@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : MARK2_HUMAN: (2013-07-23 )
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL

Atome Classification :

(71 SA) .........10........20........30........40........-----50........60........70........80........-90.-....-....100.......110.......120.......130.......140.......150.......160......-.170.......180---...---...---.190.......200----..-..-.---....210.......220.......230.......240.......250-........260.....--..--270---.--.......280.......290-----.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780......
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-N-S-SSLQ-KLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ-KFIVHRDLKAENLL---LDA---DMN---IKIADFGFSNEF------TF-GN-K---LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKY--RI--PF----Y--MSTDCENLLKKFLILNPSKR-----GTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
103 PsiBlast_CBE 70.1938%-111 - C1 -3BHH KCC2B_HUMAN B:[6-264] ---------------------------------------------------------YQLYEDIGK---SVVRRCVKLCTGHEYAAKIINTKKL-S-A-RDHQ-KLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ-MGVVHRDLKPENLL---LAS---KCKGAAVKLADFGLAIEVQGDQQAWF-G---------FAGTPGYLSPEVLRKEAYGKP-VDIWACGVILYILLVGYPPFW--DEDQHKLYQQIKAGAY--DF--PSPEWDT--VTPEAKNLINQMLTINPAKR-----ITAHEALKHPWV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51 PsiBlast_CBE 67.9440%-114 - C1 -3LIJ ? A:[39-295] ---------------------------------------------------------YQRVKKLGS---GEVLLCRDKVTHVERAIKIIRK--------SSNS-KLLEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHK-HNIVHRDLKPENLL---LESKEKDAL---IKIVDFGLSAVF------EN-QK-K---MKERLGTAYYIAPEVLR-KKYD-EKCDVWSIGVILFILLAGYPPFG--GQTDQEILRKVEKGKY--TFDSPE----WKNVSEGAKDLIKQMLQFDSQRR-----ISAQQALEHPWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16 PsiBlast_PDB 67.4348%-100 - C1 -3AQV AAPK2_HUMAN A:[4-265] -------------------------------------------HDGRVK-----IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI-R-SLDVVG-KIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR-HMVVHRDLKPENVL---LDA---HMN---AKIADFGLSNMM------SD-GE-F---L------PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD--DEHVPTLFKKIRGGVF--YI--PE----Y--LNRSVATLLMHMLQVDPLKR-----ATIKDIREHEWF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134 HHSearch 66.4839%-103 * C1 *4FG7 KCC1A_HUMAN A:[19-277] --------------------------------------------------------IYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIA--------------SMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHD-LGIVHRDLKPENLLYYSLDE---DSK---IMISDFGLSKME------DP-------------GTPGYVAPEVLAQK--S-KAVDCWSIGVIAYILLCGYPPFY--DENDAKLFEQILKAEY--EF--DSPYWDD--ISDSAKDFIRHLMEKDPEKR-----FTCEQALQHPWIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50 PsiBlast_CBE 64.0341%-104 - C1 -3HZT ? A:[6-263] ---------------------------------------------------------YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSV-T-T-TSNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK-HNIVHRDLKPENLL---LESKSRDAL---IKIVDFGLSAHF------EV-G------------TAYYIAPEVLR-KKYD-EKCDVWSCGVILYILLCGYPPFG--GQTDQEILKRVEKGKF--SFDPPD----WTQVSDEAKQLVKLMLTYEPSKR-----ISAEEALNHPWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42 PsiBlast_CBE 62.2940% -93 - C1 -3MA6 ? A:[34-292] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------E--SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWIQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 62.2440% -98 - C1 -3V5P ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66 PsiBlast_CBE 61.9337% -90 - C1 -4HYH CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK----------E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33 PsiBlast_CBE 61.9240% -95 - C1 -3SXF ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39 PsiBlast_CBE 61.8539% -93 - C1 -3MWU ? A:[24-280] ---------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-K-N-KDTS-TILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK-HNIVHRDLKPENIL---LESKEKDCD---IKIIDFGLSTCF------QQ-N--------DRIGTAYYIAPEVLRG-TYD-EKCDVWSAGVILYILLSGTPPFY--GKNEYDILKRVETGKY--AF--DLPQWRT--ISDDAKDLIRKMLTFHPSLR-----ITATQCLEHPWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36 PsiBlast_CBE 61.6340% -99 - C1 -3I7B ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32 PsiBlast_CBE 61.6340% -98 - C1 -3T3U ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17 PsiBlast_PDB 61.5645% -92 - C1 -2Y94 AAPK1_RAT A:[9-291] ------------------------------------------------HDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKI-R-SLDVVG-KIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVL---LDA---HMN---AKIADFGLSNMM------SD-GE-F---LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD--DDHVPTLFKKICDGIF--YT--PQ----Y--LNPSVISLLKHMLQVDPMKR-----ATIKDIREHEWFK-----QDLPKYLFP----EDPSYSSTMID----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43 PsiBlast_CBE 61.2339% -93 - C1 -2WEI ? A:[24-280] ---------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA-K-N-KDTS-TILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK-HNIVHRDLKPENIL---LESKEKDCD---IKIIDFGLSTCF------QQ-NT-K---MKDRIGTAYYIAPEVLRG-TYD-EKCDVWSAGVILYILLSGTPPFY--GKNEYDILKRVETGKY--AF--DLPQWRT--ISDDAKDLIRKMLTFHPSLR-----ITATQCLEHPWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29 PsiBlast_CBE 60.5440% -95 - C1 -3UPZ ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59 PsiBlast_CBE 60.4537% -94 - C1 -2HOG CHK1_HUMAN A:[3-265] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK------------NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67 PsiBlast_CBE 60.4137% -88 - C1 -3NLB CHK1_HUMAN A:[6-266] ------------------------------------------------------VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR---------E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34 PsiBlast_CBE 60.4140% -97 - C1 -3SX9 ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56 PsiBlast_CBE 60.3037% -92 - C1 -2HY0 CHK1_HUMAN A:[3-265] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK------------NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83 PsiBlast_CBE 60.2537% -89 - C1 -2CGW CHK1_HUMAN A:[6-266] ------------------------------------------------------VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-------P-E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74 PsiBlast_CBE 60.1337% -99 - C1 -2XF0 CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTL-----GEVQLAVNRVTEEAVAVKIVD--------------NIKKEICINKMLNHENVVKFYGHRRE--IQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30 PsiBlast_CBE 59.9240% -95 - C1 -3UPX ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88 PsiBlast_CBE 59.8337% -90 - C1 -2C3J CHK1_HUMAN A:[6-266] ------------------------------------------------------VEDWDLVQTLGE---GEVQLAVNRVTEEAVAVKIVDMKR---------E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144 HHSearch 59.8238% -87 - C1 -3SOA KCC2A_HUMAN A:[10-273] ------------------------------------------------------TEEYQLFEELGKG--SVVRRCVKVLAGQEYAAMIINTKKL-S-A-RDHQ-KLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ-MGVVHRNLKPENLL---LASKLKGAA---VKLADFGLAIEV------EG-EQQA---WFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFW--DEDQHRLYQQIKAGAY--DF--PSPEWDT--VTPEAKDLINKMLTINPSKR-----ITAAEALKHPWISH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62 PsiBlast_CBE 59.8037% -93 - C1 -2R0U CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTLGE---GEVQLAVNRVTEEAVAVKIVDMK------------NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26 PsiBlast_CBE 59.8040% -93 - C1 -3V5T ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109 PsiBlast_CBE 59.7937% -92 - C1 -4FTI CHK1_HUMAN A:[3-265] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDM-----------E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99 PsiBlast_CBE 59.7137% -91 - C1 -1NVQ CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK------------NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84 PsiBlast_CBE 59.5537% -89 - C1 -2CGV CHK1_HUMAN A:[6-266] ------------------------------------------------------VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR------CP-E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63 PsiBlast_CBE 59.5437% -94 - C1 -2QHN CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTLG----GEVQLAVNRVTEEAVAVKIVDMK------------NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131 HHSearch 59.4738%-102 - C1 -4GV1 AKT1_HUMAN A:[6-269] ------------------------------------------------T-----MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVI-VAK-DEVA-HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLM---LDK---DGH---IKITDFGLCKEG------IKDGA-T---MKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFY--NQDHEKLFELILMEEI--RF--PR----T--LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 59.4640% -93 - C1 -3V51 ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31 PsiBlast_CBE 59.3340% -95 - C1 -3T3V ? A:[28-285] ---------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ-K-TDKE-SLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---LESKSKDAN---IRIIDFGLSTHF------EA-SK-K---MKDKIGTAYYIAPEVLHG-TYD-EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDHEWI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92 PsiBlast_CBE 59.1837% -93 - C1 -2BRH CHK1_HUMAN A:[6-266] ------------------------------------------------------VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVD--------------NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96 PsiBlast_CBE 59.0837% -87 - C1 -1ZLT CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR------CP-E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75 PsiBlast_CBE 59.0837% -92 - C1 -2XEY CHK1_HUMAN A:[6-266] ------------------------------------------------------VEDWDLVQTLG----GEVQLAVNRVTEEAVAVKIVD------------E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60 PsiBlast_CBE 58.9337% -92 - C1 -3TKI CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK------------NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108 PsiBlast_CBE 58.8337% -96 - C1 -4FTJ CHK1_HUMAN A:[3-265] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIV----------------IKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91 PsiBlast_CBE 58.7937% -89 - C1 -2BRM CHK1_HUMAN A:[7-266] -------------------------------------------------------EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDM--------CP-E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73 PsiBlast_CBE 58.6837% -89 - C1 -2YDI CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRA-V-D-CP-E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110 PsiBlast_CBE 58.4737% -93 - C1 -4FT9 CHK1_HUMAN A:[3-265] -----------------------------------------------PF-----VEDWDLVQTLGEG--GEVQLAVNRVTEEAVAVKIVDM-----------E-NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105 PsiBlast_CBE 58.4137% -94 - C1 -4FTT CHK1_HUMAN A:[3-265] -----------------------------------------------PF-----VEDWDLVQTLGE---GEVQLAVNRVTEEAVAVKIVD--------------NIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 58.4137% -93 - C1 -2YM4 CHK1_HUMAN A:[4-266] -----------------------------------------------PF-----VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIV---------------NIKKEICINKMLNHENVVKFYGH------QYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLL---LDE---RDN---LKISDFGLATVF------RY-NN-RERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTY--LN--PWK---K--IDSAPLALLHKILVENPSAR-----ITIPDIKKDRWYN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------