@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M4K5_HUMAN: (2013-07-22 )
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGLSSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKNDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY
Atome Classification :
(48 SA)
.........10........20........30........40........50...--.....60.-.......70......-----..80........90........100....-...----110--.......120.......130..-..-...140.......150........160.......170.......180.......190..-.......200.......210----.....-------.---.--220-.......--.230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLI-QQEIFMVKECKHCNI-----VAYFGSYLSREKLWICMEYCGGGSLQDIY-HVT----GPL--SELQIAYVCRETLQGLAYLHTK-GK-MHRDIKGANILLTDH-GDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVE--KN-GGYNQLCDIWAVGITAIELG----ELQPP-------M---F--DL--HPMRALF--LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGLSSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKNDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY
26
PsiBlast_CBE
86.20
45%
-82
- C2 -
4AOT
1
STK10_HUMAN
B:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
E
E
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
-----
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
-
G
D
I
R
L
A
D
F
G
V
S
A
K
-----------
I
G
T
P
Y
W
M
A
P
E
V
V
M
--------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-------
H
---
H
--
E
L
--
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.27
45%
-80
- C2 -
3A7I
1
STK24_HUMAN
A:
[13-290]
--------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-
P
----
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
-
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
P
P
-------
H
---
S
--
E
L
--
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.39
48%
-73
- C2 -
2XIK
2
STK25_HUMAN
A:
[14-287]
------------
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
--
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
-----
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
K
-
P
----
G
P
L
--
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
-
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-------
N
---
S
--
D
L
--
H
P
M
R
V
L
F
--
L
I
P
K
N
S
--
P
P
T
L
E
G
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.82
45%
-82
- C2 -
4AOT
1
STK10_HUMAN
A:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
E
E
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
-----
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
-
G
D
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
V
V
M
---------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-------
H
---
H
--
E
L
--
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.55
45%
-76
- C2 -
3A7J
1
STK24_HUMAN
A:
[13-290]
--------
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-
P
----
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
-
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
P
P
-------
H
---
S
--
E
L
--
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.52
45%
-75
- C2 -
3A7H
1
STK24_HUMAN
A:
[11-290]
------
P
G
M
Q
N
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-
P
----
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
-
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
P
P
-------
H
---
S
--
E
L
--
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.50
46%
-76
- C2 -
3CKX
1
STK24_HUMAN
A:
[5-275]
---------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
--
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
E
-
P
----
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
-
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
P
P
-------
H
---
S
--
E
L
--
H
P
M
K
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.65
45%
-83
- C2 -
4BC6
2
STK10_HUMAN
A:
[8-280]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
E
E
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
-----
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
-
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-------
H
---
H
--
E
L
--
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
79.55
44%
-76
- C2 -
3GGF
1
MST4_HUMAN
B:
[20-298]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-
A
----
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
-
G
D
V
K
L
A
D
F
G
V
A
----------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-------
N
---
S
--
D
M
--
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.47
44%
-76
- C2 -
3GGF
1
MST4_HUMAN
A:
[20-300]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-
A
----
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
-
G
D
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-------
N
---
S
--
D
M
--
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.24
45%
-76
- C2 -
4FZF
1
?
B:
[5-276]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-
A
----
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
-
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-------
N
---
S
--
D
M
--
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.83
45%
-75
- C2 -
4FZD
1
MST4_HUMAN
B:
[5-276]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-
A
----
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
-
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-------
N
---
S
--
D
M
--
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.74
45%
-84
- C2 -
2J7T
1
STK10_HUMAN
A:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
-----
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
-
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-------
H
---
H
--
E
L
--
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.99
45%
-72
- C2 -
4FZA
3
MST4_HUMAN
B:
[5-276]
--------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
--
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
-----
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
-
A
----
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
-
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-------
N
---
S
--
D
M
--
H
P
M
R
V
L
F
--
L
I
P
K
N
N
--
P
P
T
L
V
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.46
44%
-76
- C2 -
2UV2
6
SLK_HUMAN
A:
[34-297]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
--
S
E
E
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
-----
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
----
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
-
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
-
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
TS
K
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-------
H
---
H
--
E
L
--
N
P
M
R
V
L
L
--
K
I
A
K
S
--
E
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.29
44%
-78
- C2 -
2J51
5
SLK_HUMAN
A:
[34-297]
--------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
--
S
E
E
E
L
E
D
Y
-
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
-----
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
----
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
-
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
-
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
TS
K
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-------
H
---
H
--
E
L
--
N
P
M
R
V
L
L
--
K
I
A
K
S
--
E
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
75.98
45%
-81
- C2 -
4EQU
2
STK10_HUMAN
B:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
-----
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
-
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-------
H
---
H
--
E
L
--
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.95
45%
-80
- C2 -
4EQU
2
STK10_HUMAN
A:
[16-288]
--------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--------
L
E
D
Y
-
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
-----
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
----
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
-
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
-
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-------
H
---
H
--
E
L
--
N
P
M
R
V
L
L
--
K
I
A
K
S
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
71.04
33%
-84
- C2 -
4BID
1
?
A:
[27-279]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
----------
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
70.80
33%
-81
- C2 -
4BID
1
?
B:
[27-279]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
------
S
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
70.75
33%
-82
- C2 -
2CLQ
1
B:
[30-282]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
------
S
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
70.68
33%
-86
- C2 -
3ORN
3
MP2K1_HUMAN
A:
[7-271]
------------------
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
IK
P
A
I
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
C
N
S
P
Y
I
-----
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
-------
I
PPP---------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
70.48
33%
-83
- C2 -
4BIE
2
?
A:
[27-279]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
----------
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
70.42
33%
-85
- C2 -
4BIC
2
?
A:
[27-279]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
-------
S
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
70.19
33%
-82
- C2 -
2CLQ
1
M3K5_HUMAN
A:
[30-282]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
--
D
S
---
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
70.02
33%
-77
- C2 -
4BF2
1
?
B:
[43-295]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
------------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
69.84
33%
-93
- C2 -
3OS3
2
MP2K1_HUMAN
A:
[7-271]
------------------
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
IK
P
A
I
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
C
N
S
P
Y
I
-----
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
-------
I
P------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
69.72
33%
-87
- C2 -
4AN2
2
MP2K1_HUMAN
A:
[10-264]
------------------
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
C
N
S
P
Y
I
-----
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
--
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
69.32
33%
-79
- C2 -
4BIB
3
?
A:
[27-279]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
----------
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
69.04
33%
-78
- C2 -
4BIC
2
?
B:
[27-279]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
------
S
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
68.81
33%
-80
- C2 -
4BIE
2
?
B:
[27-279]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
---------
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.74
33%
-79
- C2 -
4BIB
1
?
B:
[27-279]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
------
S
Q
P
L
-
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
68.10
33%
-86
- C2 -
3SLS
2
MP2K1_HUMAN
A:
[26-284]
------------------
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
IK
P
A
I
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
C
N
S
P
Y
I
-----
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--------
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
-------
I
---
G
----------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.86
39%
-55
- C2 -
4FIE
1
PAK4_HUMAN
B:
[158-408]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
-----
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
67.81
31%
-92
- C2 -
2Y4I
1
MP2K1_RABIT
C:
[69-363]
------------------
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
IK
P
A
I
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
C
N
S
P
Y
I
-----
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
VGRY
P
I
P
P
P
DAKELEL
M
---
F
GC------
P
M
A
I
F
EL
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
67.65
33%
-82
- C2 -
4AN3
2
MP2K1_HUMAN
A:
[10-264]
------------------
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
IK
P
A
I
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
C
N
S
P
Y
I
-----
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
----
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
67.65
33%
-87
- C2 -
4ANB
2
MP2K1_HUMAN
A:
[10-264]
------------------
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
IK
P
A
I
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
C
N
S
P
Y
I
-----
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
--
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
67.44
33%
-81
- C2 -
4BF2
2
?
A:
[43-295]
-------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
-------------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
-----
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
-
R
S
K
W---
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
-
Q
I
-
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
--
I
D
--
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-------
F
---
Y
--
E
L
G-
E
P
Q
A
A
M
F
--
K
V
G
M
F
K
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
65.63
33%
-83
- C2 -
4AN9
2
MP2K1_HUMAN
A:
[10-264]
------------------
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
-
R
-
E
L
Q
V
L
H
E
C
N
S
P
Y
I
-----
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
-
K
K
A
----
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
---
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
59.41
40%
-46
- C2 -
2F57
1
B:
[52-302]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
H
H
D
N
V
-----
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
-
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
-
L
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
Q
A
M
R
--
R
I
R
D
S
--
L
P
P
R
V
K
D
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
58.26
40%
-48
- C2 -
2F57
1
PAK7_HUMAN
A:
[52-302]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
H
H
D
N
V
-----
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
-
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
-
L
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
Q
A
M
R
--
R
I
R
D
S
--
L
P
P
R
V
K
D
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
56.10
39%
-53
- C2 -
4FIF
1
PAK4_HUMAN
B:
[81-331]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
-----
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
55.07
39%
-51
- C2 -
2CDZ
1
A:
[38-288]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
-----
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
54.50
39%
-51
- C2 -
2X4Z
3
A:
[31-281]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
-----
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
54.22
31%
-74
- C2 -
3FME
1
MP2K6_HUMAN
A:
[8-269]
------------------
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
-----
N
---
S
Q
E
-
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
DCPFT
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
-
K
Q
V
I
D
K
G
Q
T
I
--
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
-
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
-
G
Q
V
K
M
C
D
F
---------------
A
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
--
L
N
Q--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
----
I
L
R
F
P
-----------
Y
--
D
S
WG
T
P
F
Q
Q
L
K
--
Q
V
V
E
---
E
P
S
P
Q
L
P
A
D
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
53.58
39%
-50
- C2 -
2J0I
4
A:
[38-288]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
-----
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
52.40
39%
-49
- C2 -
4APP
2
A:
[31-281]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
-----
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
K
A
M
K
---
M
I
R
D
N
L
-
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
50.99
39%
-45
- C2 -
2Q0N
7
A:
[36-286]
------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
--
K
Q
Q
R
R
E
L
L
-
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
-----
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
H
T
----
R
-
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
-
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
----
D
G
E
P
P
-------
Y
---
F
--
N
E
--
P
P
L
K
A
M
---
K
M
I
R
D
N
L
-
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------