@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
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Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MLTK_HUMAN: (2013-07-23 )
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF
Atome Classification :
(54 SA)
.........10........20........30.....-.-..40....----------..------.----------.50------------.....-----...60........70.-.....-..80........90....-....-100.......110.......120.......130.......140...-....150.-...-...160.---..--...----.---170-........---180-.........190.......200.-..-.....210-........220----...----....230.......240.......250......-.260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWI-S-QDKEVAVK----------KL------L----------KIE------------KEAEI-----LSVLSHRNIIQFYGVI-LEPPN-YGIVTEYASLGSLYDYIN-SNRS-EEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASR-FHNHTTH---MS--LVG----T---FP--WMAPEVIQ---S---LPVSETCDTYSYGVVLWEMLT-R-EV-PFKGLEG--LQVAWLVVEKN----ERL----TIPSSCPRSFAELLHQCWEADAKKRPSFKQIIS-ILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF
1
PsiBlast_PDB
93.97
40%
-117
- C2 -
3P86
1
CTR1_ARATH
A:
[32-296]
--------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
-
G
-
S
D
--
V
A
V
K
----------
I
L
------
M
----------
E
Q
D
FH
A
E
R
V
N
E
F
L
--
R
E
V
A
I
-----
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
-
T
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
S
G
A
R
-
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
-
T
V
K
V
C
D
F
----------------------
G
----
T
---
P
E
--
W
M
A
P
E
V
L
R
---
D
---
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
-
Q
Q
-
P
W
G
N
L
N
P
--
A
Q
V
V
A
A
V
G
F
K
C
----
K
R
L
----
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
-
L
L
R
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.70
40%
-108
- C2 -
3PPZ
1
CTR1_ARATH
A:
[32-296]
--------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
-
G
-
S
D
--
V
A
V
K
----------
I
L
------
M
----------
E
--AE
R
V
N
E
F
L
----
R
E
V
A
I
-----
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
-
T
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
S
G
A
R
-
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
-
T
V
K
V
C
D
F
G
-
L
S
R
-
L
K
A
S
T
F
L
---
S
S
KS
A
A
G
----
T
---
P
E
--
W
M
A
P
E
V
L
R
---
D
---
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
-
Q
Q
-
P
W
G
N
L
N
P
--
A
Q
V
V
A
A
V
G
F
K
C
----
K
R
L
----
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
-
L
L
R
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.72
36%
-105
- C2 -
4L53
3
?
A:
[1-262]
-----
G
S
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
----
R
A
K
D
V
A
I
K
----------
Q
I
E-----
S
----------
E
S
E
------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
-
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
T---------------
K
----
G
----
S
---
A
A
--
W
M
A
P
E
V
F
E
---
G
---
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
W
-
A
V
H
N
G
----
T
R
P
----
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
-
I
M
T
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Fugue
86.33
33%
-110
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G----
N
K
V
A
V
K
----------
C
I
K
NDA--
Q
----------
A
F
L
------------
A
E
A
S
V
-----
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
-
V
--
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
R
G
R
-
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
---
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
-
V
A
K
V
S
D
F
G
---------------------------LLP
V
K
--
W
T
A
P
E
A
L
R
---
E
---
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
-
F
G
R
V
-
P
Y
P
R
I
P
L
---
K
D
V
V
P
R
V
E
K
G
----
Y
K
M
----
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
-
Q
L
E
H
I
K
T
H
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.23
36%
-105
- C2 -
2EVA
1
M3K7_HUMAN
A:
[1-261]
------
S
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
----
R
A
K
D
V
A
I
K
----------
Q
I
E-----
S
----------
E
S
E
------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
-
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
T--------------------
G
----
S
---
A
A
--
W
M
A
P
E
V
F
E
---
G
---
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
W
-
A
V
H
N
G
----
T
R
P
----
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
-
I
M
T
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.85
36%
-110
- C2 -
2YIY
1
M3K7_HUMAN
A:
[1-261]
------
S
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
----
R
A
K
D
V
A
I
K
----------
Q
I
E-----
S
----------
E
S
E
------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
-
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
---------------------
G
----
S
---
A
A
--
W
M
A
P
E
V
F
E
---
G
---
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
W
-
A
V
H
N
G
----
T
R
P
----
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
-
I
M
T
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
84.23
32%
-115
- C2 -
3D7T
1
CSK_HUMAN
A:
[9-262]
----------
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
----
R
G
N
K
V
A
V
K
----------
C
I
K
NDATA
Q
----------
A
F
L
------------
A
E
A
S
V
-----
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
-
V
E
E
K
G
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
R
G
R
-
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
---
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
-
V
A
K
V
S
D
F
G
-------------------------------
P
VK
W
T
A
P
E
A
L
R
---
E
---
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
-
R
V
-
P
Y
P
R
I
P
---
L
K
D
V
V
P
R
V
E
K
G
----
Y
K
M
----
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
-
Q
L
E
H
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.89
36%
-103
- C2 -
4L3P
1
?
A:
[1-262]
-----
G
S
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
----
R
A
K
D
V
A
I
K
----------
Q
I
E-----
S
----------
E
S
E
------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
-
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
---------------------
G
----
S
---
A
A
--
W
M
A
P
E
V
F
E
---
G
---
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
W
-
A
V
H
N
G
----
T
R
P
----
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
-
I
M
T
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
82.69
32%
-105
- C2 -
1OPK
3
ABL1_MOUSE
A:
[212-480]
-----
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
------
K
EDTME
V
E
---
E
F
L
------------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
--
A
K
F
----
P
---
I
K
--
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
-
M
S
-
P
Y
P
G
I
D
L
--
S
Q
V
Y
-
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
81.22
32%
-101
- C2 -
1OPJ
2
ABL1_MOUSE
B:
[19-290]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.00
32%
-106
- C2 -
1OPL
1
ABL1_HUMAN
B:
[260-518]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
80.63
33%
-101
- C2 -
3OMV
1
RAF1_HUMAN
A:
[29-301]
------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
----
D
V
A
V
K
----------
I
L
------
K
VVDPT
P
E
Q
F
Q
A
F
R
------------
N
E
V
A
V
-----
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
-
T
K
-
D
N
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
-
V
Q
E
--
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
---
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
-
T
V
K
I
G
D
F
G
-
L
A
T
-
V
-------------
P
T
G
----
S
---
V
L
--
W
M
A
P
E
V
I
R
---
M
QDN
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
-
E
L
-
P
Y
S
H
I
N
N
--
R
D
Q
I
I
F
M
V
G
R
G
----
Y
A
S
PDLS
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
-
S
I
E
L
L
Q
H
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
80.25
32%
-103
- C2 -
2HZI
1
ABL1_HUMAN
A:
[18-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
79.76
32%
-102
- C2 -
1OPJ
2
ABL1_MOUSE
A:
[19-288]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.70
32%
-101
- C2 -
3DK3
1
ABL1_MOUSE
A:
[12-273]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K----------------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
F
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
P
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
79.37
33%
-106
- C2 -
3QRK
1
ABL1_HUMAN
A:
[19-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E
DT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
79.02
33%
-107
- C2 -
3QRI
1
ABL1_HUMAN
A:
[19-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K
--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
78.96
32%
-104
- C2 -
3MS9
2
ABL1_MOUSE
A:
[19-276]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
------------------
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
--
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
78.80
34%
-103
- C2 -
3EQR
1
ACK1_HUMAN
A:
[9-276]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
----------
K
P
-
E
A
M
D
D
F
I
-----
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
-
L
M
R
A
L
P
Q
N
D
D
H
---
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
---
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
----
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
78.49
34%
-109
- C2 -
1U4D
1
ACK1_HUMAN
B:
[19-284]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
-------------A
M
D
D
F
I
------
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
----
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
-
L
M
R
A
L
P
Q
N
D
D
H
---
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
---
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
----
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
78.49
35%
-102
- C2 -
3GVU
2
ABL2_HUMAN
A:
[33-292]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
-
L
S
R
----
G
D
T
Y
---
T
----------
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
----
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
78.30
35%
-109
- C2 -
3HMI
1
ABL2_HUMAN
A:
[33-292]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
----
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.27
32%
-98
- C2 -
2G1T
1
ABL1_HUMAN
C:
[16-280]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K
--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
78.19
32%
-103
- C2 -
3CS9
1
ABL1_HUMAN
B:
[18-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
T-----
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-------------------------------
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
78.07
32%
-102
- C2 -
2G1T
1
ABL1_HUMAN
D:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
77.98
34%
-102
- C2 -
3EQR
1
ACK1_HUMAN
B:
[9-274]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
----------
K
P
D
VLSQ
P
E
A
M
D
D
F
I
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
-
L
M
R
A
L
P
Q
N
D
D
H
---
Y
V
--
M
--RKV-
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
---
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
----
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
77.90
34%
-101
- C2 -
3EQP
1
ACK1_HUMAN
B:
[9-276]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V---------
K
C
------
L
-------------QPEAMDDFI---
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
-
L
M
R
A
L
P
Q
N
D
D
H
---
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
---
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
----
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.79
32%
-102
- C2 -
2HIW
1
ABL1_HUMAN
A:
[16-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
77.72
32%
-102
- C2 -
2G1T
1
ABL1_HUMAN
B:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K
--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.41
32%
-95
- C2 -
2F4J
1
ABL1_HUMAN
A:
[15-279]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E
DT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
77.26
32%
-96
- C2 -
1M52
3
ABL1_MOUSE
B:
[19-281]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
77.05
32%
-103
- C2 -
2HIW
1
ABL1_HUMAN
B:
[16-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.01
32%
-98
- C2 -
2G2F
1
ABL1_HUMAN
B:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
76.97
31%
-111
- C2 -
3OG7
1
BRAF_HUMAN
A:
[30-289]
-------------------
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-----
H
G
D
V
A
V
K
M
L
NVTAPT
P
Q
Q
L
------
Q
----------
A
F
K
------------
N
E
V
G
V
-----
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
--
T
A
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
-
A
S
-----
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-
T
V
K
I
G
D
F
G
---------------------
G
----
S
---
I
L
--
W
M
A
P
E
V
I
R
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
--
R
D
Q
I
I
E
M
V
G
R
G
SLSP
D
L
S
----
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
-
E
I
E
E
L
A
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.89
32%
-103
- C2 -
2G1T
1
ABL1_HUMAN
A:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K
--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
76.88
35%
-99
- C2 -
2XYN
4
ABL2_HUMAN
B:
[33-291]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
DT----
M
----------
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
----
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.80
32%
-97
- C2 -
2G2H
1
ABL1_HUMAN
A:
[16-279]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
76.67
32%
-93
- C2 -
2QOH
1
ABL1_MOUSE
B:
[14-284]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K-----
M
----------
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
76.64
34%
-101
- C2 -
1U54
1
ACK1_HUMAN
B:
[19-282]
--------------
D
L
R
L
L
E
K
L
G
D
G
---
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
-------------EAM
D
D
F
I
-----
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
-
L
M
R
A
L
P
Q
N
D
D
H
---
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
---
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
----
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
76.48
34%
-101
- C2 -
4ID7
1
ACK1_HUMAN
A:
[9-269]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
----------
K
P
-PEA
M
D
D
F
I
----
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
-
L
M
R
A
L
P
Q
N
D
D
H
---
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
---
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
----
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
-
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
76.36
31%
-101
- C2 -
3C4C
1
BRAF_HUMAN
A:
[18-279]
-------------------
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-----
H
G
D
V
A
V
K
MLNVTAPT
P
Q
Q
L
------
Q
----------
A
F
K
------------
N
E
V
G
V
-----
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
-
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
-
A
S
E
T
-
K
-
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-
T
V
K
I
G
D
F
G
--------------------
S
G
----
S
---
I
L
--
W
M
A
P
E
V
I
R
MQD
S
---
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
--
R
D
Q
I
I
E
M
V
G
R
G
SLSP
D
L
S
----
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
-
E
I
E
E
L
A
R
E
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
76.35
35%
-98
- C2 -
2XYN
2
ABL2_HUMAN
A:
[33-291]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
DT----
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
----
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.30
32%
-96
- C2 -
2G2I
1
ABL1_HUMAN
B:
[16-275]
--------------
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
76.06
32%
-98
- C2 -
2QOH
1
ABL1_MOUSE
A:
[14-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E---------------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.91
32%
-93
- C2 -
2G2I
1
ABL1_HUMAN
A:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
---
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
75.80
35%
-100
- C2 -
2XYN
4
ABL2_HUMAN
C:
[33-290]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KT----
M
----------
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
----
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.71
32%
-98
- C2 -
3DK3
1
ABL1_MOUSE
B:
[12-276]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
------
M
----------
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
F
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
P
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
75.70
32%
-97
- C2 -
1M52
1
ABL1_MOUSE
A:
[19-280]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
75.60
32%
-103
- C2 -
1FPU
1
ABL1_MOUSE
B:
[19-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
------
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
75.35
33%
-101
- C2 -
2HZ0
1
ABL1_HUMAN
B:
[14-269]
--------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
------
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
-----------------------------
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
75.23
33%
-95
- C2 -
2HZ0
1
ABL1_HUMAN
A:
[14-269]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
75.22
31%
-103
- C2 -
4FK3
1
BRAF_HUMAN
A:
[30-287]
-------------------
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-----
H
G
D
V
A
V
K
M
L
NVTAPT
P
Q
Q
L
------
Q
----------
A
F
K
------------
N
E
V
G
V
-----
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
-
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
-
A
S
E
T
-
K
-
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-
T
V
K
I
G
D
F
G
--------------------
S
G
----
S
---
I
L
--
W
M
A
P
E
V
I
R
M------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
--
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
----
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
-
E
I
E
E
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.18
32%
-94
- C2 -
2G2F
1
ABL1_HUMAN
A:
[16-280]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
----------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-
L
S
R
-
L
M
T
G
D
T
Y
---
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
---
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
----
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
74.44
34%
-101
- C2 -
1U4D
1
ACK1_HUMAN
A:
[19-283]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
--------------------P
E
A
M
D
D
F
I
----
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
-
L
M
R
A
L
P
Q
--
D
H
---
Y
V
--
M
--V---
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
---
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
----
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Add PDB User Result:
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF
128
-
99%
-113
- C2 -
U128
1
A:
[15-268]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
-
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
-
99%
-113
- C2 -
U129
1
A:
[15-268]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
-
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
-
99%
-113
- C2 -
U130
1
A:
[15-268]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
-
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
-
99%
-115
- C2 -
U131
1
B:
[15-267]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
-----------------
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
-
99%
-115
- C2 -
U132
1
B:
[15-267]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
-----------------
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
-
99%
-113
- C2 -
U133
1
A:
[6-263]
-----
A
S
F
V
Q
I
K
F
D
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
Q
--
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
--
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
A
P
V
K
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
--------------
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
A
W
-
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
-
99%
-122
- C2 -
U134
1
A:
[15-267]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
-
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
-
99%
-115
- C2 -
U135
1
B:
[15-267]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
-----------------
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
-
100%
-130
- C2 -
U136
1
A:
[9-263]
--------
V
Q
I
K
F
D
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
--
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
A
P
-
K
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
---------------
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
A
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
-
99%
-117
- C2 -
U137
1
A:
[15-265]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
--
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
--
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
-
99%
-117
- C2 -
U138
1
A:
[15-263]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
-
99%
-107
- C2 -
U139
1
A:
[15-263]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
-
99%
-115
- C2 -
U140
1
B:
[15-267]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
-----------------
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
-
99%
-116
- C2 -
U141
1
A:
[7-263]
------
S
F
V
Q
I
K
F
D
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
Q
--
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
--
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
A
P
V
K
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
--------------
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
A
W
-
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
-
99%
-117
- C2 -
U142
1
A:
[15-263]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
-
99%
-113
- C2 -
U143
1
A:
[6-263]
-----
A
S
F
V
Q
I
K
F
D
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
Q
--
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
--
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
A
P
V
K
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
--------------
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
A
W
-
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
-
99%
-113
- C2 -
U144
1
A:
[6-263]
-----
A
S
F
V
Q
I
K
F
D
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
Q
--
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
--
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
A
P
V
K
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
--------------
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
A
W
-
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
-
99%
-107
- C2 -
U145
1
A:
[15-263]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
-
99%
-121
- C2 -
U146
1
B:
[15-266]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
N
H
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
-
99%
-117
- C2 -
U147
1
A:
[15-265]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
--
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
A
S
R
F
H
--
T
T
H
M
S
L
V
G
T
F
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
-
99%
-115
- C2 -
U148
1
B:
[15-267]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
-----------------
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
-
99%
-115
- C2 -
U149
1
B:
[15-267]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
-----------------
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
-
99%
-115
- C2 -
U150
1
B:
[15-267]
--------------
D
L
Q
F
F
E
N
C
G
G
G
S
F
G
S
V
Y
R
A
K
W
I
S
Q
D
K
E
V
A
V
K
K
L
L
K
I
E
K
E
A
E
I
L
S
V
L
S
H
R
N
I
I
Q
F
Y
G
V
I
L
E
P
P
N
Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N
S
N
R
S
E
E
M
D
M
D
H
I
M
T
W
A
T
D
V
A
K
G
M
H
Y
L
H
M
E
K
---
V
I
H
R
D
L
K
S
R
N
V
V
I
A
A
D
G
V
L
K
I
C
D
F
G
-----------------
P
W
M
A
P
E
V
I
Q
S
L
P
V
S
E
T
C
D
T
Y
S
Y
G
V
V
L
W
E
M
L
T
R
E
V
P
F
K
G
L
E
G
L
Q
V
-
W
L
V
V
E
K
N
E
R
L
T
I
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
A
K
K
R
P
S
F
K
Q
I
I
S
I
L
E
S
M
S
N
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------