@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MET_HUMAN: (2013-07-23 )
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
Atome Classification :
(87 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080-----......1090....--.-.--1100......1110..-....1120......1130......1140.....--.1150.-.-..--....1160.....-----.---1170-..---..------.--...1180......1190......1200......1210......1220......1230........1240.--.....1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEV-----IGRGHFGCVYHGTL--L-D--NDGKKIHCAVKSLNRI-TDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLR--SEG--S-P-LV--VLPYMKHGDLRNF-----I---RN---ET---HN------P--TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMY--DKEYYSVHNKTGAK--LPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
30
PsiBlast_CBE
68.47
100%
-124
- C2 -
4DEI
1
A:
[6-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
------
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
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L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
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P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
31
PsiBlast_CBE
68.12
100%
-125
- C2 -
4DEH
1
A:
[6-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
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P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
----
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
43
PsiBlast_CBE
68.02
100%
-120
- C2 -
3F66
4
MET_HUMAN
A:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
--------
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
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Q
F
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E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
-----
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
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D
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W
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F
G
V
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L
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E
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M
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R
G
A
P
P
Y
P
D
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N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
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F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
-----------------------------------------
33
PsiBlast_CBE
67.43
100%
-124
- C2 -
3U6I
1
A:
[4-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
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E
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H
P
N
V
L
S
L
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R
--
S
E
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--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
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R
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F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
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Y
E
V
M
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W
H
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K
A
E
M
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F
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E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
35
PsiBlast_CBE
67.36
100%
-125
- C2 -
3I5N
1
A:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
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P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
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A
V
K
S
L
N
R
------
E
V
S
Q
F
L
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E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
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Y
M
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I
---
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P
--
T
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Y
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A
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D
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A
A
R
N
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T
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A
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--
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K
E
Y
Y
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--
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P
V
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A
L
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Q
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L
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E
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A
P
P
Y
P
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V
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F
D
I
T
V
Y
L
L
Q
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R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
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K
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F
S
E
L
V
S
R
I
S
A
I
F
S
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F
I
G
--------------------------------------------
34
PsiBlast_CBE
66.90
100%
-121
- C2 -
3U6H
1
A:
[4-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
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--
L
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--
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P
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L
V
--
V
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H
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I
---
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E
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N
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P
--
T
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M
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A
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F
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D
L
A
A
R
N
C
M
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D
E
K
F
T
V
K
V
A
D
F
G
-------------------------
P
V
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W
M
A
L
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Q
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F
T
T
K
S
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S
F
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P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
32
PsiBlast_CBE
66.86
100%
-125
- C2 -
4DEG
1
A:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
24
PsiBlast_CBE
66.82
99%
-122
- C2 -
3EFK
1
MET_HUMAN
A:
[8-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
--------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
28
PsiBlast_CBE
66.15
99%
-122
- C2 -
3CCN
1
A:
[9-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------
K
I
H
C
A
V
K
S
L
N
R
------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
17
PsiBlast_PDB
66.15
98%
-126
- C2 -
3DKG
1
A:
[5-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
------
C
V
Y
H
G
T
L
--
L
-
D
-----
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
----------------------------------
37
PsiBlast_CBE
66.06
99%
-121
- C2 -
4AOI
1
A:
[3-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-------
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------
21
PsiBlast_CBE
66.04
100%
-122
- C2 -
3RHK
1
B:
[18-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------
44
PsiBlast_CBE
65.94
99%
-118
- C2 -
3LQ8
1
A:
[5-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
----
D
K
E
Y
Y
S
------
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
---------------------------------------------
26
PsiBlast_CBE
65.88
99%
-120
- C2 -
3EFJ
1
MET_HUMAN
A:
[8-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
--------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
23
PsiBlast_CBE
65.75
99%
-121
- C2 -
3EFK
1
B:
[8-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
--------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
13
PsiBlast_PDB
65.66
100%
-119
- C2 -
3RHK
1
MET_HUMAN
A:
[21-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
19
PsiBlast_PDB
65.55
99%
-128
- C2 -
2RFN
1
MET_HUMAN
A:
[11-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
----
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
27
PsiBlast_CBE
65.29
99%
-122
- C2 -
3CD8
1
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
---------
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
16
PsiBlast_PDB
65.12
100%
-119
- C2 -
4EEV
1
A:
[16-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
121
HHSearch
64.77
99%
-123
- C2 -
3C1X
1
A:
[63-373]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
-------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
45
PsiBlast_CBE
64.62
100%
-117
- C2 -
2WD1
3
A:
[1-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
18
PsiBlast_PDB
64.29
98%
-125
- C2 -
3QTI
1
MET_HUMAN
A:
[6-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
------
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
---
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
9
PsiBlast_PDB
64.10
99%
-120
- C2 -
1R0P
1
A:
[2-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
------
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
F
D
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
29
PsiBlast_CBE
64.00
99%
-120
- C2 -
2RFN
1
B:
[10-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
----
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
42
PsiBlast_CBE
63.79
100%
-121
- C2 -
3F66
3
B:
[11-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-------
K
K
I
H
C
A
V
K
S
L
N
-------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
------
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
-----------------------------------------
7
PsiBlast_PDB
63.78
99%
-112
- C2 -
3DKC
1
A:
[6-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
F
D
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
5
PsiBlast_PDB
63.64
99%
-118
- C2 -
3L8V
1
A:
[8-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
22
PsiBlast_CBE
63.33
98%
-124
- C2 -
3QTI
2
B:
[12-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-------
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
20
PsiBlast_PDB
62.76
99%
-119
- C2 -
2RFS
1
A:
[21-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------
K
I
H
C
A
V
K
S
L
N
-----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
--
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
8
PsiBlast_PDB
62.69
99%
-123
- C2 -
3DKF
1
A:
[5-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
----------
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
---------------
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
4
PsiBlast_PDB
62.23
99%
-119
- C2 -
3F82
1
A:
[9-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
--------
K
I
H
C
A
V
K
S
L
N
R
-----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
2
PsiBlast_PDB
62.18
99%
-120
- C2 -
3CTJ
1
A:
[5-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
-------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
25
PsiBlast_CBE
61.88
99%
-116
- C2 -
3EFJ
1
B:
[8-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
15
PsiBlast_PDB
61.06
100%
-108
- C2 -
4GG7
1
A:
[37-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------
14
PsiBlast_PDB
60.93
100%
-113
- C2 -
4GG5
1
A:
[37-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
----
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------
3
PsiBlast_PDB
60.75
99%
-118
- C2 -
3CE3
1
A:
[8-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
11
PsiBlast_PDB
60.58
99%
-116
- C2 -
3A4P
3
A:
[22-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
-----
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
--
D
K
----------
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
1
PsiBlast_PDB
60.37
99%
-118
- C2 -
3CTH
1
A:
[6-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
-
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----
I
---
R
N
---
E
T
---
H
N
------
P
--
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
131
HHSearch
56.57
61%
-108
- C2 -
3PLS
1
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
R
V
V
T
H
S
D
R
V
-----
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
--
I
-
D
--
Q
A
Q
N
R
I
Q
C
A
I
K
S
L
S
R
I
-
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
N
H
P
N
V
L
A
L
I
G
I
M
L
P
--
P
E
G
--
L
-
P
-
H
V
--
L
L
P
Y
M
C
H
G
D
L
L
Q
F
-----
I
---
R
S
---
P
Q
---
R
N
------
P
--
T
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
--
D
R
E
Y
Y
S
V
Q
Q
H
R
H
A
R
--
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
L
V
G
E
V
E
Q
I
V
S
A
L
L
G
D
H
Y
V
Q
L
P
-------------------------------------
47
PsiBlast_CBE
51.53
44%
-112
- C2 -
3TCP
1
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
I
L
--
G
K
I
-----
L
G
E
---
G
S
V
M
E
G
N
L
--
K
-
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
-
P
-
M
V
--
I
L
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
L
Y
S
R
L
---
E
T
GPK
H
I
------
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
-------------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----------------------------------------------
53
PsiBlast_CBE
51.24
44%
-112
- C2 -
2P0C
1
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
--
G
K
I
-----
L
G
E
---
G
S
V
M
E
G
N
L
--
K
-
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
-------IP
K
-
P
-
M
V
--
I
L
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
L
Y
S
R
L
---
E
T
GPK
H
I
------
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----------------------------------------------
48
PsiBlast_CBE
51.13
44%
-116
- C2 -
3TCP
1
MERTK_HUMAN
A:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
--
G
K
I
-----
L
G
-----
S
V
M
E
G
N
L
--
K
-
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
-----P-
K
-
P
-
M
V
--
I
L
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
L
Y
S
R
L
---
E
T
GPK
H
I
------
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----------------------------------------------
50
PsiBlast_CBE
50.91
44%
-111
- C2 -
3BPR
1
D:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
E
G
N
L
--
K
-
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
------
P
-
M
V
--
I
L
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS
R
L
---
E
T
GPK
H
I
------
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----------------------------------------------
54
PsiBlast_CBE
50.79
44%
-114
- C2 -
2P0C
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
--
G
K
I
-----
L
G
--
E
F
G
S
V
M
E
G
N
L
--
K
-
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
-------IP
K
-
P
-
M
V
--
I
L
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
L
Y
S
R
L
---
E
T
GPK
H
I
------
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----------------------------------------------
49
PsiBlast_CBE
50.76
44%
-111
- C2 -
3BRB
2
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
E
G
N
L
--
K
-
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
-
P
-
M
V
--
I
L
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
L
Y
S
R
L
---
E
T
GPK
H
I
------
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----------------------------------------------
51
PsiBlast_CBE
50.39
44%
-113
- C2 -
3BPR
1
MERTK_HUMAN
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
I
L
--
G
K
I
-----
L
G
E
-
E
F
G
S
V
M
E
G
N
L
--
K
-
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M--------
P
-
M
V
--
I
L
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
L
Y
S
R
L
---
E
T
GPK
H
I
------
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----------------------------------------------
52
PsiBlast_CBE
49.45
44%
-112
- C2 -
3BPR
1
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
E
G
N
L
--
K
-
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
------
P
-
M
V
--
I
L
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
L
Y
S
R
L
---
E
T
GPK
H
I
------
P
---
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----------------------------------------------
57
PsiBlast_CBE
47.11
41%
-109
- C2 -
3QUP
1
A:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---
F
T
L
--
G
R
M
-----
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
--
S
-----I
P
-
M
V
--
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
---------
P
---
F
N
------
L
--
P
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
-----------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
------------------------------------------------
56
PsiBlast_CBE
46.94
41%
-103
- C2 -
4FEQ
1
A:
[22-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
T
L
--
G
R
M
-----
L
G
K
G
---
S
V
R
E
A
Q
L
--
K
-----
D
G
S
F
V
K
V
A
V
K
M
L
------------
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
-----------
P
-
M
V
--
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
------------------------
P
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
--------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
------------------------------------------------
64
PsiBlast_CBE
46.60
42%
-83
- C2 -
2OJ9
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
------P-----
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
90
PsiBlast_CBE
45.29
41%
-90
- C2 -
2HYY
1
ABL1_HUMAN
D:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
-----
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------------------------------
87
PsiBlast_CBE
44.89
41%
-88
- C2 -
3PYY
1
ABL1_HUMAN
A:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
-------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------------------------------
73
PsiBlast_CBE
44.89
41%
-81
- C2 -
3LW0
2
IGF1R_HUMAN
A:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP--------------PP
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
-----
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
61
PsiBlast_CBE
44.78
42%
-81
- C2 -
3NW7
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
M
---
E
N
N
P
V
L
A
P
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
-----
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
99
PsiBlast_CBE
44.69
41%
-88
- C2 -
3QRI
1
ABL1_HUMAN
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------------------------------
86
PsiBlast_CBE
44.67
41%
-93
- C2 -
3PYY
3
ABL1_HUMAN
B:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
--------------------
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------------------------------
91
PsiBlast_CBE
44.62
41%
-92
- C2 -
2HYY
1
ABL1_HUMAN
C:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
----
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
---
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------------------------------
106
Fugue
44.49
39%
-90
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
-----
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG----------
N
K
V
A
V
K
C
I
K
------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
----
E
E
--
G
-
L
-
Y
I
--
V
T
E
Y
M
A
K
G
S
L
V
D
Y
-----
L
---
R
S
R
G--
R
---
S
V
------
L
--
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
---------------------
L
--
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
---------------------------------------------
84
PsiBlast_CBE
44.49
40%
-90
- C2 -
3IK3
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
C--
N
R
---
Q
E
------
V
--
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------------------------------
100
PsiBlast_CBE
44.34
40%
-79
- C2 -
3KFA
1
ABL1_MOUSE
B:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
C--
N
R
---
Q
E
------
V
--
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------------------------------
72
PsiBlast_CBE
44.25
41%
-80
- C2 -
3LW0
3
IGF1R_HUMAN
B:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
KG
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
LRP--------------PP
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
-----
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
58
PsiBlast_CBE
44.22
39%
-94
- C2 -
3LVP
2
IGF1R_HUMAN
A:
[39-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
M
---
E
-PVLAP-
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------------
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
101
PsiBlast_CBE
44.17
40%
-79
- C2 -
3KFA
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
C--
N
R
---
Q
E
------
V
--
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------------------------------
82
PsiBlast_CBE
43.85
41%
-83
- C2 -
3QRJ
1
ABL1_HUMAN
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------------------------------
59
PsiBlast_CBE
43.82
42%
-83
- C2 -
3I81
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
----
E
N
N
P
V
L
A
P
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
----
R
----L-
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
93
PsiBlast_CBE
43.81
41%
-87
- C2 -
2HYY
1
ABL1_HUMAN
A:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
----
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------------------------------
65
PsiBlast_CBE
43.72
42%
-85
- C2 -
1JQH
1
IGF1R_HUMAN
B:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP-------P-----
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
---------
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
67
PsiBlast_CBE
43.65
42%
-74
- C2 -
3QQU
1
IGF1R_HUMAN
C:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
KG
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
M
-----VLAP--
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
69
PsiBlast_CBE
43.59
42%
-81
- C2 -
3QQU
1
IGF1R_HUMAN
A:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
R--------P-----
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
71
PsiBlast_CBE
43.48
41%
-80
- C2 -
3LW0
3
IGF1R_HUMAN
C:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
KG
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
LRP--------------PP
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
-----
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
62
PsiBlast_CBE
43.37
42%
-84
- C2 -
3NW6
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
M
---
E
N
NPVLAP
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
83
PsiBlast_CBE
43.32
40%
-86
- C2 -
3IK3
1
ABL1_MOUSE
B:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
C--
N
R
---
Q
E
------
V
--
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------------------------------
85
PsiBlast_CBE
43.23
40%
-91
- C2 -
2Z60
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
C--
N
R
---
Q
E
------
V
--
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------------------------------
92
PsiBlast_CBE
43.14
41%
-86
- C2 -
2HYY
1
ABL1_HUMAN
B:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
----
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------------------------------
98
PsiBlast_CBE
42.93
41%
-83
- C2 -
3QRK
1
ABL1_HUMAN
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
CNR
Q
E
---
V
N
------
A
--
V
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--------------------------------------------------
75
PsiBlast_CBE
42.92
42%
-72
- C2 -
3ETA
1
INSR_HUMAN
A:
[24-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
--
R
-
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
E
L
M
A
H
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
A
---
E
N
NPGRPP
P
--
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
-
K
--
G
L
--
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
-------------------------------------------------------
70
PsiBlast_CBE
42.83
41%
-79
- C2 -
3LW0
2
D:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
KG
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
LRP--------------PP
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
-----
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
80
PsiBlast_CBE
42.81
40%
-79
- C2 -
3OY3
1
ABL1_MOUSE
B:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
---
R
E
C--
N
R
---
Q
E
------
V
--
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------------------------------
74
PsiBlast_CBE
42.56
42%
-76
- C2 -
3ETA
1
B:
[24-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
--
R
-
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
E
L
M
A
H
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
A
---
E
N
NPGRPP
P
--
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
--
K
--
G
L
--
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
-------------------------------------------------------
68
PsiBlast_CBE
42.24
42%
-75
- C2 -
3QQU
1
IGF1R_HUMAN
B:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
KG
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
R--------------
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
88
PsiBlast_CBE
42.18
42%
-90
- C2 -
2R4B
1
B:
[44-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
--
V
P
E
--
G
E
T
V
K
I
P
V
A
I
K
I
L
--------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
--------
S
-
P
-
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
-----
V
---
H
E
---
H
K
---
D
N
------
I
--
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
GD
E
K
E
Y
----
N
A
D
G
G
K
--
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
--------------------------------------------------
66
PsiBlast_CBE
42.17
42%
-82
- C2 -
3QQU
1
D:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
--
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
E
L
M
T
R
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
M
-----LAP---
P
--
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
-----------------------------------------------------
89
PsiBlast_CBE
41.83
42%
-87
- C2 -
2R4B
1
ERBB4_HUMAN
A:
[44-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
--
V
P
E
--
G
E
T
V
K
I
P
V
A
I
K
I
L
N
-------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
--------
S
-
P
-
T
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
-----
V
---
H
E
---
H
K
---
D
N
------
I
--
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
GD
E
K
E
Y
----
N
A
D
G
G
K
--
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
--------------------------------------------------
79
PsiBlast_CBE
40.91
41%
-79
- C2 -
3EKK
1
A:
[26-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
--
R
-
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
E
L
M
A
H
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
A
---
E
N
NPGRPP
P
--
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
-----------------------L-
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
-------------------------------------------------------
77
PsiBlast_CBE
40.72
42%
-74
- C2 -
1I44
1
A:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
--
R
-
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
E
L
M
A
H
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
A
---
E
N
NPGRPP
P
--
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
----------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
-------------------------------------------------------
78
PsiBlast_CBE
40.46
41%
-71
- C2 -
3EKN
1
A:
[26-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
--
R
-
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
E
L
M
A
H
G
D
L
K
S
Y
-----
L
---
R
S
L
RP
E
A
---
E
N
NPGRPP
P
--
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
Y
Y
----
R
K
G
--L-
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
-------------------------------------------------------
55
PsiBlast_CBE
39.15
41%
-81
- C2 -
4FF8
1
A:
[80-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
D
H
P
H
V
A
K
L
V
--------------------
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
------------------------
P
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
-----------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
--
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
-------------------------------------------------
Add PDB User Result:
(50 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
136
-
100%
-125
- C2 -
U136
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
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H
F
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V
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G
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L
L
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D
G
K
K
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A
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L
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L
V
V
L
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M
K
H
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L
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N
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V
K
D
L
I
G
F
G
L
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A
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M
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Y
L
A
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K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
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L
Q
T
Q
K
F
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K
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D
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L
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A
P
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Y
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T
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Y
L
L
Q
G
R
R
L
L
Q
P
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C
P
D
P
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Y
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M
L
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C
W
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P
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A
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S
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V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
137
-
100%
-121
- C2 -
U137
1
A:
[1052-1344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
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V
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N
E
V
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G
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G
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F
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Y
H
G
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L
L
----
K
K
I
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A
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L
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V
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G
D
L
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D
L
I
G
F
G
L
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V
A
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M
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Y
L
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F
V
H
R
D
L
A
A
R
N
C
M
L
D
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K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
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W
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A
L
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L
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Q
K
F
T
T
K
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D
V
W
S
F
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V
L
L
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L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
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C
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P
L
Y
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M
L
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C
W
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A
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P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------
138
-
99%
-91
- C2 -
U138
1
A:
[1084-1335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
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A
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L
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F
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M
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D
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H
P
N
V
L
S
L
L
G
I
C
S
--
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
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N
F
I
R
N
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T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
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Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
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A
L
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S
L
Q
T
Q
K
F
T
T
K
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F
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L
L
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L
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A
P
P
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P
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V
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L
L
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L
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C
W
H
P
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A
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M
R
P
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F
S
E
L
V
S
-------------------------------------------------------
139
-
100%
-121
- C2 -
U139
1
B:
[1054-1351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
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L
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G
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L
L
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D
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K
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I
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A
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----
D
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L
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L
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L
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M
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F
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D
L
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F
G
L
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L
A
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K
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D
L
A
A
R
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C
M
L
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K
F
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V
K
V
A
D
F
----------------------
P
V
K
W
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A
L
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L
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F
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A
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L
L
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G
R
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L
L
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C
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P
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L
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R
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A
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F
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T
F
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G
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H
Y
V
H
---------------------------------------
140
-
100%
-118
- C2 -
U140
1
A:
[1053-1345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
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A
L
N
P
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L
V
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A
V
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V
V
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D
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K
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I
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A
V
K
S
L
N
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---
I
G
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G
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M
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V
L
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L
L
G
I
C
L
----
S
P
L
V
V
L
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M
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H
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L
R
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F
I
R
N
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H
N
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D
L
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F
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L
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A
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L
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A
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C
M
L
D
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K
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V
K
V
A
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F
G
L
A
R
D
--
D
K
E
Y
Y
S
------
A
K
L
P
V
K
W
M
A
L
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L
Q
T
Q
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L
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L
L
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L
L
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F
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L
V
S
R
I
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A
I
F
S
T
F
I
---------------------------------------------
141
-
100%
-119
- C2 -
U141
1
A:
[1055-1360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
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C
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H
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-----
K
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----
G
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A
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M
L
D
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F
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V
K
V
A
D
F
G
-------------------
K
L
P
V
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A
L
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L
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Y
V
H
V
N
A
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Y
V
N
V
K
------------------------------
142
-
100%
-121
- C2 -
U142
1
A:
[1052-1344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
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L
V
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A
V
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H
V
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H
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----
K
K
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L
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I
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A
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T
F
----------------------------------------------
143
-
100%
-125
- C2 -
U143
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
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A
L
N
P
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L
V
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A
V
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V
A
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--------------------
L
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H
Y
V
H
---------------------------------------
144
-
100%
-125
- C2 -
U144
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
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A
L
N
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L
V
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A
V
Q
H
V
V
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C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
145
-
100%
-124
- C2 -
U145
1
B:
[1058-1360]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
----------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
146
-
100%
-123
- C2 -
U146
1
A:
[1050-1360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
147
-
100%
-121
- C2 -
U147
1
B:
[1054-1351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
148
-
100%
-125
- C2 -
U148
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
149
-
100%
-123
- C2 -
U149
1
A:
[1050-1360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
150
-
100%
-122
- C2 -
U150
1
B:
[1046-1344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------
151
-
100%
-123
- C2 -
U151
1
A:
[1050-1360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
152
-
100%
-119
- C2 -
U152
1
A:
[1055-1360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
L
N
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
153
-
100%
-119
- C2 -
U153
1
A:
[1055-1360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
L
N
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
154
-
99%
-124
- C2 -
U154
1
A:
[1054-1346]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------
K
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
155
-
100%
-123
- C2 -
U155
1
A:
[1050-1360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
156
-
100%
-121
- C2 -
U156
1
B:
[1054-1351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
157
-
100%
-121
- C2 -
U157
1
B:
[1054-1351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
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Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
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M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
158
-
100%
-120
- C2 -
U158
1
A:
[1051-1360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
159
-
100%
-125
- C2 -
U159
1
A:
[1052-1346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-----
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------
160
-
100%
-123
- C2 -
U160
1
A:
[1050-1360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
161
-
100%
-119
- C2 -
U161
1
A:
[1052-1360]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
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D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
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T
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D
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W
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F
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V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
162
-
100%
-125
- C2 -
U162
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
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L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
163
-
100%
-102
- C2 -
U163
1
D:
[1084-1342]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
---
D
G
K
K
I
H
C
A
V
K
S
L
N
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
--
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
-
D
K
E
Y
Y
S
V
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
------------------------------------------------
164
-
100%
-118
- C2 -
U164
1
A:
[1053-1345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
--
D
K
E
Y
Y
S
------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
---------------------------------------------
165
-
100%
-123
- C2 -
U165
1
A:
[1050-1360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
166
-
100%
-119
- C2 -
U166
1
A:
[1055-1360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
L
N
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
167
-
100%
-123
- C2 -
U167
1
A:
[1050-1360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
168
-
100%
-102
- C2 -
U168
1
D:
[1084-1342]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
---
D
G
K
K
I
H
C
A
V
K
S
L
N
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
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--
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
-
D
K
E
Y
Y
S
V
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
------------------------------------------------
169
-
100%
-125
- C2 -
U169
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
170
-
100%
-108
- C2 -
U170
1
A:
[1064-1344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
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L
R
N
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I
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N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
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A
K
G
M
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Y
L
A
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K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
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F
T
V
K
V
A
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F
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L
A
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D
M
Y
D
K
E
Y
Y
S
V
H
N
K
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G
A
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W
M
A
L
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L
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T
Q
K
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T
T
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V
W
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F
G
V
L
L
W
E
L
M
T
R
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A
P
P
Y
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N
T
F
D
I
T
V
Y
L
L
Q
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L
L
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C
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D
P
L
Y
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V
M
L
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C
W
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A
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R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------
171
-
99%
-86
- C2 -
U171
1
A:
[1084-1335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
S
--
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
---
K
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
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V
W
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F
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V
L
L
W
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L
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A
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D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
-------------------------------------------------------
172
-
100%
-122
- C2 -
U172
1
B:
[1065-1344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
--
N
E
V
I
G
R
-
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
------
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
-
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
-------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------
173
-
99%
-91
- C2 -
U173
1
A:
[1084-1337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
S
--
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
----
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
--
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
-----------------------------------------------------
174
-
100%
-119
- C2 -
U174
1
A:
[1055-1360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
L
N
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
175
-
100%
-119
- C2 -
U175
1
A:
[1052-1360]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
176
-
100%
-120
- C2 -
U176
1
A:
[1051-1360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
177
-
100%
-121
- C2 -
U177
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
178
-
100%
-125
- C2 -
U178
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
179
-
100%
-125
- C2 -
U179
1
A:
[1051-1351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------
180
-
100%
-118
- C2 -
U180
1
A:
[1054-1360]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
181
-
100%
-119
- C2 -
U181
1
A:
[1055-1360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
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V
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G
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H
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L
L
-----
K
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A
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K
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L
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----
G
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V
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L
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L
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A
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N
C
M
L
D
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F
T
V
K
V
A
D
F
G
-------------------
K
L
P
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W
M
A
L
E
S
L
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T
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F
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A
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Y
L
L
Q
G
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L
L
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Y
C
P
D
P
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Y
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M
L
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C
W
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A
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I
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E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
182
-
100%
-119
- C2 -
U182
1
A:
[1055-1360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
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V
V
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-----
K
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----
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A
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C
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K
V
A
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F
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-------------------
K
L
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L
L
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L
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Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
183
-
100%
-123
- C2 -
U183
1
A:
[1050-1360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
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A
A
R
N
C
M
L
D
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K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
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L
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L
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F
I
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H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
184
-
100%
-114
- C2 -
U184
1
A:
[1064-1344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
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H
V
V
I
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P
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L
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D
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----
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L
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L
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---
S
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L
V
S
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I
S
A
I
F
S
T
F
----------------------------------------------
185
-
99%
-93
- C2 -
U185
1
A:
[1084-1337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
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--
E
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V
L
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-
H
N
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L
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L
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Y
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Y
Y
--------
K
L
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A
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L
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F
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T
K
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F
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L
L
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L
L
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L
L
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A
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F
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E
L
V
S
R
I
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