@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
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Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
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Show alignment :
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Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
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EC Number
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M4K2_HUMAN: (2013-07-22 )
MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
Atome Classification :
(53 SA)
.........10---.........20........30........40.......---.50..-..-...-.60---....-.------....70........80--........90........100-...----....----110.---......------120.......-130..-......140..-.....150.......160.......170.......180.....--...--190.........200.......210..---...-..220.-.-.....230......--.240.......250.......260-----.......270.......-280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MALLRDVSLQ----DPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVK---LDPGD-DI-SSL-QQ----EITI-L------RECRHPNVVAYIGSYL--RNDRLWICMEFCGGGSLQEIY-HAT----GPLE----ERQI---AYVCRE------ALKGLHHLHS-Q-GKI-HRDIKGANLLL-TLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPE-VAAVE--RKG--G--YNELCDVWALGITAIELGELQPPL---FHL-HPMRAL-M-LMSKSSFQPPKLRD--KTRWTQNFHHFLKLALTKNPKKRP-----TAEKLLQHPFTTQQLPR-ALLTQLLDKASDPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
14
PsiBlast_PDB
80.68
46%
-77
- C1 -
3A7I
1
STK24_HUMAN
A:
[19-290]
--------------
D
P
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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.27
46%
-75
- C1 -
4FZF
1
?
B:
[3-276]
--------
M
A
----
D
P
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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
80.22
43%
-77
- C1 -
4AOT
1
STK10_HUMAN
B:
[16-296]
--------------
D
P
N
E
V
W
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--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.85
48%
-71
- C1 -
2XIK
2
STK25_HUMAN
A:
[4-287]
--
H
L
R
G
F
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SRV
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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.55
43%
-79
- C1 -
4AOT
1
STK10_HUMAN
A:
[16-296]
--------------
D
P
N
E
V
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15
PsiBlast_PDB
78.66
46%
-75
- C1 -
3A7J
1
STK24_HUMAN
A:
[19-290]
--------------
D
P
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13
PsiBlast_PDB
78.62
46%
-73
- C1 -
3A7H
1
STK24_HUMAN
A:
[19-290]
--------------
D
P
E
E
L
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A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
-
H
P
M
K
V
L
-
F
-
L
I
P
K
N
N
--
P
P
T
L
----
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.41
46%
-78
- C1 -
3GGF
1
MST4_HUMAN
B:
[19-291]
---------
A
----
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
---
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
----
E
I
T
V
-
L
------
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
--
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
A
-----
G
P
F
D
----
E
F
Q
I
---
A
T
M
L
K
E
------
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
Q
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
-
H
P
M
R
V
L
-
F
-
L
I
P
K
N
N
--
P
P
T
L
V
G
--
D
--
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.23
46%
-79
- C1 -
3GGF
1
MST4_HUMAN
A:
[18-291]
--------
I
A
----
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
---
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
----
E
I
T
V
-
L
------
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
--
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
A
-----
G
P
F
D
----
E
F
Q
I
---
A
T
M
L
K
E
------
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
Q
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
-
H
P
M
R
V
L
-
F
-
L
I
P
K
N
N
--
P
P
T
L
V
G
--
D
--
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.45
46%
-71
- C1 -
4FZA
3
MST4_HUMAN
B:
[3-276]
--------
M
A
----
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
---
L
E
E
A
E
-
D
E
-
I
E
D
I
Q
Q
----
E
I
T
V
-
L
------
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
--
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
A
-----
G
P
F
D
----
E
F
Q
I
---
A
T
M
L
K
E
------
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
Q
Q
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
---
S
D
M
-
H
P
M
R
V
L
-
F
-
L
I
P
K
N
N
--
P
P
T
L
V
G
--
D
--
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.44
46%
-72
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-275]
---------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
---
L
E
E
---
D
E
-
I
E
D
I
Q
Q
----
E
I
T
V
-
L
------
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
--
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
P
-----
G
P
L
D
----
E
T
Q
I
---
A
T
I
L
R
E
------
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
-----
K
Q
S
--
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
---
S
E
L
-
H
P
M
K
V
L
-
F
-
L
I
P
K
N
N
--
P
P
T
L
----
E
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.44
43%
-73
- C1 -
4BC6
2
STK10_HUMAN
A:
[8-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
-
E
L
-
E
D
Y
-
I
V
----
E
I
E
I
-
L
------
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
--
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
T
----
E
P
Q
I
---
Q
V
V
C
R
Q
------
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
-
L
-
K
I
A
K
S
D
--
P
P
T
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.70
43%
-74
- C1 -
2J7T
1
STK10_HUMAN
A:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
-
E
L
-
E
D
Y
-
I
V
----
E
I
E
I
-
L
------
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
--
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
T
----
E
P
Q
I
---
Q
V
V
C
R
Q
------
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
-
L
-
K
I
A
K
S
D
--
P
P
T
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
72.20
43%
-77
- C1 -
4EQU
2
STK10_HUMAN
B:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
-
E
L
-
E
D
Y
-
I
V
----
E
I
E
I
-
L
------
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
--
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
T
----
E
P
Q
I
---
Q
V
V
C
R
Q
------
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
-
L
-
K
I
A
K
S
D
--
P
P
T
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
71.36
45%
-72
- C1 -
2UV2
6
SLK_HUMAN
A:
[34-298]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
-
E
L
-
E
D
Y
-
M
V
----
E
I
D
I
-
L
------
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
--
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
----
R
P
L
T
----
E
S
Q
I
---
Q
V
V
C
K
Q
------
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
--
T
S
K
--
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
-
L
-
K
I
A
K
S
--
E
P
P
T
L
A
Q
--
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
70.64
43%
-76
- C1 -
4EQU
2
STK10_HUMAN
A:
[16-296]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----------
L
-
E
D
Y
-
I
V
----
E
I
E
I
-
L
------
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
--
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
T
----
E
P
Q
I
---
Q
V
V
C
R
Q
------
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
M
K
D
T
--
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
-
L
-
K
I
A
K
S
D
--
P
P
T
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-
K
A
L
R
E
L
V
A
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.58
45%
-74
- C1 -
2J51
5
SLK_HUMAN
A:
[34-298]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
-
E
L
-
E
D
Y
-
M
V
----
E
I
D
I
-
L
------
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
--
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
----
R
P
L
T
----
E
S
Q
I
---
Q
V
V
C
K
Q
------
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
--
T
S
K
--
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
-
L
-
K
I
A
K
S
--
E
P
P
T
L
A
Q
--
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.41
44%
-72
- C1 -
2JFL
6
SLK_HUMAN
A:
[34-298]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
-
E
L
-
E
D
Y
-
M
V
----
E
I
D
I
-
L
------
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
--
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
----
R
P
L
T
----
E
S
Q
I
---
Q
V
V
C
K
Q
------
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
--
T
S
K
--
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
---
H
E
L
-
N
P
M
R
V
L
-
L
-
K
I
A
K
S
--
E
P
P
T
L
A
Q
--
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
63.73
31%
-71
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[6-271]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
---
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
----
E
L
Q
V
-
L
------
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
--
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
P
----
E
Q
I
L
---
G
K
V
S
I
A
------
V
I
K
G
L
T
Y
L
R
E
-
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
--
S
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PPP-----
P
M
A
I
F
-
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
-----
D
L
K
Q
L
M
V
H
A
F
I
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
62.60
33%
-75
- C1 -
4BID
1
?
B:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
-----
S
-
Q
P
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
61.81
31%
-78
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[6-271]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
---
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
----
E
L
Q
V
-
L
------
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
--
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
P
----
E
Q
I
L
---
G
K
V
S
I
A
------
V
I
K
G
L
T
Y
L
R
E
-
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
--
S
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P--------
M
A
I
F
-
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
----
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
-----
D
L
K
Q
L
M
V
H
A
F
I
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
61.76
30%
-73
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-271]
---------
R
----
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
-
E
V
-
A
H
T
-
L
T
----
E
N
R
V
-
L
------
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
--
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
-
S
R
E
----
R
V
F
S
----
E
D
R
A
---
R
F
Y
G
A
E
------
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
-
Y
R
D
L
K
L
E
N
L
M
L
-
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
-
V
L
-----
E
D
N
--
D
--
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
-
D
H
E
K
L
F
-
E
-
L
I
L
M
E
E
I
R
F
P
R
-------
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
61.31
31%
-69
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[9-264]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
---
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
----
E
L
Q
V
-
L
------
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
--
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
P
----
E
Q
I
L
---
G
K
V
S
I
A
------
V
I
K
G
L
T
Y
L
R
E
-
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
--
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------
R
-
P
P
M
A
I
F
-
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
-----
D
L
K
Q
L
M
V
H
A
F
I
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
61.18
33%
-77
- C1 -
3FME
1
MP2K6_HUMAN
A:
[2-271]
--------
M
E
----
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
------
N
S
Q
E
Q
-
K
R
L
-
L
M
----
D
L
D
I
S
M
------
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
--
R
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
-
K
Q
V
I
D
K
G
Q
T
I
P
----
E
D
I
L
---
G
K
I
A
V
S
------
I
V
K
A
L
E
H
L
H
S
-
K
L
S
V
I
-
H
R
D
V
K
P
S
N
V
L
I
-
N
A
L
G
Q
V
K
M
C
D
F
---------------
A
G
C
K
P
Y
-
M
A
P
E
-
R
I
N
P
E
L-
N
Q
------
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
---
D
S
W
G
T
P
F
Q
Q
L
K
Q
-
V
V
E
E
P
S
P
Q
L
P
------
A
D
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
-----
T
Y
P
E
L
M
Q
H
P
F
F
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
61.16
33%
-73
- C1 -
4BIC
2
?
B:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
-----
S
-
Q
P
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
61.08
33%
-72
- C1 -
4BIB
1
?
B:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
-----
S
-
Q
P
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
60.67
33%
-74
- C1 -
4BIE
2
?
B:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
---------
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
60.42
33%
-73
- C1 -
4BIE
2
?
A:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
----------
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
60.26
34%
-72
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[51-315]
-----------------
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
A
T
-----
V
-
N
S
Q
-
E
Q
----
K
R
L
L
-
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
--
R
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
-
K
Q
V
I
D
K
G
Q
T
I
P
----
E
D
I
L
---
G
K
I
A
V
S
------
I
V
K
A
L
E
H
L
H
S
-
K
L
S
V
I
-
H
R
D
V
K
P
S
N
V
L
I
-
N
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
V
A
K
T
I
D
A
G
C
K
P
Y
-
M
A
P
E
-
R
I
N
P
E
L-
N
Q
K
--
G
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
---
D
S
W
G
T
P
F
Q
Q
L
K
Q
-
V
V
E
E
P
S
P
Q
L
P
------
A
D
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
-----
T
Y
P
E
L
M
Q
H
P
F
F
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
60.26
33%
-73
- C1 -
4BIC
2
?
A:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
------
S
-
Q
P
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
59.97
31%
-70
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[9-264]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
---
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
----
E
L
Q
V
-
L
------
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
--
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
P
----
E
Q
I
L
---
G
K
V
S
I
A
------
V
I
K
G
L
T
Y
L
R
E
-
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
--
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------
R
-
P
P
M
A
I
F
-
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
-----
D
L
K
Q
L
M
V
H
A
F
I
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
59.79
33%
-70
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[30-281]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
D
S
-----
Q
P
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
59.56
33%
-72
- C1 -
4BIB
3
?
A:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
----------
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
59.29
33%
-75
- C1 -
4BID
1
?
A:
[27-278]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
----------
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
59.24
33%
-75
- C1 -
4BF2
2
?
A:
[43-294]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
-------------
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
58.69
33%
-73
- C1 -
4BHN
2
?
B:
[43-294]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
-----
S
-
Q
P
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
58.32
33%
-73
- C1 -
4BF2
1
?
B:
[43-294]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
------------
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
58.25
31%
-74
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[25-284]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
---
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
----
E
L
Q
V
-
L
------
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
--
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
P
----
E
Q
I
L
---
G
K
V
S
I
A
------
V
I
K
G
L
T
Y
L
R
E
-
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--------
F
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
---
G
-------
A
I
-
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
-----
D
L
K
Q
L
M
V
H
A
F
I
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
58.05
31%
-66
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[9-264]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
---
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
----
E
L
Q
V
-
L
------
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
--
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
P
----
E
Q
I
L
---
G
K
V
S
I
A
------
V
I
K
G
L
T
Y
L
R
E
-
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
----
G
T
R
S
Y
M
S
P
------
E
--
R
L
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------
R
-
P
P
M
A
I
F
-
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
-----
D
L
K
Q
L
M
V
H
A
F
I
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
57.65
33%
-71
- C1 -
2CLQ
1
B:
[30-281]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
-----
S
-
Q
P
L
-
H
E
----
E
I
A
L
-
H
------
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
--
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
K
DN--
E
Q
T
I
---
G
F
Y
T
K
Q
------
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
-
I
I
-----
D
K
G
PR
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
---
Y
E
L
-
G
E
P
Q
A
A
-
M
-
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
57.58
40%
-52
- C1 -
2F57
1
PAK7_HUMAN
A:
[33-297]
-
A
L
Q
L
V
V
S
P
G
----
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
---
L
R
K
Q
Q
-
R
R
-
E
L
L
-
F
N
----
E
V
V
I
-
M
------
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
--
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
-----
R
M
N
----
E
E
Q
I
---
A
T
V
C
L
S
------
V
L
R
A
L
S
Y
L
H
N
-
Q
-
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
-
T
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
V
I
S
-----
R
L
--
P
--
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
---
F
N
E
-
P
P
L
Q
A
M
-
R
-
R
I
R
D
S
--
L
P
P
R
V
K
D
--
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
-----
T
A
Q
E
L
L
G
H
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
56.49
31%
-63
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[9-264]
-----------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
---
L
E
I
K
P
-
A
I
R
N
Q
I
-
I
R
----
E
L
Q
V
-
L
------
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
--
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
P
----
E
Q
I
L
---
G
K
V
S
I
A
------
V
I
K
G
L
T
Y
L
R
E
-
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
---
V
G
T
R
S
Y
M
S
P
------
E
--
R
L
Q
--
G
TH
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------
R
-
P
P
M
A
I
F
-
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
-----
D
L
K
Q
L
M
V
H
A
F
I
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
52.35
31%
-73
- C1 -
2W5A
5
NEK2_HUMAN
A:
[8-270]
-------------------
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
---
L
D
Y
G
S
-
M
T
-
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
-
L
------
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
---
I
T
----
K
G
T
K
----
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
-
H
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
-
Q
M
-----
N
R
M
-----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
-
S
Q
K
E
L
A
-
G
-
K
I
R
E
G
K
F
R
----
R
I
--
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
51.70
31%
-68
- C1 -
2XNO
13
NEK2_HUMAN
A:
[8-270]
-------------------
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
---
L
D
Y
G
S
-
M
T
-
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
-
L
------
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
---
I
T
----
K
G
T
K
----
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---------
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
-
Q
M
-----
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
-
S
Q
K
E
L
A
-
G
-
K
I
R
E
G
K
F
R
----
R
I
--
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
51.39
31%
-71
- C1 -
2XK6
1
NEK2_HUMAN
A:
[8-270]
-------------------
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
---
L
D
Y
G
S
-
M
T
-
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
-
L
------
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
---
I
T
----
K
G
T
K
----
E
R
Q
Y
LD
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---------
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
N
V
K
L
G
D
-----------------
V
G
T
P
Y
Y
M
S
P
E
-
Q
M
-----
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
-
S
Q
K
E
L
A
-
G
-
K
I
R
E
G
K
F
R
----
R
I
--
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
50.65
31%
-69
- C1 -
2XNP
6
NEK2_HUMAN
A:
[8-270]
-------------------
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
---
L
D
Y
G
S
-
M
T
-
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
-
L
------
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
---
I
T
----
K
G
T
K
----
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
H
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
-
Q
M
-----
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
-
S
Q
K
E
L
A
-
G
-
K
I
R
E
G
K
F
R
----
R
I
--
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
50.12
31%
-70
- C1 -
2XK4
1
NEK2_HUMAN
A:
[8-270]
-------------------
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
---
L
D
Y
G
S
-
M
T
-
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
-
L
------
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
---
I
T
----
K
G
T
K
----
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---------
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
-
Q
M
-----
N
R
M
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
-
S
Q
K
E
L
A
-
G
-
K
I
R
E
G
K
F
R
----
R
I
--
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
49.65
31%
-64
- C1 -
2XNN
6
NEK2_HUMAN
A:
[8-270]
-------------------
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
---
L
D
Y
G
S
-
M
T
-
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
-
L
------
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
---
I
T
----
K
G
T
K
----
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---------
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
N
V
K
L
G
D
F
G
--------------
F
V
G
T
P
Y
Y
M
S
P
E
-
Q
M
-----
N
R
------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
-
S
Q
K
E
L
A
-
G
-
K
I
R
E
G
K
F
R
----
R
I
--
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
49.58
31%
-68
- C1 -
2XK3
1
NEK2_HUMAN
A:
[8-270]
-------------------
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
---
L
D
Y
G
S
-
M
T
-
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
-
L
------
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
---
I
T
----
K
G
T
K
----
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---------
R
D
L
K
P
A
N
V
F
L
-
D
G
K
Q
N
V
K
L
G
D
F
G
---------------
V
G
T
P
Y
Y
M
S
P
E
-
Q
M
-----
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
-
S
Q
K
E
L
A
-
G
-
K
I
R
E
G
K
F
R
----
R
I
--
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
47.32
31%
-72
- C1 -
2XKE
1
NEK2_HUMAN
A:
[8-270]
-------------------
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
---
L
D
Y
G
S
-
M
T
-
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
-
L
------
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
---
I
T
----
K
G
T
K
----
E
R
Q
Y
LD
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D
----------
L
K
P
A
N
V
F
L
-
D
G
K
Q
N
V
K
L
G
D
F
------------------
T
P
Y
Y
M
S
P
E
-
Q
M
-----
N
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
---
T
A
F
-
S
Q
K
E
L
A
-
G
-
K
I
R
E
G
K
F
R
----
R
I
--
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
46.64
32%
-58
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[18-297]
-----
D
F
T
A
E
----
D
L
K
D
----
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T-
V
D
E
K
E
-
Q
K
-
Q
L
L
-
M
D
----
L
D
V
V
-
M
------
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
--
R
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
-
Y
V
Y
----
S
V
L
D
D
V
I
P
E
E
I
L
---
G
K
I
T
L
A
------
T
V
K
A
L
N
H
L
K
E
-
N
-
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
---
P
-------------------
D
P
P
Q
L
S
N
SE
E
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
-----
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
-
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
43.73
32%
-52
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[18-297]
-----
D
F
T
A
E
----
D
L
K
D
----
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T-
V
D
E
K
E
-
Q
K
-
Q
L
L
-
M
D
----
L
D
V
V
-
M
------
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
--
R
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
-
Y
V
Y
----
S
V
L
D
DVIP
E
E
I
L
---
G
K
I
T
L
A
------
T
V
K
A
L
N
H
L
K
E
-
N
-
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
---
P
K
W
-----------
T
Q
V
V
K
G
D
P
P
Q
L
S
N
SE
E
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
-----
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
-
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
39.16
32%
-48
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[18-297]
-----
D
F
T
A
E
----
D
L
K
D
----
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
ST-
V
D
E
K
E
-
Q
K
-
Q
L
L
-
M
D
----
L
D
V
V
-
M
------
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
--
R
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
-
Y
V
Y
----
S
V
L
D
DVIP
E
E
I
L
---
G
K
I
T
L
A
------
T
V
K
A
L
N
H
L
K
E
-
N
-
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Y
-
M
A
P
E
R
I
D
P
------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
---
P
K
W
-
N
S
V
F
D
--
Q
-
L
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
-----
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
-
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------