EIE----REVSILRQVL-HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKE----S----LSEEEATSFIKQILDGVNYLH-TKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA--HEIE-DGVE-FKNIF-GTPEFVAPEIVN------YEP-LGLEADMWSIGVITYILLSGASPFLGD--TKQ-------ETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLT-----I-----QEALRHPWI----TPVD----T----QQAMVRRESVVNLEN-------F---KKQY---V----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92 PsiBlast_CBE 55.1137%-107 - C1 -2YAA DAPK2_MOUSE A:[3-302] -ETFKQQKVEDFYDIGEELGSGQFAIVKKCREK---STGLEYAAKF--IKKR---QS-R-AS----RRGVCRE-EIE----REVSILRQVL-HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKE----S----LSEEEATSFIKQILDGVNYLH-TKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA--HEIE-DGVE-FKNIF-GTPEFVAPEIVN------YEP-LGLEADMWSIGVITYILLSGASPFLGD--TKQ-------ETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLT-----I-----QEALRHPWI----TPVD----T----QQAMVRRESVVNLEN-------F---KKQY---V----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106 PsiBlast_CBE 55.0937%-105 - C1 -2CKE DAPK2_HUMAN D:[14-302] ------------YDIGEELGSGQFAIVKKCREK---STGLEYAAKF--IKKR---QS-R-ASRRGVSR----E-EIE----REVSILRQVL-HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKE----S----LSEEEATSFIKQILDGVNYLH-TKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLA--HEIE--DGVEFKNIF-GTPEFVAPEIVN------YEP-LGLEADMWSIGVITYILLSGASPFLGD--TKQ-------ETLANITSVSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLT-----I-----QEALRHPWI----TPVD----N-----QQAMVRRESVVN---------L---ENFRKQYV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159 HHSearch 54.9639%-104 - C1 -3NYV ? A:[21-325] -----TAIFSDRYKGQRVLGKGSFGEVILCKDK---ITGQECAVKV--ISKR---QV-KQKT----DK----E-SLL----REVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRK----R----FSEVDAARIIRQVLSGITYMH-KNKIVHRD