@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K10_HUMAN: (2013-07-22 )
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
Atome Classification :
(10 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-.----.120........130.......140.......150.......160.......170.......180....----...-----190......----...200.......210.......220.......230.......240.......250.....----..260--....---...270.....--..280.......290......-.300.....--.-.310.......--320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALW-R----GE-EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL----AGR-----R--VPPHVL----VNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHK----TTKMS--AAGT---YAWMAPEVIRL--SLFSKSSDVWSFGVLLWELLT-GEVPYREID--A-LAVAYGVAMNK--LTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
8
PsiBlast_PDB
73.65
38%
-118
- C1 -
3PPZ
1
CTR1_ARATH
A:
[32-298]
------------------------------------------------------------------------------------------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
-
H
----
G
S
-
D
V
A
V
K
I
--
L
M
E
----
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSG
A
R
E
-----
Q
--
L
D
E
R
R
R
----
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
--------
Y
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
----
T
F
L
S
S
KS
A
A
G
T
---
P
E
W
M
A
P
E
V
L
R
D
--
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
--
P
-
A
Q
V
V
A
A
V
G
F
K
C
--
K
R
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.24
38%
-124
- C1 -
3P86
1
CTR1_ARATH
A:
[32-298]
------------------------------------------------------------------------------------------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
-
H
----
G
S
-
D
V
A
V
K
I
--
L
M
E
Q
D
F
H
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
KSG
A
R
E
-----
Q
--
L
D
E
R
R
R
----
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
--------
T
V
K
V
C
D
F
---------------------
G
T
---
P
E
W
M
A
P
E
V
L
R
D
--
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
--
P
-
A
Q
V
V
A
A
V
G
F
K
C
--
K
R
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
66.95
33%
-112
* C1 *
4AOJ
1
NTRK1_HUMAN
A:
[35-320]
-----------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
-
H
NLLP
K
M
-
L
V
A
V
K
A
L
K
E
A
S
----
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
----
R
S
H
GPDPG
P
--
L
G
L
G
Q
L
----
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
---
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
--------
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
---
I
R
W
M
P
P
E
S
I
L
Y
--
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
--
N
-
T
E
A
I
D
C
I
T
-
Q
G
--
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
62.67
32%
-115
- C1 -
3T9T
3
A:
[9-265]
------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
----
K
D
-
K
V
A
I
K
T
I
R
-----
E
G
A
M
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
----
R
T
Q
-----
R
GL
F
A
A
E
T
L
----
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
---
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
--------
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
----
D
Q
Y
T
S
--
S
T
G
T
KFP
V
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
--
N
-
S
E
V
V
E
D
I
S
-
T
G
--
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.64
38%
-107
- C1 -
4L52
1
?
A:
[6-259]
--------------------------------------------------------------------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
-
R
----
A
K
-
D
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
----
H
G
A
-----
E
--
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
T
-------------------
G
S
---
A
A
W
M
A
P
E
V
F
E
G
--
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
GP
A
-
F
R
I
M
W
A
V
H
-
N
G
--
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.24
38%
-105
- C1 -
2EVA
1
M3K7_HUMAN
A:
[5-258]
--------------------------------------------------------------------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
-
R
----
A
K
-
D
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
----
H
G
A
-----
E
--
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
T
-------------------
G
S
---
A
A
W
M
A
P
E
V
F
E
G
--
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
GP
A
-
F
R
I
M
W
A
V
H
-
N
G
--
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
56.98
38%
-103
- C1 -
4L53
3
?
A:
[6-259]
--------------------------------------------------------------------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
-
R
----
A
K
-
D
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
----
H
G
A
-----
E
--
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
T
------------------
K
G
S
---
A
A
W
M
A
P
E
V
F
E
G
--
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
GP
A
-
F
R
I
M
W
A
V
H
-
N
G
--
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
56.10
38%
-110
- C1 -
2YIY
1
M3K7_HUMAN
A:
[5-258]
--------------------------------------------------------------------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
-
R
----
A
K
-
D
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
----
H
G
A
-----
E
--
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
--------------------
G
S
---
A
A
W
M
A
P
E
V
F
E
G
--
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
GP
A
-
F
R
I
M
W
A
V
H
-
N
G
--
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
55.92
38%
-105
- C1 -
4L3P
1
?
A:
[6-259]
--------------------------------------------------------------------------------------------
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
-
R
----
A
K
-
D
V
A
I
K
Q
I
E
S
E
S
E
R
K
A
F
I
V
------
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
L
N
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
----
H
G
A
-----
E
--
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
-------
G
T
V
L
K
I
C
D
F
G
--------------------
G
S
---
A
A
W
M
A
P
E
V
F
E
G
--
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
R
K
P
F
D
E
I
G
GP
A
-
F
R
I
M
W
A
V
H
-
N
G
--
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
50.77
30%
-102
- C1 -
4ITJ
1
RIPK1_HUMAN
A:
[10-288]
------------------------------------------------------------------------------------------
I
K
M
K
S
S
D
F
L
E
--------
F
G
K
V
S
L
A
F
H
-
R
----
T
Q
G
L
M
I
M
K
T
V
Y
K
G
P
N
C
--
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
----
K
A
E
M
----
S
--
T
P
L
S
V
K
----
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
---
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
--------
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N---------
G
T
---
L
Y
Y
M
A
P
E
H
L
N
D
VN
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
K
E
P
Y
E
N
A
I
--
A
E
Q
Q
L
I
M
A
I
K
S
G
N
RP
D
V
D
D
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------