@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : MARK4_HUMAN: (2013-07-23 )
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL

Atome Classification :

(75 SA) .........10........20........30........40........50....-----....60........70........80........90..---..-....100-.-..----......110..-.....120.......130.......140.......150-.......160.......170.-......180......---.190--.---.......200......-.210---........220.......230.-----......240.......250.....--..260.......270.--..--..----.--.280.......290.......-----300.....----------..310..----.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKT---QL-NPSSL---Q-KL----FREVRIMKGLN-HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR-MKEKEARAKFRQIVSAVHYCH-QKNIVHRDLKAENLL---LDA---E---ANIKIADFGFSNEFTL-GS-K---LDTFCGSPPYAAPELFQGKKYD-----GPEVDIWSLGVILYTLVSGSLPFD--GHNLKELRERVLRGKY--RV--PF----Y--MSTDCESILRRFLVLNPAKRC-----TLEQIMKD----------KWINIGY----EGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
17 PsiBlast_PDB 66.4544%-106 - C3 -2Y94 AAPK1_RAT A:[9-282] ------------------------------------------------------HDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQ---KIRSLDVV---G-KI----RREIQNLKLFR-HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR-LDEKESRRLFQQILSGVDYCH-RHMVVHRDLKPENVL---LDA---H---MNAKIADFGLSNMMSD-GE-F---LRTSCGSPNYAAPEVISGRLYA-----GPEVDIWSSGVILYALLCGTLPFD--DDHVPTLFKKICDGIF--YT--PQ----Y--LNPSVISLLKHMLQVDPMKRA-----TIKDIREH----------EWFK---------QDLPKYLFPED-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49 PsiBlast_CBE 65.6640%-115 - C3 -3HZT ? A:[6-263] ---------------------------------------------------------------YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKS---SV-TTTSN---SGAL----LDEVAVLKQLD-HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQK-FSEVDAAVIMKQVLSGTTYLH-KHNIVHRDLKPENLL---LESKSRD---ALIKIVDFGLSAHFEV-G------------TAYYIAPEVLR-KKYD------EKCDVWSCGVILYILLCGYPPFG--GQTDQEILKRVEKGKF--SFDPPD----WTQVSDEAKQLVKLMLTYEPSKRI-----SAEEALNH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53 PsiBlast_CBE 65.1135%-118 - C3 -3Q5I ? A:[38-305] ---------------------------------------------------------------YFKVRKLGS--YGEVLLCKEKNGHSEKAIKVIKK------------KFHE-EI----YNEISLLKSLD-HPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHK-FDECDAANIMKQILSGICYLH-KHNIVHRDIKPENIL---LEN---KNSLLNIKIVDFGLSSFFSK-DY-K---LRDRLGTAYYIAPEVLK-KKYN------EKCDVWSCGVIMYILLCGYPPFG--GQNDQDIIKKVEKGKY--YF--DFNDWKN--ISDEAKELIKLMLTYDYNKRC-----TAEEALNS----------RWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18 PsiBlast_PDB 65.0045%-105 - C3 -4BL1 MELK_HUMAN A:[12-286] ---------------------------------------------------------------YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKN---TL-----L---P-RI----KTEIEALKNLR-HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR-LSEEETRVVFRQIVSAVAYVH-SQGYAHRDLKPENLL---FDE---Y---HKLKLIDFGLCAK-----------------SLAYAAPELIQGK--------GSEADVWSMGILLYVLMCGFLPFD--DDNVMALYKKIMRGKY--DV--PK----W--LSPSSILLLQQMLQVDPKKRI-----SMKNLLNH----------PWIMQDYNYPVEWQSKNPFIHLDDD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106 PsiBlast_CBE 64.8738%-108 - C3 -2WEL KCC2D_HUMAN A:[6-264] ---------------------------------------------------------------YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KL-SARDH---Q-KL----EREARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY-YSEADASHCIQQILESVNHCH-LNGIVHRDLKPENLL---LAS---KSKGAAVKLADFGLAIEVQG-DQ-QA--WFGFAGTPGYLSPEVLRKDPYG-----KP-VDMWACGVILYILLVGYPPFW--DEDQHRLYQQIKAGAY--DF--PSPEWDT--VTPEAKDLINKMLTINPAKRI-----TASEALKH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60 PsiBlast_CBE 64.7635%-117 - C3 -3DJ5 AURKA_MOUSE A:[9-265] -----------------------------------------------------WT-----LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKT---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---N---GELKIADFGW---------------TTLCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGMPPFE--AHTYQETYRRISRVEF--TF--PD----F--VTEGARDLISRLLKHNASQRL-----TLAEVLEH----------PWIK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59 PsiBlast_CBE 64.4535%-116 - C3 -3DJ6 AURKA_MOUSE A:[9-265] -----------------------------------------------------WT-----LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKT---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---N---GELKIADFGW---------------TTLCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGMPPFE--AHTYQETYRRISRVEF--TF--PD----F--VTEGARDLISRLLKHNASQRL-----TLAEVLEH----------PWIK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44 PsiBlast_CBE 64.2338%-109 - C3 -3IGO ? A:[24-280] ---------------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKA---SA-KNK-T---S-TI----LREVELLKKLD-HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR-FSEHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---LESKEKD---CDIKIIDFGLSTCFQQ-NT-----------TAYYIAPEVLRG-TYD------EKCDVWSAGVILYILLSGTPPFY--GKNEYDILKRVETGKY--AF--DLPQWRT--ISDDAKDLIRKMLTFHPSLRI-----TATQCLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134 HHSearch 64.1540%-118 * C3 *4FG7 KCC1A_HUMAN A:[19-277] --------------------------------------------------------------IYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIA------------------SM----ENEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGF-YTERDASRLIFQVLDAVKYLH-DLGIVHRDLKPENLLYYSLDE---D---SKIMISDFGLSKMEDP-------------GTPGYVAPEVLAQK--S------KAVDCWSIGVIAYILLCGYPPFY--DENDAKLFEQILKAEY--EF--DSPYWDD--ISDSAKDFIRHLMEKDPEKRF-----TCEQALQH----------PWIA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107 PsiBlast_CBE 64.0936%-105 - C3 -1QL6 PHKG1_RABIT A:[18-291] --------------------------------------------------------------NYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSF-SAEEV---Q-ELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVT-LSEKETRKIMRALLEVICALH-KLNIVHRDLKPENIL---LDD---D---MNIKLTDFGFSCQLDP-GE-K---LRSVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFW--HRKQMLMLRMIMSGNY--QFGSPE----WDDYSDTVKDLVSRFLVVQPQKRY-----TAEEALAH----------PFFQ-QY----V-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129 HHSearch 63.7637%-111 - C3 -4GV1 AKT1_HUMAN A:[7-269] ------------------------------------------------------------MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKE---VIVAKDEV---A-HT----LTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV-FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLM---LDK---D---GHIKITDFGLCKEGIKDGA-T---MKTFCGTPEYLAPEVLEDNDY------GRAVDWWGLGVVMYEMMCGRLPFY--NQDHEKLFELILMEEI--RF--PR----T--LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH----------RFFA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54 PsiBlast_CBE 63.3134%-121 - C3 -3EFW AURKA_HUMAN B:[132-383] --------------------------------------------------------------DFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---A---GELKIADF-----------------------LDYLPPEMIE----------E-KVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEF--TF--PD----F--VTEGARDLISRLLKHNPSQRP-----MLREVLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16 PsiBlast_PDB 63.2345%-104 - C3 -3AQV AAPK2_HUMAN A:[10-276] ------------------------------------------------------------IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ---KIRSLDVV---G-KI----KREIQNLKLFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCH-RHMVVHRDLKPENVL---LDA---H---MNAKIADFGLSNMMSD-GE-F---L------PNYAAPEVISGRLYA-----GPEVDIWSCGVILYALLCGTLPFD--DEHVPTLFKKIRGGVF--YI--PE----Y--LNRSVATLLMHMLQVDPLKRA-----TIKDIREH----------EWFK---------QDLPSYLFPE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61 PsiBlast_CBE 63.1535%-112 - C3 -3D2I AURKA_MOUSE A:[8-265] ----------------------------------------------------QWT-----LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKT---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---N---GELKIADFGWSVH-AP------------CGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGMPPFE--AHTYQETYRRISRVEF--TF--PD----F--VTEGARDLISRLLKHNASQRL-----TLAEVLEH----------PWIK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50 PsiBlast_CBE 62.8939%-122 - C3 -3LIJ ? A:[39-295] ---------------------------------------------------------------YQRVKKLGS---GEVLLCRDKVTHVERAIKIIRK---------SSN---S-KL----LEEVAVLKLLD-HPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMK-FNEVDAAVIIKQVLSGVTYLH-KHNIVHRDLKPENLL---LESKEKD---ALIKIVDFGLSAVFEN-QK-K---MKERLGTAYYIAPEVLR-KKYD------EKCDVWSIGVILFILLAGYPPFG--GQTDQEILRKVEKGKY--TFDSPE----WKNVSEGAKDLIKQMLQFDSQRRI-----SAQQALEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55 PsiBlast_CBE 62.8334%-127 - C3 -3EFW AURKA_HUMAN A:[132-383] --------------------------------------------------------------DFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---A---GELKIADF-----------------------LDYLPPEMIE------------KVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEF--TF--PD----F--VTEGARDLISRLLKHNPSQRP-----MLREVLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38 PsiBlast_CBE 62.7439%-105 - C3 -3MA6 ? A:[34-292] ---------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQKTDK---E-SL----LREVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR-FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LESKSKD---ANIRIIDFGLSTHFE--SK-K---MKDKIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMRI-----SARDALDH----------EWIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19 PsiBlast_PDB 62.6239%-117 - C3 -3HX4 ? A:[52-310] ---------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISK----------DK---E-SL----LREVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR-FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LESKSKD---ANIRIIDFGLSTHFEA-SK-K---MKDKIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMRI-----SARDALDH----------EWIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144 HHSearch 62.6037% -98 - C3 -3SOA KCC2A_HUMAN A:[10-273] ------------------------------------------------------------TEEYQLFEELGKG--SVVRRCVKVLAGQEYAAMIINTK---KL-SARDH---Q-KL----EREARICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY-YSEADASHCIQQILEAVLHCH-QMGVVHRNLKPENLL---LASKLKG---AAVKLADFGLAIEVEG-EQQA---WFGFAGTPGYLSPEVLRKDPY------GKPVDLWACGVILYILLVGYPPFW--DEDQHRLYQQIKAGAY--DF--PSPEWDT--VTPEAKDLINKMLTINPSKRI-----TAAEALKH----------PWISH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58 PsiBlast_CBE 62.5035%-109 - C3 -3DJ7 AURKA_MOUSE A:[8-265] ----------------------------------------------------QWT-----LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKT---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---N---GELKIADFGWSVH-AP-S----------CGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGMPPFE--AHTYQETYRRISRVEF--TF--PD----F--VTEGARDLISRLLKHNASQRL-----TLAEVLEH----------PWIK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43 PsiBlast_CBE 62.2038%-105 - C3 -3MWU ? A:[24-280] ---------------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKA---SA-KNKDT---S-TI----LREVELLKKLD-HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR-FSEHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---LESKEKD---CDIKIIDFGLSTCFQQ-N--------DRIGTAYYIAPEVLRG-TYD------EKCDVWSAGVILYILLSGTPPFY--GKNEYDILKRVETGKY--AF--DLPQWRT--ISDDAKDLIRKMLTFHPSLRI-----TATQCLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78 PsiBlast_CBE 62.1034%-113 - C3 -2WTW AURKA_HUMAN A:[10-265] -----------------------------------------------------WA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPRGEVYKELQKLSK-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---A---GELKIADFGWSVH-AP-S----------CGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEF--TF--PD----F--VTEGARDLISRLLKHNPSQRP-----MLREVLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63 PsiBlast_CBE 62.0435%-107 - C3 -3D14 AURKA_MOUSE A:[8-265] ----------------------------------------------------QWT-----LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKT---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---N---GELKIADFGWSVH-AP-S----------CGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGMPPFE--AHTYQETYRRISRVEF--TF--PD----F--VTEGARDLISRLLKHNASQRL-----TLAEVLEH----------PWIK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42 PsiBlast_CBE 61.9438%-106 - C3 -3NCG ? A:[24-280] ---------------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKA---SA-KNKDT---S-TI----LREVELLKKLD-HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR-FSEHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---LESKEKD---CDIKIIDFGLSTCFQQ-NT---------IGTAYYIAPEVLRG-TYD------EKCDVWSAGVILYILLSGTPPFY--GKNEYDILKRVETGKY--AF--DLPQWRT--ISDDAKDLIRKMLTFHPSLRI-----TATQCLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86 PsiBlast_CBE 61.6734%-106 - C3 -3UOL AURKA_HUMAN A:[5-261] ----------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---A---GELKIADFGWSVH-AP-SS-R---RDTLCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEF--TF--PD----F--VTEGARDLISRLLKHNPSQRP-----MLREVLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 61.3832%-115 - C3 -4B8L ? A:[11-268] ----------------------------------------------------KFT-----IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKS---QL-EKEGV---EHQL----RREIEIQSHLR-HPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGR-FDEQRSATFMEELADALHYCH-ERKVIHRDIKPENLL---MGY---K---GELKIADF----------------------TLDYLPPEMIEGKTHD------EKVDLWCAGVLCYEFLVGMPPFD--SPSHTETHRRIVNVDL--KF--PP----F--LSDGSKDLISKLLRYHPPQRL-----PLKGVMEH----------PWVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62 PsiBlast_CBE 61.3335%-107 - C3 -3D15 AURKA_MOUSE A:[8-265] ----------------------------------------------------QWT-----LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKT---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---N---GELKIADFGWSVH-AP-S-----------GTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGMPPFE--AHTYQETYRRISRVEF--TF--PD----F--VTEGARDLISRLLKHNASQRL-----TLAEVLEH----------PWIK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85 PsiBlast_CBE 61.3034%-107 - C3 -3UOL AURKA_HUMAN B:[5-261] ----------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---A---GELKIADFGWSVH-AP-SS-R---RDTLCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEF--TF--PD----F--VTEGARDLISRLLKHNPSQRP-----MLREVLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45 PsiBlast_CBE 61.2238%-102 - C3 -2WEI ? A:[24-286] ---------------------------------------------------------------YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKA---SA-KNKDT---S-TI----LREVELLKKLD-HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR-FSEHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---LESKEKD---CDIKIIDFGLSTCFQQ-NT-K---MKDRIGTAYYIAPEVLRG-TYD------EKCDVWSAGVILYILLSGTPPFY--GKNEYDILKRVETGKY--AF--DLPQWRT--ISDDAKDLIRKMLTFHPSLRI-----TATQCLEH----------PWIQ-KY----SSE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20 PsiBlast_PDB 61.1239%-110 - C3 -3KU2 ? A:[51-309] ---------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQKTDK---E-SL----LREVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR-FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LESKSKD---ANIRIIDFGLSTHFEA-SK-K---MKDKIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMRI-----SARDALDH----------EWIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32 PsiBlast_CBE 60.8039%-106 - C3 -3SXF ? A:[28-286] ---------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQKTDK---E-SL----LREVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR-FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LESKSKD---ANIRIIDFGLSTHFEA-SK-K---MKDKIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMRI-----SARDALDH----------EWIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31 PsiBlast_CBE 60.7839%-108 - C3 -3T3U ? A:[28-286] ---------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQKTDK---E-SL----LREVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR-FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LESKSKD---ANIRIIDFGLSTHFEA-SK-K---MKDKIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMRI-----SARDALDH----------EWIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 60.7639%-103 - C3 -3UPZ ? A:[28-286] ---------------------------------------------------------------YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR---QVKQKTDK---E-SL----LREVQLLKQLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR-FSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---LESKSKD---ANIRIIDFGLSTHFEA-SK-K---MKDKIGTAYYIAPEVLHG-TYD------EKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFEL--PQ----WKKVSESAKDLIRKMLTYVPSMRI-----SARDALDH----------EWIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82 PsiBlast_CBE 60.7034%-104 - C3 -4DEA AURKA_HUMAN A:[5-261] ----------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---A---GELKIADFGWSVH-AP-SS-R---RDTLCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEF--TF--PD----F--VTEGARDLISRLLKHNPSQRP-----MLREVLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95 PsiBlast_CBE 60.5934% -98 - C3 -3UO6 AURKA_HUMAN A:[5-261] ----------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---A---GELKIADFGWSVH-AP-SS-R---RDTLCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEF--TF--PD----F--VTEGARDLISRLLKHNPSQRP-----MLREVLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93 PsiBlast_CBE 60.4334%-103 - C3 -3UOD AURKA_HUMAN A:[5-261] ----------------------------------------------------QWA-----LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKA---QL-EKAGV---EHQL----RREVEIQSHLR-HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK-FDEQRTATYITELANALSYCH-SKRVIHRDIKPENLL---LGS---A---GELKIADFGWSVH-AP-SS-R---RDTLCGTLDYLPPEMIEGRMHD------EKVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEF--TF--PD----F--VTEGARDLISRLLKHNPSQRP-----MLREVLEH----------PWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------