@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KIT_HUMAN: (2013-07-21 )
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV
Atome Classification :
(96 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560......---.570.......-580--------.........590-.......600.......610..--.--....620.......630........640.......650.......660-.......670.......680.......690.......700.......710...--....720...--....730.......740.......750.......760.----......770.......780.......790.......800.......810.......820....-.--..830.......840.......850.......860.......870.-......880.......890.......900.......910.......920.......930.......940.......950.......960.......970....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNY---VYIDPTQLPYD-H----------KWEFPRNRLSFG-KTLGAGAFGKVVEATAYGLIKS--D--AAMTVAVKMLKPSAHL-TEREALMSELKVLSYLGNHMNIVNLLGACTI-GGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCS--DSTNEYMDMK--PGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELA----LDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVK-G--NARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV
127
HHSearch
78.52
100%
-111
- C5 -
1T46
1
A:
[1-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
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Y
---
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-
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----------------------------------------------------------------------------
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Q
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N
-------------------------------------------
3
PsiBlast_PDB
75.28
78%
-109
- C5 -
4HVS
1
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
Y
E
V
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-
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C
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-------------------------
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--
S
S
-----------------------------------
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A
----
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S
---------------------------------------------
122
HHSearch
71.00
68%
-105
- C5 -
2I1M
1
A:
[13-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
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-------------------------------------------------------------------------
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D
---------------------------------------------
136
HHSearch
70.56
49%
-104
- C5 -
3VHE
1
A:
[4-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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--------------------------------------------------------------------
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---------------------------------------------
6
PsiBlast_PDB
70.38
58%
-115
- C5 -
2I0Y
1
A:
[14-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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-------------------------------------------------------
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----------------------------------------------
13
PsiBlast_PDB
70.23
47%
-117
- C5 -
1Y6B
1
A:
[14-353]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
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---------------------------------------------------------------------------F---
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------------------------------------------------------
12
PsiBlast_PDB
68.59
47%
-119
- C5 -
1Y6A
1
A:
[15-353]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
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D
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Q
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--
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T
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A
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R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------------------------DF--
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-----------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
4
PsiBlast_PDB
68.58
59%
-110
- C5 -
4HW7
1
A:
[36-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
--
A
V
L
K
V
A
V
K
M
L
K
S
T
A
H
A
-
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
------------
A
E
A
M
L
G
P
S
-----------------------------------------------------------
G
R
P
----
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
-
G
--
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
-
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
E
Q
A
------------------------------------------------
5
PsiBlast_PDB
68.37
58%
-107
- C5 -
2I0V
1
A:
[10-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Y
Q
V
R
W
K
I
I
E
S
Y
E
G
N
S
Y
---
T
F
I
D
P
T
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
--
A
V
L
K
V
A
V
K
M
L
K
S
T
A
H
A
-
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
-------------------------
N
F
L
R
R
K
R
-------------------------------------------------------
Q
----
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
-
G
---
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
-
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
E
----------------------------------------------
11
PsiBlast_PDB
68.36
47%
-105
- C5 -
3VHK
2
A:
[16-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------------------------YKD
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-----
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
43
PsiBlast_CBE
67.69
48%
-120
- C5 -
3EFL
1
B:
[7-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
---
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
---------------------------
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
---------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
51
PsiBlast_CBE
67.63
43%
-113
- C5 -
2PVY
1
?
D:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
G
-------------------
V
P
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------
35
PsiBlast_CBE
67.50
49%
-118
- C5 -
3B8R
1
B:
[7-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
---
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------------
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
--------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
61
PsiBlast_CBE
67.39
43%
-107
- C5 -
3RI1
1
?
A:
[13-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
-----------------------
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------
50
PsiBlast_CBE
67.38
43%
-107
- C5 -
2PZP
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
-------------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
32
PsiBlast_CBE
67.20
49%
-118
- C5 -
3CP9
1
B:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
---
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
------
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
--------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
36
PsiBlast_CBE
67.06
49%
-119
- C5 -
3B8R
2
VGFR2_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
--------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
45
PsiBlast_CBE
66.87
48%
-123
- C5 -
2P2I
1
B:
[6-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
----
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
---------------------------
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-----------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
67
PsiBlast_CBE
66.85
43%
-104
- C5 -
2PY3
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
-------------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
17
PsiBlast_PDB
66.51
46%
-111
- C5 -
4AGC
1
A:
[33-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLS
I
V
M
D
P
D
E
L
P
----LPYDAS----
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
-----------------------
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-
G
--
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
68
PsiBlast_CBE
66.45
42%
-104
- C5 -
3B2T
1
B:
[10-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
----PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
------------------------
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------
30
PsiBlast_CBE
66.43
49%
-118
- C5 -
3CPB
1
B:
[6-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
---
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
-----------------------
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
---------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
33
PsiBlast_CBE
66.30
49%
-114
- C5 -
3CP9
1
VGFR2_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
---------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
31
PsiBlast_CBE
66.27
49%
-117
- C5 -
3CPB
1
VGFR2_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
----------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
65
PsiBlast_CBE
66.18
43%
-104
- C5 -
2PZ5
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
-------------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
40
PsiBlast_CBE
66.18
49%
-122
- C5 -
2QU6
1
B:
[8-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
-----------------------------
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
----------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
38
PsiBlast_CBE
66.04
49%
-114
- C5 -
3B8Q
1
VGFR2_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
----------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
69
PsiBlast_CBE
66.01
42%
-103
- C5 -
3B2T
1
FGFR2_HUMAN
A:
[10-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
-----PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
------------------------
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
Q
------------------------------------------
28
PsiBlast_CBE
65.95
49%
-118
- C5 -
3CPC
1
B:
[6-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
---
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
------------------------
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
---------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
46
PsiBlast_CBE
65.93
48%
-112
- C5 -
2P2I
1
VGFR2_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-------
T
C
R
T
V
A
V
K
M
L
----
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
52
PsiBlast_CBE
65.92
43%
-106
- C5 -
2PZR
1
B:
[23-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
----------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
37
PsiBlast_CBE
65.87
49%
-113
- C5 -
3B8Q
1
B:
[6-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------------
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
---------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
59
PsiBlast_CBE
65.86
43%
-105
- C5 -
2Q0B
1
FGFR2_HUMAN
A:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
-------------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------
15
PsiBlast_PDB
65.84
49%
-109
- C5 -
3EWH
2
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-------
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
--------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
18
PsiBlast_PDB
65.82
46%
-111
- C5 -
4AGD
1
A:
[34-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LS-
I
V
M
D
P
D
E
L
P
----LPYDAS----
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
-----------------------
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-
G
--
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
53
PsiBlast_CBE
65.73
43%
-104
- C5 -
2PZR
1
FGFR2_HUMAN
A:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
----------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------
29
PsiBlast_CBE
65.68
49%
-117
- C5 -
3CPC
1
VGFR2_HUMAN
A:
[6-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
----------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
121
HHSearch
65.53
37%
-108
- C5 -
4AOJ
1
NTRK1_HUMAN
A:
[33-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
C
----------
V
H
H
I
K
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-------
K
M
L
V
A
V
K
A
L
K
E
-
A
S
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
----------------------------------------------------------------------------
P
G
P
----
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
-------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
-
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
----------------------------------------------
42
PsiBlast_CBE
65.53
49%
-116
- C5 -
2P2H
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
44
PsiBlast_CBE
65.50
48%
-106
- C5 -
3EFL
1
VGFR2_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
-------
T
C
R
T
V
A
V
K
M
L
K
E
--
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
----------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
25
PsiBlast_CBE
65.49
49%
-106
- C5 -
4AG8
1
A:
[14-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
-----------------------
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-
G
--
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
41
PsiBlast_CBE
65.38
49%
-111
- C5 -
2QU5
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
26
PsiBlast_CBE
65.35
49%
-108
- C5 -
2XIR
1
A:
[14-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
-----------------------
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-
G
--
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
64
PsiBlast_CBE
65.14
43%
-106
- C5 -
2PZ5
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
-----------------------
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
27
PsiBlast_CBE
65.09
49%
-111
- C5 -
3DTW
1
VGFR2_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
------
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
----------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
58
PsiBlast_CBE
65.04
43%
-103
- C5 -
2Q0B
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
----------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
49
PsiBlast_CBE
65.01
43%
-105
- C5 -
2PZP
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
G
---------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
34
PsiBlast_CBE
64.89
49%
-109
- C5 -
3BE2
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-------
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
----------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
63
PsiBlast_CBE
64.84
43%
-97
- C5 -
2PWL
1
FGFR2_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--------------------------
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------
19
PsiBlast_PDB
64.83
46%
-103
- C5 -
4ASD
1
A:
[39-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
E
L
P
L
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
-----------------------
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-
G
--
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
16
PsiBlast_PDB
64.77
49%
-105
- C5 -
3U6J
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
----
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-
G
--
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
66
PsiBlast_CBE
64.76
43%
-102
- C5 -
2PY3
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
G
---------------------
E
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
60
PsiBlast_CBE
64.59
43%
-105
- C5 -
3RI1
1
FGFR2_HUMAN
B:
[13-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
-----PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
-----------------------
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------
124
HHSearch
64.44
36%
-107
- C5 -
4FYO
1
A:
[11-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
---
K
--
K
--
V
V
K
T
V
A
V
K
I
L
------P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
H
------------------------------------------------------------------------------------
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
------
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
-
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
--------------------------------------------
39
PsiBlast_CBE
64.38
49%
-112
- C5 -
2RL5
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
-------------------------
L
R
S
K
R
---------
N
E
F
------------
V
P
Y
K
----------------
V
A
P
E
D
L
Y
K
D
--
F
----
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
62
PsiBlast_CBE
64.33
43%
-101
- C5 -
2PWL
1
FGFR2_HUMAN
B:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
PK
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------------------------------
P
--
P
G
----------------------
E
Q
M
T
----------------
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------
139
HHSearch
64.22
40%
-108
- C5 -
1OPK
3
ABL1_MOUSE
A:
[212-479]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
----------
K
W
E
M
E
R
T
D
I
T
M
K
-
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
---------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------------------------------------------------------------------------------
Q
E
----
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
-
D
T
Y
T
A
H
-
A
--
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------
85
PsiBlast_CBE
63.97
41%
-97
- C5 -
4F64
3
FGFR1_HUMAN
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
----------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------
88
PsiBlast_CBE
63.11
41%
-97
- C5 -
3TT0
4
B:
[57-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
R--------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------
138
HHSearch
62.98
40%
-101
- C5 -
3CBL
3
A:
[106-374]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
----------
K
W
V
L
N
H
E
D
L
V
L
G
-
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
---------
N
T
L
V
A
V
K
S
C
R
E
T
L
P
P
-
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
-------------------------------------------------------------------------------
R
----
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
-
V
Y
A
A
S
G
G
--
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-----------------------------------------------
71
PsiBlast_CBE
62.97
41%
-91
- C5 -
3RHX
5
FGFR1_HUMAN
A:
[5-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
----------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------
77
PsiBlast_CBE
62.81
41%
-91
- C5 -
1AGW
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
----------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------
73
PsiBlast_CBE
62.81
41%
-92
- C5 -
2FGI
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-
D
I
H
H
I
D
Y
Y
K
K
T
----
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------
86
PsiBlast_CBE
62.51
41%
-96
- C5 -
4F63
3
B:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
R--------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------
83
PsiBlast_CBE
62.39
41%
-97
- C5 -
4F65
6
FGFR1_HUMAN
A:
[8-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
---------------------------------
P
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------
70
PsiBlast_CBE
62.19
41%
-95
- C5 -
3RHX
2
B:
[5-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
R--------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------
84
PsiBlast_CBE
62.04
41%
-96
- C5 -
4F64
3
B:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
R--------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------
75
PsiBlast_CBE
61.82
41%
-90
- C5 -
1FGI
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
----------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------
87
PsiBlast_CBE
61.75
41%
-94
- C5 -
4F63
3
FGFR1_HUMAN
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
----------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------
74
PsiBlast_CBE
61.67
41%
-94
- C5 -
1FGI
1
B:
[9-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
R--------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------
80
PsiBlast_CBE
61.64
41%
-88
- C5 -
3JS2
1
B:
[16-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
-----------------------------------
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------
82
PsiBlast_CBE
61.59
41%
-94
- C5 -
4F65
4
B:
[8-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
--P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP-------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------
81
PsiBlast_CBE
61.27
41%
-85
- C5 -
3JS2
1
FGFR1_HUMAN
A:
[16-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
G
L
-----------------------------
H
N
P
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------
76
PsiBlast_CBE
61.15
41%
-95
- C5 -
1AGW
1
B:
[9-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
R--------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------
89
PsiBlast_CBE
60.93
41%
-85
- C5 -
3TT0
1
FGFR1_HUMAN
A:
[57-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
G
L
E
Y
---------------
S
Y
-----
N
P
S
--
H
N
P
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------
72
PsiBlast_CBE
60.70
41%
-93
- C5 -
2FGI
1
B:
[9-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
----------------------------------------
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
R--------------------------------------
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------
47
PsiBlast_CBE
60.06
45%
-89
- C5 -
3VO3
2
A:
[16-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
-------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
--
S
-----
F
Q
V
A
--
K
G
M
E
F
L
A
S
R
K
C
-----------
I
H
R
D
---------------------------------------------
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-
G
--
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
97
PsiBlast_CBE
59.87
33%
-101
- C5 -
4AOJ
1
C:
[49-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
---
Q
--
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
--
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
--------
N
R
F
L
R
S
H
G
P
D
----------------------------------
G
-----------------------------------
P
----
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
-------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
-
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
--------------------------------------------------------
98
PsiBlast_CBE
59.49
33%
-104
- C5 -
4AOJ
1
NTRK1_HUMAN
B:
[49-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-------
K
M
L
V
A
V
K
A
L
K
E
A
S
E
--
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
--------
N
R
F
L
R
S
H
G
P
D
----------------------------------
G
-----------------------------------
P
----
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
-
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
--------------------------------------------------------
48
PsiBlast_CBE
59.40
45%
-87
- C5 -
3VNT
4
A:
[16-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
---------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
--
S
-----
F
Q
V
A
--
K
G
M
E
F
L
A
S
R
K
C
-----------
I
H
R
D
---------------------------------------------
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
-
G
--
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
-
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
------------------------------------------------------
94
PsiBlast_CBE
58.59
39%
-84
- C5 -
3C4F
1
B:
[1-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
---
T
E
K
D
--------
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
----------------
H
K
N
I
I
N
L
L
G
------
A
C
T
Q
-----
D
G
P
L
Y
V
I
V
----
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
----------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------
95
PsiBlast_CBE
58.33
39%
-83
- C5 -
3C4F
1
FGFR1_HUMAN
A:
[1-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
---
T
E
K
D
--------
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
----------------
H
K
N
I
I
N
L
L
G
------
A
C
T
Q
-----
D
G
P
L
Y
V
I
V
----
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
----------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
-
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------
91
PsiBlast_CBE
57.51
39%
-95
- C5 -
3GQL
1
C:
[16-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
---
T
E
K
D
--------
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
----------------
H
K
N
I
I
N
L
L
G
------
A
C
T
Q
-----
D
G
P
L
Y
V
I
V
----
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
-----------------------------------
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
----------------------------------------
96
PsiBlast_CBE
57.36
34%
-85
- C5 -
2IVS
5
RET_HUMAN
A:
[14-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
-
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
R
--
A
--
G
Y
T
T
V
A
V
K
M
L
K
E
N
A
S
P
-
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
--
V
G
P
G
Y
L
----------------
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
--
Q
G
M
Q
Y
L
A
----------------------------
E
M
K
----
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
------------------------
V
Y
E
E
D
S
Y
V
K
R
-
S
--
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
-
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
------------------------------------------------
93
PsiBlast_CBE
56.60
39%
-83
- C5 -
3GQL
1
FGFR1_HUMAN
A:
[16-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
---
T
E
K
D
--------
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
----------------
H
K
N
I
I
N
L
L
G
------
A
C
T
Q
-----
D
G
P
L
Y
V
I
V
----
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
-----------------------------------
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
L
D
L
S
------------------------------------
10
PsiBlast_PDB
56.59
96%
-98
- C5 -
3G0E
1
A:
[147-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
I
C
S
K
T
S
P
A
I
M
E
D
D
E
L
A
----
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
-
G
--
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
-
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
92
PsiBlast_CBE
56.48
39%
-87
- C5 -
3GQL
1
FGFR1_HUMAN
B:
[16-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
---
T
E
K
D
--------
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
----------------
H
K
N
I
I
N
L
L
G
------
A
C
T
Q
-----
D
G
P
L
Y
V
I
V
----
E
Y
A
S
K
--
G
N
L
R
E
Y
L
Q
A
R
RP
P
---------------------------------
P
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
-
P
V
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------
101
PsiBlast_CBE
53.20
31%
-66
- C5 -
2HZ0
1
ABL1_HUMAN
A:
[6-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
------------
K
W
E
M
E
R
T
D
I
T
M
K
-
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-----
V
W
K
--
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
-------
A
T
Q
I
--
S
S
A
M
E
Y
L
E
K
K
----------------------
N
F
I
H
R
D
---------------------------------------------
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
-
A
--
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---------------------------------------------------
100
PsiBlast_CBE
53.10
31%
-81
- C5 -
2HZ0
1
ABL1_HUMAN
B:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
------------
K
W
E
M
E
R
T
D
I
T
M
K
-
H
K
L
------
E
V
Y
E
G
-----
V
W
K
--
K
--
Y
S
L
T
V
A
V
K
T
L
-------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
-
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
-------
A
T
Q
I
--
S
S
A
M
E
Y
L
E
K
K
----------------------
N
F
I
H
R
D
---------------------------------------------
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---------------------------------------------------
105
PsiBlast_CBE
51.68
41%
-91
- C5 -
2OSC
1
A:
[107-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
----
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
-----------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
-
T
C
-
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
-------------------------------------
106
PsiBlast_CBE
51.60
41%
-91
- C5 -
2OO8
1
X:
[107-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
----
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
-----------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
-
T
C
-
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
-------------------------------------
107
PsiBlast_CBE
51.52
41%
-84
- C5 -
2WQB
1
A:
[114-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
----
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
Q
E
V
Y
V
K
K
-
T
---
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
-
T
C
-
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
-------------------------------------
103
PsiBlast_CBE
51.14
41%
-86
- C5 -
2P4I
1
B:
[107-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
----
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
------------------
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
-
T
C
-
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
-------------------------------------
104
PsiBlast_CBE
49.91
41%
-84
- C5 -
2P4I
1
TIE2_HUMAN
A:
[107-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
----
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
--------
V
K
K
-
T
--
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
-
T
C
-
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
-------------------------------------
102
PsiBlast_CBE
49.19
41%
-76
- C5 -
3L8P
1
A:
[107-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
----
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
Q
E
V
Y
V
K
K
--------
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
-
T
C
-
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
-------------------------------------
108
PsiBlast_CBE
49.04
45%
-76
- C5 -
3PLS
1
A:
[123-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
E
Y
Y
S
V
Q
-
Q
HR
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
--
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
L
V
G
E
V
E
Q
I
V
S
-----------------------------------------------
Add PDB User Result:
(59 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV
141
-
100%
-113
- C5 -
U141
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
D
A
A
M
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
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--
A
R
L
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V
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W
M
A
P
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I
F
N
C
V
Y
T
F
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D
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W
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Y
G
I
F
L
W
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L
F
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L
G
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P
Y
P
G
M
P
V
D
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K
F
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K
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A
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A
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Y
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L
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R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
142
-
98%
-129
- C5 -
U142
1
B:
[576-922]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
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---
K
V
V
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A
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M
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----
H
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G
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Y
C
C
Y
G
D
L
L
N
F
L
-------------------------
H
S
K
E
-------
N
E
Y
V
P
T
K
-------------------------------------
A
L
D
L
E
D
L
L
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F
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Y
Q
V
A
K
G
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A
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A
A
R
N
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L
L
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G
R
I
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K
I
C
D
F
--------------------
P
V
K
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N
C
V
Y
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F
E
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D
V
W
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Y
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Y
P
G
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D
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Y
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M
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C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
143
-
100%
-113
- C5 -
U143
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
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G
A
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L
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
A
L
D
L
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D
L
L
S
F
S
Y
Q
V
A
K
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L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
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I
K
N
D
S
N
Y
V
V
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--
A
R
L
P
V
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A
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L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
144
-
100%
-113
- C5 -
U144
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
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K
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L
G
A
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A
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G
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L
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L
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L
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L
L
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A
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I
G
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
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--
A
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Y
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M
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P
L
K
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
145
-
100%
-113
- C5 -
U145
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
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F
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L
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L
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N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
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Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
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L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
146
-
100%
-113
- C5 -
U146
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
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C
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L
L
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F
L
R
R
K
R
D
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F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
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D
L
L
S
F
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Y
Q
V
A
K
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L
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--
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
147
-
99%
-114
- C5 -
U147
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
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G
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P
T
L
V
I
T
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Y
C
C
Y
G
D
L
L
N
F
L
-------------------------
H
S
K
E
-------
N
E
Y
----------
V
P
T
E
D
D
-------------------------
A
L
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L
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L
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V
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I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
148
-
100%
-113
- C5 -
U148
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
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F
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C
Y
G
D
L
L
N
F
L
R
R
K
R
D
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F
I
C
S
K
----------------------------------------------------------------
E
D
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L
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L
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L
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L
L
S
F
S
Y
Q
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A
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--
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L
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
149
-
100%
-113
- C5 -
U149
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
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W
E
F
P
R
N
R
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D
L
L
N
F
L
R
R
K
R
D
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F
I
C
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----------------------------------------------------------------
E
D
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L
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L
L
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F
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Y
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A
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--
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F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
150
-
100%
-113
- C5 -
U150
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
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F
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A
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L
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C
C
Y
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L
L
N
F
L
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R
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K
----------------------------------------------------------------
E
D
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L
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L
L
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F
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Y
Q
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--
A
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
151
-
100%
-113
- C5 -
U151
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
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L
L
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F
L
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R
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K
----------------------------------------------------------------
E
D
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L
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L
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L
L
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F
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Y
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--
A
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
152
-
100%
-113
- C5 -
U152
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
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N
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C
C
Y
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L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
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L
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L
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D
L
L
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F
S
Y
Q
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A
K
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--
A
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L
K
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
153
-
100%
-113
- C5 -
U153
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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L
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
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--
A
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
154
-
100%
-113
- C5 -
U154
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
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N
R
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C
Y
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L
L
N
F
L
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R
K
R
D
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F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
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L
D
L
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D
L
L
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F
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Y
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
155
-
100%
-113
- C5 -
U155
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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C
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L
L
N
F
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R
K
R
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F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
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L
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L
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L
L
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F
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Y
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
156
-
100%
-113
- C5 -
U156
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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C
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D
L
L
N
F
L
R
R
K
R
D
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F
I
C
S
K
----------------------------------------------------------------
E
D
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L
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L
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
157
-
100%
-113
- C5 -
U157
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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C
C
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D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
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A
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
158
-
100%
-113
- C5 -
U158
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
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W
E
F
P
R
N
R
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C
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L
L
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F
L
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R
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D
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F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
A
L
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L
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L
L
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F
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Y
Q
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A
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--
A
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A
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
159
-
98%
-117
- C5 -
U159
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
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---
A
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-------------------------
H
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-------
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--------------------------
V
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--
A
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----
D
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-----
L
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Y
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Y
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M
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K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
160
-
100%
-113
- C5 -
U160
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
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F
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L
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
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F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
A
L
D
L
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L
L
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F
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Y
Q
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A
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L
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D
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Y
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--
A
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L
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R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
161
-
100%
-113
- C5 -
U161
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
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L
L
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
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A
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L
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L
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A
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D
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Y
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V
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--
A
R
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F
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Y
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A
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A
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M
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P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
162
-
100%
-113
- C5 -
U162
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
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L
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L
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L
L
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G
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
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A
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L
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D
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N
Y
V
V
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--
A
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M
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A
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L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
163
-
100%
-113
- C5 -
U163
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
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L
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L
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L
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
A
L
D
L
E
D
L
L
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F
S
Y
Q
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A
K
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--
A
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M
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L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
164
-
100%
-113
- C5 -
U164
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
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L
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L
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L
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A
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
A
L
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L
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D
L
L
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F
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Y
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A
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--
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M
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L
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R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
165
-
100%
-113
- C5 -
U165
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
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L
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L
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A
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G
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
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D
L
L
S
F
S
Y
Q
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A
K
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L
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R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
166
-
100%
-113
- C5 -
U166
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
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F
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L
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A
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G
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
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L
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L
L
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F
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Y
Q
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A
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--
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
167
-
100%
-113
- C5 -
U167
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
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W
E
F
P
R
N
R
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C
Y
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D
L
L
N
F
L
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R
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R
D
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F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
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D
L
L
S
F
S
Y
Q
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A
K
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Y
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L
K
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
168
-
100%
-113
- C5 -
U168
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
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K
W
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F
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R
N
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C
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L
L
N
F
L
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R
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I
C
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K
----------------------------------------------------------------
E
D
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L
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L
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L
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L
L
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F
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Y
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--
A
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T
F
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Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
169
-
100%
-113
- C5 -
U169
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
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N
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
A
L
D
L
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D
L
L
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F
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Y
Q
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A
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--
A
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P
T
F
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Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
170
-
100%
-113
- C5 -
U170
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
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K
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E
F
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R
N
R
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
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L
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L
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D
L
L
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F
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Y
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--
A
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L
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
171
-
100%
-113
- C5 -
U171
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
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R
N
R
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C
Y
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L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
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L
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L
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L
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L
L
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F
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Y
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
172
-
100%
-113
- C5 -
U172
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
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L
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L
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D
L
L
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F
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Y
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T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
173
-
100%
-113
- C5 -
U173
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
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Q
L
P
Y
D
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F
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R
N
R
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C
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D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
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L
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L
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L
L
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F
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Y
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T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
174
-
100%
-113
- C5 -
U174
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
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P
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Q
L
P
Y
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F
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N
R
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C
Y
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D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
A
L
D
L
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D
L
L
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F
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Y
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T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
175
-
100%
-113
- C5 -
U175
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
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P
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Q
L
P
Y
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C
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D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
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L
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L
L
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F
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T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
176
-
100%
-113
- C5 -
U176
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
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Q
L
P
Y
D
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F
P
R
N
R
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C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
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--
A
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R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
177
-
100%
-113
- C5 -
U177
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
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Q
L
P
Y
D
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L
L
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R
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----------------------------------------------------------------
E
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L
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L
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L
L
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Y
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--
A
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Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
178
-
98%
-117
- C5 -
U178
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
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R
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---
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-------------------------
H
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-------
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V
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--------------------------
V
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--
A
L
D
L
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L
L
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F
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F
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-------------------
P
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C
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C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
179
-
100%
-113
- C5 -
U179
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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C
Y
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L
L
N
F
L
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R
K
R
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F
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K
----------------------------------------------------------------
E
D
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L
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L
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L
L
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F
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Y
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A
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P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
180
-
100%
-113
- C5 -
U180
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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L
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C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
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C
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K
----------------------------------------------------------------
E
D
D
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L
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L
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L
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D
L
L
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F
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Y
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A
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T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
181
-
100%
-113
- C5 -
U181
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
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Q
L
P
Y
D
H
K
W
E
F
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R
N
R
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L
L
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F
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R
R
K
R
D
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F
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K
----------------------------------------------------------------
E
D
D
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L
A
L
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L
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L
L
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F
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Y
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A
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Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
182
-
98%
-117
- C5 -
U182
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
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A
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---
A
A
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L
L
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F
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-------------------------
H
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-------
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V
P
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--------------------------
V
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--
A
L
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L
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K
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C
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F
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-------------------
P
V
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A
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F
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C
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Y
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F
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L
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M
K
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C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
183
-
100%
-113
- C5 -
U183
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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C
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L
L
N
F
L
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R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
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L
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L
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D
L
L
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F
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Y
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T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
184
-
100%
-113
- C5 -
U184
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
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P
T
Q
L
P
Y
D
H
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W
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F
P
R
N
R
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R
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R
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F
I
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----------------------------------------------------------------
E
D
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L
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L
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F
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Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
185
-
100%
-113
- C5 -
U185
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
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Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
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L
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A
C
T
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G
G
P
T
L
V
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T
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Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
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A
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N
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L
A
A
R
N
I
L
L
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H
G
R
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T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
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--
A
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K
W
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A
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I
F
N
C
V
Y
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W
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Y
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W
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L
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L
G
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Y
P
G
M
P
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K
F
Y
K
M
I
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F
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M
L
S
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H
A
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A
E
M
Y
D
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M
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C
W
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A
D
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L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
186
-
100%
-113
- C5 -
U186
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
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A
Y
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L
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D
A
A
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A
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K
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A
L
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L
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L
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Y
L
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N
L
L
G
A
C
T
I
G
G
P
T
L
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Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
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A
F
L
A
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N
C
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L
A
A
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N
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L
L
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H
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R
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T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
--
A
R
L
P
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K
W
M
A
P
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S
I
F
N
C
V
Y
T
F
E
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W
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Y
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L
W
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L
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L
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Y
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Y
D
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W
D
A
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P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
187
-
98%
-118
- C5 -
U187
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
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L
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L
K
V
L
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Y
L
G
N
H
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N
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L
L
G
A
C
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I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------------------------
H
S
K
E
-------
N
E
Y
V
P
T
K
--------------------------
V
T
P
A
I
M
E
D
D
--
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
-------------
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
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G
F
R
M
L
S
P
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H
A
P
A
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M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
188
-
98%
-117
- C5 -
U188
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
---
A
A
M
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
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L
K
V
L
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Y
L
G
N
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N
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N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------------------------
H
S
K
E
-------
N
E
Y
V
P
T
K
--------------------------
V
T
P
A
I
M
E
D
D
--
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
-------------------
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
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D
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K
F
Y
K
M
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K
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G
F
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M
L
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A
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M
Y
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I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
189
-
98%
-117
- C5 -
U189
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
---
A
A
M
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
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L
G
N
H
M
N
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N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------------------------
H
S
K
E
-------
N
E
Y
V
P
T
K
--------------------------
V
T
P
A
I
M
E
D
D
--
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
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N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
-------------------
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
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D
V
W
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Y
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F
L
W
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L
F
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L
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G
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D
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K
F
Y
K
M
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K
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G
F
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M
L
S
P
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A
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A
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M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
190
-
98%
-118
- C5 -
U190
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
--
G
K
V
V
E
A
T
A
Y
G
L
I
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--
A
A
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V
A
V
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A
H
L
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R
E
A
L
M
S
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L
K
V
L
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Y
L
G
N
H
M
N
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V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------------------------
H
S
K
E
-------
N
E
Y
V
P
T
K
--------------------------
V
T
P
A
I
M
E
D
D
--
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
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K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
-------------------
L
P
V
K
W
M
A
P
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S
I
F
N
C
V
Y
T
F
E
S
D
V
W
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Y
G
I
F
L
W
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F
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L
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P
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P
G
M
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D
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K
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Y
K
M
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K
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G
F
R
M
L
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P
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H
A
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A
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M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
191
-
98%
-118
- C5 -
U191
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
---
K
V
V
E
A
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A
Y
G
L
I
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A
A
M
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A
V
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A
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L
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A
L
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S
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L
K
V
L
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Y
L
G
N
H
M
N
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N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------------------------
H
S
K
E
-------
N
E
Y
V
P
T
K
--------------------------
V
T
P
A
I
M
E
D
D
--
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
N
--------------
A
R
L
P
V
K
W
M
A
P
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S
I
F
N
C
V
Y
T
F
E
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D
V
W
S
Y
G
I
F
L
W
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L
F
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L
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P
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G
M
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K
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Y
K
M
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G
F
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M
L
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A
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A
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M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
192
-
98%
-117
- C5 -
U192
1
A:
[575-922]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
---
A
A
M
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V
A
V
K
M
L
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A
H
L
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R
E
A
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L
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V
L
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L
G
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M
N
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N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-------------------------
H
S
K
E
-------
N
E
Y
V
P
T
K
--------------------------
V
T
P
A
I
M
E
D
D
--
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
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G
M
A
F
L
A
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C
I
H
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D
L
A
A
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N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
-------------------
P
V
K
W
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A
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I
F
N
C
V
Y
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F
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D
V
W
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Y
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F
L
W
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L
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K
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M
L
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Y
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I
M
K
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C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------
193
-
100%
-111
- C5 -
U193
1
A:
[565-933]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
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F
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G
A
G
A
F
G
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V
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A
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G
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A
A
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A
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K
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A
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A
L
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L
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L
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Y
L
G
N
H
M
N
I
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N
L
L
G
A
C
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G
G
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L
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I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
------------------------------------------------------------------------
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
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C
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L
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G
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P
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Q
I
V
Q
L
I
E
K
Q
I
S
E
S
T
N
-------------------------------------------
194
-
100%
-113
- C5 -
U194
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
D
P
T
Q
L
P
Y
D
H
K
W
E
F
P
R
N
R
L
S
F
G
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T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
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K
S
D
A
A
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A
V
K
M
L
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P
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A
H
L
T
E
R
E
A
L
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E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
----------------------------------------------------------------
E
D
D
E
L
A
L
D
L
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--
A
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F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
---------------------------------------------
195
-
100%
-113
- C5 -
U195
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
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P
T
Q
L
P
Y
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F
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----------------------------------------------------------------
E
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V
Q
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I
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K
Q
I
S
E
S
---------------------------------------------
196
-
100%
-113
- C5 -
U196
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
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----------------------------------------------------------------
E
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Q
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V
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K
Q
I
S
E
S
---------------------------------------------
197
-
100%
-113
- C5 -
U197
1
A:
[570-931]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
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----------------------------------------------------------------
E
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V
Q
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I
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K
Q
I
S
E
S
---------------------------------------------
198
-
100%
-116
- C5 -
U198
1
A:
[573-928]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
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------------
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A
A
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-------------------------------------------------------
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K
Q
I
------------------------------------------------
199
-
100%
-116
- C5 -
U199
1
A:
[573-928]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
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------------
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-------------------------------------------------------
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Q
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------------------------------------------------