@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC2B_HUMAN: (2013-07-21 )
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
Atome Classification :
(57 SA)
.........10-........20........30..---......40...--....---.50.-..----.-.----.--...----60........-70........80.....-...90........100....----...110.......120......-.130.......140.....-..150-........160.......170...-....180.....------.---.------190.......200.......210...---.---.--..220.......230.......240.......250.......260-----.-----......270----....----.----.---.280......--.290.......300.......310........320.......330.......340.....---..350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATTVTCTRFT-DEYQLYEDIGKGAFSVVRRCVK---LCTGHEYAAKI--INTK---KL-S-AR----D-H----Q--KLE----REARICRLLK-HSNIVRLHDSISEEGFH-YLVFDLVTGGELFEDIVARE----YYSEADASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASK-CKG-A-AVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLR------K---E------AYGKPVDIWACGVILYILLVGYPPFW---D---E--DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRIT-----A-----HEALKHPWV----CQRS----T----V---ASMMHRQETV--ECLKKFNARRKLKGAILTTMLA-TRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNK---KADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
142
HHSearch
82.67
93%
-97
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-444]
-------
T
R
F
T
-
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
---
V
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
-
H
----
Q
--
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
-
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
L
K
G
-
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
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------
K
---
D
------
P
Y
G
K
P
V
D
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A
C
G
V
I
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Y
I
L
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Y
P
P
F
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---
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---
E
--
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E
A
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-----
A
-----
A
E
A
L
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H
P
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I
----
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H
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----
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----
V
---
A
S
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--
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N
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M
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A
-
T
R
N
F
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
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D
F
E
S
Y
T
K
M
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M
T
A
F
E
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E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
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N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
S
----
1
PsiBlast_PDB
79.45
99%
-119
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[2-293]
---------
M
T
-
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
---
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
-
H
----
Q
--
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
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D
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I
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E
E
G
F
H
-
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
-
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
---
E
------
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
--
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
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E
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D
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A
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M
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N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
----
C
Q
R
S
----
T
----
V
---
A
S
M
M
H
R
Q
E
T
V
--
E
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
78.09
99%
-119
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-293]
---------
M
T
-
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
---
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
-
H
----
Q
--
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
-
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
-
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
---
E
------
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
--
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
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S
P
E
W
D
T
V
T
P
E
A
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N
L
I
N
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M
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N
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A
K
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I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
----
C
Q
R
S
----
T
----
V
---
A
S
M
M
H
R
Q
E
T
V
--
E
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.69
92%
-117
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[2-301]
---------
M
T
-
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
---
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
-
H
----
Q
--
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
-
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
K
G
-
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
---
D
------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
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P
F
W
---
D
---
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
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P
E
A
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D
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I
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N
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A
K
R
I
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-----
A
-----
S
E
A
L
K
H
P
W
I
----
C
Q
R
S
----
T
----
V
---
A
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M
M
H
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Q
E
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--
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F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.03
91%
-112
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[25-321]
-----
T
C
T
R
F
T
-
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
---
K
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
-
H
----
Q
--
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
-
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
-
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
-
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
E
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
---
D
------
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
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Y
I
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G
Y
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F
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---
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---
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--
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A
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A
Y
D
F
P
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E
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M
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A
-----
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A
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----
C
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----
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----
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---
A
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M
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E
T
V
--
E
C
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.82
84%
-126
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[2-308]
---------
M
T
-
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
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---
I
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Y
A
A
K
I
--
I
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---
K
L
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----
Q
--
K
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E
----
R
E
A
R
I
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-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
-
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
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A
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E
----
Y
Y
S
E
A
D
A
S
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C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
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I
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R
D
L
K
P
E
N
L
L
L
A
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K
-
S
K
G
-
A
-
A
V
K
L
A
D
F
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L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
-
G
T
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G
Y
L
S
P
E
V
L
R
------
K
---
D
------
P
Y
G
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P
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D
M
W
A
C
G
V
I
L
Y
I
L
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V
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Y
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---
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---
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
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F
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E
W
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T
V
T
P
E
A
K
D
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N
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A
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I
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-----
A
-----
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E
A
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K
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P
W
I
----
C
Q
R
---------------
S
M
M
H
R
Q
E
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--
D
C
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F
N
A
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A
I
L
T
T
M
L
A
-
T
R
N
F
S
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
73.81
92%
-116
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[2-301]
---------
M
T
-
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
---
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
-
S
-
A
R
----
D
-
H
----
Q
--
K
L
E
----
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
-
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
K
G
-
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
---
D
------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
----
C
Q
R
S
----
T
----
V
---
A
S
M
M
H
R
Q
E
T
V
--
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
63.46
39%
-117
- C1 -
2PHK
2
PHKG1_RABIT
A:
[2-276]
---------
F
Y
-
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
---
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
-
S
-
A
E
----
E
-
V
----
Q
--
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
-
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
N
-----
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
K
L
R
-
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
------
C
---
S
M
N
DNHP
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
--
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
-----
E
E
A
L
A
H
P
F
F
----
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
63.17
48%
-103
- C1 -
3MFS
1
CSKP_HUMAN
A:
[22-320]
---------
F
E
-
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
---
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
-
T
----
E
--
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
N
S
-
A
-
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
---
T
--
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
---
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
63.00
41%
-118
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[18-277]
------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
--------------------------
S
M
E
----
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
-
S
-
K
I
M
I
S
D
F
G
L
S
-
K
M
E
D
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.59
48%
-102
- C1 -
3MFU
1
CSKP_HUMAN
A:
[22-320]
---------
F
E
-
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
---
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
-
T
----
E
--
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
N
S
-
A
-
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
---
T
--
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
---
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
62.54
40%
-114
- C1 -
3UPX
1
?
A:
[24-285]
---------
F
S
-
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
-
K
----
E
--
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
-
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
-
A
-
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
-
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
----------
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.29
48%
-101
- C1 -
3MFR
1
CSKP_HUMAN
A:
[22-320]
---------
F
E
-
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
---
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
-
T
----
E
--
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
N
S
-
A
-
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
---
T
--
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
---
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
61.91
40%
-115
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[92-363]
---------
F
Y
-
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
---
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
---
R
L
-
S
-
P
E
----
Q
-
L
----
E
--
E
V
R
EATR
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
-
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
Q
-----
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
L
R
-
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
---
P
------
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
--
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
61.87
38%
-114
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-291]
---------
F
Y
-
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
---
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
-
S
-
A
E
----
E
-
V
----
Q
--
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
-
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
N
-----
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
K
L
R
-
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
DN
H
---
P
------
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
--
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
-----
E
E
A
L
A
H
P
F
F
-----
Q
Q
Y
----
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
61.83
38%
-113
- C1 -
1QL6
1
PHKG1_RABIT
A:
[15-291]
---------
F
Y
-
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
---
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
-
S
-
A
E
----
E
-
V
----
Q
--
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
-
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
-
M
N
-----
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
K
L
R
-
S
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
---
P
------
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
--
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
-----
E
E
A
L
A
H
P
F
F
-----
Q
Q
Y
----
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.82
46%
-106
- C1 -
3C0H
1
CSKP_HUMAN
A:
[22-318]
---------
F
E
-
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
---
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
-
T
----
E
--
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
-
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
---
T
--
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
---
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.76
40%
-117
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[92-363]
---------
F
Y
-
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
---
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
---
R
L
-
S
-
P
E
----
Q
-
L
----
E
--
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
-
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
Q
-----
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
L
R
-
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
ET
H
---
P
------
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
--
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.50
46%
-103
- C1 -
3C0G
1
CSKP_HUMAN
A:
[22-326]
---------
F
E
-
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
---
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
-
T
----
E
--
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
-
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
---
T
--
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
---
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
A
R
R
K
L
K
--
V
L
A
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
HHSearch
61.26
47%
-104
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-317]
-------
V
L
F
E
-
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
---
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
-
T
----
E
--
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
-
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
---
T
--
K
-
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
---
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
61.07
46%
-106
- C1 -
3C0H
1
CSKP_HUMAN
B:
[22-318]
---------
F
E
-
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
---
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
-
T
----
E
--
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
DAGF
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
-
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
---
T
--
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
---
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
60.08
36%
-111
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[12-302]
------------
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
---
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
R
R
G
V
S
-
R
----
E
--
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
I
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
--
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
N
----
Q
---
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
59.82
40%
-117
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[92-363]
---------
F
Y
-
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
---
R
A
T
G
H
E
F
A
V
K
I
ME
V
------
R
L
-
S
-
P
E
----
Q
-
L
----
E
--
E
V
R
EATR
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
-
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
-
M
Q
-----
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
L
R
-
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
---
P
------
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
--
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
59.39
41%
-113
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[18-299]
------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
-------------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
-
S
-
K
I
M
I
S
D
F
-------------------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
G
D
T
----
A
----
L
---
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
59.02
36%
-107
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[12-302]
------------
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
---
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
RRGV
S
-
R
----
E
--
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
I
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
--
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
N
----
Q
---
Q
A
M
V
R
R
E
S
V
V
NL
E
N
F
R
K
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.72
39%
-118
- C1 -
3LIJ
1
?
A:
[26-335]
M
F
I
T
S
K
K
G
H
L
S
-
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
---
K
V
T
H
V
E
R
A
I
K
I
--
I
R
K
----------
S
----
S
-
N
----
S
--
K
L
L
----
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
-
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
----
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
E
K
D
-
A
-
L
I
K
I
V
D
F
G
L
S
A
-
V
F
E
N
Q
K
K
M
K
E
R
L
-
G
T
A
Y
Y
I
A
P
E
V
L
R
------
K
---
K
-------
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
---
G
---
Q
--
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
-----
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
E
----
S
----------
L
P
S
L
A
N
A
I
--
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
58.55
46%
-102
- C1 -
3C0G
1
CSKP_HUMAN
B:
[22-326]
---------
F
E
-
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
---
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
F
-
T
-
S
S
PGL-
S
-
T
----
E
--
D
L
K
----
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
-
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
---
T
--
K
E
-
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
-----
Y
E
A
L
N
H
P
W
L
----
K
E
R
D
----
R
----
Y
---
A
Y
K
I
H
L
P
E
T
V
--
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
58.44
36%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[12-302]
------------
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
---
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
RRGV
S
-
R
----
E
--
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
I
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
--
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
N
----
Q
---
Q
A
M
V
R
R
E
S
V
V
NL
E
N
F
R
K
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
58.43
40%
-110
- C1 -
3V5P
1
?
A:
[24-285]
---------
F
S
-
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
-
K
----
E
--
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
-
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
-
A
-
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
-
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
----------
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
58.13
40%
-109
- C1 -
3T3U
5
?
A:
[24-285]
---------
F
S
-
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
-
K
----
E
--
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
-
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
-
A
-
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
-
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
----------
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
57.59
40%
-110
- C1 -
3I7B
4
?
A:
[24-285]
---------
F
S
-
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
-
K
----
E
--
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
-
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
-
A
-
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
-
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
----------
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
57.37
36%
-112
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[12-302]
------------
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
---
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
R
R
G
V
S
-
R
----
E
--
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
I
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
--
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
N
----
Q
---
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
56.99
41%
-110
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[18-299]
------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
--------------------------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
-
S
-
K
I
M
I
S
D
F
G
--------
G
S
V
L
S
T
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
G
D
T
----
A
----
L
---
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
56.63
40%
-110
- C1 -
3N51
3
?
A:
[24-285]
---------
F
S
-
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
-
Q
K
T---
D
-
K
----
E
--
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
-
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
-
A
-
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
-
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
----------
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
56.36
41%
-103
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[18-310]
------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
--------------------------
E
----
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
-
S
-
K
I
M
I
S
D
F
--------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
G
D
T
----
A
----
L
---
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
56.11
37%
-120
- C1 -
3HX4
3
?
A:
[48-348]
---------
F
S
-
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
---------------
D
-
K
----
E
--
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
-
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
-
A
-
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
D
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
----------
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
Q
T
Y-
T
K
E
Q
----
I
----
S
---
V
D
V
P
S
L
D
N
A
I
--
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
PsiBlast_CBE
55.77
33%
-105
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[11-302]
------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
---
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
-
S
R
RGV-
S
-
R
----
E
--
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
--
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
P
K
D
----
T
----
Q
---
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
55.58
36%
-107
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[4-302]
---
T
F
K
Q
Q
K
V
E
-
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
---
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
----
R
-
R
GVC
R
E
--
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
I
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
--
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
T
----
Q
---
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
HHSearch
55.26
37%
-104
- C1 -
3NYV
1
?
A:
[20-325]
-----
S
T
A
I
F
S
-
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-
K
Q
K
T
----
D
-
K
----
E
--
S
L
L
----
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
-
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
K
D
-
A
-
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
-
K
M
K
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
----------
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
T
Y
T
----
K
---------
D
V
P
S
L
D
N
A
I
--
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
55.24
36%
-104
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-302]
---
T
F
K
Q
Q
K
V
E
-
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
---
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
-
R
-
A
S
----
R
-
R
GVC
R
E
--
E
I
E
----
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
I
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
--
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----
T
P
V
D
----
T
----
Q
---
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
HHSearch
55.04
34%
-116
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-269]
--------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
T
G
R
Y
Y
A
M
K
I
--
L
K
K
E
---
V
I
-
V
-
A
K
----
D
E
V
----
A
--
H
T
L
----
T
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
-
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-----
G
-
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
---
N
------
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
---
N
---
Q
--
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
-----
K
E
I
M
Q
H
R
F
F
----
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
54.52
41%
-106
- C1 -
2W4O
1
KCC4_HUMAN
A:
[51-346]
---------
L
S
-
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
---
K
G
T
Q
K
P
Y
A
L
K
V
--
L
K
--------
K
--------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
-
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
-
A
P
D
-
A
-
P
L
K
I
A
D
F
------------------
G
T
P
G
Y
C
A
P
E
I
L
R
------
G
---
C
------
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
---
D
---
E
RG
D
Q
F
-
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
-----
F
Q
A
L
Q
H
P
W
V
----
T
G
K
A
-------------
A
N
F
V
H
M
D
T
A
Q
--
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
53.60
40%
-99
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
--------
N
I
R
-
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
---
R
L
T
G
K
L
F
A
L
K
C
--
I
--
K
---
K
S
-------------------
S
L
E
----
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
-
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
E
N
-
S
-
K
I
M
I
T
D
F
G
L
S
---
K
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
---
E
--
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
----
D
G
N
T
----
A
----
L
---
H
R
D
I
Y
P
S
V
S
L
--
Q
I
Q
K
N
F
-
A
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
53.48
40%
-101
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[4-289]
------
T
T
N
I
R
-
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
---
R
L
T
G
K
L
F
A
L
K
C
--
I
--
K
---
K
S
-------------------
S
L
E
----
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
-
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
E
N
-
S
-
K
I
M
I
T
D
F
G
L
S
---
K
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
---
E
--
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
----
D
G
N
T
----
A
----
L
---
H
R
D
I
Y
P
S
V
S
L
--
Q
I
Q
K
N
F
-
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
PsiBlast_CBE
53.46
37%
-115
- C1 -
4BDH
4
?
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
---
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------------------
N
V
E
----
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
--
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
E
D
-
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
T
S
L
M
R
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
------
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
52.62
41%
-103
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[18-310]
------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
---------------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
E
D
-
S
-
K
I
M
I
S
D
F
-----------
V
L
S
T
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
----
A
G
D
T
----
A
----
L
---
D
K
N
I
H
-
Q
S
V
S
--
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
PsiBlast_CBE
52.61
32%
-102
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[11-291]
------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
---
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
-
S
R
RGV-
S
-
R
----
E
--
D
I
E
----
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
-
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
-
F
K
N
I
F
-
G
T
P
A
F
V
A
P
E
I
V
N
------
Y
---
E
------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
--
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----
K
P
K
D
----
T
----
Q
---
Q
A
L
S
R
K
A
S
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
PsiBlast_CBE
51.60
37%
-110
- C1 -
4BDK
4
?
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
---
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-----------------------A
L
N
V
E
----
T
E
I
E
I
L
K
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
--
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
E
D
-
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
L
G
E
T
S
L
M
R
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
------
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
-----
E
E
A
L
R
H
P
W
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
HHSearch
50.58
39%
-99
- C1 -
3MWU
1
?
A:
[18-322]
-------
G
T
F
A
-
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
---
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
-
K
-
N
K
----
D
-
T
----
S
--
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
-
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
-
C
-
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
-----
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
R
------
G
----------
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
--
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
----
S
E
T
P
T
I
---
S
D
L
P
S
L
E
S
A
M
--
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
HHSearch
50.54
34%
-113
- C1 -
3Q5I
1
?
A:
[30-345]
-----
K
E
G
K
I
G
-
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
---
K
N
G
H
S
E
K
A
I
K
V
--
I
K
K
----------
K
----
F
-
H
----
E
--
E
I
Y
----
N
E
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
-
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
----
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
-
N
S
L
-
L
-
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
-
Y
K
L
R
D
R
L
-
G
T
A
Y
Y
I
A
P
E
V
L
K
------
K
----------
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
---
G
---
Q
--
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
-----
E
E
A
L
N
S
R
W
I
----
K
K
Y
A
----
N
----
N
INK
S
D
Q
K
T
L
C
G
A
L
--
S
N
M
R
K
F
E
G
S
Q
K
L
A
Q
A
A
I
L
F
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
50.50
39%
-98
- C1 -
2WEI
1
?
A:
[20-285]
---------
F
A
-
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
---
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
-
K
-
N
K
----
D
-
T
----
S
--
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
-
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
-
C
-
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
K
M
K
-
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
R
------
G
----------
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
--
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
48.91
32%
-80
- C1 -
3NCG
1
?
A:
[20-386]
---------
F
A
-
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
---
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
-
K
-
N
K
----
D
-
T
----
S
--
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
-
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
-
C
-
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
------
I
-
G
T
A
Y
Y
I
A
P
E
V
L
R
------
G
----------
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
--
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
S
E
T
P
T
----
I
---
S
D
L
P
S
L
E
S
A
M
--
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
---------------------
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
DT
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
N
------
G
S
T
I
E
D
Q
I
D
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
47.94
32%
-81
- C1 -
3IGO
8
?
A:
[20-386]
---------
F
A
-
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
---
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
A
-
K
-
N
K
------
T
----
S
--
T
I
L
----
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
-
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
K
D
-
C
-
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
---------
T
A
Y
Y
I
A
P
E
V
L
R
------
G
----------
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
--
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
S
E
T
P
T
----
I
---
S
D
L
P
S
L
E
S
A
M
--
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
---------------------
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
DT
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
N
S
L
I
Q
--
G
S
T
I
E
D
Q
I
D
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
PsiBlast_CBE
45.99
33%
-100
- C1 -
4D9U
1
A:
[19-316]
--------
Q
F
T
-
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
---
K
A
T
N
M
E
F
A
V
K
I
--
I
D
K
S
---
K
-----
R
----
D
---------
P
T
E
----
E
I
E
I
L
L
R
Y
G
Q
-
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
-
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
----
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
-
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
G
N
P
E
-
S
I
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
L
L
M
T
P
C
-
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
------
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
--
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
-----
A
-----
A
L
V
L
R
H
P
W
I
----
V
H
W
D
----
Q
----
L
---
P
Q
Y
Q
----------
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
PsiBlast_CBE
45.41
33%
-97
- C1 -
4D9T
1
A:
[19-315]
--------
Q
F
T
-
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
---
K
A
T
N
M
E
F
A
V
K
I
--
I
D
K
S
---
K
-----
R
----
D
---------
P
T
E
----
E
I
E
I
L
L
R
Y
G
Q
-
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
-
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
----
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
-
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
G
N
P
E
-
S
I
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
L
L
M
T
P
C
-
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
------
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
--
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
-----
A
-----
A
L
V
L
R
H
P
W
I
----
V
H
W
D
----
Q
----
L
---
P
Q
Y
Q
----------
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
HHSearch
44.30
31%
-101
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-286]
------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
A
R
Q
L
Y
A
M
K
V
--
L
K
K
A
---
T
L
-
K
-
V
R
----
D
-
R
----
V
------------
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
-
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
-----
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
S
F
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
------
R
---
R
------
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
---
G
---
K
--
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-----
A
GPD
G
V
E
E
I
K
R
H
S
F
F
----
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
PsiBlast_CBE
43.58
35%
-99
- C1 -
2WNT
2
B:
[26-292]
----------
S
-
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
---
K
A
T
N
M
E
Y
A
V
K
V
--
I
D
K
S
---
K
-----
R
----
D
-
P
----
S
----
E
----
E
I
E
I
L
L
R
Y
G
Q
-
H
P
N
I
I
T
L
K
D
-
V
Y
D
D
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
K
----
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
-
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
G
N
P
E
-
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
L
L
M
T
P
C
-
Y
----------
K
------
R
---
Q
------
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
---
N
GPS
D
--
T
P
E
E
I
L
T
R
I
G
S
G
K
F
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
-----
A
-----
K
Q
V
L
Q
H
P
W
V
----
T
Q
K
D
----
K
----
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------