@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M4K4_HUMAN: (2013-07-22 )
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
Atome Classification :
(44 SA)
.........10........20........30........40........50....--..---.-.60.....--..--.70........80---........90........100.......110.......120....--...130.......140..-.....150.......160--........170.......180.......190.......200.......210.......220.......230..--..-...---240.----......250.--------------------------..-....260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MD---V-TEDEEEEI--KL--EINMLKKYSHHRN---IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLK--EDWIAYISREILRGLAHL-HIHHVIHRDIKGQNVLL---TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLC--DM-HPM---RALF----LIPRNPPPRL--------------------------KS-KKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
3
PsiBlast_PDB
74.83
44%
-64
- C2 -
2XIK
2
STK25_HUMAN
A:
[16-293]
-------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
-
E
I
E
--
D
I
Q
Q
E
I
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V
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Q
-
C
D
S
P
Y
---
I
T
R
Y
F
G
S
Y
L
K
S
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
---
G
P
L
E
--
E
T
Y
I
A
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I
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R
E
I
L
K
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L
D
Y
L
-
H
S
E
R
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R
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I
K
A
A
N
V
L
L
---
S
E
Q
G
D
V
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A
D
F
G
V
A
G
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L
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T
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N
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V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
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F
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A
D
I
W
S
L
G
I
T
A
I
E
L
A
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G
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P
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N
S
--
D
L
-
H
P
M
---
R
V
L
F
----
L
I
P
K
N
S
P
P
T
L
--------------------------
E
G
-
Q
H
-
S
K
P
F
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E
F
V
E
A
C
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N
K
D
P
R
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R
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A
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F
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Y
T
K
K
T
S
F
L
T
E
L
---
I
D
R
Y
K
R
W
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.36
43%
-63
- C2 -
3A7I
1
STK24_HUMAN
A:
[19-299]
-------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
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A
L
D
L
L
E
P
---
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
-
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
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T
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N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
--
E
L
-
H
P
M
---
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
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L
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H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.30
43%
-69
- C2 -
4FZD
1
MST4_HUMAN
B:
[3-283]
-----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
--
E
I
T
V
L
S
Q
-
C
D
S
S
Y
---
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
--
E
F
Q
I
A
T
M
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K
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I
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K
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L
D
Y
L
-
H
S
E
K
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I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
--
D
M
-
H
P
M
---
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
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R
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A
K
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L
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K
F
I
V
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N
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K
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T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.48
43%
-62
- C2 -
3A7J
1
STK24_HUMAN
A:
[19-299]
-------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
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D
N
R
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Q
K
V
V
A
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K
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--
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---
L
-
E
E
A
E
D
E
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--
D
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Q
Q
E
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-
C
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P
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---
V
T
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Y
Y
G
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Y
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K
------
D
T
K
L
W
I
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E
Y
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G
G
G
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A
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D
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L
E
P
---
G
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L
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--
E
T
Q
I
A
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I
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L
D
Y
L
-
H
S
E
K
K
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D
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A
A
N
V
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---
S
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A
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A
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-----
Q
S
A
Y
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A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
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P
H
S
--
E
L
-
H
P
M
---
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.42
43%
-64
- C2 -
4FZF
1
?
B:
[3-283]
-----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
--
E
I
T
V
L
S
Q
-
C
D
S
S
Y
---
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
--
E
F
Q
I
A
T
M
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K
E
I
L
K
G
L
D
Y
L
-
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
Q
G
D
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K
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A
A
F
G
V
A
G
Q
L
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V
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T
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F
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M
A
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V
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Q
-----
Q
S
A
Y
D
S
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A
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I
W
S
L
G
I
T
A
I
E
L
A
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G
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N
S
--
D
M
-
H
P
M
---
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
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F
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P
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A
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E
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L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.17
43%
-65
- C2 -
3CKX
1
STK24_HUMAN
A:
[5-283]
--------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
--
I
D
---
L
-
E
E
--
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
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G
G
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A
L
D
L
L
E
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---
G
P
L
D
--
E
T
Q
I
A
T
I
L
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E
I
L
K
G
L
D
Y
L
-
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
H
G
E
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K
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F
G
V
A
G
Q
L
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D
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N
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F
V
G
T
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F
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M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
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A
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I
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S
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T
A
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A
R
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E
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H
S
--
E
L
-
H
P
M
---
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
---
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.00
43%
-64
- C2 -
4FZA
3
MST4_HUMAN
B:
[3-283]
-----------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
--
E
I
T
V
L
S
Q
-
C
D
S
S
Y
---
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
-
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
--
D
M
-
H
P
M
---
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.60
43%
-61
- C2 -
3A7H
1
STK24_HUMAN
A:
[19-298]
-------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
---
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
-
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
--
E
L
-
H
P
M
---
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
67.20
41%
-70
- C2 -
4AOT
1
STK10_HUMAN
B:
[16-289]
-------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
--
I
E
---
T
K
S
E
E
E
L
E
D
Y
--
I
V
--
E
I
E
I
L
A
T
-
C
D
H
P
Y
---
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
-----------
I
G
T
P
Y
W
M
A
P
E
V
V
M
-------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
--
E
L
-
N
P
M
---
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
--------------------------
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.62
43%
-65
- C2 -
3GGF
1
MST4_HUMAN
A:
[18-298]
-----------------
I
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
---
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
-
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
--
D
M
-
H
P
M
---
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
65.69
43%
-63
- C2 -
3GGF
1
MST4_HUMAN
B:
[19-298]
------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
S
Y
---
V
T
K
Y
Y
G
S
Y
L
K
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---
A
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
-
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
--
D
M
-
H
P
M
---
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
---
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
64.96
41%
-70
- C2 -
4AOT
1
STK10_HUMAN
A:
[16-289]
-------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
--
I
E
---
T
K
S
E
E
E
L
E
D
Y
--
I
V
--
E
I
E
I
L
A
T
-
C
D
H
P
Y
---
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
--
E
L
-
N
P
M
---
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
--------------------------
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
61.80
41%
-71
- C2 -
2UV2
6
SLK_HUMAN
A:
[34-303]
-------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
--
I
D
---
T
K
S
E
E
E
L
E
D
Y
--
M
V
--
E
I
D
I
L
A
S
-
C
D
H
P
N
---
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
E
L
E
R
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
-
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
--
E
L
-
N
P
M
---
R
V
L
L
----
K
I
A
K
S
E
P
P
T
L
A-------------------------
Q
P
-
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
61.20
41%
-61
- C2 -
2J7T
1
STK10_HUMAN
A:
[16-289]
-------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
--
I
E
-------
E
E
L
E
D
Y
--
I
V
--
E
I
E
I
L
A
T
-
C
D
H
P
Y
---
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
--
E
L
-
N
P
M
---
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
--------------------------
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.10
41%
-69
- C2 -
2JFL
6
SLK_HUMAN
A:
[34-303]
-------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
--
I
D
---
T
K
S
E
E
E
L
E
D
Y
--
M
V
--
E
I
D
I
L
A
S
-
C
D
H
P
N
---
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
E
L
E
R
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
-
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
--
E
L
-
N
P
M
---
R
V
L
L
----
K
I
A
K
S
E
P
P
T
L
A-------------------------
Q
P
-
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.84
41%
-70
- C2 -
2J51
5
SLK_HUMAN
A:
[34-303]
-------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
--
I
D
---
T
K
S
E
E
E
L
E
D
Y
--
M
V
--
E
I
D
I
L
A
S
-
C
D
H
P
N
---
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
E
L
E
R
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
-
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
--
E
L
-
N
P
M
---
R
V
L
L
----
K
I
A
K
S
E
P
P
T
L
A-------------------------
Q
P
-
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
59.60
31%
-72
- C2 -
3ORN
3
MP2K1_HUMAN
A:
[8-270]
------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
---
I
-
K
P
A
I
R
N
Q
I
--
I
R
--
E
L
Q
V
L
H
E
-
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
--
K
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
---
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PP-----
P
---
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
--------------------------
P
S
-
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
59.06
32%
-82
- C2 -
3SLS
2
MP2K1_HUMAN
A:
[27-283]
------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
---
I
-
K
P
A
I
R
N
Q
I
--
I
R
--
E
L
Q
V
L
----
H
E
C
N
SPY
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
--
K
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
---
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--------
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
--------------------------
P
S
-
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.05
41%
-61
- C2 -
4BC6
2
STK10_HUMAN
A:
[8-281]
-------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
--
I
E
---
T
K
S
E
E
E
L
E
D
Y
--
I
V
--
E
I
E
I
L
A
T
-
C
D
H
P
Y
---
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
--
E
L
-
N
P
M
---
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
--------------------------
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
58.81
41%
-65
- C2 -
4EQU
2
STK10_HUMAN
B:
[16-289]
-------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
--
I
E
-------
E
E
L
E
D
Y
--
I
V
--
E
I
E
I
L
A
T
-
C
D
H
P
Y
---
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
--
E
L
-
N
P
M
---
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
--------------------------
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
58.42
32%
-73
- C2 -
4ANB
2
MP2K1_HUMAN
A:
[11-263]
------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
---
I
-
K
P
A
I
R
N
Q
I
--
I
R
--
E
L
Q
V
L
H
E
-
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
--
K
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
---
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
--
P
M
-
A
I
F
---
E
L
L
D
----
Y
I
V
N
E
P
P
P
K
L
--------------------------
P
S
-
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
57.61
32%
-72
- C2 -
4AN2
2
MP2K1_HUMAN
A:
[11-263]
------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
---
I
-
K
P
A
I
R
N
Q
I
--
I
R
--
E
L
Q
V
L
H
E
-
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
--
K
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
---
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
--
P
M
-
A
I
F
---
E
L
L
D
----
Y
I
V
N
E
P
P
P
K
L
--------------------------
P
S
-
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
57.57
31%
-59
- C2 -
3ZDU
3
CDKL3_HUMAN
A:
[4-289]
-----------------------
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
I
--
F
Y
---------
N
K
I
A
--
M
R
--
E
I
K
F
L
K
Q
F
-
H
H
E
N
---
L
V
N
L
I
E
V
F
R
Q
------
K
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
H
Y
C
H
--
G
L
E
--
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
-
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
---
S
Q
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
----
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
L
P
--
S
S
-
S
D
L
D
L
L
H
K
I
V
----
L
K
V
G
N
L
S
P
H
L
Q
N
I
F
S
K
SPIFAGVV
L
P
Q
V
Q
H
P
KN
A
R
K
K
Y
-
P
K
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
57.08
32%
-73
- C2 -
4AN3
2
MP2K1_HUMAN
A:
[11-263]
------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
---
I
-
K
P
A
I
R
N
Q
I
--
I
R
--
E
L
Q
V
L
H
E
-
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
--
K
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
---
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
--
P
M
-
A
I
F
---
E
L
L
D
----
Y
I
V
N
E
P
P
P
K
L
--------------------------
P
S
-
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
56.40
32%
-71
- C2 -
4AN9
2
MP2K1_HUMAN
A:
[11-263]
------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
---
I
-
K
P
A
I
R
N
Q
I
--
I
R
--
E
L
Q
V
L
H
E
-
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
--
K
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
---
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
--
P
M
-
A
I
F
---
E
L
L
D
----
Y
I
V
N
E
P
P
P
K
L
--------------------------
P
S
-
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
55.61
37%
-48
- C2 -
2X4Z
3
A:
[21-277]
-------------------
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
--
M
D
---
L
-
R
K
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
---
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
-----
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
---
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
--
N
E
-
P
P
L
---
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
--------------------------
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
54.23
31%
-75
- C2 -
3OS3
2
MP2K1_HUMAN
A:
[8-270]
------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
---
I
-
K
P
A
I
R
N
Q
I
--
I
R
--
E
L
Q
V
L
H
E
-
C
N
S
P
Y
---
I
V
G
F
Y
G
A
F
Y
S
------
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
--
K
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
---
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-----------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
--------------------------
P
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
54.16
32%
-63
- C2 -
4BIB
1
?
B:
[26-281]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-
R
----
S
Q
P
--
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
53.85
37%
-45
- C2 -
2J0I
4
A:
[28-284]
-------------------
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
--
M
D
---
L
-
R
K
Q
Q
R
R
E
L
--
L
F
N-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
---
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
-----
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
---
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
--
N
E
-
P
P
L
---
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
--------------------------
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
53.51
43%
-31
- C2 -
3A7H
1
STK24_HUMAN
B:
[19-298]
-------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
--
I
D
---
L
-
E
E
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
D
S
P
Y
---
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
---
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
-
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
---
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
--
E
L
-
H
P
M
---
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--------------------------
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
52.84
32%
-62
- C2 -
4BIC
2
?
B:
[26-282]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-
R
----
S
Q
P
--
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
52.55
32%
-63
- C2 -
4BF2
1
?
B:
[42-297]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-
R
-------------
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
52.54
32%
-59
- C2 -
4BIE
2
?
A:
[26-281]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-----------
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
52.52
32%
-60
- C2 -
4BIE
2
?
B:
[26-282]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-
R
---------
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
52.21
37%
-38
- C2 -
2F57
1
PAK7_HUMAN
A:
[53-299]
------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
--
M
D
---
L
-
R
K
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
---
V
V
D
M
Y
S
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
-----
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
-
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
---
T
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
L
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
--
N
E
-
P
P
L
---
Q
A
M
R
----
R
I
R
D
S
L
P
P
R
V
--------------------------
K
D
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
51.97
32%
-64
- C2 -
2CLQ
1
M3K5_HUMAN
A:
[29-284]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-
R
D
S
---
Q
P
--
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
51.63
32%
-60
- C2 -
4BIC
2
?
A:
[26-281]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
------
S
Q
P
--
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
51.34
37%
-44
- C2 -
4APP
2
A:
[21-277]
-------------------
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
--
M
D
---
L
-
R
K
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
---
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
-----
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
---
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
--
N
E
-
P
P
L
---
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
--------------------------
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
50.93
32%
-60
- C2 -
4BHN
2
?
B:
[42-295]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-
R
----
S
Q
P
--
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
49.79
32%
-58
- C2 -
4BIB
3
?
A:
[26-280]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-----------
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
49.70
32%
-62
- C2 -
4BF2
2
?
A:
[42-296]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
---------------
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
48.85
32%
-59
- C2 -
4BID
1
?
A:
[26-280]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-----------
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
48.26
32%
-63
- C2 -
2CLQ
1
B:
[29-284]
-----------------------------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
--
I
P
---
E
-
R
----
S
Q
P
--
L
H
--
E
E
I
A
L
H
K
H
L
K
H
K
N
---
I
V
Q
Y
L
G
S
F
------
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N--
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
--
D
K
G
P
R
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
--
E
L
G
E
P
Q
---
A
A
M
F
----
K
V
G
M
F
K
V
H
P
E
--------------------------
I
P
-
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
32.82
31%
-47
- C2 -
3I7B
3
?
A:
[33-227]
-----------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
KRQ
V
-
K
Q
K
T
D
K
E
S
--
L
L
R
-
E
V
Q
L
L
K
Q
L
D
H
-
P
N
---
I
M
K
L
Y
E
F
F
E
D
K
G
------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
--
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
-
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------