@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
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Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK2_HUMAN: (2013-07-23 )
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Atome Classification :
(71 SA)
.........10........20........30........40........-----50........60........70........80........-90.-....-....100.......110.......120.......130.......140.......150.......160......-.170.......180---...---...---.190.......200----..-..-.---....210.......220.......230.......240.......250-........260.....--..--270---.--.......280.......290-----.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-N-S-SSLQ-KLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ-KFIVHRDLKAENLL---LDA---DMN---IKIADFGFSNEF------TF-GN-K---LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKY--RI--PF----Y--MSTDCENLLKKFLILNPSKR-----GTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
103
PsiBlast_CBE
70.19
38%
-111
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-264]
---------------------------------------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
-
A
-
R
D
H
Q
-
K
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
A
S
---
K
C
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
QGDQQA
W
F
-
G
---------
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
-----
I
T
A
H
E
A
L
K
H
P
W
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
67.94
40%
-114
- C1 -
3LIJ
1
?
A:
[39-295]
---------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
--------
S
S
N
S
-
K
L
L
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KEK
D
A
L
---
I
K
I
V
D
F
G
L
S
A
V
F
------
E
N
-
Q
K
-
K
---
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
-
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
--
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
--
T
F
DS
P
E
----
W
KN
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
-----
I
S
A
Q
Q
A
L
E
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.43
48%
-100
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[4-265]
-------------------------------------------
H
D
G
R
V
K
-----
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
-
S
L
D
V
V
G
-
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
D
A
---
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
------
S
D
-
G
E
-
F
---
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
--
Y
I
--
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
-----
A
T
I
K
D
I
R
E
H
E
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
66.48
39%
-103
* C1 *
4FG7
1
KCC1A_HUMAN
A:
[19-277]
--------------------------------------------------------
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--------------
S
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
S
K
---
I
M
I
S
D
F
G
L
S
K
M
E
------
D
P
-------------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
--
E
F
--
D
S
PYWD
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
-----
F
T
C
E
Q
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
64.03
41%
-104
- C1 -
3HZT
9
?
A:
[6-263]
---------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
-
T
-
T
-
T
S
N
S
G
A
L
L
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSR
D
A
L
---
I
K
I
V
D
F
G
L
S
A
H
F
------
E
V
-
G
------------
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
-
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
--
G
Q
T
D
Q
E
I
L
K
R
V
E
K
G
K
F
--
S
F
DP
P
D
----
W
TQ
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
-----
I
S
A
E
E
A
L
N
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
62.29
40%
-93
- C1 -
3MA6
1
?
A:
[34-292]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
--
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
62.24
40%
-98
- C1 -
3V5P
1
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
61.93
37%
-90
- C1 -
4HYH
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
61.92
40%
-95
- C1 -
3SXF
3
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
61.85
39%
-93
- C1 -
3MWU
1
?
A:
[24-280]
---------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-
K
-
N
-
K
D
T
S
-
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
S
KEK
D
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
------
Q
Q
-
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
-
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
F
--
D
L
P
Q
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-----
I
T
A
T
Q
C
L
E
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
61.63
40%
-99
- C1 -
3I7B
4
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
61.63
40%
-98
- C1 -
3T3U
5
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
61.56
45%
-92
- C1 -
2Y94
1
AAPK1_RAT
A:
[9-291]
------------------------------------------------
H
D
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
-
S
L
D
V
V
G
-
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
D
A
---
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
------
S
D
-
G
E
-
F
---
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-----
A
T
I
K
D
I
R
E
H
E
W
F
K
-----
Q
D
L
P
K
Y
L
F
P
----
E
D
P
S
Y
S
S
T
M
I
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
61.23
39%
-93
- C1 -
2WEI
1
?
A:
[24-280]
---------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-
K
-
N
-
K
D
T
S
-
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
S
KEK
D
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
------
Q
Q
-
N
T
-
K
---
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
-
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
F
--
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-----
I
T
A
T
Q
C
L
E
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
60.54
40%
-95
- C1 -
3UPZ
1
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
60.45
37%
-94
- C1 -
2HOG
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
60.41
37%
-88
- C1 -
3NLB
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
60.41
40%
-97
- C1 -
3SX9
1
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
60.30
37%
-92
- C1 -
2HY0
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
60.25
37%
-89
- C1 -
2CGW
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-------
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
60.13
37%
-99
- C1 -
2XF0
5
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.92
40%
-95
- C1 -
3UPX
1
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
59.83
37%
-90
- C1 -
2C3J
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
59.82
38%
-87
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[10-273]
------------------------------------------------------
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
-
S
-
A
-
R
D
H
Q
-
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
A
S
KLK
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
------
E
G
-
E
Q
Q
A
---
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
-----
I
T
A
A
E
A
L
K
H
P
W
I
S
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
59.80
37%
-93
- C1 -
2R0U
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
59.80
40%
-93
- C1 -
3V5T
1
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
59.79
37%
-92
- C1 -
4FTI
3
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
59.71
37%
-91
- C1 -
1NVQ
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
59.55
37%
-89
- C1 -
2CGV
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
59.54
37%
-94
- C1 -
2QHN
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
59.47
38%
-102
- C1 -
4GV1
5
AKT1_HUMAN
A:
[6-269]
------------------------------------------------
T
-----
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
-
D
E
V
A
-
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
---
D
G
H
---
I
K
I
T
D
F
G
L
C
K
E
G
------
I
K
D
G
A
-
T
---
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
--
R
F
--
P
R
----
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
LGGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
59.46
40%
-93
- C1 -
3V51
1
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
59.33
40%
-95
- C1 -
3T3V
2
?
A:
[28-285]
---------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-
K
-
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
------
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
59.18
37%
-93
- C1 -
2BRH
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
59.08
37%
-87
- C1 -
1ZLT
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
59.08
37%
-92
- C1 -
2XEY
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
------------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
58.93
37%
-92
- C1 -
3TKI
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
58.83
37%
-96
- C1 -
4FTJ
3
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
58.79
37%
-89
- C1 -
2BRM
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
58.68
37%
-89
- C1 -
2YDI
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
-
D
-
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
58.47
37%
-93
- C1 -
4FT9
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
58.41
37%
-94
- C1 -
4FTT
4
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
58.41
37%
-93
- C1 -
2YM4
4
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
58.36
37%
-86
- C1 -
2X8I
2
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
58.31
37%
-89
- C1 -
4HYI
4
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
58.13
37%
-89
- C1 -
2QHM
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
57.99
37%
-87
- C1 -
2BR1
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.97
37%
-86
- C1 -
2HXL
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
57.87
37%
-94
- C1 -
4FTR
3
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-------------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
57.80
37%
-96
- C1 -
3TKH
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
57.78
37%
-95
- C1 -
2YM8
10
CHK1_HUMAN
A:
[8-266]
--------------------------------------------------------
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.64
37%
-85
- C1 -
2CGU
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
57.55
37%
-86
- C1 -
2C3K
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
57.48
37%
-88
- C1 -
2X8D
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
-
V
-
D
-
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
57.43
37%
-94
- C1 -
2YM3
6
CHK1_HUMAN
A:
[8-266]
--------------------------------------------------------
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
57.40
37%
-91
- C1 -
1NVS
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
57.39
37%
-89
- C1 -
2BRO
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.37
37%
-88
- C1 -
2HXQ
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
57.36
37%
-95
- C1 -
2YM6
6
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
57.34
37%
-91
- C1 -
4FT0
2
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
------------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
57.31
37%
-86
- C1 -
2BRG
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
57.15
37%
-89
- C1 -
2C3L
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------------
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
57.13
37%
-96
- C1 -
4FTO
4
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-------------
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
57.06
37%
-87
- C1 -
2CGX
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
56.98
37%
-90
- C1 -
2BRN
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
56.67
37%
-84
- C1 -
2GDO
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
56.66
37%
-85
- C1 -
2BRB
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
------
C
P
-
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
56.53
37%
-96
- C1 -
2WMU
1
CHK1_HUMAN
A:
[9-266]
---------------------------------------------------------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
56.17
37%
-95
- C1 -
2WMS
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
----------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
55.53
37%
-95
- C1 -
2YM7
5
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
55.50
37%
-85
- C1 -
2WMQ
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
--------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
------
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-----
I
T
I
P
D
I
K
K
D
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------