@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPCD3_HUMAN: (2013-07-22 )
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
Atome Classification :
(43 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580---.........590.......600.......--610---..-....----.----620.......630.......640.......650.-..-.-.-..660.........670........680.......690.-......700.......710........720..-..-...730-.......740......-.750-.........760.......770....--.--.---.--780-.--.......-------------------.790---..----...----..800.......810.......820-----.......830..-----.....-----840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADE-----VLGSGQFGIVYGGKHRKTGRDVAIKVIDK--MRF---PT-KQES----Q----LRNEVAILQNLHHPGIVNLECMFETPERVFVVME-KL-H-G-DML--EMILSSEKSRL-PERITKFMVTQILVALRNLHFK-NIVHCDLKPENVLLASAE-PFPQVKLCDFGFA-RI-IGEKSF-RRSVVGTPAYLAPEVL-RS---KGYNRSLDMWSVGVIIYVSLSGTFPF--N--E---D--E---D--INDQIQN-------------------AAFM---YP----PNP----WREISGEAIDLINNLLQVKMRKRYS-----VDKSLSHPWLQD-----YQTWL-----DLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
33
PsiBlast_CBE
70.27
34%
-107
- C1 -
3MFR
1
CSKP_HUMAN
A:
[19-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
-------------------
G
K
Y
K
---
M
N
----
P
R
Q
----
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
-------------------------------------------
32
PsiBlast_CBE
70.00
34%
-107
- C1 -
3MFS
1
CSKP_HUMAN
A:
[18-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
-------------------
G
K
Y
K
---
M
N
----
P
R
Q
----
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
RDRY
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
-------------------------------------------
31
PsiBlast_CBE
68.83
34%
-103
- C1 -
3MFU
1
CSKP_HUMAN
A:
[19-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
SS
P
G
-
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
D
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
-------------------
G
K
Y
K
---
M
N
----
P
R
Q
----
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
-------------------------------------------
47
PsiBlast_CBE
66.50
33%
-104
- C1 -
3C0I
1
CSKP_HUMAN
A:
[20-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
C
--
E
-----
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
--
A
K
F
T
S
S
P
G
-
L
S
T
E
----
D
----
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
-
F
M
-
D
-
G
-
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
-
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-
K
R
---
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y-
G
--
T
---
K
--
E
---
R
--
L
F
E
G
I
I
K
-------------------
G
K
Y
K
---
M
N
----
P
R
Q
----
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
RDRYA
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
-------------------------------------------
116
HHSearch
66.11
35%
-112
* C1 *
4FG7
1
KCC1A_HUMAN
A:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
--
R
D
-----
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--------------------
S
----
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
-
L
V
-
S
G
G
-
E
L
F
--
D
R
I
V
--
E
K
G
F
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
-
K
M
-
E
D
P
G
---------
T
P
G
Y
V
A
P
E
V
L
-
A
Q
---
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
EN-
D
--
A
---
K
--
L
F
E
Q
I
L
K
-------------------
A
E
Y
E
---
F
D
----
S
P
Y
----
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
-------------------------------------------------------------------
136
HHSearch
65.96
35%
-104
- C1 -
3Q5I
1
?
A:
[21-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
P
G
M
Y
V
R
K
K
E
G
K
I
G
E
S
Y
F
K
--
V
R
-----
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
-----------
K
F
H
E
----
E
----
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
-
F
Y
-
E
-
G
G
E
L
F
--
E
Q
I
I
N
--
R
H
K
F
-
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
-
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
-
S
L
L
N
I
K
I
V
D
F
G
L
S
-
S
F
-
F
S
K
D
Y
K
-
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-
K
K
----
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
--
G
--
G
QN-
D
--
Q
---
D
--
I
I
K
K
V
E
K
-------------------
G
K
Y
Y
---
F
D
----
F
N
D
----
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
E
E
A
L
N
S
R
W
I
K
K
-----
Y
A
-----------------------------------------------------------
57
PsiBlast_CBE
65.79
35%
-107
- C1 -
3HX4
3
?
A:
[47-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
KGQR
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----------
D
K
E
S
----
L
----
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
-
G
-
G
-
E
L
F
--
D
E
I
I
S
--
R
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
G
---
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
GA
N
---
E
--
Y
---
D
--
I
L
K
K
V
E
K
-------------------
G
K
Y
T
---
F
E
----
L
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
------------------------------------------------------------
54
PsiBlast_CBE
65.30
34%
-96
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
-
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
20
PsiBlast_PDB
64.84
34%
-118
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
-
F
R
D
------
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--
E
-----------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
V
--
E
K
G
F
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
--------------------
T
P
G
Y
V
A
P
E
V
L
-
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
---
E
--
N
---
D
A
K
L
F
E
Q
I
L
K
-------------------
A
E
Y
E
---
F
D
----
S
P
Y
----
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------
94
PsiBlast_CBE
64.69
33%
-94
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
89
PsiBlast_CBE
64.61
33%
-95
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
88
PsiBlast_CBE
64.50
33%
-99
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
95
PsiBlast_CBE
64.41
33%
-97
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
125
HHSearch
64.07
34%
-102
- C1 -
4GV1
5
AKT1_HUMAN
A:
[10-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
Y
L
--
K
-----
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
--
E
V
I
---
V
A
K
D
E
V
A
----
H
----
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
-
Y
A
-
N
-
G
G
E
L
F
--
F
H
L
S
--
R
E
R
V
F
-
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
----
H
I
K
I
T
D
F
G
L
C
-
K
E
G
I
K
D
G
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
-
E
D
---
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
Q
D
-
H
--
E
---
K
--
L
F
E
L
I
L
M
-------------------
E
E
I
R
---
F
P
------------
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
-----
I
V
-
W
Q
-----
H
V
Y
E
-----------------------------------------------
30
PsiBlast_CBE
63.52
36%
-102
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
-----
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
-
R
D
H
Q
----
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
-
G
-
E
L
F
--
E
D
I
V
A
R
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W-
D
--
E
---
D
--
Q
---
H
R
-
L
Y
Q
Q
I
K
A
-------------------
G
A
Y
D
---
F
P
----
S
P
E
----
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------
7
PsiBlast_PDB
63.31
39%
-106
- C1 -
2YCS
1
CHK2_HUMAN
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
-------------------
G
K
Y
N
---
F
I
----
P
E
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
------------------------------------------------------------------
9
PsiBlast_PDB
63.08
39%
-106
- C1 -
2CN5
1
CHK2_HUMAN
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--
R
-----------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
-------------------
G
K
Y
N
---
F
I
----
P
E
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
------------------------------------------------------------------
2
PsiBlast_PDB
63.05
39%
-107
- C1 -
2YCR
1
CHK2_HUMAN
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
-------------------
G
K
Y
N
---
F
I
----
P
E
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
------------------------------------------------------------------
58
PsiBlast_CBE
62.98
34%
-108
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
Y
E
D
-------
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
-
R
D
H
Q
----
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
-
G
-
E
L
F
--
E
D
I
V
A
R
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
-
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
K
---
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W-
D
--
E
---
D
--
Q
H--
K
--
L
Y
Q
Q
I
K
A
-------------------
G
A
Y
D
---
F
P
----
S
P
E
----
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
H
E
A
L
K
H
P
W
V
--------------------------------------------------------------------
39
PsiBlast_CBE
62.96
35%
-104
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[33-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
-----
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
-
R
D
H
Q
----
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
-
G
-
E
L
F
--
E
D
I
V
A
R
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
-
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
E
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
K
---
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W-
D
--
E
---
D
--
Q
H
--
K
--
L
Y
Q
Q
I
K
A
-------------------
G
A
Y
D
---
F
P
----
S
P
E
----
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
D
Q
A
L
K
H
P
W
V
--------------------------------------------------------------------
23
PsiBlast_CBE
62.82
34%
-116
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
Y
D
-
F
R
D
------
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
V
--
E
K
G
F
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
---------
G
S
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
-
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
---
E
--
N
---
D
A
K
L
F
E
Q
I
L
K
-------------------
A
E
Y
E
---
F
D
----
S
P
Y
----
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------
59
PsiBlast_CBE
62.67
34%
-106
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
Y
E
D
-------
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
-
R
D
H
Q
----
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
-
G
-
E
L
F
--
E
D
I
V
A
R
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
-
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
K
---
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W-
D
--
E
---
D
--
Q
H
--
K
--
L
Y
Q
Q
I
K
A
-------------------
G
A
Y
D
---
F
P
----
S
P
E
----
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
H
E
A
L
K
H
P
W
V
--------------------------------------------------------------------
77
PsiBlast_CBE
62.63
33%
-97
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
K
-
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
74
PsiBlast_CBE
62.58
33%
-92
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
--
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
38
PsiBlast_CBE
62.48
37%
-107
- C1 -
3HZT
9
?
A:
[12-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
--
S
S
V
---
T
T
-
T
S
N
S
G
---
A
----
L
L
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
-
V
Y
-
R
-
G
-
G
E
L
F
D
E
I
I
L
---
R
Q
K
F
-
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
R
D
A
L
I
K
I
V
D
F
G
L
S
-
A
H
-
F
E
V
G
---------
T
A
Y
Y
I
A
P
E
V
L
-
R
K
---
K
-
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
GG
Q
--
T
---
D
--
Q
---
E
--
I
L
K
R
V
E
K
-------------------
G
K
F
S
---
F
D
----
P
P
D
----
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
E
E
A
L
N
H
P
W
I
--------------------------------------------------------------------
29
PsiBlast_CBE
62.38
35%
-95
- C1 -
3IGO
8
?
A:
[29-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
--
A
S
A
---
K
N
-
K
-
T
S
----
T
----
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
-
G
-
G
-
E
L
F
--
D
E
I
I
--
K
R
K
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
-
F
Q
Q
N
T
--------
T
A
Y
Y
I
A
P
E
V
L
-
R
G
---
T
-
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
YG
K
--
N
---
E
--
Y
---
D
--
I
L
K
R
V
E
T
-------------------
G
K
Y
A
---
F
D
----
L
P
Q
----
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
----------------------------------------------------------
42
PsiBlast_CBE
62.36
35%
-103
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[18-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
G
VC
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
-
L
V
-
S
-
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
I
T
A
-------------------
V
S
Y
D
---
F
D
----
E
E
F
----
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
--------------------------------------------------------------------
43
PsiBlast_CBE
62.21
35%
-102
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[18-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
G
VC
R
E
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
-
L
V
-
S
-
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
I
T
A
-------------------
V
S
Y
D
---
F
D
----
E
E
F
----
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
--------------------------------------------------------------------
25
PsiBlast_CBE
62.14
34%
-119
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
-
F
R
D
------
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--
E
----------------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
V
--
E
K
G
F
Y
-
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
---------------------
P
G
Y
V
A
P
E
V
L
-
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
---
E
--
N
---
D
A
K
L
F
E
Q
I
L
K
-------------------
A
E
Y
E
---
F
D
----
S
P
Y
----
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------
12
PsiBlast_PDB
62.13
39%
-110
- C1 -
4BDG
2
?
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------N---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
-------------------
G
K
Y
N
---
F
I
----
P
E
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
------------------------------------------------------------------
70
PsiBlast_CBE
61.51
35%
-99
- C1 -
3I7B
4
?
A:
[23-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
RQ
V
K
Q
---
K
T
-
D
K
E
S
----
L
----
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
-
G
-
G
-
E
L
F
--
D
E
I
I
S
--
R
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
G
---
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
GA
N
---
E
--
Y
---
D
--
I
L
K
K
V
E
K
-------------------
G
K
Y
T
---
F
E
----
L
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
------------------------------------------------------------
105
PsiBlast_CBE
61.07
34%
-101
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[18-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
G
VSRE
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
-
L
V
-
S
-
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
TK
Q
---
E
--
T
L
A
N
I
T
S
-------------------
V
S
Y
D
---
F
D
----
E
E
F
----
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
--------------------------------------------------------------------
83
PsiBlast_CBE
60.85
33%
-97
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
---
K
S
-
S
R
R
G
VS
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
-------
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
F
G
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
11
PsiBlast_PDB
60.80
39%
-99
- C1 -
4A9T
4
CHK2_HUMAN
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
-------------------
G
K
Y
N
---
F
I
----
P
E
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
------------------------------------------------------------------
17
PsiBlast_PDB
60.73
37%
-105
- C1 -
2W4O
1
KCC4_HUMAN
A:
[61-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
----------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
-
L
V
T
G
-
G
-
E
L
F
--
D
R
I
V
--
E
K
G
Y
Y
-
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
-------------------
G
T
P
G
Y
C
A
P
E
I
L
-
R
G
---
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
--
Y
--
D
ERG
D
--
Q
---
F
--
M
F
R
R
I
L
N
-------------------
C
E
Y
Y
---
F
I
----
S
P
W
----
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
F
Q
A
L
Q
H
P
W
V
--------------------------------------------------------------------
69
PsiBlast_CBE
60.69
35%
-96
- C1 -
3N51
3
?
A:
[23-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
RQ
V
K
Q
---
K
T
-
D
K
E
S
----
L
----
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
-
G
-
G
-
E
L
F
--
D
E
I
I
S
--
R
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
E
A
S
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-
H
G
---
T
-
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
GA
N
---
E
--
Y
---
D
--
I
L
K
K
V
E
K
-------------------
G
K
Y
T
---
F
E
----
L
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
------------------------------------------------------------
10
PsiBlast_PDB
60.50
39%
-104
- C1 -
2XM9
1
CHK2_HUMAN
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
-
L
M
-
E
-
G
G
E
L
F
--
D
K
V
V
G
N
K
--
R
L
-
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
-
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
D
C
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
G
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-
V
S
VGT
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
---
H
--
R
TQV
S
--
L
K
D
Q
I
T
S
-------------------
G
K
Y
N
---
F
I
----
P
E
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
------------------------------------------------------------------
37
PsiBlast_CBE
60.43
36%
-105
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[6-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
--
E
-----
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
--
K
K
L
---
S
A
-
R
D
H
Q
----
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
-
G
-
E
L
F
--
E
D
I
V
A
R
E
--
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
G
D
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W-
D
--
E
---
D
--
Q
---
H
R
-
L
Y
Q
Q
I
K
A
-------------------
G
A
Y
D
---
F
P
----
S
P
E
----
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------
16
PsiBlast_PDB
59.90
37%
-105
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
--
S
----------------
S
----
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
L
--
E
R
G
V
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
--
E
Q
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
-
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
E
---
E
--
T
---
E
S
K
L
F
E
K
I
K
E
-------------------
G
Y
Y
E
---
F
E
----
S
P
F
----
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------
106
PsiBlast_CBE
59.80
34%
-99
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[18-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
--
R
Q
S
---
R
A
-
S
R
R
G
VSRE
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
-
L
V
-
S
-
G
-
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
-
E
E
E
A
T
S
F
-
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
-
I
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
TK
Q
---
E
--
T
L
A
N
I
T
S
-------------------
V
S
Y
D
---
F
D
----
E
E
F
----
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
--------------------------------------------------------------------
87
PsiBlast_CBE
59.10
33%
-98
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
--
D
Y
Y
D
--
T
G
E
-----
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
--
R
R
T
----------R
E
--
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
-
L
V
-
A
-
G
-
G
E
L
--
F
D
F
L
A
E
K
E
S
L
T
-
E
E
E
A
T
E
F
L
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
-
I
D
-------------
E
F
V
A
P
E
I
V
-
N
Y
---
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
---
D
T
K
Q
---
E
--
T
L
A
N
V
S
A
-------------------
V
N
Y
E
---
F
E
----
D
E
Y
----
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------------
22
PsiBlast_CBE
57.79
37%
-101
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
--
S
----------------
S
----
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
-
L
V
-
S
-
G
G
E
L
F
--
D
R
I
L
--
E
R
G
V
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
--
E
Q
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
-
A
Q
---
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
E
---
E
--
T
---
E
S
K
L
F
E
K
I
K
E
-------------------
G
Y
Y
E
---
F
E
----
S
P
F
----
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------
130
HHSearch
55.37
30%
-89
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[4-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
E
T
L
--
G
-----
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
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F
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--------------
N
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----
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----
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K
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-
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--
D
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N
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L
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----
I
T
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C
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F
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-
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-----
D
I
-
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D
D
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A
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Y
R
A
P
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L
V
L
K
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---
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
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N
P
Y
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--
P
--
S
---
S
--
S
---
D
--
L
-
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L
L
H
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KVGNLS
P
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D
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-----
S
S
D
L
L
H
H
E
Y
F
T
R
------------------------------------------------------------------