@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPCD2_HUMAN: (2013-07-22 )
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDVRWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
Atome Classification :
(47 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550...-----....560.......570.......580..--...---..-590----..----.....600.......610.......620.......630.-...--....640....-...650.......660......-.670.......680....-...690.......-700........-710........720...---....730.......740.......750--.--.---.--.---.--...760.......770.......780.......790....-----.-----..800.......810---........820.......830.......840.......850.......860.......870......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDE-----VLGSGQFGVVYGGKHRKTGRDVAVKVIDK--LRF---PT-KQE----SQ----LRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKL-HG-DML--EMILSSEKGRL-PERLTKFLITQILVALRHLHFK-NIVHCDLKPENVLLASAD-PFPQVKLCDFGFA-RI-IGEKSFRR-S-VVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVSLSGTFPF---N--E---D--E---D--INDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRY-----S-----VDKSLSHPWLQEYQ----TWLDLRELEGKMGERYITHESDDVRWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
29
PsiBlast_CBE
67.00
36%
-115
- C1 -
3MFR
1
CSKP_HUMAN
A:
[19-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
G
G
-
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
-----------------------------------------------------------------
27
PsiBlast_CBE
65.98
36%
-112
- C1 -
3MFU
1
CSKP_HUMAN
A:
[19-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
SS
P
G
-
L
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
G
G
-
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
-----------------------------------------------------------------
28
PsiBlast_CBE
65.93
36%
-115
- C1 -
3MFS
1
CSKP_HUMAN
A:
[18-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
G
G
-
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
-----------------------------------------------------------------
75
PsiBlast_CBE
65.57
36%
-113
- C1 -
3HX4
3
?
A:
[47-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
KGQR
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----------
D
K
E
----
S
L
----
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
-
T
G
G
E
L
F
--
D
E
I
I
S
--
R
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
GA
N
---
E
--
Y
---
D
--
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
------------------------------------------------------------------------
42
PsiBlast_CBE
65.39
35%
-114
- C1 -
3C0H
1
CSKP_HUMAN
B:
[19-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
TSS
P
G
-
L
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
-
A
D
L
CF
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
-----------------------------------------------------------------
44
PsiBlast_CBE
64.33
35%
-115
- C1 -
3C0G
1
CSKP_HUMAN
B:
[19-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
-----------------------------------------------------------------
45
PsiBlast_CBE
63.98
35%
-112
- C1 -
3C0G
1
CSKP_HUMAN
A:
[20-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
-----------------------------------------------------------------
137
HHSearch
63.87
33%
-107
- C1 -
3Q5I
1
?
A:
[18-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
I
N
P
G
M
Y
V
R
K
K
E
G
K
I
G
E
S
Y
F
K
--
V
R
-----
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
-----------
K
F
H
----
E
E
----
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
-
E
G
G
E
L
F
--
E
Q
I
I
N
--
R
H
K
F
-
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
-
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
-
S
L
L
N
I
K
I
V
D
F
G
L
S
-
S
F
-
F
S
K
D
Y
K
L
R
-
D
-
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
----
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
---
G
--
G
QN-
D
--
Q
---
D
--
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
-----
T
-----
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
-----------------------------------------------------------------------
41
PsiBlast_CBE
63.61
35%
-110
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
-----------------------------------------------------------------
46
PsiBlast_CBE
63.54
35%
-99
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[6-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
30
PsiBlast_CBE
63.52
36%
-105
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[6-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
-----
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
-
R
D
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
-
T
G
G
E
L
F
--
E
D
I
V
A
R
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W--
D
--
E
---
D
--
Q
---
H
R-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
----
T
------------------------------------------------------------------
32
PsiBlast_CBE
63.15
34%
-99
- C1 -
3NCG
1
?
A:
[29-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
--
A
S
A
---
K
N
-
K
D
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
-
T
G
G
E
L
F
--
D
E
I
I
--
K
R
K
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
Q
N
T
-------
I
G
T
A
Y
Y
I
A
P
E
V
-
L
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG-
K
--
N
---
E
--
Y
---
D
--
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
---------
N
I
R
--
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
---------------------------
71
PsiBlast_CBE
63.09
34%
-101
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[6-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
63
PsiBlast_CBE
62.96
34%
-99
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[6-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
64
PsiBlast_CBE
62.81
34%
-98
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[6-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
31
PsiBlast_CBE
62.54
36%
-107
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[6-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
-----
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
-
R
D
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
-
T
G
G
E
L
F
--
E
D
I
V
A
R
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W--
D
--
E
---
D
--
Q
---
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
----
T
------------------------------------------------------------------
43
PsiBlast_CBE
62.50
35%
-111
- C1 -
3C0H
1
CSKP_HUMAN
A:
[19-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
----
E
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
-
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y--
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
----
R
Y
-----------------------------------------------------------------
78
PsiBlast_CBE
62.09
34%
-111
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[18-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
G
V
S
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
-----
I
Q
E
A
L
R
H
P
W
I
---------------------------------------------------------------------------
104
PsiBlast_CBE
61.59
36%
-106
- C1 -
3I7B
4
?
A:
[23-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
RQ
V
K
Q
---
K
T
-
D
K
E
----
S
L
----
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
-
T
G
G
E
L
F
--
D
E
I
I
S
--
R
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
GA
N
---
E
--
Y
---
D
--
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
------------------------------------------------------------------------
55
PsiBlast_CBE
61.54
34%
-97
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[6-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
--
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
125
HHSearch
61.44
33%
-106
- C1 -
4GV1
5
AKT1_HUMAN
A:
[10-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
Y
L
--
K
-----
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
--
E
V
I
---
V
A
K
D
E
V
----
A
H
----
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
-
N
G
G
E
L
F
--
F
H
L
S
--
R
E
R
V
F
-
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
----
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
I
K
D
G
A
T
M
K
-
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
--
N
Q
D
-
H
--
E
---
K
--
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
-----
W
Q
H
V
Y
-------------------------------------------------------------
50
PsiBlast_CBE
61.39
35%
-109
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[18-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
GVC
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
-----
I
Q
E
A
L
R
H
P
W
I
---------------------------------------------------------------------------
57
PsiBlast_CBE
61.37
34%
-100
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
-
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
89
PsiBlast_CBE
61.34
34%
-98
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[6-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVSR
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
TK
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
47
PsiBlast_CBE
61.30
35%
-106
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[33-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
-----
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
-
R
D
H
----
Q
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
-
T
G
G
E
L
F
--
E
D
I
V
A
R
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
-
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
E
Q
Q
A
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
---
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W--
D
--
E
---
D
--
Q
H
--
K
--
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
----
T
------------------------------------------------------------------
61
PsiBlast_CBE
61.29
34%
-100
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
103
PsiBlast_CBE
61.25
36%
-104
- C1 -
3N51
3
?
A:
[23-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
RQ
V
K
Q
---
K
T
-
D
K
E
----
S
L
----
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
-
T
G
G
E
L
F
--
D
E
I
I
S
--
R
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
-
L
H
---
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
---
N
GA
N
---
E
--
Y
---
D
--
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
------------------------------------------------------------------------
73
PsiBlast_CBE
60.95
34%
-100
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[6-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
34
PsiBlast_CBE
60.73
34%
-99
- C1 -
3IGO
8
?
A:
[29-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
--
A
S
A
---
K
N
-
K
-
T
----
S
T
----
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
-
T
G
G
E
L
F
--
D
E
I
I
--
K
R
K
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
Q
N
T
---------
T
A
Y
Y
I
A
P
E
V
-
L
R
---
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG-
K
--
N
---
E
--
Y
---
D
--
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
---------
N
I
R
--
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
---------------------------
67
PsiBlast_CBE
60.61
34%
-113
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------------VS
R
-
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
----
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
------------
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
60
PsiBlast_CBE
60.19
34%
-97
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
77
PsiBlast_CBE
60.13
34%
-107
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[18-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
GVSR
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
TK
Q
---
E
--
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
-----
I
Q
E
A
L
R
H
P
W
I
---------------------------------------------------------------------------
2
PsiBlast_PDB
59.84
37%
-112
- C1 -
2CN5
1
CHK2_HUMAN
A:
[22-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--
R
-----------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
-------------------------------------------------------------------------
79
PsiBlast_CBE
59.71
34%
-107
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[18-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
G
V
S
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
-----
I
Q
E
A
L
R
H
P
W
I
---------------------------------------------------------------------------
76
PsiBlast_CBE
59.64
34%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[18-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
GVSR
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
TK
Q
---
E
--
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
-----
I
Q
E
A
L
R
H
P
W
I
---------------------------------------------------------------------------
26
PsiBlast_CBE
59.22
36%
-108
- C1 -
2W4O
1
KCC4_HUMAN
A:
[61-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
----------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
-
T
G
G
E
L
F
--
D
R
I
V
--
E
K
G
Y
Y
-
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
--------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
---
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
---
Y
--
D
ERG
D
--
Q
---
F
--
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
-----
T
-----
T
F
Q
A
L
Q
H
P
W
V
---------------------------------------------------------------------------
16
PsiBlast_PDB
58.91
37%
-106
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
--
S
----------------
S
----
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
-
S
G
G
E
L
F
--
D
R
I
L
--
E
R
G
V
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
--
E
Q
N
G
I
M
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
---
Y
--
E
---
E
--
T
---
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
-----
C
E
K
A
L
S
H
P
W
I
---------------------------------------------------------------------------
22
PsiBlast_CBE
58.48
37%
-103
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
--
S
----------------
S
----
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
-
S
G
G
E
L
F
--
D
R
I
L
--
E
R
G
V
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
--
E
Q
N
G
I
M
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
---
Y
--
E
---
E
--
T
---
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
-----
C
E
K
A
L
S
H
P
W
I
---------------------------------------------------------------------------
70
PsiBlast_CBE
57.96
34%
-99
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---------R---
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
--------------
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
62
PsiBlast_CBE
57.81
34%
-101
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
-------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
4
PsiBlast_PDB
57.14
37%
-105
- C1 -
4A9T
4
CHK2_HUMAN
A:
[22-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
-------------------------------------------------------------------------
3
PsiBlast_PDB
56.89
37%
-109
- C1 -
2XM9
1
CHK2_HUMAN
A:
[22-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
-
E
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
---
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
-------------------------------------------------------------------------
69
PsiBlast_CBE
56.16
34%
-100
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
--
R
R
GVS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
-
G
E
L
--
F
D
F
L
A
E
K
--
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
------------
T
P
E
F
V
A
P
E
I
V
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
---
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------
40
PsiBlast_CBE
54.47
32%
-84
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
----------
F
Y
T
V
S
K
T
E
-----
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
--
R
G
M
---
K
D
-
K
E
E
----------
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
-
D
G
-
G
E
L
--
F
D
R
I
I
D
E
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
-
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
-
Y
K
P
R
E
K
L
K
-
V
-
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
---
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
LGD
N
--
D
---
A
--
E
---
T
--
L
N
N
-
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
-----
A
S
E
A
L
K
H
P
W
L
S
D
H
K
-----------------------------------------------------------------------
90
PsiBlast_CBE
45.41
35%
-66
- C1 -
2GNI
1
KAPCA_BOVIN
A:
[47-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
--
Q
K
V
V
--
K
L
-
K
Q
I
----
E
H
----
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
-
D
M
F
--
S
H
L
--
R
R
I
G
R
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-
K
R
-
V
K
G
R
T
W
-----
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
---
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
--
A
---
D
--
Q
P
I
-
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
-----
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------
88
PsiBlast_CBE
44.81
35%
-67
- C1 -
2GNF
1
KAPCA_BOVIN
A:
[47-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
--
Q
K
V
V
--
K
L
-
K
Q
I
----
E
H
----
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
-
D
M
F
--
S
H
L
--
R
R
I
G
R
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-
K
R
-
V
K
G
R
T
W
-----
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
---
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
--
A
---
D
--
Q
P
I
-
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
-----
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------
91
PsiBlast_CBE
43.31
35%
-65
- C1 -
2GNH
2
KAPCA_BOVIN
A:
[47-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
--
Q
K
V
V
--
K
L
-
K
Q
I
----
E
H
----
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
-
D
M
F
--
S
H
L
--
R
R
I
G
R
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-
K
R
-
V
K
G
R
T
W
-----
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
---
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
--
A
---
D
--
Q
P
I
-
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
-----
V
N
D
I
K
N
H
K
W
F
---------------------------------------------------------------------------