@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MELK_HUMAN: (2013-07-23 )
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Atome Classification :
(72 SA)
.........10........20........30........40....--..--.--.--50........60...-.....70........80........90........100.-......110.......120...-....130.......140-...---..---....150......-.160.......170.......180.......190.......200.......-210........220...--.--..-------------------.230----------.--........240.......250.-----.------.....260....---...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKN--TL--G--S--DLPRIKTEIEALKNL-RHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR-LSEEETRVVFRQIVSAVAYVHS-QGYAHRDLKPENLLF---DEY---HK---LKLIDFGLCAKPK-GNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPF-DD-DNVMALYKKIMRGK--Y--DV-------------------PK------------W--LSPSSILLLQQMLQVDPKKRIS-----M------KNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
1
PsiBlast_PDB
96.02
99%
-129
- C1 -
4BL1
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
--
T
L
---------
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
A
K
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
D
-
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
V
-------------------
P
K
------------
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
-----
M
------
K
N
L
L
N
H
P
W
I
M
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
69.09
34%
-126
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-266]
----------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
--
K
L
--
S
--
A
R
-
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
-
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
F
PS-----------------
P
E
------------
W
DT
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
------
H
E
A
L
K
H
P
W
V
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
68.95
34%
-126
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-266]
----------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
--
K
L
--
S
--
A
R-
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
C
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
-
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
F
PS-----------------
P
E
------------
W
DT
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
------
H
E
A
L
K
H
P
W
V
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
68.15
34%
-121
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[6-266]
----------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
--
K
L
--
S
--
A
R
-
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
-
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
F
PS-----------------
P
E
------------
W
DT
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
------
S
E
A
L
K
H
P
W
I
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.92
46%
-113
- C1 -
2Y94
1
AAPK1_RAT
A:
[15-298]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
--
K
I
--
R
--
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
S
-
D
G
E
--
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
-
D
H
V
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
T
-------------------
P
Q
------------
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
-----
I
------
K
D
I
R
E
H
E
W
F
K
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
--
D
D
E
A
L
K
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
66.66
36%
-126
- C1 -
3HX4
3
?
A:
[52-309]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
-
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
L
-------------------
P
Q
------------
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
------
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
66.27
34%
-118
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[11-277]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-----------------
S
M
E
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
K
---
I
M
I
S
D
F
G
L
S
K
M
E
D
-
P
G
----------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
-
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
S
-------------------
P
Y
------------
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
------
E
Q
A
L
Q
H
P
W
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.14
35%
-130
- C1 -
3LIJ
1
?
A:
[35-295]
------
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
----------
S
--
S
N
S
K
L
L
E
E
V
A
V
L
K
L
L
-
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
-
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
E
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
-
N
Q
K
--
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
K
--
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
-
G
G
-
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
--
Y
TF
D
S
-------------------
P
E
------------
W
KN
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
------
Q
Q
A
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
64.87
34%
-125
- C1 -
4GV1
5
AKT1_HUMAN
A:
[7-269]
-------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
--
V
I
--
V
A
K
D
--
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
K
D
---
G
H
---
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
-
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
-
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
--
R
F
-------------------
P
R
------------
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
------
K
E
I
M
Q
H
R
F
F
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.32
47%
-117
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[10-275]
-------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
--
K
I
--
R
--
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
S
-
D
G
E
--
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
-
E
H
V
P
T
L
F
K
K
I
R
G
G
V
--
F
--
Y
I
-------------------
P
E
------------
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
-----
I
------
K
D
I
R
E
H
E
W
F
K
Q
D
LPS
Y
L
F
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
64.21
36%
-124
- C1 -
3SX9
1
?
A:
[28-285]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
--
Q
V
--
K
QK
T
--
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
-
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
L
-------------------
P
Q
------------
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
------
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.03
36%
-122
- C1 -
3HZT
9
?
A:
[6-265]
----------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
SV
T
T
--
T
--
S
--
N
S
G
A
L
L
D
E
V
A
V
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
F
E
V
G
-----------
T
A
Y
Y
I
A
P
E
V
L
R
K
K
--
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
-
G
G
-
Q
T
D
Q
E
I
L
K
R
V
E
K
G
K
FS
F
--
D
P
-------------------
P
D
------------
W
TQ
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
------
E
E
A
L
N
H
P
W
I
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
63.62
36%
-124
- C1 -
3UPX
1
?
A:
[28-285]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
--
Q
V
--
K
QK
T
--
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
-
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
L
-------------------
P
Q
------------
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
------
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
63.29
36%
-122
- C1 -
3T3U
5
?
A:
[28-285]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
--
Q
V
--
K
QK
T
--
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
-
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
L
-------------------
P
Q
------------
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
------
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
63.10
36%
-124
- C1 -
3V5P
1
?
A:
[28-285]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
--
Q
V
--
K
QK
T
--
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
-
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
L
-------------------
P
Q
------------
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
------
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
62.97
36%
-121
- C1 -
3I7B
4
?
A:
[28-285]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
--
Q
V
--
K
QK
T
--
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
-
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
L
-------------------
P
Q
------------
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
------
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
62.83
34%
-134
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-279]
----
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
K
---
I
M
I
S
D
F
G
----------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
-
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
S
-------------------
P
Y
------------
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
------
E
Q
A
L
Q
H
P
W
I
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
62.23
36%
-119
- C1 -
3N51
3
?
A:
[28-285]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
--
Q
V
--
K
QK
T
--
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
-
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
L
-------------------
P
Q
------------
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
------
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
62.08
34%
-111
- C1 -
3TKI
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
61.53
34%
-111
- C1 -
4FSR
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
61.38
34%
-111
- C1 -
4FT9
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
61.31
34%
-108
- C1 -
4FTI
3
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
61.26
34%
-138
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[11-279]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
------------------
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
K
---
I
M
I
S
D
F
--------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
-
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
S
-------------------
P
Y
------------
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
------
E
Q
A
L
Q
H
P
W
I
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
61.19
35%
-130
- C1 -
3COK
1
PLK4_HUMAN
A:
[8-267]
-----
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
--
A
M
Y
K
A
--
G
--
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
N
---
M
N
---
I
K
I
A
D
F
G
L
A
T
Q
L
K
-------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-
D
T
-
D
T
V
K
-----
V
V
L
A
D
--
Y
--
E
M
-------------------
P
S
------------
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
-----
L
------
S
S
V
L
D
H
P
F
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
61.12
34%
-104
- C1 -
2X8D
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
A
--
V
--
D
--
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
61.09
34%
-108
- C1 -
4FSN
2
CHK1_HUMAN
A:
[7-276]
----------
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
61.03
34%
-134
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-279]
----
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
K
---
I
M
I
S
D
F
-------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
-
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
S
-------------------
P
Y
------------
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
------
E
Q
A
L
Q
H
P
W
I
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
60.74
35%
-119
- C1 -
2W4O
1
KCC4_HUMAN
A:
[49-320]
----
D
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
---------------------
I
G
V
L
L
R
L
-
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
---
A
T
P
APD
A
P
---
L
K
I
A
D
F
-------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
-
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
--
Y
--
Y
F
IS-----------------
P
W
------------
W
DE
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
------
F
Q
A
L
Q
H
P
W
V
T
G
-----------
K
A
A
N
-
F
V
H
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
60.59
34%
-132
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[11-279]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-----------------
E
N
E
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
K
---
I
M
I
S
D
F
---------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
-
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
S
-------------------
P
Y
------------
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
------
E
Q
A
L
Q
H
P
W
I
A
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
60.47
34%
-107
- C1 -
2HY0
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
60.42
34%
-110
- C1 -
2HOG
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
60.23
34%
-113
- C1 -
4FSQ
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-------------------
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
60.11
34%
-110
- C1 -
4FT0
2
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
----
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
60.06
34%
-112
- C1 -
3TKH
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
59.97
34%
-106
- C1 -
2QHM
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
59.93
34%
-113
- C1 -
4FTJ
3
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-------------------
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
59.77
35%
-113
- C1 -
3IGO
8
?
A:
[30-282]
----------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
--
S
A
K-
N
--
K
---
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
E
S
K
---
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
-
Q
N
T
---------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
--
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
-
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
--
Y
AF
D
L
-------------------
P
Q
------------
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
------
T
Q
C
L
E
H
P
W
I
Q
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
59.53
34%
-111
- C1 -
2QHN
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
59.51
34%
-115
- C1 -
4FTK
2
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
59.51
34%
-110
- C1 -
4FTT
4
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-----------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
59.46
34%
-108
- C1 -
3NLB
1
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
-----------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
59.29
34%
-115
- C1 -
2XEY
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
59.07
34%
-113
- C1 -
4FTR
3
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
59.04
34%
-104
- C1 -
2YDI
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
A
--
V
--
D
--
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
58.93
34%
-100
- C1 -
4HYI
4
CHK1_HUMAN
A:
[9-274]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
---------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
58.92
34%
-112
- C1 -
2YM6
6
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----------------
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
58.88
34%
-108
- C1 -
2R0U
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
58.84
34%
-113
- C1 -
4FSM
3
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
58.83
34%
-102
- C1 -
2HXQ
1
CHK1_HUMAN
A:
[8-275]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
---------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
58.58
34%
-109
- C1 -
2C3L
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
-------------
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
58.54
34%
-111
- C1 -
4FTM
5
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
58.52
34%
-107
- C1 -
4HYH
1
CHK1_HUMAN
A:
[9-272]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
58.46
34%
-103
- C1 -
2HXL
1
CHK1_HUMAN
A:
[8-275]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
---------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
58.41
34%
-113
- C1 -
4FTL
2
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
58.35
35%
-125
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[9-265]
--------
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
---------------
S
L
E
N
E
I
A
V
L
K
K
I
-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
LTP
E
E
N
---
S
K
---
I
M
I
T
D
F
G
L
S
---
K
-
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-
Y
E
-
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
--
Y
--
E
F
ES-----------------
P
F
------------
W
DD
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
------
E
K
A
L
S
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
58.14
34%
-106
- C1 -
2CGV
1
CHK1_HUMAN
A:
[9-272]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
---------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
58.14
34%
-107
- C1 -
2CGW
1
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
----------
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
58.11
34%
-110
- C1 -
2X8I
2
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
58.00
34%
-104
- C1 -
2CGU
1
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
---------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
57.93
34%
-117
- C1 -
4FTO
4
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------------
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
57.83
34%
-114
- C1 -
2YM4
4
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
57.74
34%
-106
- C1 -
2GDO
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
57.51
34%
-114
- C1 -
2YM8
10
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
57.40
34%
-104
- C1 -
2CGX
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--
R
---------
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
57.17
34%
-113
- C1 -
2XF0
5
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-----------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
57.14
34%
-118
- C1 -
2WMS
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
-------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
57.11
32%
-108
- C1 -
3TXO
1
A:
[23-285]
--------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
--
V
I
--
L
Q
D
D
--
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
-
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
---
D
H
E
---
G
H
---
C
K
L
A
D
F
G
M
C
K
E
G
I
-
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
-
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
-
E
A
-
E
N
E
D
D
L
F
E
A
I
L
N
D
E
--
V
--
V
Y
-------------------
P
T
------------
W
--
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
-----
S
LTQGG
E
H
A
I
L
R
H
P
F
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
56.87
34%
-113
- C1 -
2YM3
6
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-----------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
56.58
34%
-113
- C1 -
2WMU
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-----------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
56.21
34%
-114
- C1 -
2YM7
5
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
56.16
30%
-106
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[3-289]
--------
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
I
F
Y
---------------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
-
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
H
Y
C
H
G
-
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
-
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
---
S
Q
S
---
G
I
---
T
K
L
C
D
F
G
F
A
R
T
-------
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
L
-
P
S
-
S
S
D
L
D
L
L
H
K
I
V
L
K
V
--
G
--
N
L
S
P
H
L
Q
N
I
F
S
K
SPIFAGVV
L
P
Q
V
Q
H
P
KN
A
R
K
K
Y
P
K
--
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
-----
S
------
S
D
L
L
H
H
E
Y
F
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
55.96
34%
-106
- C1 -
2WMQ
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
-----------------
N
I
K
K
E
I
C
I
N
K
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
--------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
L
-------------------
N
P
------------
W
KK
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
------
P
D
I
K
K
D
R
W
-------
Y
N
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------