@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KS6B1_HUMAN: (2013-07-22 )
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
Atome Classification :
(50 SA)
.........10........20........30........40........50........60........70........80....---....90........100.......110.......120.......130....-...140.....-..-150........160.......170.......180....-...--190.......200.......210........220.......230.......240-.......250..-......260...--.-----...----270---.......280.......290....----...300......--.--310..--.---..---..320.......330......-.340.-......350.......360.......370..----.....380--.......---390.......400----...-.....410.......--420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEK---IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKD-TAHTKAERNIL-EE-V-KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLER-EGI--FMEDTACFYLAEISMALGHLHQ-KGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVT-HTF-CGTIEYMAPEIL--M-----RSG----HNR---AVDWWSLGALMYDMLTGAPPFTGE----NRKKTIDKILKC--K--LNLPP--Y---LT---QEARDLLKKLLKRNAASRLGA-GPGDA-GEVQAHPFFRHINWEELLARKVEPPFKPLLQ----SEEDVSQF--DSKFTRQ---TPVDSPDDSTLS-----ESA-NQVFLGFTYVAPSVL--ESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
78
HHSearch
83.92
100%
-120
* C1 *
3A62
1
KS6B1_HUMAN
A:
[13-300]
------------------------------------------------------------------------------------
K
---
I
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---------------
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P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.21
100%
-120
- C1 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
-----------------------------------------------------------------------------------------
R
P
E
C
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-------------------
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----
H
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R
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A
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M
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---
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W
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A
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P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.47
100%
-119
- C1 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
------------------------------------------------------------------------------------
K
---
I
R
P
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K
A
M
------------
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E
----------------
T
I
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---
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A
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----
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--
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--
Y
---
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A
A
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A
-
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A
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V
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P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.63
100%
-112
- C1 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
------------------------------------------------------------------------------------
K
---
I
R
P
E
C
F
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L
L
R
V
L
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K
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A
N
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A
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K
---------------------------
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H
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-
S
------------
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A
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----
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P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.55
45%
-103
- C1 -
2JDR
1
AKT2_HUMAN
A:
[6-340]
------------------------------------------------------------------------------------
K
---
V
T
M
N
D
F
D
Y
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L
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T
F
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---
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A
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Y
Y
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--
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A
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---
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-
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A
Q
SIT---------------------
Q
E
M
F
E
D
F
D
Y
I
A
----------------------------------------------------------------------------------------------------------------
68
HHSearch
74.30
47%
-100
- C1 -
4GV1
5
AKT1_HUMAN
A:
[3-337]
-----------------------------------------------------------------------------------
S
R
---
V
T
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---
E
K
A
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Y
Y
A
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K
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V
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V
A
-
K
D
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-
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-
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A
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S
MECVD
S
E
R
-
R
P
H
F
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Q
F
D
Y
S
A
S
---------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.28
45%
-106
- C1 -
2JDO
2
AKT2_HUMAN
A:
[6-340]
------------------------------------------------------------------------------------
K
---
V
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M
N
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--
A
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SIT-----------------------
M
F
E
D
F
D
Y
I
A
----------------------------------------------------------------------------------------------------------------
75
HHSearch
73.71
46%
-102
- C1 -
1O6L
1
AKT2_HUMAN
A:
[1-336]
------------------------------------------------------------------------------------
K
---
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
-
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
--
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
-
G
I
S
D
G
A
T
M
-
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
-----
D
N
D
----
Y
G
R
---
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
--
E
--
I
R
F
P
R
--
T
---
L
S
---
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
----
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
---
S
I
T
------------------
Q
E
M
F
E
D
F
D
Y
I
A
D
---------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.25
45%
-104
- C1 -
2XH5
1
AKT2_HUMAN
A:
[6-340]
------------------------------------------------------------------------------------
K
---
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
--
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
-
G
I
S
D
G
A
T
M
-
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
-----
D
N
D
----
Y
G
R
---
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
--
E
--
I
R
F
P
R
--
T
---
L
S
---
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
----
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
SIT---------------------
Q
E
M
F
E
D
F
D
Y
I
A
----------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.35
45%
-104
- C1 -
2X39
1
AKT2_HUMAN
A:
[6-340]
------------------------------------------------------------------------------------
K
---
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
--
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
-
G
I
S
D
G
A
T
M
-
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
-----
D
N
D
----
Y
G
R
---
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
--
E
--
I
R
F
P
R
--
T
---
L
S
---
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
----
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
SIT---------------------
Q
E
M
F
E
D
F
D
Y
I
A
----------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.13
45%
-103
- C1 -
2UW9
1
AKT2_HUMAN
A:
[6-340]
------------------------------------------------------------------------------------
K
---
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
--
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
-
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
--
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
-
G
I
S
D
G
A
T
M
-
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
-----
D
N
D
----
Y
G
R
---
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
R
L
F
E
L
I
L
M
E
--
E
--
I
R
F
P
R
--
T
---
L
S
---
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
----
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
SIT---------------------
Q
E
M
F
E
D
F
D
Y
I
A
----------------------------------------------------------------------------------------------------------------
85
HHSearch
69.69
37%
-95
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[34-350]
---------------------------------------------------------------------------------
S
Q
N
T
---
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
A
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
-
D
Y
E
E
E
---
E
I
R
V
S
I
N
E
K
----------
C
-
G
K
E
F
T
E
F
--------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
67.47
34%
-110
- C1 -
3QFV
2
MRCKB_HUMAN
A:
[70-409]
------------------------------------------------------------------------------------
Q
---
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
-
E
-
T
A
C
F
R
E
E
R
D
V
L
-
V
N
-
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
--
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
-
M
N
D
D
G
T
V
Q
-
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
-----
E
D
G
----
M
G
K
YGP
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
EE
R
--
F
Q
F
P
S
--
H
---
V
T
DVS
E
E
A
K
D
L
I
Q
R
L
I
---
C
S
R
E
R
R
L
-
G
Q
N
G
I
-
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
----
S
P
S
D
T
S
N
F
DV---------------------------
S
G
L
-
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
------------------------------------------------------------------------------------------------------------
81
HHSearch
67.36
37%
-101
- C1 -
4AW2
3
MRCKA_RAT
A:
[69-412]
-----------------------------------------------------------------------------------
M
R
---
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
---
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
-
T
A
C
F
R
E
E
R
D
V
L
-
V
N
-
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
--
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
-
L
M
E
D
G
T
V
Q
S
S
V
A
-
V
G
T
P
D
Y
I
S
P
E
I
L
--
Q
A
M
E
GG
K
G
R
----
Y
G
P
---
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
KE
R
--
F
Q
F
P
T
--
Q
VTD
V
S
---
E
N
A
K
D
L
I
R
R
L
I
C
S
R
-
E
H
R
L
G
Q
---
N
G
I
-
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
----
S
P
T
D
T
S
N
F
--
D
V
D
------------------------
S
G
H
-
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
--
S
D
R
-------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.99
35%
-107
- C1 -
3TKU
3
MRCKB_HUMAN
B:
[86-425]
------------------------------------------------------------------------------------
Q
---
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
-
E
-
T
A
C
F
R
E
E
R
D
V
L
-
V
N
-
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
--
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
-
M
N
D
D
G
T
V
Q
-
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
QA
M
-----
E
D
G
----
M
G
K
YGP
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
EE
R
--
F
Q
F
P
S
--
H
---
V
T
DVS
E
E
A
K
D
L
I
Q
R
L
I
C
-
S
R
E
R
R
L
G
Q
-
N
G
I
E
---
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
----
S
P
S
D
T
S
N
F
D----------------------
F
-----
S
G
L
-
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.41
55%
-109
- C1 -
3G51
1
KS6A3_MOUSE
A:
[14-304]
------------------------------------------------------------------------------
V
K
E
G
H
E
K
---
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
--
K
V
R
D
----------
I
L
-
V
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
I
-------------
T
V
E
Y
M
A
P
E
V
V
--
N
-----
R
R
G
----
H
T
Q
---
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
--
K
--
L
G
M
P
Q
--
F
---
L
S
---
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
65.05
35%
-105
- C1 -
3TKU
3
MRCKB_HUMAN
A:
[86-425]
------------------------------------------------------------------------------------
Q
---
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
-
E
-
T
A
C
F
R
E
E
R
D
V
L
-
V
N
-
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
--
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
-
M
N
D
D
G
T
V
Q
-
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
-----
E
D
G
----
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
EE
R
--
F
Q
F
P
S
--
H
---
V
T
DVS
E
E
A
K
D
L
I
Q
R
L
I
C
-
S
R
E
R
R
L
G
Q
-
N
G
I
E
---
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
----
S
P
S
D
T
S
N
F
DV---------------------------
S
G
L
-
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
64.84
39%
-101
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[44-329]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
63.95
39%
-97
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[44-329]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.95
54%
-113
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
---------------------------------------------------------------------------------
G
S
E
K
---
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
--
K
V
------------
I
L
-
A
D
-
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
--
N
-----
R
Q
G
----
H
S
H
---
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
--
K
--
L
G
M
P
Q
--
F
---
L
S
---
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
G
A
-
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
63.88
39%
-100
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[29-314]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
63.86
39%
-102
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[44-329]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
63.57
39%
-102
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[29-314]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.51
54%
-114
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
------------------------------------------------------------------------------------
K
---
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
K
--------------------
I
L
-
A
D
-
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
--
N
-----
R
Q
G
----
H
S
H
---
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
--
K
--
L
G
M
P
Q
--
F
---
L
S
---
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
G
A
-
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
63.50
39%
-99
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[44-329]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
63.24
43%
-93
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
D
D
-
V
E
C
T
M
T
E
K
R
I
L
-
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
R
--
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
-
G
I
C
-----------
G
T
P
D
Y
I
A
P
E
I
L
--
Q
-----
E
M
L
----
Y
G
P
---
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
----
N
E
D
D
L
F
E
A
I
L
N
D
--
E
--
V
V
Y
P
T
--
W
---
L
H
---
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
-
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
----
S
R
E
D
V
S
N
F
--
D
P
D
F
I
K
E
---
E
P
V
L
T
P
I
D
E
G
H
L
-----
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
---------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
62.81
34%
-107
- C1 -
3QFV
3
MRCKB_HUMAN
B:
[70-409]
------------------------------------------------------------------------------------
Q
---
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
-
E
-
T
A
C
F
R
E
E
R
D
V
L
-
V
N
-
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
--
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
-
M
N
D
D
G
T
V
Q
-
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
QA
M
-----
E
D
G
----
M
G
K
YGP
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
EE
R
--
F
Q
F
P
S
--
H
---
V
T
DVS
E
E
A
K
D
L
I
Q
R
L
I
---
C
S
R
E
R
R
L
-
G
Q
N
G
I
-
E
D
F
K
K
H
A
F
F
E
G
L
N
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
----
S
P
S
D
T
S
N
F
D---------------------
G
F
-----
S
G
L
-
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.69
33%
-94
- C1 -
2ESM
1
ROCK1_HUMAN
A:
[70-401]
------------------------------------------------------------------------------------
R
---
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
-
D
-
S
A
F
F
W
E
E
R
D
I
M
-
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
---
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
-
M
N
K
E
G
M
V
R
C
D
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
--
K
-----
S
Q
G
GDGY
Y
G
R
---
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
----
S
L
V
G
T
Y
S
K
I
M
N
H
--
K
NS
L
T
F
P
D
DN
D
---
I
S
---
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
-
N
--
G
V
-
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
----
S
D
I
D
T
S
N
F
--
D
D
L
E
E
D
K
---
G
E
E
E
T
F
P
I
P
K
A
F
-----
V
G
N
-
Q
L
P
F
V
G
F
T
Y
Y
S
----------------------------------------------------------------------------------------------------------------
84
HHSearch
62.24
36%
-100
- C1 -
2ACX
1
GRK6_HUMAN
A:
[179-518]
-----------------------------------------------------------------------------------
Q
P
---
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
-
R
K
G
-
E
A
M
A
L
N
E
K
Q
I
L
-
E
K
-
V
-
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
-
M
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
P
-
E
G
Q
T
I
-
K
G
R
-
V
G
T
V
G
Y
M
A
P
E
V
V
--
K
-----
N
E
R
----
Y
T
F
---
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
--
P
--
E
E
Y
S
E
--
R
---
F
S
---
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
AIYC-------------------------------
E
-----
P
T
D
-
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
----------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
62.08
39%
-101
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[29-314]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
62.08
39%
-105
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[44-329]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
61.77
33%
-96
- C1 -
2ETK
1
ROCK1_HUMAN
B:
[70-401]
------------------------------------------------------------------------------------
R
---
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
-
D
-
S
A
F
F
W
E
E
R
D
I
M
-
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
---
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
-
M
N
K
E
G
M
V
R
C
D
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
--
K
-----
S
Q
G
GD
G
Y
Y
G
R
---
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
----
S
L
V
G
T
Y
S
K
I
M
N
H
--
K
NS
L
T
F
P
D
DN
D
---
I
S
---
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
-
N
--
G
V
-
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
----
S
D
I
D
T
S
N
F
--
D
D
L
E
E
D
K
---
G
E
E
E
T
F
P
I
P
K
A
F
-----
V
G
N
-
Q
L
P
F
V
G
F
T
Y
Y
S
----------------------------------------------------------------------------------------------------------------
74
HHSearch
61.38
47%
-118
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
----------------------------------------------------------------------------------
N
P
H
---
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
-
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
-
N
I
E
H
N
S
T
T
-
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
--
H
-----
K
Q
P
----
Y
D
R
---
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
--
P
--
L
Q
L
K
P
--
N
---
I
T
---
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
D
F
-
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
----
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.32
54%
-114
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
------------------------------------------------------------------------------------
K
---
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
---------------------
I
L
-
A
D
-
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
--
N
-----
R
Q
G
----
H
S
H
---
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
--
K
--
L
G
M
P
Q
--
F
---
L
S
---
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
G
A
-
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
61.20
33%
-93
- C1 -
2ETR
1
ROCK1_HUMAN
B:
[70-401]
------------------------------------------------------------------------------------
R
---
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
-
D
-
S
A
F
F
W
E
E
R
D
I
M
-
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
---
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
-
M
N
K
E
G
M
V
R
C
D
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
--
K
-----
S
Q
G
GD
G
Y
Y
G
R
---
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
----
S
L
V
G
T
Y
S
K
I
M
N
H
--
K
NS
L
T
F
P
D
DN
D
---
I
S
---
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
-
N
--
G
V
-
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
----
S
D
I
D
T
S
N
F
--
D
D
L
E
E
D
K
---
G
E
E
E
T
F
P
I
P
K
A
F
-----
V
G
N
-
Q
L
P
F
V
G
F
T
Y
Y
S
----------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
61.13
33%
-98
- C1 -
2ETK
1
ROCK1_HUMAN
A:
[70-401]
------------------------------------------------------------------------------------
R
---
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
-
D
-
S
A
F
F
W
E
E
R
D
I
M
-
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
---
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
-
M
N
K
E
G
M
V
R
C
D
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
--
K
-----
S
Q
G
GDGY
Y
G
R
---
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
----
S
L
V
G
T
Y
S
K
I
M
N
H
--
K
NS
L
T
F
P
D
DN
D
---
I
S
---
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
-
N
--
G
V
-
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
----
S
D
I
D
T
S
N
F
--
D
D
L
E
E
D
K
---
G
E
E
E
T
F
P
I
P
K
A
F
-----
V
G
N
-
Q
L
P
F
V
G
F
T
Y
Y
S
----------------------------------------------------------------------------------------------------------------
77
HHSearch
60.87
41%
-103
- C1 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
D
D
-
V
E
C
T
M
V
E
K
R
V
L
-
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
-
N
M
L
G
D
A
K
T
-
N
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
--
L
-----
G
Q
K
----
Y
N
H
---
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
--
N
--
P
F
Y
P
R
--
W
---
L
E
---
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
----------------------------------------------------
Q
N
M
F
R
N
F
S
F
------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
60.56
33%
-94
- C1 -
2ESM
1
ROCK1_HUMAN
B:
[70-401]
------------------------------------------------------------------------------------
R
---
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
-
D
-
S
A
F
F
W
E
E
R
D
I
M
-
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
---
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
-
M
N
K
E
G
M
V
R
C
D
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
--
K
-----
S
Q
G
GD
G
Y
Y
G
R
---
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
----
S
L
V
G
T
Y
S
K
I
M
N
H
--
K
NS
L
T
F
P
D
DN
D
---
I
S
---
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
-
N
--
G
V
-
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
----
S
D
I
D
T
S
N
F
--
D
D
L
E
E
D
K
---
G
E
E
E
T
F
P
I
P
K
A
F
-----
V
G
N
-
Q
L
P
F
V
G
F
T
Y
Y
S
----------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.50
56%
-108
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[15-305]
------------------------------------------------------------------------------
V
K
E
G
H
E
K
---
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
--
K
V
R
D
-
R
V
R
-----
D
I
L
-
V
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
---
E
K
K
A
-
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
-----
R
R
G
----
H
T
Q
---
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
--
K
--
L
G
M
P
Q
--
F
---
L
S
---
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
60.11
33%
-92
- C1 -
3D9V
1
ROCK1_HUMAN
B:
[70-401]
------------------------------------------------------------------------------------
R
---
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
-
D
-
S
A
F
F
W
E
E
R
D
I
M
-
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
---
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
-
M
N
K
E
G
M
V
R
C
D
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
--
K
-----
S
Q
G
GD
G
Y
Y
G
R
---
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
----
S
L
V
G
T
Y
S
K
I
M
N
H
--
K
NS
L
T
F
P
D
DN
D
---
I
S
---
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
-
N
--
G
V
-
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
----
S
D
I
D
T
S
N
F
--
D
D
L
E
E
D
K
---
G
E
E
E
T
F
P
I
P
K
A
F
-----
V
G
N
-
Q
L
P
F
V
G
F
T
Y
Y
S
----------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
60.07
33%
-95
- C1 -
2ETR
1
ROCK1_HUMAN
A:
[70-401]
------------------------------------------------------------------------------------
R
---
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
-
D
-
S
A
F
F
W
E
E
R
D
I
M
-
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
---
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
-
M
N
K
E
G
M
V
R
C
D
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
--
K
-----
S
Q
G
GDGY
Y
G
R
---
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
----
S
L
V
G
T
Y
S
K
I
M
N
H
--
K
NS
L
T
F
P
D
DN
D
---
I
S
---
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
-
N
--
G
V
-
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
----
S
D
I
D
T
S
N
F
--
D
D
L
E
E
D
K
---
G
E
E
E
T
F
P
I
P
K
A
F
-----
V
G
N
-
Q
L
P
F
V
G
F
T
Y
Y
S
----------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
59.94
33%
-95
- C1 -
3D9V
1
ROCK1_HUMAN
A:
[70-401]
------------------------------------------------------------------------------------
R
---
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
-
D
-
S
A
F
F
W
E
E
R
D
I
M
-
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
---
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
-
M
N
K
E
G
M
V
R
C
D
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
--
K
-----
S
Q
G
GDGY
Y
G
R
---
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
----
S
L
V
G
T
Y
S
K
I
M
N
H
--
K
NS
L
T
F
P
D
DN
D
---
I
S
---
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
R
-
N
--
G
V
-
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
----
S
D
I
D
T
S
N
F
--
D
D
L
E
E
D
K
---
G
E
E
E
T
F
P
I
P
K
A
F
-----
V
G
N
-
Q
L
P
F
V
G
F
T
Y
Y
S
----------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.79
56%
-107
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[15-305]
------------------------------------------------------------------------------
V
K
E
G
H
E
K
---
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
--
K
V
R
D
-
R
V
--------
L
-
V
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------
K
K
A
-
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
-----
R
R
G
----
H
T
Q
---
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
--
K
--
L
G
M
P
Q
--
F
---
L
S
---
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
59.09
55%
-107
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[7-304]
----------------------------------------------------------------------
E
I
A
I
T
H
-
H
V
K
E
G
H
E
K
---
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
--
K
V
R
D
-
R
V
------
D
I
L
-
V
E
-
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------
K
K
A
-
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
--
N
-----
R
R
G
----
H
T
Q
---
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
--
K
--
L
G
M
P
Q
--
F
---
L
S
---
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
58.60
39%
-97
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[29-314]
---------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
-
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-
V
---
K
G
R
T
-
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
G
----
Y
N
K
---
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
----
Q
P
I
Q
I
Y
E
K
I
V
S
G
--
K
--
V
R
F
P
S
--
H
---
F
S
---
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
P
G
D
T
S
N
F
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
58.58
38%
-106
- C1 -
2PE2
9
PDPK1_HUMAN
A:
[1-277]
----------------------------------------------------------------------------------
P
R
K
---
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
--
V
P
Y
V
T
R
E
R
D
V
M
-
S
R
-
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
--
T
-----
E
K
S
----
A
C
K
---
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
----
N
E
Y
L
I
F
Q
K
I
I
K
L
--
E
--
Y
D
F
P
E
--
K
---
F
F
---
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
58.56
38%
-105
- C1 -
2PE1
5
PDPK1_HUMAN
A:
[1-277]
----------------------------------------------------------------------------------
P
R
K
---
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
--
V
P
Y
V
T
R
E
R
D
V
M
-
S
R
-
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
--
T
-----
E
K
S
----
A
C
K
---
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
----
N
E
Y
L
I
F
Q
K
I
I
K
L
--
E
--
Y
D
F
P
E
--
K
---
F
F
---
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.01
46%
-109
- C1 -
3HDM
1
SGK1_HUMAN
A:
[25-320]
------------------------------------------------------------------------------
I
N
L
G
P
S
S
NPH
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
E
E
---
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
-
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
-
N
I
E
H
N
S
T
T
-
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
--
H
-----
K
Q
P
----
Y
D
R
---
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
--
P
--
L
Q
L
K
P
--
N
---
I
T
---
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
D
F
-
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
----
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
57.74
38%
-107
- C1 -
2PE0
4
PDPK1_HUMAN
A:
[1-277]
----------------------------------------------------------------------------------
P
R
K
---
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
--
V
P
Y
V
T
R
E
R
D
V
M
-
S
R
-
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
--
T
-----
E
K
S
----
A
C
K
---
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
----
N
E
Y
L
I
F
Q
K
I
I
K
L
--
E
--
Y
D
F
P
E
--
K
---
F
F
---
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.14
46%
-110
- C1 -
3HDN
1
SGK1_HUMAN
A:
[25-316]
------------------------------------------------------------------------------
I
N
L
G
P
S
S
NPH
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
E
E
---
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
-
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
--
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
-
N
I
E
H
N
S
T
T
-
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
--
H
-----
K
Q
P
----
Y
D
R
---
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
----
N
T
A
E
M
Y
D
N
I
L
N
K
--
P
--
L
Q
L
K
P
--
N
---
I
T
---
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
D
F
-
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------