@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K1_HUMAN: (2013-07-23 )
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
Atome Classification :
(42 SA)
.........10........20........30........40........50........60.....--...70........80..---......90........100.......110.....-..120.......130.......140.......150----.......160---.........170.......180.......190.......200-.......210.......220...-......230-----..----.-----....240.......250.......260.......270.......280.......290.......300.......310.......320..--....---.330.......340.......350.......360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDD--DFEKISELGAGNGGVVF---KVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKKAGR-----IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLIDSMA--NSF-VGTRSYMSP-----ER----L-----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPK--LPSG---VFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
7
PsiBlast_PDB
96.17
99%
-116
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
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P
A
I
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N
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I
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L
Q
V
-
L
H
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C
N
S
P
Y
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F
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F
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D
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Q
V
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R
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Y
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-
E
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Q
L
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A
--
N
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-
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Y
M
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P
-----
E
R
----
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Q
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Y
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A
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Y
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I
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D
A
K
E
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E
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C
-----------------------------
P
M
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---
V
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E
F
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A
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A
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I
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D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
111
HHSearch
94.92
99%
-117
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
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T
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L
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--
D
F
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A
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N
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V
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F
---
K
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-
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A
------
V
G
T
R
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Y
M
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-----
E
R
----
L
-----
Q
G
T
H
Y
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I
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G
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S
L
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E
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A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
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E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
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Q
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A
F
I
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D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
3
PsiBlast_PDB
94.89
99%
-115
- C1 -
3EQD
1
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
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Q
K
V
G
E
L
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D
--
D
F
E
K
I
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E
L
G
A
G
N
G
G
V
V
F
---
K
V
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H
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V
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A
R
K
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I
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P
A
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Q
I
I
R
E
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Q
V
-
L
H
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C
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P
Y
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F
Y
G
A
F
Y
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D
G
E
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S
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G
S
L
D
----
Q
V
L
K
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A
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R
-----
I
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I
A
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Y
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-
E
I
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F
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A
--
N
S
F
-
V
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T
R
S
Y
M
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P
-----
E
R
----
L
-----
Q
G
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H
Y
S
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Q
S
D
I
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A
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R
Y
P
I
P
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P
D
A
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E
L
E
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M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
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N
E
P
P
P
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--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
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C
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N
P
A
E
R
A
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S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
9
PsiBlast_PDB
94.32
99%
-119
- C1 -
3ZLS
1
?
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
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Q
K
V
G
E
L
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D
D
--
D
F
E
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E
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A
G
N
G
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V
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F
---
K
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-
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H
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C
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Y
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A
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----
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A
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R
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-
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-----
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Q
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L
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Y
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I
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A
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E
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E
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C
-----------------------------
P
M
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Y
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N
E
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--
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---
V
F
S
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F
Q
D
F
V
N
K
C
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P
A
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A
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Q
L
M
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A
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I
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D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
5
PsiBlast_PDB
94.15
99%
-117
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
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D
D
--
D
F
E
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A
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N
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---
K
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C
-----------------------------
P
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P
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--
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---
V
F
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E
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Q
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F
V
N
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C
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N
P
A
E
R
A
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A
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D
A
E
E
V
D
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A
G
W
L
C
S
T
I
G
L
------------
10
PsiBlast_PDB
93.83
99%
-118
- C1 -
3ZLX
1
?
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
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E
A
F
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E
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--
D
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N
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---
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-----------------------------
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E
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F
A
G
W
L
C
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T
I
G
L
N
-----------
12
PsiBlast_PDB
92.77
98%
-118
- C1 -
3ZLW
1
?
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
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--
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---
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I
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A
K
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-----------------------------
P
M
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L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
8
PsiBlast_PDB
92.61
99%
-119
- C1 -
3ZLY
1
?
A:
[5-347]
---------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
4
PsiBlast_PDB
91.84
99%
-116
- C1 -
3EQF
1
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
6
PsiBlast_PDB
91.14
99%
-115
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
11
PsiBlast_PDB
91.04
99%
-113
- C1 -
3ZM4
1
?
A:
[5-347]
---------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
-------
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
17
PsiBlast_PDB
89.65
100%
-125
- C1 -
3E8N
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
--
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
20
PsiBlast_PDB
88.89
100%
-122
- C1 -
4ARK
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
19
PsiBlast_PDB
88.13
100%
-127
- C1 -
3V04
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
18
PsiBlast_PDB
87.90
100%
-127
- C1 -
3V01
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
13
PsiBlast_PDB
87.30
100%
-126
- C1 -
2P55
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
15
PsiBlast_PDB
87.25
100%
-127
- C1 -
1S9J
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
22
PsiBlast_CBE
87.11
99%
-124
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
23
PsiBlast_CBE
86.43
99%
-128
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[2-321]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
21
PsiBlast_CBE
86.36
100%
-127
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
----
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
16
PsiBlast_PDB
85.82
100%
-126
- C1 -
3DY7
2
MP2K1_HUMAN
A:
[2-304]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
----
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
----------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-----------------------------
14
PsiBlast_PDB
85.74
100%
-128
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
1
PsiBlast_PDB
84.80
99%
-115
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[39-383]
------------------------------------
L
L
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
27
PsiBlast_CBE
82.49
87%
-119
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[4-304]
--------------------------------------------
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--------
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
--------------------------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------
25
PsiBlast_CBE
81.85
90%
-120
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[2-288]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
----------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-------------
28
PsiBlast_CBE
78.94
86%
-120
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
30
PsiBlast_CBE
78.78
86%
-122
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
---
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
29
PsiBlast_CBE
77.54
86%
-121
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
--
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
31
PsiBlast_CBE
76.21
86%
-122
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
S
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
24
PsiBlast_CBE
76.10
90%
-132
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-286]
-------------------------------------------------------------
E
L
K
D
D
--
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
--
L
P
-----
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
---------------
36
PsiBlast_CBE
57.84
36%
-115
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[22-311]
-----------------------------------------------------------------
E
--
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
---
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
V
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
-
N
I
K
L
C
D
F
G
I
S
G
Q
------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
------------------------------------------------
T
Q
V
V
K
G
D
P
P
Q
--
L
S
N
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
---------
33
PsiBlast_CBE
56.06
37%
-109
- C1 -
3FME
1
MP2K6_HUMAN
A:
[3-289]
-------------------------------------------------------------
E
V
K
A
D
--
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
---
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
G
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
-
Q
V
K
M
C
D
F
-----------------
A
G
C
K
P
Y
M
A
P
-----
E
R
I
N
PE
L
-----
N
Q
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
------------------
D
S
W
G
T
P
-----------------------
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
--
L
P
A
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-------------
35
PsiBlast_CBE
54.91
36%
-119
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[22-312]
-----------------------------------------------------------------
E
--
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
---
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
V
Y
S
VLD
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
-
N
I
K
L
C
D
F
G
I
S
G
Q
L
-----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
--------------------------------------------------------
D
P
P
Q
--
L
S
N
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
--------
34
PsiBlast_CBE
51.96
36%
-106
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[22-311]
-----------------------------------------------------------------
E
--
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
---
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
V
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
-
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
--
K
T
R
D
A
G
C
R
P
Y
M
A
P
-----
E
R
----
I
-----
D
P
--
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
N
-----------------------------------------
S
V
F
D
Q
L
T
Q
V
V
K
G
D
P
P
Q
--
L
S
N
S
EE
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
---------
32
PsiBlast_CBE
48.33
37%
-99
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[47-333]
-------------------------------------------------------------
E
V
K
A
D
--
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
---
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
G
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
-
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
V
A
--
K
T
I
D
A
G
C
K
P
Y
M
A
P
-----
E
R
I
N
PE
L
-----
N
Q
K
G
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
------------------
D
S
W
G
T
P
-----------------------
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
--
L
P
A
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-------------
49
PsiBlast_CBE
45.04
31%
-108
- C1 -
2UV2
6
SLK_HUMAN
A:
[36-297]
----------------------------------------------------------------
E
D
--
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
---
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
-
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
M
L
E
L
E
R
P
----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
-
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
-
I
G
T
P
Y
W
M
A
P
-----
E
V
----
V
M
CETS
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
----------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------
50
PsiBlast_CBE
44.26
31%
-106
- C1 -
2J51
5
SLK_HUMAN
A:
[36-297]
----------------------------------------------------------------
E
D
--
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
-
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
M
L
E
L
E
R
P----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
-
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
-
I
G
T
P
Y
W
M
A
P
-----
E
V
----
V
M
CETS
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
----------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------
42
PsiBlast_CBE
41.78
32%
-82
- C1 -
4FZA
3
MST4_HUMAN
B:
[10-263]
---------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
-
R
A
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
KR
N
T
F
-
V
G
T
P
F
W
M
A
P
-----
E
V
----
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
----------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
N
N
P
P
T
--
L
-
V
G
---
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-----------------------------
116
HHSearch
40.97
33%
-91
- C1 -
4G3F
1
A:
[58-310]
-----------------------------------------------------------------
H
--
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
---
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
------
F
R
V
E
E
L
V
A
-
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
----
Q
L
I
K
Q
M
G
C
-----
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
-
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
-------
D
Y
I
-
P
G
T
E
T
H
M
A
P
-----
E
V
----
V
-----
M
G
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
Y
F
R
------------------------------------------
G
P
L
C
L
K
I
A
S
E
P
P
P
I
RE
I
P
P
----
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
-----------------------------------
44
PsiBlast_CBE
39.60
31%
-108
- C1 -
4EQU
2
STK10_HUMAN
B:
[21-279]
---------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
L
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------
F
-
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
----
M
-----
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
45
PsiBlast_CBE
36.90
31%
-110
- C1 -
4EQU
2
STK10_HUMAN
A:
[21-279]
---------------------------------------------------------------------
W
E
I
V
G
E
L
G
-----
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
L
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
----
M
-----
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
53
PsiBlast_CBE
27.20
33%
-84
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-237]
---------------------------------------------------------------
K
A
D
PS
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
-----------------
I
-
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
----
T
R
L
S
K
E
V
M
-----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
-
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
-----
E
V
----
V
-----
N
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
--------------------------------------------------------------------------------------------------------------------------------