@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : MARK3_HUMAN: (2013-07-23 )
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL

Atome Classification :

(68 SA) .........10........20........30........40........50.-----.......60........70........80........90--..-.-....---.-.100--.......-..110.......120.......130.......140.......150--........160.......170........180...---..---.---.---190--........200...-....210--........220.......230---.........240.......250.......260.......270.--.--..----.--....280.......290...-----....300..----...----.-----.310.......320.------......330.......340.......350.......360.......370.......380.......390.......400-.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT---QL-N-PTSL---Q-KL----FREVRIM-KILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMK---EKEARSKFRQIVSAVQYCH-QKRIVHRDLKAENLL---LD---A---D---MN---IKIADFGFSNEFTV-GGKLDT---FCGSPPYAAPELFQGKKYD-----GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY--R--I--PF----Y--MSTDCENLLKRFLVLNPIKR-----GTLEQIMKD----RWI----N-----AGHEEDELKPFVEPE------LDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
15 PsiBlast_PDB 69.3538% -84 - C2 -2Y94 AAPK1_RAT A:[9-385] ---------------------------------------------------HDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQ---KI-R-SLDV---VGKI----RREIQNL-KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLD---EKESRRLFQQILSGVDYCH-RHMVVHRDLKPENVL---LD---A---H---MN---AKIADFGLSNMMSD-GEFLRT---SCGSPNYAAPEVISGRLYA-----GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIF--Y--T--PQ----Y--LNPSVISLLKHMLQVDPMKR-----ATIKDIREH----EWF--------------KQDLPKYLFPEDPSYSSTMIDDEALKEVCEK-----------------------------RRIMNEAKD------FYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62 PsiBlast_CBE 67.6538%-106 - C2 -3BHH KCC2B_HUMAN B:[6-264] ------------------------------------------------------------YQLYEDIGK---SVVRRCVKLCTGHEYAAKIINTK---KL-S-ARDH---Q-KL----EREARIC-RLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYS---EADASHCIQQILEAVLHCH-QMGVVHRDLKPENLL---LA---S---K---CKGAAVKLADFGLAIE--V-QGDQQAWFGFAGTPGYLSPEVLRKEAYG-----KP-VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY--D--F--PSPEWDT--VTPEAKNLINQMLTINPAKR-----ITAHEALKH----PWV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63 PsiBlast_CBE 67.5038%-107 - C2 -3BHH KCC2B_HUMAN A:[6-264] ------------------------------------------------------------YQLYEDIG----SVVRRCVKLCTGHEYAAKIINTK---KL-S-ARDH---Q-KL----EREARIC-RLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYS---EADASHCIQQILEAVLHCH-QMGVVHRDLKPENLL---LA---S---K---CKGAAVKLADFGLAIE--V-QGDQQAWFGFAGTPGYLSPEVLRKEAYG-----KP-VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY--D--F--PSPEWDT--VTPEAKNLINQMLTINPAKR-----ITAHEALKH----PWV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82 PsiBlast_CBE 65.9738% -99 - C2 -2VN9 KCC2D_HUMAN A:[6-264] ------------------------------------------------------------YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KL-S-ARDH---Q-KL----EREARIC-RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYS---EADASHCIQQILESVNHCH-LNGIVHRDLKPENLL---LA---S---KSKGAA---VKLADFGLAIE--V-QGDQQAWFGFAGTPGYLSPEVLRKDPYG-----KP-VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAY--D--F--PSPEWDT--VTPEAKDLINKMLTINPAKR-----ITASEALKH----PWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81 PsiBlast_CBE 65.5638% -98 - C2 -2VN9 KCC2D_HUMAN B:[6-264] ------------------------------------------------------------YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KL-S-ARDH---Q-KL----EREARIC-RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYS---EADASHCIQQILESVNHCH-LNGIVHRDLKPENLL---LA---S---KSKGAA---VKLADFGLAIE--V-QGDQQAWFGFAGTPGYLSPEVLRKDPYG-----KP-VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAY--D--F--PSPEWDT--VTPEAKDLINKMLTINPAKR-----ITASEALKH----PWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74 PsiBlast_CBE 65.3334%-102 - C2 -2WTW AURKA_HUMAN A:[10-267] --------------------------------------------------WA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPRGEVYKELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-S---------CGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17 PsiBlast_PDB 65.3046% -95 - C2 -3AQV AAPK2_HUMAN A:[5-276] -----------------------------------------------DGRVK-----IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ---KI-R-SLDV---VGKI----KREIQNL-KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE---EMEARRLFQQILSAVDYCH-RHMVVHRDLKPENVL---LD---A---H---MN---AKIADFGLSNMMSD-GEFL---------PNYAAPEVISGRLYA-----GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF--Y--I--PE----Y--LNRSVATLLMHMLQVDPLKR-----ATIKDIREH----EWF--------------KQDLPSYLFPE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47 PsiBlast_CBE 65.1038%-100 - C2 -3IGO ? A:[24-280] ------------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKA---SA-K-NK-T---S-TI----LREVELL-KKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFS---EHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---LE---SKEKD---CD---IKIIDFGLSTCFQQ-NT----------TAYYIAPEVLRG-TYD------EKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKY--AFDL--PQ----WRTISDDAKDLIRKMLTFHPSLR-----ITATQCLEH----PWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 64.8638%-103 - C2 -2WEL KCC2D_HUMAN A:[6-264] ------------------------------------------------------------YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KL-S-ARDH---Q-KL----EREARIC-RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYS---EADASHCIQQILESVNHCH-LNGIVHRDLKPENLL---LA---S---KSKGAA---VKLADFGLAIE--V-QGDQQAWFGFAGTPGYLSPEVLRKDPYG-----KP-VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAY--D--F--PSPEWDT--VTPEAKDLINKMLTINPAKR-----ITASEALKH----PWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110 PsiBlast_CBE 64.5438% -98 - C2 -1PHK PHKG1_RABIT A:[18-282] -----------------------------------------------------------NYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSF-S-AEEV---Q-ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLS---EKETRKIMRALLEVICALH-KLNIVHRDLKPENIL---LD---D---D---MN---IKLTDFGFSCQLDP-GEKLRE---VCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNY--Q--FGSPE----WDDYSDTVKDLVSRFLVVQPQKR-----YTAEEAL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38 PsiBlast_CBE 64.4742%-106 - C2 -3HZT ? A:[6-263] ------------------------------------------------------------YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKS---SV-T-TTSN---SGAL----LDEVAVL-KQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFS---EVDAAVIMKQVLSGTTYLH-KHNIVHRDLKPENLL---LE---SKSRD---AL---IKIVDFGLSAHFEV-G-----------TAYYIAPEVLR-KKYD------EKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKF--S--FDPPD----WTQVSDEAKQLVKLMLTYEPSKR-----ISAEEALNH----PWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134 HHSearch 64.3540%-106 * C2 *4FG7 KCC1A_HUMAN A:[19-277] -----------------------------------------------------------IYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIA-------------------SM----ENEIAVL-HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYT---ERDASRLIFQVLDAVKYLH-DLGIVHRDLKPENLLYYSLD---E---D---SK---IMISDFGLSKMEDP------------GTPGYVAPEVLAQK--S------KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEY--E--F--DSPYWDD--ISDSAKDFIRHLMEKDPEKR-----FTCEQALQH----PWI----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69 PsiBlast_CBE 64.1136% -88 - C2 -2UZT KAPCA_BOVIN A:[20-276] ----------------------------------------------AQNTAH-----LDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQ---KVVK-LKQI---E-HT----LNEKRIL-QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS---EPHARFYAAQIVLTFEYLH-SLDLIYRDLKPENLL---ID---Q---Q---GY---IQVTDFGFAKR--V-KGRTWT---LCGTPEYLAPEIILSKGYN-----KA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV--R--F--PS----H--FSSDLKDLLRNLLQVDLTKRF----GNLKDGVND-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24 PsiBlast_CBE 63.7139%-110 - C2 -3HX4 ? A:[52-310] ------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISK-----------DK---E-SL----LREVQLL-KQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFS---EVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LE---SKSKD---AN---IRIIDFGLSTHFEA-SKKMKD---KIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFE--L--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDH----EWI----Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130 HHSearch 63.4938%-104 - C2 -4GV1 AKT1_HUMAN A:[7-269] ---------------------------------------------------------MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE---VI-VAKDEV---A-HT----LTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS---EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLM---LD---K---D---GH---IKITDFGLCKEGIKDGATMKT---FCGTPEYLAPEVLEDNDY------GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI--R--F--PR----T--LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH----RFF----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70 PsiBlast_CBE 63.4538% -92 - C2 -3SOA KCC2A_HUMAN A:[13-272] ------------------------------------------------------------YQLFEELGKG--SVVRRCVKVLAGQEYAAMIINTK---KL-S-ARDH---Q-KL----EREARIC-RLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYS---EADASHCIQQILEAVLHCH-QMGVVHRNLKPENLL---LA---S---K---LKGAAVKLADFGLAIE--V-EGEQQAWFGFAGTPGYLSPEVLRKDPYG-----KP-VDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAY--D--F--PSPEWDT--VTPEAKDLINKMLTINPSKR-----ITAAEALKH----PWI----S-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18 PsiBlast_PDB 63.3241% -92 - C2 -4BL1 MELK_HUMAN A:[12-313] ------------------------------------------------------------YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKN---TL------L---P-RI----KTEIEAL-KNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLS---EEETRVVFRQIVSAVAYVH-SQGYAHRDLKPENLL---FD---E---Y---HK---LKLIDFGLCAK----------------SLAYAAPELIQGK--------GSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY--D--V--PK----W--LSPSSILLLQQMLQVDPKKR-----ISMKNLLNH----PWIMQDYN-----YPVEWQSKNPFIH----------LDDDCVTELSVHHRNNRQTMEDLISLWQYDH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73 PsiBlast_CBE 62.9536%-108 - C2 -3Q5I ? A:[38-305] ------------------------------------------------------------YFKVRKLGS--YGEVLLCKEKNGHSEKAIKVIKK-------------KFHE-EI----YNEISLL-KSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFD---ECDAANIMKQILSGICYLH-KHNIVHRDIKPENIL---LENKNS---L---LN---IKIVDFGLSSFFSK-DYKLRD---RLGTAYYIAPEVLK-KKYN------EKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKY--Y--F--DFNDWKN--ISDEAKELIKLMLTYDYNKR-----CTAEEALNS----RWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52 PsiBlast_CBE 62.4540%-115 - C2 -3LIJ ? A:[39-295] ------------------------------------------------------------YQRVKKLGS---GEVLLCRDKVTHVERAIKIIRK----------SSN---S-KL----LEEVAVL-KLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFN---EVDAAVIIKQVLSGVTYLH-KHNIVHRDLKPENLL---LE---SKEKD---AL---IKIVDFGLSAVFEN-QKKMKE---RLGTAYYIAPEVLR-KKYD------EKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKY--T--FDSPE----WKNVSEGAKDLIKQMLQFDSQRR-----ISAQQALEH----PWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66 PsiBlast_CBE 62.1336% -85 - C2 -2UZW KAPCA_BOVIN E:[20-276] ----------------------------------------------AQNTAH-----LDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQ---KVVK-LKQI---E-HT----LNEKRIL-QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS---EPHARFYAAQIVLTFEYLH-SLDLIYRDLKPENLL---ID---Q---Q---GY---IQVTDFGFAKR--V-KGRTWT---LCGTPEYLAPEIILSKGYN-----KA-VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKV--R--F--PS----H--FSSDLKDLLRNLLQVDLTKRF----GNLKDGVND-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46 PsiBlast_CBE 61.8938% -94 - C2 -3MWU ? A:[24-280] ------------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKA---SA-K-NKDT---S-TI----LREVELL-KKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFS---EHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---LE---SKEKD---CD---IKIIDFGLSTCFQQ-N----D---RIGTAYYIAPEVLRG-TYD------EKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKY--AFDL--PQ----WRTISDDAKDLIRKMLTFHPSLR-----ITATQCLEH----PWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101 PsiBlast_CBE 61.8034% -86 - C2 -3UO6 AURKA_HUMAN A:[5-263] -------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-SSRRDT---LCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45 PsiBlast_CBE 61.6038% -97 - C2 -3NCG ? A:[24-280] ------------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKA---SA-K-NKDT---S-TI----LREVELL-KKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFS---EHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---LE---SKEKD---CD---IKIIDFGLSTCFQQ-NT--------IGTAYYIAPEVLRG-TYD------EKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKY--AFDL--PQ----WRTISDDAKDLIRKMLTFHPSLR-----ITATQCLEH----PWI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40 PsiBlast_CBE 61.5039% -96 - C2 -3MA6 ? B:[34-295] ------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQ--TDK---E-SL----LREVQLL-KQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFS---EVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LE---SKSKD---AN---IRIIDFGLSTHFEA-SKKMKD---KIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFE--L--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDH----EWI----Q-----TYT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104 PsiBlast_CBE 61.2034% -89 - C2 -3UNZ AURKA_HUMAN B:[5-263] -------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-SSRRDT---LCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32 PsiBlast_CBE 61.1739% -99 - C2 -3T3U ? A:[28-286] ------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQ-KTDK---E-SL----LREVQLL-KQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFS---EVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LE---SKSKD---AN---IRIIDFGLSTHFEA-SKKMKD---KIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFE--L--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDH----EWI----Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64 PsiBlast_CBE 61.1231%-109 - C2 -3EFW AURKA_HUMAN B:[126-385] ---------------------------------------R---------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADF----------------------LDYLPPEMIE----------E-KVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41 PsiBlast_CBE 61.1039% -93 - C2 -3MA6 ? A:[34-296] ------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQ-KTDK---E-SL----LREVQLL-KQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFS---EVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LE---SKSKD---AN---IRIIDFGLSTHFE--SKKMKD---KIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFE--L--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDH----EWI----Q-----TYTK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90 PsiBlast_CBE 61.0334% -92 - C2 -3UP2 AURKA_HUMAN A:[5-263] -------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-SSRRDT---LCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88 PsiBlast_CBE 61.0334% -92 - C2 -4DEA AURKA_HUMAN A:[5-263] -------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-SSRRDT---LCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65 PsiBlast_CBE 60.7231%-112 - C2 -3EFW AURKA_HUMAN A:[126-385] ---------------------------------------R---------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADF----------------------LDYLPPEMIE------------KVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96 PsiBlast_CBE 60.7034% -88 - C2 -3UOJ AURKA_HUMAN A:[5-263] -------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-SSRRDT---LCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99 PsiBlast_CBE 60.6634% -91 - C2 -3UOD AURKA_HUMAN A:[5-263] -------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-SSRRDT---LCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33 PsiBlast_CBE 60.5539% -96 - C2 -3SXF ? A:[28-286] ------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQ-KTDK---E-SL----LREVQLL-KQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFS---EVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LE---SKSKD---AN---IRIIDFGLSTHFEA-SKKMKD---KIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFE--L--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDH----EWI----Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95 PsiBlast_CBE 60.4934% -87 - C2 -3UOJ AURKA_HUMAN B:[5-263] -------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-SSRRDT---LCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 60.4839% -98 - C2 -3V5P ? A:[28-286] ------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQ-KTDK---E-SL----LREVQLL-KQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFS---EVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LE---SKSKD---AN---IRIIDFGLSTHFEA-SKKMKD---KIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFE--L--PQ----WKKVSESAKDLIRKMLTYVPSMR-----ISARDALDH----EWI----Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87 PsiBlast_CBE 60.4634% -93 - C2 -4DEB AURKA_HUMAN A:[5-263] -------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-E-KAGV---EHQL----RREVEIQ-SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD---EQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LG---S---A---GE---LKIADFGWSVH-AP-SSRRDT---LCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF--T--F--PD----F--VTEGARDLISRLLKHNPSQR-----PMLREVLEH----PWI----T-----A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100 PsiBlast_CBE 60.4434% -87 - C2 -3UO6