@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAPK3_HUMAN: (2013-07-22 )
MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
Atome Classification :
(35 SA)
.........10........20........30........40........50........60..---......70...--------------.-------...--------.80.--....------...------------.90.-----.......100.......110.......120.......130.......140.......150.......-160.......170.......180........190--.-.--..--..-..200.......210.......220.......230.......240.......250.---......260.......270.......280.......290..-----.....300....-...310-------........320.......330.......340.......350---.........360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFH---RRTGQKCALKL--------------L-------YDS--------PK-A--RQEV------DHH------------WQAS-----GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHS-HNIAHRDVKPENLLYTSKEKD-AVLKLTDFGF-A--K-E--TT--QN-ALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG---MKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLT-----ITQFMNHPWINQ-SMVVP--------QTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVK-----IKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
1
PsiBlast_PDB
86.08
100%
-113
- C1 -
3FHR
1
MAPK3_HUMAN
A:
[20-336]
--------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
---
R
R
T
G
Q
K
C
A
L
K
L
--------------
L
-------
Y
D
S
--------
P
K
-
A
--
R
Q
E
V
------
D
H
H
------------
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
-
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
-
A
V
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
-------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
-----
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
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L
Q
E
D
K
D
H
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K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
--------------------------------------
4
PsiBlast_PDB
85.65
100%
-114
- C1 -
3SHE
1
MAPK3_HUMAN
A:
[1-316]
--------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
---
R
R
T
G
Q
K
C
A
L
K
L
--------------
L
-------
Y
D
S
--------
P
K
-
A
--
R
Q
E
V
------
D
H
H
------------
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
----
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
-
H
N
I
A
H
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D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
-
A
V
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
-------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
-----------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
-----
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
---------------------------------------
2
PsiBlast_PDB
84.50
100%
-113
- C1 -
3FXW
1
MAPK3_HUMAN
A:
[20-336]
--------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
-
G
K
V
L
E
C
F
H
---
R
R
T
G
Q
K
C
A
L
K
L
--------------
L
-------
Y
D
S
--------
P
K
-
A
--
R
Q
E
V
------
D
H
H
------------
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
-
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
-
A
V
L
K
L
T
D
F
G
F
-
A
--
K
-
E
----------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
-----
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
--------------------------------------
3
PsiBlast_PDB
84.17
100%
-109
- C1 -
3R1N
1
MAPK3_HUMAN
A:
[1-316]
--------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
---
R
R
T
G
Q
K
C
A
L
K
L
--------------
L
-------
Y
D
S
--------
P
K
-
A
--
R
Q
E
V
------
D
H
H
------------
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
G
--
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
-
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
-
A
V
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
-----------------------
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
-----------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
-----
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
---------------------------------------
12
PsiBlast_PDB
78.83
76%
-117
- C1 -
3KA0
1
MAPK2_HUMAN
A:
[9-318]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
--------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---------
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
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I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
10
PsiBlast_PDB
75.21
76%
-112
- C1 -
3FYK
1
MAPK2_HUMAN
X:
[11-320]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
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I
Q
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R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
S------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
16
PsiBlast_PDB
73.28
74%
-108
- C1 -
2PZY
1
MAPK2_HUMAN
A:
[4-306]
---------------------
P
Q
F
H
V
K
S
G
L
Q
I
--
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
-------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
--------------------------------------------------------------
45
PsiBlast_CBE
72.67
76%
-103
- C1 -
2PZY
1
MAPK2_HUMAN
C:
[15-319]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
-------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
-------------------------------------------------
21
PsiBlast_CBE
72.36
75%
-119
- C1 -
1NY3
1
MAPK2_HUMAN
A:
[55-345]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
S-
H
----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
46
PsiBlast_CBE
72.23
76%
-111
- C1 -
2PZY
1
MAPK2_HUMAN
B:
[15-305]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
-------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
8
PsiBlast_PDB
70.84
76%
-109
- C1 -
2P3G
1
MAPK2_HUMAN
X:
[11-320]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
S------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
19
PsiBlast_PDB
70.70
76%
-120
- C1 -
3R2Y
1
MAPK2_HUMAN
A:
[10-300]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
---------------------------
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
-------------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
7
PsiBlast_PDB
69.85
73%
-109
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[55-345]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
-------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
9
PsiBlast_PDB
69.22
76%
-106
- C1 -
3FYJ
1
MAPK2_HUMAN
X:
[11-320]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
S------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
139
HHSearch
68.75
76%
-100
- C1 -
3M2W
1
MAPK2_HUMAN
A:
[7-299]
------------------------------
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
-----------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
69
PsiBlast_CBE
68.41
71%
-105
- C1 -
3M42
1
MAPK2_HUMAN
A:
[11-299]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
-----------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
71
PsiBlast_CBE
68.08
71%
-106
- C1 -
3KGA
1
MAPK2_HUMAN
A:
[11-299]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
---
K
R
T
Q
E
K
F
A
L
K
M
--------------
L
-------
Q
D
C
--------
P
K
-
A
--
R
R
E
V
------
E
L
H
------------
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
-
A
I
L
K
L
T
D
F
G
F
-
A
--
K
-
E
--
T
T
-----------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
73
PsiBlast_CBE
60.08
40%
-122
- C1 -
3LIJ
1
?
A:
[20-297]
-----------------------
L
Q
A
T
P
G
M
F
I
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
K
K
-
L
G
S
---
G
E
V
L
L
C
R
D
---
K
V
T
H
V
E
R
A
I
K
I
--------------
I
R
K-----
S
S
N
--------
S
K
-
L
--
L
E
E
V
A
V
L
K
L
L
D
H
------------------------
P
N
I
M
K
L
Y
D
F
F
E
D
----
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
--
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
K
D
-
A
L
I
K
I
V
D
F
G
L
S
A
--
V
-
F
--
E
N
--
Q
K
-
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-
R
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
-------
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
Q
Q
A
L
E
H
P
W
I
K
E
------------------------------------------------------------------------------------------
85
PsiBlast_CBE
56.24
40%
-133
- C1 -
2W4O
1
KCC4_HUMAN
A:
[50-310]
-------------------------------------
A
L
S
D
F
F
E
V
E
S
E
-
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
---
K
G
T
Q
K
P
Y
A
L
K
V
--------------
L
K
K-------------------------
I
------
G
V
L
------------
L
R
L
S
-----
H
-
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
----
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
--
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
P
D
-
A
P
L
K
I
A
D
F
------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
------
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
F
Q
A
L
Q
H
P
W
V
T
-------------------------------------------------------------------------------------------
72
PsiBlast_CBE
55.97
40%
-121
- C1 -
3HZT
9
?
A:
[3-263]
---------------------------------------
S
D
R
Y
Q
R
V
K
K
-
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
---
K
L
T
G
A
E
R
A
I
K
I
I
KKSSVTTTSN
S
G
A
L
-------
L
D
E
--------
V
A
-
V
--
L
K
Q
L
------
D
H
------------------------
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
--
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
R
D
-
A
L
I
K
I
V
D
F
G
L
S
A
--
H
-
F
--
E
V
--
G
---------
T
A
Y
Y
I
A
P
E
V
L
-
R
K
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
-------
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
E
E
A
L
N
H
P
W
I
--------------------------------------------------------------------------------------------
103
PsiBlast_CBE
52.14
35%
-109
- C1 -
3UPZ
1
?
A:
[21-285]
-----------------------------------
T
A
I
F
S
D
R
Y
K
-
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
---
K
I
T
G
Q
E
C
A
V
K
V
--------------
I
--------
S
K
--------
R
Q
-
V
--
K
Q
K
T
------
D
K
E
S
L
L
R
E
V
Q
L
----
L
K
Q
L
-----
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
-
A
N
I
R
I
I
D
F
G
L
-
S
--
T
-
H
F
-
E
A
--
S
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
----
N
G
A
N
E
Y
D
---
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
--------------------------------------------------------------------------------------------
80
PsiBlast_CBE
51.22
38%
-114
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
-------------------------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--------------
I
-------
A
--------------------------
S
M
E
------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
-
S
K
I
M
I
S
D
F
G
L
-
S
--
K
M
E
--
D
P
--
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
----
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------
77
PsiBlast_CBE
51.15
38%
-125
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-276]
--------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--------------
I
-------
A
K
E
---------------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
-
S
K
I
M
I
S
D
F
-------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
----
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------
112
PsiBlast_CBE
50.91
35%
-113
- C1 -
3Q5I
1
?
A:
[18-307]
----------------------
G
I
A
I
N
P
G
M
Y
V
R
K
K
E
G
K
I
G
E
S
Y
-
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
---
K
N
G
H
S
E
K
A
I
K
V
--------------
I
-------
K
K
----------------------------KF
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
-----
D
H
P
N
I
I
K
L
F
D
V
F
E
D
----
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
--
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
-
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
S
L
-
L
N
I
K
I
V
D
F
G
L
-
S
--
S
-
F
--
F
S
--
K
D
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-
K
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
I
I
-------
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
E
E
A
L
N
S
R
W
I
K
K
------------------------------------------------------------------------------------------
79
PsiBlast_CBE
48.90
38%
-124
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-276]
--------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--------------
I
-------
A
K
E
--------------------------
E
------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
-
S
K
I
M
I
S
D
F
--------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
----
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------
93
PsiBlast_CBE
48.20
35%
-115
- C1 -
3KN5
1
KS6A5_HUMAN
A:
[11-291]
-----------------------------------------
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
---
K
K
S
N
Q
A
F
A
V
K
I
--------------
I
-------
S
K
R
--------
M
E
-
A
N
T
Q
K
E
I
------
T
A
L
------------
K
L
C
E
-----
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
----
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
-
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-----
L
E
I
K
I
I
D
F
G
F
-
A
R
L
K
-
P
--
P
-------------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
-------
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
S
G
L
R
Y
N
E
W
L
Q
D
-
G
S
Q
L
S
--------
S
N
P
L
M
T
P
D
I
L
------------------------------------------------------------------
76
PsiBlast_CBE
48.17
38%
-122
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-276]
------------------------------------
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--------------
I
-------
A
K
----------------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
-
S
K
I
M
I
S
D
F
G
--------------
G
S
-
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
----
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------
88
PsiBlast_CBE
47.86
35%
-92
- C1 -
3IGO
8
?
A:
[29-350]
------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
---
R
I
T
Q
Q
E
Y
A
V
K
V
--------------
I
N
KASAKN
K
-
T
--------
S
T
-
I
--
L
R
E
V
------
E
L
-------------
L
K
K
L
-----
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
-
C
D
I
K
I
I
D
F
G
L
-
S
--
T
-
C
--
F
Q
--
Q
N
-
T
------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
-------
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
----
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
------------------
78
PsiBlast_CBE
47.73
38%
-127
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-276]
------------------------------------
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
T
Q
K
L
V
A
I
K
C
--------------
I
-------
A
K
-----------------------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
-
S
K
I
M
I
S
D
F
------------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
----
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------
92
PsiBlast_CBE
47.24
35%
-108
- C1 -
3KN5
1
B:
[11-291]
-----------------------------------------
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
---
K
K
S
N
Q
A
F
A
V
K
I
--------------
I
-------
S
K
R
--------
M
E
-
A
N
T
Q
K
E
I
------
T
A
L
------------
K
L
C
E
-----
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
----
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
-
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-----
L
E
I
K
I
I
D
F
G
F
-
A
R
L
K
-
P
--
P
-------------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
H
D
R
S
L
T
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
S
G
L
R
Y
N
E
W
L
Q
D
-
G
S
Q
L
S
--------
S
N
P
L
M
T
P
D
I
L
------------------------------------------------------------------
131
HHSearch
43.41
34%
-115
- C1 -
4GV1
5
AKT1_HUMAN
A:
[7-271]
---------------------------------------
M
N
E
F
E
Y
L
K
-
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
T
G
R
Y
Y
A
M
K
I
--------------
L
-------
K
K
E
V
I
V
A
K
DE
V
A
H
-
T
--
L
T
E
N
------
R
V
L
------------
Q
N
S
------
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
----
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
K
D
-
G
H
I
K
I
T
D
F
G
L
-
C
--
K
-
E
--
G
I
KD
G
A
-
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
----
H
E
K
---
L
F
E
L
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
-
I
----------------------------------------------------------------------------------------
75
PsiBlast_CBE
43.34
40%
-109
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-266]
-----------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
---
R
L
T
G
K
L
F
A
L
K
C
--------------
I
-------
K
K
S
-----------------
S
------
L
E
N
------------
E
I
A
V
L
K
K
I-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
--
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
-
S
K
I
M
I
T
D
F
G
L
-
S
--
K
-
M
--
E
Q
--
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
----
E
S
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
D
-------------------------------------------------------------------------------------------
74
PsiBlast_CBE
41.70
40%
-108
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-266]
-----------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
---
R
L
T
G
K
L
F
A
L
K
C
--------------
I
-------
K
K
S
-----------------
S
------
L
E
N
------------
E
I
A
V
L
K
K
I-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
--
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
-
S
K
I
M
I
T
D
F
G
L
-
S
--
K
-
M
--
E
Q
--
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
----
E
S
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
D
-------------------------------------------------------------------------------------------
83
PsiBlast_CBE
40.57
35%
-94
- C1 -
2WNT
2
B:
[26-297]
----------------------------------------
S
D
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
---
K
A
T
N
M
E
Y
A
V
K
V
--------------
I
-------
D
K
S
--------
K
R
D
P
--
S
E
E
I
------
E
I
L
------------
L
R
Y
G
-----
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
H
----
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
--
K
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
-
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
C
L
R
I
C
D
F
G
F
-
A
--
K
-
Q
LR
A
E
--
N
G
-
L
L
M
T
P
C
Y
----------
K
R
Q
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
-
A
N
G
P
S
D
T
P
E
E
---
I
L
T
R
I
G
S
G
K
F
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
-----
A
K
Q
V
L
Q
H
P
W
V
T
Q
-
K
D
K
L
P
--------
Q
S
Q
L
------------------------------------------------------------------------
133
HHSearch
30.42
32%
-111
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[23-288]
---------------------------------------
P
S
Q
F
E
L
L
K
-
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
A
R
Q
L
Y
A
M
K
V
--------------
L
-------
K
K
A
T
L
K
V
R
D
R
-
V
---------------
D
I
L
------------
V
E
V
------
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
----
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
E
-
G
H
I
K
L
T
D
F
G
L
-
S
--
K
--------
E
K
-
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
----
R
K
E
---
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
AGPD
G
V
E
E
I
K
R
H
S
F
F
S
T
-
I
----------------------------------------------------------------------------------------