@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NEK4_HUMAN: (2013-07-23 )
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMNF
Atome Classification :
(26 SA)
.........10........20....--...-.30........40...-----.....50--.........60........70.-..---..--------...80........90......--..100.......110.......120....-...130.......---140.---......150.......160.......170......---.180.......190.......200......-.210.......-220---..---....--.230.......240.......250.....----..260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPLAAYCYLRVVGKGSYGEVTLVKH--RRD-GKQYVIKKLNLRNASS-----RERRAA---EQEAQLLSQLKHPNIVTYKESW-EG---GD--------GLLYIVMGFCEGGDLYRKLKE--QKGQLLPENQVVEWFVQIAMALQYLHEKH-ILHRDLKTQNVFL---TRTN---IIKVGDLGIARVLENHCDMASTLIGTPYYMSPELF---SNKPYNYKSDVWALGCCVYEMATLKHAFNA-KDMNSLVYRII-EGK---LP---PMPR--DYSPELAELIRTMLSKRPEERPSVRSILR----QPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMNF
21
PsiBlast_CBE
81.72
50%
-109
- C1 -
4B9D
2
NEK1_HUMAN
B:
[26-288]
-----
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
--
T
E
D
-
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
S
-----
K
E
R
E
E
S
---
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
-
E
E
----
N
--------
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
---
T
K
D
G
---
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
---
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
-
G
S
M
K
N
L
V
L
K
I
I
-
S
G
S
---
F
P
---
P
V
S
L
--
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
----
K
G
F
I
A
K
R
I
E
K
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
77.50
44%
-101
- C1 -
4B9D
1
NEK1_HUMAN
A:
[22-306]
-
S
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
--
T
E
D
-
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
S
-----
K
E
R
E
E
S
---
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
-
E
E
----
N
--------
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
---
T
K
D
G
---
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
---
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
-
G
S
M
K
N
L
V
L
K
I
I
-
S
G
S
---
F
P
---
P
V
S
L
--
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
----
K
G
F
I
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.40
40%
-112
- C1 -
2XKD
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
--------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.95
40%
-111
- C1 -
2W5A
5
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.83
40%
-110
- C1 -
2XKF
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.66
40%
-103
- C1 -
2W5B
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.65
40%
-109
- C1 -
2XK7
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.51
40%
-109
- C1 -
2XK6
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.16
40%
-109
- C1 -
2XK8
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.05
40%
-111
- C1 -
2JAV
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
---------------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
-----------
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.62
40%
-106
- C1 -
2XNM
10
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
---------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.55
40%
-104
- C1 -
2XNP
6
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
H
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.53
40%
-114
- C1 -
2XKE
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
------------------
T
P
Y
Y
M
S
P
E
Q
M
---
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.12
40%
-103
- C1 -
2XNO
13
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.67
40%
-103
- C1 -
2XKC
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.63
40%
-109
- C1 -
2WQO
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-------
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.18
40%
-107
- C1 -
2XK3
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
G
---------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.74
40%
-106
- C1 -
2XK4
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.04
40%
-101
- C1 -
2XNN
6
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
--
K
S
D
-
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
-----
A
E
K
Q
M
L
---
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
---
D
G
K
Q
---
N
V
K
L
G
D
F
G
--------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
R
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
-
E
G
K
---
F
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
----
N
P
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
62.40
32%
-106
- C1 -
3HX4
3
?
A:
[56-318]
---------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
--
K
I
T
-
G
Q
E
C
A
V
K
V
I
S
K
-----------
D
K
E
S
L
---
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
----
D
K
--------
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--
R
K
--
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
-
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
D
A
---
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
----
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
---
Y
T
FEL
P
Q
W
K
--
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
58.69
31%
-101
- C1 -
2XM9
1
CHK2_HUMAN
A:
[18-285]
-----
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
--
R
K
T
-
C
K
K
V
A
I
K
I
I
S
K
--------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
-
D
A
---
E
D
----------
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--
N
K
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
E
ED
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
-
S
G
K
YNF
I
P
---
E
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
----
H
P
W
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
57.74
31%
-102
- C1 -
4A9U
10
CHK2_HUMAN
A:
[18-285]
-----
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
--
R
K
T
-
C
K
K
V
A
I
K
I
I
S
K
-------------
D
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
-
D
A
---
E
D
----------
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--
N
K
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
E
ED
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
-
S
G
K
YNF
I
P
---
E
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
----
H
P
W
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
57.26
31%
-97
- C1 -
4A9T
4
CHK2_HUMAN
A:
[18-285]
-----
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
--
R
K
T
-
C
K
K
V
A
I
K
I
I
S
K
--------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
-
D
A
---
E
D
----------
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--
N
K
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
E
ED
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
-
S
G
K
YNF
I
P
---
E
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
----
H
P
W
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
50.56
31%
-97
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[33-272]
--------
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VT
R
P
D
S
G
H
L
Y
A
M
K
V
L
--------------------------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
-
Q
T
----
E
--------
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
--
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
E
G
---
H
I
K
L
T
D
F
G
L
S
K
E
------------
G
T
V
E
Y
M
A
P
E
V
V
---
N
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
-
K
D
R
K
E
T
M
T
L
I
L
-
K
A
K
---
L
----
G
M
P
Q
--
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
49.36
32%
-105
- C1 -
2A19
1
E2AK2_HUMAN
C:
[16-267]
--------
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
--
R
I
D
-
G
K
T
Y
V
I
K
R
V
K
Y
N
N
E
K
-----------
A
---
E
R
E
V
K
A
L
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
-
D
G
---
F
D
YDPETSK
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
-----------------
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
-
L
I
N
R
D
L
K
P
S
N
I
F
L
---
V
D
T
K
---
Q
V
K
I
G
D
F
G
L
V
---------------------------------
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
--
L
--------------------
G
I
---
I
S
---
D
I
-----
F
D
K
K
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
49.24
31%
-63
- C1 -
3ORP
1
?
A:
[19-292]
----------
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
--
L
R
D
-
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
-------
E
A
Q
N
A
A
A
L
N
H
P
A
I
V
A
V
Y
D
T
G
-
E
A
E
T
P
A
G
--------
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
-
R
D
I
V
H
--
T
E
G
P
M
T
P
K
-
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
-
I
I
H
R
D
V
K
P
A
N
I
M
I
---
S
A
T
N
---
A
V
K
V
M
D
F
G
I
A
-------------
I
G
T
A
Q
Y
L
S
P
E
Q
A
---
R
G
D
S
V
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
-
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
---
I
P
---
P
S
A
R
HE
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
----
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
V
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------