@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK3_HUMAN: (2013-07-23 )
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Atome Classification :
(68 SA)
.........10........20........30........40........50.-----.......60........70........80........90--..-.-....---.-.100--.......-..110.......120.......130.......140.......150--........160.......170........180...---..---.---.---190--........200...-....210--........220.......230---.........240.......250.......260.......270.--.--..----.--....280.......290...-----....300..----...----.-----.310.......320.------......330.......340.......350.......360.......370.......380.......390.......400-.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKT---QL-N-PTSL---Q-KL----FREVRIM-KILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMK---EKEARSKFRQIVSAVQYCH-QKRIVHRDLKAENLL---LD---A---D---MN---IKIADFGFSNEFTV-GGKLDT---FCGSPPYAAPELFQGKKYD-----GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY--R--I--PF----Y--MSTDCENLLKRFLVLNPIKR-----GTLEQIMKD----RWI----N-----AGHEEDELKPFVEPE------LDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
15
PsiBlast_PDB
69.35
38%
-84
- C2 -
2Y94
2
AAPK1_RAT
A:
[9-385]
---------------------------------------------------
H
D
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
I
-
R
-
S
L
D
V
---
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
D
---
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
F
L
R
T
---
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
--
Y
--
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-----
A
T
I
K
D
I
R
E
H
----
E
W
F
--------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYS
S
T
M
I
D
D
E
A
L
K
E
V
C
E
K
-----------------------------
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
R
H
T
L
D
E
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
67.65
38%
-106
- C2 -
3BHH
1
KCC2B_HUMAN
B:
[6-264]
------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
---
K
L
-
S
-
A
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
A
---
S
---
K
---
C
K
GAA
V
K
L
A
D
F
G
L
A
I
E
--
V
-
Q
G
D
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
--
D
--
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
-----
I
T
A
H
E
A
L
K
H
----
P
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.50
38%
-107
- C2 -
3BHH
1
KCC2B_HUMAN
A:
[6-264]
------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
---
K
L
-
S
-
A
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
A
---
S
---
K
---
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
-
Q
G
D
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
--
D
--
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
-----
I
T
A
H
E
A
L
K
H
----
P
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
65.97
38%
-99
- C2 -
2VN9
2
KCC2D_HUMAN
A:
[6-264]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
L
-
S
-
A
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
---
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
--
V
-
Q
G
D
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
--
D
--
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
T
A
S
E
A
L
K
H
----
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
65.56
38%
-98
- C2 -
2VN9
1
KCC2D_HUMAN
B:
[6-264]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
L
-
S
-
A
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
---
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
--
V
-
Q
G
D
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
--
D
--
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
T
A
S
E
A
L
K
H
----
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
65.33
34%
-102
- C2 -
2WTW
1
AURKA_HUMAN
A:
[10-267]
--------------------------------------------------
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
---------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.30
46%
-95
- C2 -
3AQV
1
AAPK2_HUMAN
A:
[5-276]
-----------------------------------------------
D
G
R
V
K
-----
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
I
-
R
-
S
L
D
V
---
V
G
K
I
----
K
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
---
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
D
---
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
F
L
---------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
--
Y
--
I
--
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
-----
A
T
I
K
D
I
R
E
H
----
E
W
F
--------------
K
Q
D
L
P
S
Y
L
F
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
65.10
38%
-100
- C2 -
3IGO
8
?
A:
[24-280]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
-
N
K
-
T
---
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
---
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
T
----------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
FD
L
--
P
Q
----
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-----
I
T
A
T
Q
C
L
E
H
----
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
64.86
38%
-103
- C2 -
2WEL
7
KCC2D_HUMAN
A:
[6-264]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
L
-
S
-
A
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
---
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
--
V
-
Q
G
D
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
--
D
--
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
T
A
S
E
A
L
K
H
----
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
64.54
38%
-98
- C2 -
1PHK
1
PHKG1_RABIT
A:
[18-282]
-----------------------------------------------------------
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
GGG
S
F
-
S
-
A
E
E
V
---
Q
-
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
T
L
S
---
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
---
D
---
D
---
M
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
-
G
E
K
L
R
E
---
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPGY
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
--
Q
--
F
GS
P
E
----
W
DD
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
-----
Y
T
A
E
E
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.47
42%
-106
- C2 -
3HZT
9
?
A:
[6-263]
------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
---
S
V
-
T
-
T
T
S
N
---
S
G
A
L
----
L
D
E
V
A
V
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
---
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSR
D
---
A
L
---
I
K
I
V
D
F
G
L
S
A
H
F
E
V
-
G
-----------
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
------
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
K
R
V
E
K
G
K
F
--
S
--
F
DP
P
D
----
W
TQ
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
-----
I
S
A
E
E
A
L
N
H
----
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
64.35
40%
-106
* C2 *
4FG7
1
KCC1A_HUMAN
A:
[19-277]
-----------------------------------------------------------
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-------------------
S
M
----
E
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
---
E
---
D
---
S
K
---
I
M
I
S
D
F
G
L
S
K
M
E
D
P
------------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
------
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
--
E
--
F
--
D
S
PYWD
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
-----
F
T
C
E
Q
A
L
Q
H
----
P
W
I
----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.11
36%
-88
- C2 -
2UZT
1
KAPCA_BOVIN
A:
[20-276]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
D
G
V
N
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
63.71
39%
-110
- C2 -
3HX4
3
?
A:
[52-310]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----------
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
63.49
38%
-104
- C2 -
4GV1
5
AKT1_HUMAN
A:
[7-269]
---------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
---
V
I
-
V
A
K
D
E
V
---
A
-
H
T
----
L
T
E
N
R
V
L
-
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
---
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
---
K
---
D
---
G
H
---
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
------
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
--
R
--
F
--
P
R
----
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
LGGGS
E
D
A
K
E
I
M
Q
H
----
R
F
F
----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
63.45
38%
-92
- C2 -
3SOA
1
KCC2A_HUMAN
A:
[13-272]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
---
K
L
-
S
-
A
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
A
---
S
---
K
---
L
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
--
V
-
E
G
E
Q
Q
A
W
FG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
--
D
--
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
-----
I
T
A
A
E
A
L
K
H
----
P
W
I
----
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.32
41%
-92
- C2 -
4BL1
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
L
------
L
---
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
-
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
D
---
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
A
K
----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
--
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
62.95
36%
-108
- C2 -
3Q5I
1
?
A:
[38-305]
------------------------------------------------------------
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
-------------KF
H
E
-
E
I
----
Y
N
E
I
S
L
L
-
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
K
F
D
---
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
---
L
E
NKN
S
---
L
---
L
N
---
I
K
I
V
D
F
G
L
S
S
F
F
S
K
-
D
Y
K
L
R
D
---
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
-
K
K
Y
N
------
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
--
Y
--
F
--
D
F
NDWK
N
--
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
-----
C
T
A
E
E
A
L
N
S
----
R
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
62.45
40%
-115
- C2 -
3LIJ
1
?
A:
[39-295]
------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
----------
S
S
N
---
S
-
K
L
----
L
E
E
V
A
V
L
-
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
---
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KEK
D
---
A
L
---
I
K
I
V
D
F
G
L
S
A
V
F
E
N
-
Q
K
K
M
K
E
---
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
------
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
--
T
--
F
DS
P
E
----
W
KN
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
-----
I
S
A
Q
Q
A
L
E
H
----
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
62.13
36%
-85
- C2 -
2UZW
1
KAPCA_BOVIN
E:
[20-276]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
D
G
V
N
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
61.89
38%
-94
- C2 -
3MWU
1
?
A:
[24-280]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
-
N
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
---
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
----
D
---
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
FD
L
--
P
Q
----
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-----
I
T
A
T
Q
C
L
E
H
----
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
61.80
34%
-86
- C2 -
3UO6
3
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
61.60
38%
-97
- C2 -
3NCG
1
?
A:
[24-280]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
-
N
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
---
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
T
--------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
FD
L
--
P
Q
----
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-----
I
T
A
T
Q
C
L
E
H
----
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
61.50
39%
-96
- C2 -
3MA6
1
?
B:
[34-295]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
--
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-----
T
Y
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
61.20
34%
-89
- C2 -
3UNZ
3
AURKA_HUMAN
B:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
61.17
39%
-99
- C2 -
3T3U
5
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
61.12
31%
-109
- C2 -
3EFW
1
AURKA_HUMAN
B:
[126-385]
---------------------------------------
R
---------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
----------------------
L
D
Y
L
P
P
E
M
I
E
----------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
61.10
39%
-93
- C2 -
3MA6
1
?
A:
[34-296]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
--
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-----
T
Y
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
61.03
34%
-92
- C2 -
3UP2
3
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.03
34%
-92
- C2 -
4DEA
4
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
60.72
31%
-112
- C2 -
3EFW
1
AURKA_HUMAN
A:
[126-385]
---------------------------------------
R
---------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
----------------------
L
D
Y
L
P
P
E
M
I
E
------------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
60.70
34%
-88
- C2 -
3UOJ
1
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
60.66
34%
-91
- C2 -
3UOD
3
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
60.55
39%
-96
- C2 -
3SXF
3
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
60.49
34%
-87
- C2 -
3UOJ
1
AURKA_HUMAN
B:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
60.48
39%
-98
- C2 -
3V5P
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
60.46
34%
-93
- C2 -
4DEB
3
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
60.44
34%
-87
- C2 -
3UO6
3
AURKA_HUMAN
B:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
60.43
39%
-100
- C2 -
3KU2
1
?
A:
[51-309]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
60.41
36%
-84
- C2 -
2UZV
1
KAPCA_BOVIN
A:
[20-276]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
D
G
V
N
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
60.40
32%
-89
- C2 -
2J4Z
4
AURKA_HUMAN
A:
[29-288]
---------------------------------------
R
---------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
60.40
34%
-93
- C2 -
3UO4
4
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
60.36
32%
-90
- C2 -
2J4Z
2
AURKA_HUMAN
B:
[29-288]
---------------------------------------
R
---------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
60.35
34%
-90
- C2 -
3UO5
1
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
60.33
34%
-89
- C2 -
3UNZ
3
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
60.20
34%
-89
- C2 -
3UOK
1
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
60.12
39%
-99
- C2 -
3I7B
4
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
59.96
34%
-88
- C2 -
3UOK
1
AURKA_HUMAN
B:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
59.82
34%
-90
- C2 -
3UOH
4
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
59.68
38%
-91
- C2 -
2WEI
1
?
A:
[24-286]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
-
N
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
---
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
T
K
M
K
D
---
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
FD
L
--
P
Q
----
W
RT
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-----
I
T
A
T
Q
C
L
E
H
----
P
W
I
----
Q
-----
K
Y
S
S
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
59.56
39%
-98
- C2 -
3SX9
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
59.25
34%
-90
- C2 -
4DEE
1
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
59.22
34%
-90
- C2 -
3UOH
3
AURKA_HUMAN
B:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.21
39%
-95
- C2 -
3UPX
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
59.20
36%
-83
- C2 -
2UZU
1
KAPCA_BOVIN
E:
[20-276]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
D
G
V
N
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
59.16
39%
-97
- C2 -
3N51
3
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
59.11
39%
-94
- C2 -
3UPZ
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
58.97
39%
-94
- C2 -
3V51
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
58.87
39%
-95
- C2 -
3T3V
2
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
58.71
34%
-91
- C2 -
4DED
4
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
58.63
34%
-89
- C2 -
3UP7
1
AURKA_HUMAN
A:
[5-263]
-------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
-
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
---
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
R
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
58.44
39%
-93
- C2 -
3V5T
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
---
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.19
33%
-73
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
57.11
33%
-67
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
56.95
33%
-64
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
56.67
33%
-66
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
56.65
38%
-102
- C2 -
3COK
1
PLK4_HUMAN
A:
[1-261]
-----------------------------------------
S
L
A
T
C
I
G
E
K
-------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
M
-
Y
-
K
A
G
M
V
--
Q
-
R
V
----
Q
N
E
V
K
I
H
-
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
R
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
-
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
---
R
---
N
---
M
N
---
I
K
I
A
D
F
G
L
A
T
Q
L
K
-------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----
V
V
L
A
D
Y
--
E
--
M
--
P
S
----
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-----
L
S
L
S
S
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
55.98
33%
-64
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
-
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
---
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F----
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------