@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K2_HUMAN: (2013-07-23 )
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
Atome Classification :
(41 SA)
.........10........20........30........40........50........60........70........80........90........-100.......110.......120........130.......140.......150....----...160..-----.....170.......180.......190.......200....-...210.......220..--...-..230......----.240.-.......250.......260.......270....-...---280.......290.......300.......310.......320.....--..330--...------.---...340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMA-RKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKEAKR-----IPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRG-EIKLCDFGVSGQLIDSMA--NSF-VGTRSYMAPER----LQG-T-HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELE-AIF---GRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVN--EPPPK--LPN------G---VFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
67
HHSearch
94.18
86%
-110
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[6-349]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
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---
G
C
---------------------------------
P
M
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--
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P
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--
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---
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A
E
E
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D
F
A
G
W
L
C
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T
I
G
L
N
----------
10
PsiBlast_PDB
93.26
85%
-111
- C1 -
3ZLX
1
?
A:
[4-347]
------------------------------------------
E
L
E
L
D
E
Q
Q
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----
L
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---
G
C
---------------------------------
P
M
A
I
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Y
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--
E
P
P
P
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--
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P
S
------
G
---
V
F
S
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A
E
E
V
D
F
A
G
W
L
C
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T
I
G
L
N
----------
8
PsiBlast_PDB
92.94
85%
-112
- C1 -
3ZLY
1
?
A:
[5-347]
-------------------------------------------
L
E
L
D
E
Q
Q
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A
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-
G
G
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A
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----
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V
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A
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R
-----
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V
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E
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----
L
Q
G
-
T
-
H
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P
P
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A
K
E
L
E
-
L
M
F
---
G
C
---------------------------------
P
M
A
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L
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Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
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P
A
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R
A
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L
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I
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D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
6
PsiBlast_PDB
92.68
85%
-108
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[6-349]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
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E
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A
G
N
G
G
V
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P
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M
A
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K
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-----
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Y
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--
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S
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----
L
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-
T
-
H
Y
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L
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E
M
A
V
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R
Y
P
I
P
P
P
D
A
K
E
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E
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M
F
---
G
C
---------------------------------
P
M
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Y
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V
N
--
E
P
P
P
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--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
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I
K
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A
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R
A
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Q
L
M
V
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A
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I
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R
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D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
4
PsiBlast_PDB
92.50
85%
-112
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[6-348]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
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Q
K
V
G
E
L
K
D
D
D
F
E
K
I
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E
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G
A
G
N
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G
V
V
F
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M
A
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I
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---
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C
---------------------------------
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---
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F
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P
A
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A
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A
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E
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D
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A
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W
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C
S
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I
G
L
-----------
2
PsiBlast_PDB
92.27
85%
-108
- C1 -
3EQD
1
MP2K1_HUMAN
A:
[6-349]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
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Q
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Q
K
V
G
E
L
K
D
D
D
F
E
K
I
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E
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A
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N
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A
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---------------------------------
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A
E
E
V
D
F
A
G
W
L
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T
I
G
L
N
----------
9
PsiBlast_PDB
92.18
85%
-111
- C1 -
3ZLS
1
?
A:
[4-347]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
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R
L
E
A
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Q
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V
G
E
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L
E
-
L
M
F
---
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
12
PsiBlast_PDB
91.44
85%
-110
- C1 -
3ZLW
1
?
A:
[4-347]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
A
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
---
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
5
PsiBlast_PDB
90.63
85%
-108
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[6-348]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
---
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
16
PsiBlast_PDB
90.00
85%
-123
- C1 -
3V01
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
-------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
3
PsiBlast_PDB
89.76
85%
-110
- C1 -
3EQF
1
MP2K1_HUMAN
A:
[6-348]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
---
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
17
PsiBlast_PDB
89.58
85%
-123
- C1 -
3V04
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
-------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
11
PsiBlast_PDB
89.43
85%
-107
- C1 -
3ZM4
1
?
A:
[5-347]
-------------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
-------
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
---
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
15
PsiBlast_PDB
88.97
85%
-120
- C1 -
3E8N
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
--
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
-------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
22
PsiBlast_CBE
88.95
85%
-124
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[2-321]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
--------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
13
PsiBlast_PDB
88.80
85%
-123
- C1 -
1S9J
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
-------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
20
PsiBlast_PDB
88.29
85%
-123
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
-------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
21
PsiBlast_CBE
87.91
85%
-119
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
--------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
18
PsiBlast_PDB
87.53
85%
-118
- C1 -
4ARK
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
--------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
19
PsiBlast_PDB
87.47
85%
-122
- C1 -
2P55
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
-------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
23
PsiBlast_CBE
86.90
85%
-122
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
----
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
--------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
7
PsiBlast_PDB
85.31
79%
-110
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[39-383]
----------------------------------------
L
L
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
-
L
M
F
---
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
14
PsiBlast_PDB
83.59
85%
-124
- C1 -
3DY7
2
MP2K1_HUMAN
A:
[2-304]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
----
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
------------------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
----------------------------
27
PsiBlast_CBE
81.73
78%
-116
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[4-304]
------------------------------------------------
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--------
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
----------------------------------------------------
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
---------
25
PsiBlast_CBE
80.39
79%
-114
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[2-288]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
------------------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
------------
28
PsiBlast_CBE
78.98
75%
-118
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[3-282]
---------------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
--------------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
30
PsiBlast_CBE
78.71
75%
-118
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[3-282]
---------------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
---
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
--------------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
29
PsiBlast_CBE
77.93
75%
-118
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[3-282]
---------------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
--
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
--------------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
31
PsiBlast_CBE
77.54
75%
-119
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[3-282]
---------------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
--------------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
S
------
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
24
PsiBlast_CBE
75.64
79%
-127
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-286]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
-
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
A
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
Q
G
-
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
---------------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
--
E
P
P
P
K
--
L
P
-----------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
--------------
35
PsiBlast_CBE
58.59
37%
-111
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[22-311]
---------------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
-
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
V
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
-
N
I
K
L
C
D
F
G
I
S
G
Q
----------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
--------------------------------------------------------
T
Q
V
V
K
--
G
D
P
P
Q
--
L
S
N
------
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
--------
34
PsiBlast_CBE
58.33
37%
-118
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[22-312]
---------------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
-
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
V
Y
S
VLD
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
-
N
I
K
L
C
D
F
G
I
S
G
Q
L
---------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
------------------------------------------------------------------
D
P
P
Q
--
L
S
N
------
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
-------
36
PsiBlast_CBE
55.13
36%
-109
- C1 -
3FME
1
MP2K6_HUMAN
A:
[3-284]
-----------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
-
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
G
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
-
Q
V
K
M
C
D
F
-----------------
A
G
C
K
P
Y
M
A
P
E
R
I
N
PE
L
N
Q
----
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
S
----------
W
---
G
T
P
------------------------------------
F
Q
Q
L
K
Q
V
V
E
--
E
P
S
P
Q
--
L
P
A
------
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
-----------------
33
PsiBlast_CBE
54.58
37%
-102
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[22-311]
---------------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
-
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
V
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
-
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
--
K
T
R
D
A
G
C
R
P
Y
M
A
P
E
R
----
I
D
P
----
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
N
-------------------------------------------------
S
V
F
D
Q
L
T
Q
V
V
K
--
G
D
P
P
Q
--
L
S
N
------
S
EE
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
--------
32
PsiBlast_CBE
48.59
36%
-97
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[47-328]
-----------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
-
V
K
R
I
R
A
T
V
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
G
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
-
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
V
A
--
K
T
I
D
A
G
C
K
P
Y
M
A
P
E
R
I
N
PE
L
N
Q
-
K
-
G
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
S
----------
W
---
G
T
P
------------------------------------
F
Q
Q
L
K
Q
V
V
E
--
E
P
S
P
Q
--
L
P
A
------
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
-----------------
42
PsiBlast_CBE
41.08
31%
-83
- C1 -
4FZA
3
MST4_HUMAN
B:
[10-263]
-----------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
-
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
R
-
A
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
KR
N
T
F
-
V
G
T
P
F
W
M
A
P
E
V
----
I
Q
Q
-
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
------------------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
--
N
N
P
P
T
--
L
V
-------
G
---
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
----------------------------
70
HHSearch
40.20
30%
-78
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[3-291]
---------------------------------------------------------------------
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
-
I
K
I
F
Y
-------
N
K
I
A
M
R
E
I
K
F
-
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
----
E
L
Q
H
Y
C
H
G
-----
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
-
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
-
I
T
K
L
C
D
F
G
F
A
R
T
---
D
I
Y
--
D
D
E
-
V
A
T
R
W
Y
R
A
P
E
L
----
V
L
K
-
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
KV
G
N
L
S
P
H
-----------------------------
L
Q
N
I
F
S
K
S
P
I
F
A
G
VV
L
P
Q
V
Q
--
H
P
K
N
A
R
K
K
Y
P
---
K
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
---------------------------
72
HHSearch
39.47
34%
-91
- C1 -
4G3F
1
A:
[57-310]
--------------------------------------------------------------------
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
-
V
K
K
V
R
L
E
V
------
F
R
V
E
E
L
V
A
-
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
----
Q
L
I
K
Q
M
G
C
-----
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
-
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
-------
D
Y
I
-
P
G
T
E
T
H
M
A
P
E
V
----
V
M
G
-
K
-
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
Y
F
R
--------------------------------------------------
G
P
L
C
L
K
I
A
S
--
E
P
P
P
I
RE
I
P
P
----------
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
----------------------------------
47
PsiBlast_CBE
22.20
31%
-83
- C1 -
4AGU
1
CDKL1_HUMAN
B:
[4-199]
----------------------------------------------------------------------
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
--
D
P
V
I
K
K
I
A
L
R
E
I
R
M
-
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
----
E
L
D
R
Y
Q
R
G
-----
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
-
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
-
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-------------
R
W
Y
R
S
P
E
L
----
L
V
G
D
T
-
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
20.99
31%
-84
- C1 -
4AGU
1
CDKL1_HUMAN
A:
[3-199]
---------------------------------------------------------------------
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
-
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
----
E
L
D
R
Y
Q
R
G
-----
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
-
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
-
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-------------
R
W
Y
R
S
P
E
L
----
L
V
G
D
T
-
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
20.29
31%
-78
- C1 -
4AGU
1
CDKL1_HUMAN
C:
[3-199]
---------------------------------------------------------------------
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
-
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
----
E
L
D
R
Y
Q
R
G
-----
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
-
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
-
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-------------
R
W
Y
R
S
P
E
L
----
L
V
G
D
T
-
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------