@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LIMK1_HUMAN: (2015-06-17 )
MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340------------...-.....350.----.....-----.360.--..--.....370--.--.......380.......390.......400.......410.......420.......---430-.......440.......450.......460.......470.......480.......490......-.500.......510.......520.......530.......540.--...----...550.......560.-......-------570------...-......580.......590.......600.......610.-......620.......630.......640.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
L
T
L
L
C
CT
W
R
E
E
RMGEEGSEL
P
V
C
A
S
CGQRIYD
G
Q
Y
L
Q
A
LNAD
W
H
A
D
C
F
R
CCDC
S
A
S
L
S
H
Q
Y
Y
E
KDG
Q
L
F
C
K
K
D
Y
W
A
RYGESCHG
C
S
E
Q
I
TKG
L
V
M
V
A
GELKYHP
E
C
F
I
C
L
TCGTFIGDG
D
T
Y
T
L
V
E
HS
K
L
Y
C
G
H
C
Y
Y
Q
T
V
V
T
P
V
I
E
Q
ILPDSPGSHL
P
H
T
V
T
L
V
S
IPASSHGKRG
L
S
V
SIDPPHGPPGCGTEH
S
H
T
V
R
V
QGVDPGCMSPDVKNSIHVG
D
R
I
L
E
INGTPIRNV
P
L
D
E
I
D
L
L
I
Q
E
T
S
R
L
L
Q
L
TLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKP
V
L
R
SCSIDRSPGAGSLGS
P
A
S
Q
R
K
DLGRSE
S
L
R
V
V
CRPHRIFRPSDLI
H
-------------
G
E
V-LGKGCFG
Q
A
----
I
K
V
T
H-----RE-TG--
E
V
--
M
V
M
K
E
L
I
---R--F
D
E
E
T
Q
R
T
F
L
K
E
V
K
V
M
R
C
LEHP
N
V
L
K
F
I
G
V
L
YKD
K
R
L
N
F
I
T
E
Y
IKGG
T
L
R
G
I
I
K
S
MD---SQY-
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
G
M
A
Y
L
H
S
M
N
I
I
H
RDLNSH
N
C
L
V
RENK
N
V
V
V
ADF
G
L
A
R
L
MVDEKTQ
P
E
G
L
R
S
L-KKPDRK
K
R
Y
T
VVGNPYWMAPEMINGRSYDEK
V
D
V
F
S
F
G
I
V
L
C
E
I
I--GRV----NADPDYLPR
T
M
DFGL
N
V
-
R
G
F
L
DR-------Y--------CPP-NCPPS
F
F
P
I
T
V
R
C
CDLDPEKRP
S
F
V
K
L
E
H
W
L
E
T
L
R
M
H
LAG-HLPLGP
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
RRGESGLPAHPEVPD
1
PsiBlast_PDB
93.86
100%
-132
- C3 -
3S95
9
LIMK1_HUMAN
A:
[3-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
R
I
F
R
P
S
D
L
I
H
-------------
G
E
V
-
L
G
K
G
C
F
G
Q
A
----
I
K
V
T
H
-----
R
E
-
T
G
--
E
V
--
M
V
M
K
E
L
I
---
R
--
F
D
E
E
T
Q
R
T
F
L
K
E
V
K
V
M
R
C
L
E
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
G
I
I
K
S
M
D
---
S
Q
Y
-
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
G
M
A
Y
L
H
S
M
N
I
I
H
R
D
L
N
S
H
N
C
L
V
R
E
N
K
N
V
V
V
A
D
F
G
L
A
R
L
M
V
---------------------
Y
T
V
V
G
N
P
Y
W
M
A
P
E
M
I
N
G
R
S
Y
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
I
I
--
G
R
V
----
N
A
D
P
D
Y
L
P
R
T
M
D
F
G
L
N
V
-
R
G
F
L
D
R
-------
Y
--------
C
P
P
-
N
C
P
P
S
F
F
P
I
T
V
R
C
C
D
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
L
E
T
L
R
M
H
L
A
G
-
H
L
P
L
G
P
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
----------
111
HHSearch
93.52
100%
-132
- C3 -
3S95
9
LIMK1_HUMAN
A:
[3-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
R
I
F
R
P
S
D
L
I
H
-------------
G
E
V
-
L
G
K
G
C
F
G
Q
A
----
I
K
V
T
H
-----
R
E
-
T
G
--
E
V
--
M
V
M
K
E
L
I
---
R
--
F
D
E
E
T
Q
R
T
F
L
K
E
V
K
V
M
R
C
L
E
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
G
I
I
K
S
M
D
---
S
Q
Y
-
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
G
M
A
Y
L
H
S
M
N
I
I
H
R
D
L
N
S
H
N
C
L
V
R
E
N
K
N
V
V
V
A
D
F
G
L
A
R
L
M
V
---------------------
Y
T
V
V
G
N
P
Y
W
M
A
P
E
M
I
N
G
R
S
Y
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
I
I
--
G
R
V
----
N
A
D
P
D
Y
L
P
R
T
M
D
F
G
L
N
V
-
R
G
F
L
D
R
-------
Y
--------
C
P
P
-
N
C
P
P
S
F
F
P
I
T
V
R
C
C
D
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
L
E
T
L
R
M
H
L
A
G
-
H
L
P
L
G
P
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
----------
21
PsiBlast_CBE
92.09
100%
-129
- C3 -
3S95
6
B:
[3-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
R
I
F
R
P
S
D
L
I
H
-------------
G
E
V
-
L
G
K
G
C
F
G
Q
A
----
I
K
V
T
H
-----
R
E
-
T
G
--
E
V
--
M
V
M
K
E
L
I
---
R
--
F
D
E
E
T
Q
R
T
F
L
K
E
V
K
V
M
R
C
L
E
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
G
I
I
K
S
M
D
---
S
Q
Y
-
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
G
M
A
Y
L
H
S
M
N
I
I
H
R
D
L
N
S
H
N
C
L
V
R
E
N
K
N
V
V
V
A
D
F
G
L
A
R
L
M
V
---------------------
Y
T
V
V
G
N
P
Y
W
M
A
P
E
M
I
N
G
R
S
Y
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
I
I
--
G
R
V
----
N
A
D
P
D
Y
L
P
R
T
M
D
F
G
L
N
V
-
R
G
F
L
D
R
-------
Y
--------
C
P
P
-
N
C
P
P
S
F
F
P
I
T
V
R
C
C
D
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
L
E
T
L
R
M
H
L
A
G
-
H
L
P
L
G
P
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
----------
2
PsiBlast_PDB
85.90
68%
-137
- C3 -
4TPT
1
?
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
I
H
-------------
G
E
V
-
L
G
K
G
F
F
G
Q
A
----
I
K
V
T
H
-----
K
A
-
T
G
--
K
V
--
M
V
M
K
E
L
I
---
R
--
C
D
E
E
T
Q
K
T
F
L
T
E
V
K
V
M
R
S
L
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
F
L
R
S
M
D
---
P
-
F
-
P
W
Q
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
M
C
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
------------------
K
K
R
Y
T
V
V
G
N
P
Y
W
M
A
P
E
M
L
N
G
K
S
Y
D
E
T
V
D
I
F
S
F
G
I
V
L
C
E
I
I
--
G
Q
V
----
Y
A
D
P
D
C
L
P
R
T
L
D
F
G
L
N
V
-
K
L
F
W
E
K
-------
F
--------
V
P
T
-
D
C
P
P
A
F
F
P
L
A
A
I
C
C
R
L
E
P
E
S
R
P
A
F
S
K
L
E
D
S
F
E
A
L
S
L
Y
L
G
E
L
G
I
P
L
P
A
E
L
E
E
L
D
H
T
V
S
M
Q
Y
G
--------------
22
PsiBlast_CBE
84.93
68%
-142
- C3 -
4TPT
1
?
B:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
I
H
-------------
G
E
V
-
L
G
K
G
F
F
G
Q
A
----
I
K
V
T
H
-----
K
A
-
T
G
--
K
V
--
M
V
M
K
E
L
I
---
R
--
C
D
E
E
T
Q
K
T
F
L
T
E
V
K
V
M
R
S
L
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
F
L
R
S
M
D
---
P
-
F
-
P
W
Q
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
M
C
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
---------------------
Y
T
V
V
G
N
P
Y
W
M
A
P
E
M
L
N
G
K
S
Y
D
E
T
V
D
I
F
S
F
G
I
V
L
C
E
I
I
--
G
Q
V
----
Y
A
D
P
D
C
L
P
R
T
L
D
F
G
L
N
V
-
K
L
F
W
E
K
-------
F
--------
V
P
T
-
D
C
P
P
A
F
F
P
L
A
A
I
C
C
R
L
E
P
E
S
R
P
A
F
S
K
L
E
D
S
F
E
A
L
S
L
Y
L
G
E
L
G
I
P
L
P
A
E
L
E
E
L
D
H
T
V
S
M
Q
Y
G
L
-------------
99
PsiBlast_CBE
59.08
33%
-114
- C3 -
4LUD
2
HCK_HUMAN
B:
[196-440]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
-----
N
K
-
H
T
--
K
V
--
A
V
--
K
T
M
---
K
--
P
G
--
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------
P
-
I
K
--------------
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
PYPG
M
S
N
P
E
V
I
-
R
A
L
E
R
G
Y
R
M
-
P
R
---------------------
P
E
-
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
-
Q
Y
E
E
------------------------------
112
HHSearch
58.19
29%
-117
- C3 -
4AOJ
1
NTRK1_HUMAN
A:
[36-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
-
R
R
D
I
V
L
-------------
K
W
E
-
L
G
E
G
A
F
G
K
V
----
F
L
A
E
C
H
NLLP----
K
--
M
L
--
V
A
V
K
A
L
K
---
E
--
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
PDP
G
P
L
-
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
-----------------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
-------
P
-
W
------
Y
Q
L
S
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
--------
R
P
R
-
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
------------------------------------
12
PsiBlast_PDB
57.45
30%
-111
- C3 -
4G2F
1
A:
[39-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
-
E
I
--
S
V
--
A
I
K
T
L
K
V
---
G
--
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
---
A
Q
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
----------------
P
I
R
-----------
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
-
Y
----
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
--
R
-------
L
--------
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
-
L
K
I
I
T
P
S
N
L
L
L
-----------------------
8
PsiBlast_PDB
57.11
29%
-111
- C3 -
2QO9
1
A:
[34-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
EFAKELDATN
I
S
I
D
K
V
-
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
-
E
I
--
S
V
--
A
I
K
T
L
K
V
---
G
--
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
---
A
Q
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------
K
I
P
I
R
-----------
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
-
Y
----
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
--
R
-------
L
--------
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
-
L
K
I
I
T
N
L
L
L
D
------------------------
5
PsiBlast_PDB
56.89
29%
-113
- C3 -
2QOD
-
EPHA3_HUMAN
A:
[595-881]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
---------
V
H
EFAKELDATNISI
D
K
V
-
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
-
E
I
--
S
V
--
A
I
K
T
L
K
V
---
G
--
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
---
A
Q
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
----------------------
P
I
R
-----------
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
-
Y
----
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
--
R
-------
L
--------
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
-----------------------------------------
28
PsiBlast_CBE
56.73
34%
-110
- C3 -
4DGG
1
SRC_CHICK
B:
[16-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
E
S
L
R
-------------
L
E
V
K
L
G
Q
G
C
F
G
E
V
----
W
M
G
T
W
-----
N
G
-
T
T
--
R
V
--
A
I
--
K
T
L
---
K
--
P
------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
-
S
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
---
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------
F
P
-
I
K
--------------
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
----
P
Y
P
----------
G
M
V
N
-
R
E
V
L
D
Q
-------
V
E
R
G
Y
R
M
P
-
C
P
P
-
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
-
Q
Y
Q
P
G
E
N
L
--------------------------
100
PsiBlast_CBE
56.70
33%
-114
- C3 -
4LUD
1
HCK_HUMAN
A:
[196-440]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
-----
N
K
-
H
T
--
K
V
--
A
V
--
K
T
M
---
K
--
P
---
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------
P
-
I
K
--------------
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
PYPG
M
S
N
P
E
-----
L
E
R
G
Y
R
M
-
P
R
---------------------
P
E
-
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
-
Q
Y
E
E
I
P
----------------------------
9
PsiBlast_PDB
56.65
29%
-108
- C3 -
3FXX
1
A:
[30-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
T
V
H
E
F
AKELDATN
I
S
I
D
K
V
-
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
-
E
I
--
S
V
--
A
I
K
T
L
K
V
---
G
--
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
---
A
Q
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
---------
G
-
K
I
P
I
R
-----------
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
-
Y
----
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
--
R
-------
L
--------
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
-
L
K
I
I
T
A
A
R
P
S
N
L
L
L
D
-------------------
118
HHSearch
56.56
29%
-116
- C3 -
4HZS
-
ACK1_HUMAN
A:
[123-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
L
R
L
-------------
L
E
K
-
L
G
D
G
S
F
G
V
V
----
R
R
G
E
W
-----
D
A
P
S
G
--
K
T
V
S
V
A
V
K
C
L
K
PDV
L
--
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
L
T
P
-
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
---
G
H
F
-
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
-------------------------
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
--------
P
W
------
I
G
L
N
G
-
S
Q
I
L
H
K
-------
I
DKEGERLP
R
P
E
-
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
M
R
-
A
L
Q
D
F
E
E
P
D
K
L
H
I
Q
M
N
D
V
I
T
V
I
E
G
R
A
E
N
Y
W
W
R
G
Q
18
PsiBlast_PDB
56.16
29%
-108
- C3 -
2QO7
4
A:
[21-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
H
T
-------
V
H
EFAKELDATN
I
S
I
D
K
V
-
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
-
E
I
--
S
V
--
A
I
K
T
L
K
V
---
G
--
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
---
A
Q
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
---------------------
P
I
R
-----------
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
-
Y
----
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
--
R
-------
L
--------
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
-
L
K
I
I
T
S
P
S
N
L
L
L
D
---------------------
3
PsiBlast_PDB
55.95
29%
-112
- C3 -
2QOO
-
EPHA3_HUMAN
A:
[595-881]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
D
P
---------
V
H
EFAKELDATNISI
D
K
V
-
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
-
E
I
--
S
V
--
A
I
K
T
L
K
V
---
G
--
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
---
A
Q
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
F
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
----------------------
P
I
R
-----------
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
-
Y
----
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
--
R
-------
L
--------
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
-----------------------------------------
97
PsiBlast_CBE
55.88
33%
-116
- C3 -
4LUE
3
HCK_HUMAN
B:
[196-440]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
----
W
M
A
T
Y
-----
N
K
-
H
T
--
K
V
--
A
V
--
K
T
M
---
K
--
P
--------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--
S
K
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------
P
-
I
K
--------------
W
T
A
P
E
A
I
N
F
---
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
PYPG
M
S
N
P
E
V
I
-
R
A
L
E
R
G
Y
R
M
-
P
R
---------------------
P
E
-
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
-
Q
Y
E
E
I
-----------------------------
4
PsiBlast_PDB
55.88
29%
-111
- C3 -
2QOI
1
A:
[21-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
D
P
---------
V
H
EFAKELDATNISI
D
K
V
-
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-----
K
K
-
E
I
--
S
V
--
A
I
K
T
L
K
V
---
G
--
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
---
A
Q
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
----------------------
P
I
R
-----------
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
--
S
-
Y
----
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
--
R
-------
L
--------
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
-
L
K
I
I
T
S
N
L
L
L
D
-----------------------
20
PsiBlast_PDB
55.61
31%
-105
- C3 -
3ZFX
-
EPHB1_HUMAN
A:
[25-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
-
I
G
A
--
F
G
E
V
----
Y
K
G
R
L
-----
K
L
-
P
G
KR
E
I
--
Y
V
A
I
K
T
L
---
K
AG-
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
R
P
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
N
D
---
G
Q
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
Q
------------G
K
I
P
V
R
-----------
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
--
S
F
------
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
-
I
E
Q
D
Y
R
-------
L
--------
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
K
M
I
R
N
P
A
S
-
L
K
T
V
A
T
----------------------------
44
PsiBlast_CBE
55.31
34%
-106
- C3 -
3EN4
1
SRC_CHICK
B:
[16-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
E
S
L
R
-------------
L
E
V
K
L
G
Q
G
C
F
G
E
V
----
W
M
G
T
W
-----
N
G
-
T
T
--
R
V
--
A
I
--
K
T
L
---
K
--
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
-
S
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
---
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------
A
K
F
P
-
I
K
--------------
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
----
P
Y
P
----------
G
M
V
N
-
R
E
V
L
D
Q
-------
V
E
R
GYRMP-
C
P
P
-
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
-
Q
Y
Q
P
G
E
N
L
--------------------------