@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK4_HUMAN: (2013-07-23 )
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
Atome Classification :
(75 SA)
.........10........20........30........40........50....-----....60........70........80........90..---..-....100-.-..----......110..-.....120.......130.......140.......150-.......160.......170.-......180......---.190--.---.......200......-.210---........220.......230.-----......240.......250.....--..260.......270.--..--..----.--.280.......290.......-----300.....----------..310..----.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKT---QL-NPSSL---Q-KL----FREVRIMKGLN-HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR-MKEKEARAKFRQIVSAVHYCH-QKNIVHRDLKAENLL---LDA---E---ANIKIADFGFSNEFTL-GS-K---LDTFCGSPPYAAPELFQGKKYD-----GPEVDIWSLGVILYTLVSGSLPFD--GHNLKELRERVLRGKY--RV--PF----Y--MSTDCESILRRFLVLNPAKRC-----TLEQIMKD----------KWINIGY----EGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
17
PsiBlast_PDB
66.45
44%
-106
- C3 -
2Y94
1
AAPK1_RAT
A:
[9-282]
------------------------------------------------------
H
D
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
I
R
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
D
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
-
F
---
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.66
40%
-115
- C3 -
3HZT
9
?
A:
[6-263]
---------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
---
S
V
-
T
T
T
S
N
---
S
G
A
L
----
L
D
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSR
D
---
A
L
I
K
I
V
D
F
G
L
S
A
H
F
E
V
-
G
------------
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
------
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
--
G
Q
T
D
Q
E
I
L
K
R
V
E
K
G
K
F
--
S
F
DP
P
D
----
W
TQ
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
A
L
N
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
65.11
35%
-118
- C3 -
3Q5I
1
?
A:
[38-305]
---------------------------------------------------------------
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
------------KF
H
E
-
E
I
----
Y
N
E
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
K
-
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
---
L
E
N
---
K
NSL
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
-
D
Y
-
K
---
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
-
K
K
Y
N
------
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
--
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
--
Y
F
--
D
F
NDWK
N
--
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
-----
T
A
E
E
A
L
N
S
----------
R
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.00
45%
-105
- C3 -
4BL1
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
L
-----
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
-
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
D
E
---
Y
---
H
K
L
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
64.87
38%
-108
- C3 -
2WEL
7
KCC2D_HUMAN
A:
[6-264]
---------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
L
-
S
A
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
A
S
---
K
SKG
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
-
D
Q
-
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
64.76
35%
-117
- C3 -
3DJ5
1
AURKA_MOUSE
A:
[9-265]
-----------------------------------------------------
W
T
-----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
L
K
I
A
D
F
G
W
---------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
64.45
35%
-116
- C3 -
3DJ6
1
AURKA_MOUSE
A:
[9-265]
-----------------------------------------------------
W
T
-----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
L
K
I
A
D
F
G
W
---------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
64.23
38%
-109
- C3 -
3IGO
8
?
A:
[24-280]
---------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
N
K
-
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
S
KEK
D
---
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
T
-----------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
F
--
D
L
P
Q
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
64.15
40%
-118
* C3 *
4FG7
1
KCC1A_HUMAN
A:
[19-277]
--------------------------------------------------------------
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
------------------
S
M
----
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
---
D
---
S
K
I
M
I
S
D
F
G
L
S
K
M
E
D
P
-------------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
------
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
--
E
F
--
D
S
PYWD
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
----------
P
W
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
64.09
36%
-105
- C3 -
1QL6
1
PHKG1_RABIT
A:
[18-291]
--------------------------------------------------------------
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
GGG
S
F
-
S
A
E
E
V
---
Q
-
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
D
D
---
D
---
M
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
-
G
E
-
K
---
L
R
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPGY
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
--
Q
F
GS
P
E
----
W
DD
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
----------
P
F
F
Q
-
Q
Y
----
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
63.76
37%
-111
- C3 -
4GV1
5
AKT1_HUMAN
A:
[7-269]
------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
---
V
I
V
A
K
D
E
V
---
A
-
H
T
----
L
T
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
---
D
---
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
-
T
---
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
------
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
--
R
F
--
P
R
----
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
----------
R
F
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
63.31
34%
-121
- C3 -
3EFW
1
AURKA_HUMAN
B:
[132-383]
--------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
-----------------------
L
D
Y
L
P
P
E
M
I
E
----------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.23
45%
-104
- C3 -
3AQV
1
AAPK2_HUMAN
A:
[10-276]
------------------------------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
I
R
S
L
D
V
V
---
G
-
K
I
----
K
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
D
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
-
F
---
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
--
Y
I
--
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
S
Y
L
F
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
63.15
35%
-112
- C3 -
3D2I
1
AURKA_MOUSE
A:
[8-265]
----------------------------------------------------
Q
W
T
-----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
62.89
39%
-122
- C3 -
3LIJ
1
?
A:
[39-295]
---------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
---------
S
S
N
---
S
-
K
L
----
L
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
-
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KEK
D
---
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
-
Q
K
-
K
---
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
------
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
--
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
--
T
F
DS
P
E
----
W
KN
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
A
Q
Q
A
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
62.83
34%
-127
- C3 -
3EFW
1
AURKA_HUMAN
A:
[132-383]
--------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
-----------------------
L
D
Y
L
P
P
E
M
I
E
------------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
62.74
39%
-105
- C3 -
3MA6
1
?
A:
[34-292]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
--
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.62
39%
-117
- C3 -
3HX4
3
?
A:
[52-310]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----------
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
62.60
37%
-98
- C3 -
3SOA
1
KCC2A_HUMAN
A:
[10-273]
------------------------------------------------------------
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
---
K
L
-
S
A
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
A
S
KLK
G
---
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
G
-
E
Q
Q
A
---
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
------
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
-----
T
A
A
E
A
L
K
H
----------
P
W
I
S
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
62.50
35%
-109
- C3 -
3DJ7
1
AURKA_MOUSE
A:
[8-265]
----------------------------------------------------
Q
W
T
-----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
62.20
38%
-105
- C3 -
3MWU
1
?
A:
[24-280]
---------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
N
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
S
KEK
D
---
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
F
--
D
L
P
Q
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
62.10
34%
-113
- C3 -
2WTW
1
AURKA_HUMAN
A:
[10-265]
-----------------------------------------------------
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
62.04
35%
-107
- C3 -
3D14
1
AURKA_MOUSE
A:
[8-265]
----------------------------------------------------
Q
W
T
-----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
61.94
38%
-106
- C3 -
3NCG
1
?
A:
[24-280]
---------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
N
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
S
KEK
D
---
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
T
---------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
F
--
D
L
P
Q
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
61.67
34%
-106
- C3 -
3UOL
6
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
61.38
32%
-115
- C3 -
4B8L
1
?
A:
[11-268]
----------------------------------------------------
K
F
T
-----
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
L
-
E
K
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
-
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
---
K
---
G
E
L
K
I
A
D
F
----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
61.33
35%
-107
- C3 -
3D15
1
AURKA_MOUSE
A:
[8-265]
----------------------------------------------------
Q
W
T
-----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
N
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
-----------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
61.30
34%
-107
- C3 -
3UOL
8
AURKA_HUMAN
B:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
61.22
38%
-102
- C3 -
2WEI
1
?
A:
[24-286]
---------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
A
-
K
N
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
E
S
KEK
D
---
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
-
N
T
-
K
---
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
F
--
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
Q
-
K
Y
----
S
S
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.12
39%
-110
- C3 -
3KU2
1
?
A:
[51-309]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
60.80
39%
-106
- C3 -
3SXF
3
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
60.78
39%
-108
- C3 -
3T3U
5
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
60.76
39%
-103
- C3 -
3UPZ
1
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
60.70
34%
-104
- C3 -
4DEA
4
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
60.59
34%
-98
- C3 -
3UO6
3
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
60.43
34%
-103
- C3 -
3UOD
3
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
60.39
39%
-106
- C3 -
3V5P
1
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
60.34
35%
-99
- C3 -
2HY0
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
-
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
---
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
60.26
33%
-101
- C3 -
2J4Z
2
AURKA_HUMAN
B:
[30-286]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
60.25
39%
-106
- C3 -
3SX9
1
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
60.23
39%
-103
- C3 -
3UPX
1
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
60.11
39%
-110
- C3 -
3I7B
4
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
60.07
39%
-108
- C3 -
3MA6
1
?
B:
[34-292]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
60.05
34%
-103
- C3 -
3UOH
4
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
59.78
33%
-73
- C3 -
2F7X
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
59.77
34%
-101
- C3 -
3UNZ
3
AURKA_HUMAN
B:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
59.74
33%
-78
- C3 -
2UZT
1
KAPCA_BOVIN
A:
[25-328]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
D
G
V
N
D
I
K
N
HKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
59.65
34%
-103
- C3 -
3UOH
3
AURKA_HUMAN
B:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
59.60
34%
-99
- C3 -
3UO6
3
AURKA_HUMAN
B:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
59.56
34%
-104
- C3 -
4DEB
3
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.51
39%
-104
- C3 -
3T3V
2
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
59.49
39%
-107
- C3 -
3N51
3
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
59.47
34%
-102
- C3 -
3UP2
3
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
59.46
33%
-75
- C3 -
2F7E
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
59.33
39%
-101
- C3 -
3V51
1
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
59.32
33%
-77
- C3 -
2OJF
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
59.28
34%
-101
- C3 -
3UNZ
3
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
59.27
33%
-101
- C3 -
2J4Z
3
AURKA_HUMAN
A:
[30-286]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
59.23
33%
-76
- C3 -
2UZW
1
KAPCA_BOVIN
E:
[25-328]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
D
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
59.19
34%
-101
- C3 -
3UOK
1
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
59.16
34%
-100
- C3 -
3UOK
1
AURKA_HUMAN
B:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
59.07
33%
-78
- C3 -
2OH0
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
58.73
34%
-102
- C3 -
4DEE
1
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
58.72
37%
-112
- C3 -
3COK
1
PLK4_HUMAN
A:
[1-261]
--------------------------------------------
S
L
A
T
C
I
G
E
K
-------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
M
-
Y
K
A
G
M
V
--
Q
-
R
V
----
Q
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
-
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
R
---
N
---
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
--------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
--
T
D
T
V
K
-----
V
V
L
A
D
Y
--
E
M
--
P
S
----
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
58.71
34%
-105
- C3 -
3UO4
4
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
58.71
34%
-99
- C3 -
3UOJ
1
AURKA_HUMAN
B:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
58.70
34%
-103
- C3 -
3UO5
1
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
58.67
34%
-99
- C3 -
3UOJ
1
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
58.58
39%
-102
- C3 -
3V5T
1
?
A:
[28-286]
---------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
V
K
Q
K
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
E
S
KSK
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
-
S
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
58.46
33%
-80
- C3 -
2F7Z
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
58.08
35%
-91
- C3 -
2HXQ
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------------
P
F
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
--
C
P
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
-
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
D
E
---
R
---
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
-
N
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
57.63
34%
-102
- C3 -
4DED
4
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
57.43
34%
-99
- C3 -
3UP7
1
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------
Q
W
A
-----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
L
-
E
K
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
---
A
---
G
E
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-
S
S
-
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
57.24
33%
-75
- C3 -
2UZV
1
KAPCA_BOVIN
A:
[25-328]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
D
G
V
N
D
I
K
N
HKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
57.10
33%
-73
- C3 -
2UZU
1
KAPCA_BOVIN
E:
[25-328]
------------------------------------------------------
H
-----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
V
V
K
L
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
---
Q
---
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
-
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
D
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------