@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NTRK1_HUMAN: (2013-07-23 )
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Atome Classification :
(91 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.....------..500.-----......510.-.-.....520.......530.-....--------------.----.540.....-.-.-550--........560.....-..570.......580.......590.......600.------......610.......620-.-........630.......640.......650......---.-----660.......670.---......-680.......690.......700.......710.......720...-....730........740---.....--....750.......760.......770.......780.......790....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYF------SDACVH-----HIKRRDIVLK-W-ELGEGAFGKVFLAECHNLL-PEQD--------------K----MLVAVKALK-E-A-S-E--SARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRS------HGPDAKLLAGGEDVAPG---P-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G-----QGLVVKIGDFGMSR---DIYSTD-YYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQ-LSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
22
PsiBlast_CBE
92.04
100%
-132
- C3 -
4AOJ
1
C:
[33-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
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23
PsiBlast_CBE
91.87
100%
-134
- C3 -
4AOJ
1
NTRK1_HUMAN
B:
[33-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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122
HHSearch
91.72
100%
-135
- C3 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
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5
PsiBlast_PDB
86.08
75%
-123
- C3 -
4AT3
1
A:
[4-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
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Q
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6
PsiBlast_PDB
85.63
75%
-126
- C3 -
4AT4
1
A:
[4-299]
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7
PsiBlast_PDB
85.53
75%
-120
- C3 -
4AT5
2
A:
[4-299]
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8
PsiBlast_PDB
84.52
76%
-129
- C3 -
3V5Q
1
NTRK3_HUMAN
A:
[9-297]
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V
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R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
P
-------
60
PsiBlast_CBE
75.98
41%
-120
- C3 -
4FOB
1
A:
[51-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
-----------
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
58
PsiBlast_CBE
75.70
41%
-124
- C3 -
2XB7
1
A:
[16-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
----------------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
------------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
59
PsiBlast_CBE
75.50
41%
-120
- C3 -
4FOC
1
A:
[51-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
48
PsiBlast_CBE
75.34
40%
-112
- C3 -
3LCS
3
A:
[30-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
FAG
K
T
S
S
I
S
D
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
-
N
D
P
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
51
PsiBlast_CBE
75.22
41%
-124
- C3 -
4DCE
1
B:
[31-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
----
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
-------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
50
PsiBlast_CBE
75.09
41%
-118
- C3 -
4FOD
2
A:
[31-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
49
PsiBlast_CBE
75.05
41%
-121
- C3 -
4FNW
2
A:
[25-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
L
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
57
PsiBlast_CBE
74.76
41%
-127
- C3 -
2XBA
1
A:
[16-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
-------
V
Y
E
G
Q
V
S
----------------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
-----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
130
HHSearch
74.65
41%
-119
- C3 -
3CBL
3
A:
[110-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
-
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
------
A
D
--------------
N
----
T
L
V
A
V
K
S
C
R
-
E
-
T
L
P
-
P
--
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
------
E
G
A
-----------------
R
-
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
---
E
E
A
D
G
V
-
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
-
S
P
Y
P
N
-
L
S
N
Q
Q
T
R
E
F
V
-----
E
K
G
G
R
--
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
---------
56
PsiBlast_CBE
74.60
41%
-121
- C3 -
2YFX
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
-----------------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
54
PsiBlast_CBE
74.49
41%
-119
- C3 -
4FNZ
1
A:
[25-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
------
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
-------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
39
PsiBlast_CBE
74.45
40%
-111
- C3 -
3L9P
4
A:
[50-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
AG
K
T
S
S
I
S
D
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
------
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
62
PsiBlast_CBE
74.41
41%
-124
- C3 -
4FNY
1
A:
[25-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
---------------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
----------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
--------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
52
PsiBlast_CBE
74.25
41%
-120
- C3 -
4DCE
1
ALK_HUMAN
A:
[31-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
------
P
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
36
PsiBlast_CBE
74.24
45%
-116
- C3 -
4BKJ
10
?
A:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
-
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----
P
Q
D
LVSLDFPLNVRKG
H
P
----
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
--
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
------
H
Q
L
E
D
---------------
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
---
N
L
Y
A
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
------------------
47
PsiBlast_CBE
74.20
40%
-107
- C3 -
3LCT
3
A:
[27-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
AG
K
T
S
S
I
S
D
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
-
N
D
P
S
--------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
61
PsiBlast_CBE
74.18
41%
-121
- C3 -
4ANQ
1
A:
[39-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
-----------------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
A
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
64
PsiBlast_CBE
74.07
41%
-120
- C3 -
4ANS
1
A:
[39-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
-----------------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
A
D
F
G
M
A
R
---
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
28
PsiBlast_CBE
73.83
42%
-115
- C3 -
3LW0
3
IGF1R_HUMAN
B:
[11-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
-----------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
35
PsiBlast_CBE
73.64
45%
-112
- C3 -
4BKJ
10
?
B:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
-
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----
P
Q
D
LVSLDFPLNVRKG
H
P
----
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
--
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
------
H
Q
L
E
D
K
----------
G
---
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
---
N
L
Y
A
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
------------------
53
PsiBlast_CBE
73.53
41%
-119
- C3 -
3AOX
5
A:
[41-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
S
----------------------
P
----
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
------
T
R
P
R
P
S
--------
Q
P
S
---
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
------
16
PsiBlast_PDB
73.27
42%
-117
- C3 -
3LW0
2
IGF1R_HUMAN
A:
[11-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
-----------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
27
PsiBlast_CBE
73.23
42%
-116
- C3 -
3LW0
3
IGF1R_HUMAN
C:
[11-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
-----------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
26
PsiBlast_CBE
73.02
42%
-114
- C3 -
3LW0
2
D:
[11-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
-----------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
37
PsiBlast_CBE
72.87
45%
-106
- C3 -
3ZOS
3
B:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
-
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----
P
Q
D
LVSLDFPLNVRKG
H
P
----
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
--
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
------
H
Q
L
E
D
K
---------
Q
G
---
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
---
N
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
------------------
24
PsiBlast_CBE
72.54
41%
-114
- C3 -
1JQH
1
IGF1R_HUMAN
B:
[6-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
EW
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
-----------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
-----------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
81
PsiBlast_CBE
72.53
39%
-118
- C3 -
3ZBF
1
?
A:
[32-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
L
T
L
R
-
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
L
G
V
G
S
G
--------------
E
----
I
K
V
A
V
K
T
L
K
-
K
-
G
-
S
T
D
--
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
ATF
Y
G
P
L
L
T
L
V
D
------------------
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
---
D
I
Y
-------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
-
Q
P
Y
P
A
-
H
S
N
L
D
V
L
N
Y
V
-----
Q
T
G
G
R
--
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
--------------
38
PsiBlast_CBE
72.46
45%
-109
- C3 -
3ZOS
4
DDR1_HUMAN
A:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
-
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----
P
Q
D
LVSLDFP
L
N
V
R
KG
H
P
----
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
--
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
------
H
Q
L
E
D
--------
A
A
Q
G
---
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
---
N
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
------------------
19
PsiBlast_PDB
72.43
41%
-115
- C3 -
2OJ9
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
----------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
140
HHSearch
72.40
34%
-110
- C3 -
4FL3
1
KSYK_HUMAN
A:
[364-630]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
-
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
----
K
K
V
--------------
V
----
K
T
V
A
V
K
I
L
K
-
N
-
E
-
A
-
N
DP
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
------
N
R
------------------
H
-
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
---
A
L
R
A
-------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
-
K
P
Y
R
G
-
M
K
G
S
E
V
T
A
M
L
-----
E
K
G
E
R
--
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
-----------
14
PsiBlast_PDB
72.38
41%
-114
- C3 -
3I81
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
-
E
-----
N
N
P
V
L
A
---
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
20
PsiBlast_PDB
72.29
41%
-113
- C3 -
3NW5
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
M
E
-----
N
N
P
V
L
A
---
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
65
PsiBlast_CBE
72.22
39%
-119
- C3 -
1MQB
1
B:
[52-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-----
K
E
-------------------
V
P
V
A
I
K
T
L
K
-
A
-
G
Y
T
-
E
--
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
------
K
D
--------------
G
---
E
-
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
-----
S
N
L
V
C
K
V
S
D
F
G
L
S
R
VL--------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
-
R
P
Y
W
E
-
L
S
N
H
E
V
M
K
A
I
-----
N
D
G
F
R
--
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------
33
PsiBlast_CBE
72.15
41%
-113
- C3 -
3NW6
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
M
E
-----
N
N
P
V
L
A
---
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
107
PsiBlast_CBE
72.13
39%
-108
- C3 -
4HW7
1
A:
[49-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
N
L
Q
F
G
-
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
-
K
E
D
A
--------------
V
----
L
K
V
A
V
K
M
L
K
-
S
T
A
-
H
-
A
--
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
------
K
A
-
E
A
M
L
---
G
P
S
----G
R
-
P
-
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
-----
N
G
H
V
A
K
I
G
D
F
G
L
A
R
---
D
I
M
N
D
S
-
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
-
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
-----
K
D
G
Y
Q
--
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
E
Q
A
-----------
105
PsiBlast_CBE
72.10
40%
-119
- C3 -
3GQL
1
FGFR1_HUMAN
B:
[24-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
-----------
P
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
32
PsiBlast_CBE
71.88
41%
-114
- C3 -
3NW7
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
M
E
-----
N
N
P
V
L
A
---
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
104
PsiBlast_CBE
71.83
40%
-123
- C3 -
3GQL
1
C:
[24-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
----------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
70
PsiBlast_CBE
71.71
36%
-114
- C3 -
2IVS
5
RET_HUMAN
A:
[14-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
K
W
------------------
E
F
P
R
K
N
L
V
L
G
-
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
-
G
R
A
G
--------------
Y
----
T
T
V
A
V
K
M
L
K
-
E
N
A
-
S
-
P
--
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
----------------
S
R
K
V
G
P
G
YLR
A
-
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
---
D
V
Y
E
E
D
-
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
-
N
P
Y
P
G
-
I
P
P
E
R
L
F
N
L
L
-----
K
T
G
H
R
--
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
------------
84
PsiBlast_CBE
71.61
40%
-128
- C3 -
4F65
4
B:
[16-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
-----------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
------------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
----------
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
41
PsiBlast_CBE
71.54
43%
-124
- C3 -
3EKK
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
-
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
A
-------
E
N
N
P
G
RP-
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
----------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
-------------------
69
PsiBlast_CBE
71.48
35%
-119
- C3 -
3FXX
1
A:
[30-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
T
------
V
H
E
F
A
K
-----
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
--
L
-
P
S
K
K
--------------
E
----
I
S
V
A
I
K
T
L
K
-
V
-
G
Y
T
-
E
--
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
------
H
D
A
Q
F
T
V
I
------------------
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
-----
S
N
L
V
C
K
V
S
D
F
G
L
S
R
VLE
D
D
----------
G
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
-
R
P
Y
W
E
-
M
S
N
Q
D
V
I
K
A
V
-----
D
E
G
Y
R
--
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--------
46
PsiBlast_CBE
71.36
43%
-116
- C3 -
1I44
1
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
-
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
A
-------
E
N
N
P
G
RP-
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
--------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
-------------------
15
PsiBlast_PDB
71.34
44%
-112
- C3 -
3ETA
1
INSR_HUMAN
A:
[12-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
-
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
A
-------
E
N
N
P
G
RP-
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
-------------------
98
PsiBlast_CBE
71.30
40%
-121
- C3 -
3JS2
1
B:
[24-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PNR
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
----------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
29
PsiBlast_CBE
71.30
41%
-115
- C3 -
3QQU
1
D:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
M
----------
L
A
---
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
71
PsiBlast_CBE
71.29
37%
-123
- C3 -
2QOC
2
A:
[24-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
--
L
-
P
S
K
K
--------------
E
----
I
S
V
A
I
K
T
L
K
-
V
-
G
Y
T
-
E
--
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
------
H
D
A
Q
F
T
V
I
------------------
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
-----
S
N
L
V
C
K
V
S
D
F
G
L
S
R
VLE
D
------------
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
-
R
P
Y
W
E
-
M
S
N
Q
D
V
I
K
A
V
-----
D
E
G
Y
R
--
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--------
93
PsiBlast_CBE
71.17
40%
-120
- C3 -
1FGI
1
FGFR1_HUMAN
A:
[20-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---------------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
------------
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
99
PsiBlast_CBE
71.16
40%
-119
- C3 -
3JS2
1
FGFR1_HUMAN
A:
[24-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
G
L
-------
H
N
P
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
25
PsiBlast_CBE
71.16
44%
-112
- C3 -
3ETA
1
B:
[12-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
-
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
A
-------
E
N
N
P
G
RP-
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
-------------------
31
PsiBlast_CBE
71.01
41%
-118
- C3 -
3QQU
1
IGF1R_HUMAN
B:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
--------------------
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
13
PsiBlast_PDB
70.98
41%
-117
- C3 -
3LVP
2
IGF1R_HUMAN
A:
[39-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEW-
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
M
E
-------
P
V
L
A
---
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
--------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
30
PsiBlast_CBE
70.88
41%
-113
- C3 -
3QQU
1
IGF1R_HUMAN
C:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
M
---------
V
L
A
---
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
75
PsiBlast_CBE
70.86
37%
-125
- C3 -
3DZQ
1
A:
[41-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
--
L
-
P
S
K
K
--------------
E
----
I
S
V
A
I
K
T
L
K
-
V
-
G
Y
T
-
E
--
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
------
H
D
A
Q
F
T
V
I
------------------
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
-----
S
N
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
-
R
P
Y
W
E
-
M
S
N
Q
D
V
I
K
A
V
-----
D
E
G
Y
R
--
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--------
17
PsiBlast_PDB
70.86
41%
-118
- C3 -
3QQU
1
IGF1R_HUMAN
A:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
-
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
------
L
R
------------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
--------------
134
HHSearch
70.85
35%
-114
- C3 -
2OZO
1
ZAP70_HUMAN
A:
[331-598]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
R
D
N
L
L
I
A
-
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
R
----
K
K
--------------
Q
----
I
D
V
A
I
K
V
L
K
-
Q
-
G
-
T
E
K
--
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
------
K
--------------
R
E
---
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
---
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
---
A
L
G
--------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
-
K
P
Y
K
K
-
M
K
G
P
E
V
M
A
F
I
-----
E
Q
G
K
R
--
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
----------
101
PsiBlast_CBE
70.69
40%
-122
- C3 -
3RHX
4
FGFR1_HUMAN
A:
[16-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
------------
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
77
PsiBlast_CBE
70.62
37%
-115
- C3 -
3GVU
2
ABL2_HUMAN
A:
[20-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
------
Q
S
M
D
K
W
-----
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-----
V
-
W
K
K
Y
--------------
S
----
L
T
V
A
V
K
T
L
K
-
E
-
D
-
T
-
M
--
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
--------------
C
N
R
E
E
V
T
A
V
---------
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-------
G
D
-
T
Y
T
----
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
-
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
-----
E
K
G
Y
R
--
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------------
89
PsiBlast_CBE
70.60
40%
-129
- C3 -
4F63
3
FGFR1_HUMAN
A:
[16-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---------------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
------------
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
100
PsiBlast_CBE
70.53
40%
-122
- C3 -
3RHX
2
B:
[16-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---------------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
-------------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
---------
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
40
PsiBlast_CBE
70.53
43%
-115
- C3 -
3EKN
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
-
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
------
L
R
P
E
A
-------
E
N
N
P
G
RP-
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
---
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
-------------------
85
PsiBlast_CBE
70.44
40%
-126
- C3 -
4F65
5
FGFR1_HUMAN
A:
[16-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
----------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
-----------
P
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
--------------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
82
PsiBlast_CBE
70.42
40%
-123
- C3 -
3TT0
4
B:
[65-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
-------------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
---------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
103
PsiBlast_CBE
70.25
40%
-118
- C3 -
3C4F
1
FGFR1_HUMAN
A:
[12-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
------------
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
76
PsiBlast_CBE
70.18
37%
-119
- C3 -
3HMI
1
ABL2_HUMAN
A:
[25-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-----
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-----
V
-
W
K
K
Y
--------------
S
----
L
T
V
A
V
K
T
L
K
-
E
-
D
-
T
-
M
--
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
--------------
C
N
R
E
E
V
T
A
V
---------
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
-
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
-----
E
K
G
Y
R
--
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------------
66
PsiBlast_CBE
70.09
39%
-119
- C3 -
1MQB
1
EPHA2_HUMAN
A:
[52-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
----
K
K
E
-------------------
V
P
V
A
I
K
T
L
K
-
A
-
G
Y
T
-
E
--
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
------
K
D
--------------
G
---
E
-
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
-----
S
N
L
V
C
K
V
S
D
F
G
L
------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
-
R
P
Y
W
E
-
L
S
N
H
E
V
M
K
A
I
-----
N
D
G
F
R
--
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------
102
PsiBlast_CBE
70.05
40%
-118
- C3 -
3C4F
1
B:
[12-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PNRV
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
------------
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
86
PsiBlast_CBE
69.99
40%
-125
- C3 -
4F64
3
B:
[16-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---------------------PNRV
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
-------------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
---------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
111
PsiBlast_CBE
69.72
38%
-111
- C3 -
2PWL
1
FGFR2_HUMAN
B:
[34-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
-
K
D
K
P
--------------
K
E
A
--
V
T
V
A
V
K
M
L
K
-
D
D
A
-
T
-
E
--
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------
R
R
P
P
G
---------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
---------------------
91
PsiBlast_CBE
69.60
40%
-126
- C3 -
2FGI
1
FGFR1_HUMAN
A:
[20-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---------------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
-----------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
----
D
I
H
H
I
D
-
Y
Y
K
K
T
-
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
92
PsiBlast_CBE
69.56
40%
-123
- C3 -
1FGI
1
B:
[20-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---------------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
-------------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
---------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
74
PsiBlast_CBE
69.53
37%
-121
- C3 -
4G2F
1
A:
[41-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
--
L
-
P
S
K
K
--------------
E
----
I
S
V
A
I
K
T
L
K
-
V
-
G
Y
T
-
E
--
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
------
H
D
A
Q
F
T
V
I
------------------
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
-----
S
N
L
V
C
K
V
S
D
F
G
L
S
R
VL------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
-
R
P
Y
W
E
-
M
S
N
Q
D
V
I
K
A
V
-----
D
E
G
Y
R
--
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--------
131
HHSearch
69.45
37%
-113
- C3 -
1OPK
3
ABL1_MOUSE
A:
[215-481]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-----
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
--------------
S
----
L
T
V
A
V
K
T
L
K
-
E
-
D
-
T
-
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------
C
N
R
-------------
Q
---
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
---
L
M
T
G
-
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
-
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
-----
E
K
D
Y
R
--
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------
83
PsiBlast_CBE
69.30
40%
-111
- C3 -
3TT0
1
FGFR1_HUMAN
A:
[65-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
---
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
78
PsiBlast_CBE
69.19
37%
-114
- C3 -
2XYN
4
ABL2_HUMAN
C:
[27-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-----
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-----
V
-
W
K
K
Y
--------------
S
----
L
T
V
A
V
K
T
L
K
-----
T
-
M
--
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
--------------
C
N
R
E
E
V
T
A
V
---------
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
-
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
-----
E
K
G
Y
R
--
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------------
94
PsiBlast_CBE
68.83
40%
-122
- C3 -
1AGW
1
B:
[20-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---------------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
-------------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
---------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
106
PsiBlast_CBE
68.76
40%
-116
- C3 -
3GQL
1
FGFR1_HUMAN
A:
[24-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
P
P
----------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
79
PsiBlast_CBE
68.70
37%
-116
- C3 -
2XYN
4
ABL2_HUMAN
B:
[26-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-----
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-----
V
-
W
K
K
Y
--------------
S
----
L
T
V
A
V
K
T
L
----
D
-
T
-
M
--
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
--------------
C
N
R
E
E
V
T
A
V
---------
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
-
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
-----
E
K
G
Y
R
--
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------------
88
PsiBlast_CBE
68.65
40%
-123
- C3 -
4F63
3
B:
[16-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
---------------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
-------------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
---------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
90
PsiBlast_CBE
68.62
40%
-116
- C3 -
2FGI
1
B:
[20-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---------------------PN
R
V
T
K
V
A
V
K
M
L
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------
R
R
-------------------Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
---------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
-------------------
80
PsiBlast_CBE
68.50
37%
-118
- C3 -
2XYN
2
ABL2_HUMAN
A:
[26-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-----
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-----
V
-
W
K
K
Y
--------------
S
----
L
T
V
A
V
K
T
L
----
D
-
T
-
M
--
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
--------------
C
N
R
E
E
V
T
A
V
---------
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
M
T
G
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
-
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
-----
E
K
G
Y
R
--
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
------------
109
PsiBlast_CBE
68.31
38%
-113
- C3 -
2PZP
1
B:
[34-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
G
-
K
-
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
-
K
D
K
P
--------------
K
E
A
--
V
T
V
A
V
K
M
L
K
-
D
D
A
-
T
-
E
--
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------
R
R
P
P
G
-----------
E
---
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
---------------------
110
PsiBlast_CBE
67.30
38%
-116
- C3 -
2PZP
1
FGFR2_HUMAN
A:
[34-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
G
-
K
-
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
-
K
D
K
P
--------------
K
E
A
--
V
T
V
A
V
K
M
L
K
-
D
D
A
-
T
-
E
--
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------
R
R
P
-------------
E
---
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
R
--
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
---------------------
124
HHSearch
66.72
34%
-118
- C3 -
4FYO
1
A:
[12-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
-
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
----
K
K
V
--------------
V
----
K
T
V
A
V
K
I
L
---------P-
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
------
N
R
------------------
H
-
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
---
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
-
K
P
Y
R
G
-
M
K
G
S
E
V
T
A
M
L
-----
E
K
G
E
R
--
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
------------
Add PDB User Result:
(80 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
143
-
100%
-131
- C3 -
U143
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
------
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
-------------------
144
-
100%
-130
- C3 -
U144
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
----
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
A
-----
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
V
L
G
145
-
100%
-135
- C3 -
U145
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
-------
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
--------
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
--------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
------
146
-
100%
-124
- C3 -
U146
1
A:
[502-784]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
-----
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
--
A
S
E
S
A
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
--------
A
G
G
E
D
V
A
P
G
-----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
------------
147
-
100%
-131
- C3 -
U147
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
------
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
-------------------
148
-
100%
-130
- C3 -
U148
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
----
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
A
-----
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
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M
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A
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
V
L
G
149
-
100%
-130
- C3 -
U149
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
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----
K
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A
K
L
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A
-----
A
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G
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A
R
L
Q
A
L
A
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A
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V
Y
L
D
V
L
G
150
-
100%
-130
- C3 -
U150
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
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G
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----
K
M
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A
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L
K
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H
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A
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L
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A
-----
A
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G
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L
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A
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A
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A
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R
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A
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A
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A
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P
V
Y
L
D
V
L
G
151
-
100%
-130
- C3 -
U151
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
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G
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L
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----
K
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H
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A
K
L
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A
-----
A
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G
P
L
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L
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A
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V
Y
L
D
V
L
G
152
-
100%
-138
- C3 -
U152
1
A:
[504-777]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
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R
R
D
I
V
L
K
W
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L
G
E
G
A
F
G
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-------
D
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------------------
M
L
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I
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D
V
-------------------
153
-
100%
-129
- C3 -
U153
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
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--
G
A
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--------
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--------
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------
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A
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A
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A
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P
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------
154
-
100%
-131
- C3 -
U154
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
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H
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------------
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D
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-------------------
155
-
100%
-131
- C3 -
U155
1
C:
[500-789]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
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------------
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----------------
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-------
156
-
100%
-131
- C3 -
U156
1
C:
[500-789]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
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------------
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-------
157
-
100%
-130
- C3 -
U157
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
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-----
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L
A
Q
A
P
P
V
Y
L
D
V
L
G
158
-
100%
-117
- C3 -
U158
1
B:
[507-778]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
---------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
------------------
159
-
98%
-122
- C3 -
U159
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-
D
A
K
L
G
E
D
-------
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
160
-
100%
-131
- C3 -
U160
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
------
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
-------------------
161
-
98%
-122
- C3 -
U161
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-
D
A
K
L
G
E
D
-------
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
162
-
98%
-122
- C3 -
U162
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-
D
A
K
L
G
E
D
-------
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
163
-
100%
-125
- C3 -
U163
1
D:
[504-782]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
----------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
--------------
164
-
100%
-135
- C3 -
U164
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
-------
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
--------
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
--------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
------
165
-
100%
-122
- C3 -
U165
1
A:
[504-785]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
---------------
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
------------
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
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C
I
T
Q
G
R
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L
E
R
P
R
A
C
P
P
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V
Y
A
I
M
R
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C
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Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
166
-
100%
-135
- C3 -
U166
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
-------
V
F
L
A
E
C
H
-------
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
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E
L
L
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L
Q
H
Q
H
I
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F
F
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C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
--------
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
----------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
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N
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A
I
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C
I
T
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G
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L
E
R
P
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A
C
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P
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V
Y
A
I
M
R
G
C
W
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R
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P
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Q
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S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
------
167
-
100%
-130
- C3 -
U167
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
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A
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G
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V
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L
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C
H
N
L
L
----
K
M
L
V
A
V
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A
L
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E
A
S
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S
A
R
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D
F
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L
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H
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H
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V
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F
F
G
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C
T
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L
L
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E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
A
-----
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
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L
H
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A
T
R
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C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
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R
W
M
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S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
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Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
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V
Y
A
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M
R
G
C
W
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R
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Q
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H
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I
K
D
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H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
V
L
G
168
-
98%
-122
- C3 -
U168
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
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A
V
K
A
L
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A
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L
L
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M
L
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H
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F
F
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C
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G
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L
L
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F
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Y
M
R
H
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D
L
N
R
F
L
R
S
H
G
-
D
A
K
L
G
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D
-------
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
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L
H
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L
A
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R
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C
L
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V
K
I
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F
G
M
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Y
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G
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R
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M
L
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M
P
P
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R
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F
T
T
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S
D
V
W
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F
G
V
V
L
W
E
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F
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Y
G
K
Q
P
W
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N
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A
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A
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C
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Q
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Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
169
-
98%
-122
- C3 -
U169
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
K
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A
S
E
S
A
R
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D
F
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A
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L
L
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M
L
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H
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H
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F
F
G
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C
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L
L
M
V
F
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Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-
D
A
K
L
G
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D
-------
P
L
G
L
G
Q
L
L
A
V
A
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Q
V
A
A
G
M
V
Y
L
A
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L
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F
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H
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D
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A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
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R
W
M
P
P
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S
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L
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R
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F
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W
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F
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V
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L
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Y
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C
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Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
170
-
98%
-122
- C3 -
U170
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
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D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
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L
L
T
M
L
Q
H
Q
H
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V
R
F
F
G
V
C
T
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G
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P
L
L
M
V
F
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Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-
D
A
K
L
G
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D
-------
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
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H
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A
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N
C
L
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G
Q
G
L
V
V
K
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G
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F
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M
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T
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Y
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R
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M
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A
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Q
Q
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H
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I
K
D
V
H
A
R
L
Q
A
L
A
-----------
171
-
100%
-123
- C3 -
U171
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
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-----
Q
D
K
M
L
V
A
V
K
A
L
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E
A
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-
A
R
Q
D
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R
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A
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L
L
T
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L
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H
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H
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V
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F
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C
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G
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L
L
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V
F
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Y
M
R
H
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D
L
N
R
F
L
R
S
H
G
-------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
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Q
V
A
A
G
M
V
Y
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A
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L
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F
V
H
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A
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N
C
L
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G
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V
K
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M
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-
D
Y
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G
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I
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D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
172
-
99%
-129
- C3 -
U172
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
E
--
Q
D
K
M
L
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A
V
K
A
L
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E
A
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S
A
R
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A
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L
L
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L
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H
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H
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F
F
G
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C
T
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R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
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M
V
Y
L
A
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L
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G
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V
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Y
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V
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R
G
C
W
Q
R
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Q
Q
R
H
S
I
K
D
V
-------------------
173
-
100%
-123
- C3 -
U173
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
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R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
H
-----
Q
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A
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A
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-
A
R
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A
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L
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H
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F
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M
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D
L
N
R
F
L
R
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H
G
-------------
P
G
P
L
G
L
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Q
L
L
A
V
A
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A
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V
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I
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-
D
Y
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R
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G
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A
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A
L
A
Q
A
P
P
-------
174
-
100%
-131
- C3 -
U174
1
C:
[500-789]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
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-
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D
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M
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------------
G
P
L
G
L
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L
L
A
V
A
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Q
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A
A
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V
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I
G
D
F
G
M
----------------
M
L
P
I
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W
M
P
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I
L
Y
R
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F
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I
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D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
175
-
100%
-130
- C3 -
U175
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
H
H
I
K
R
R
D
I
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L
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W
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L
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----
K
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A
-----
A
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G
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A
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A
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V
Y
L
D
V
L
G
176
-
100%
-122
- C3 -
U176
1
A:
[504-782]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
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V
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N
L
L
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A
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-----
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A
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A
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V
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---
M
L
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I
R
W
M
P
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I
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R
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F
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H
S
I
K
D
V
H
A
R
L
Q
--------------
177
-
100%
-123
- C3 -
U177
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
D
I
V
L
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W
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G
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V
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A
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C
H
-----
Q
D
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L
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A
L
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-
A
R
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N
R
F
L
R
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H
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-------------
P
G
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A
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M
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-
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W
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A
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C
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A
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Y
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I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
178
-
98%
-122
- C3 -
U178
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
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L
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-
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A
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-------
P
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L
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Q
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S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
179
-
98%
-122
- C3 -
U179
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
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A
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H
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-
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A
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-------
P
L
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L
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A
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A
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L
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C
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V
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I
K
D
V
H
A
R
L
Q
A
L
A
-----------
180
-
98%
-122
- C3 -
U180
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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H
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-
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A
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-------
P
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L
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A
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A
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I
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D
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H
A
R
L
Q
A
L
A
-----------
181
-
100%
-123
- C3 -
U181
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
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I
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L
K
W
E
L
G
E
G
A
F
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F
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A
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C
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-----
Q
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M
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D
L
N
R
F
L
R
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H
G
-------------
P
G
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L
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A
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A
A
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Q
A
L
A
Q
A
P
P
-------
182
-
98%
-122
- C3 -
U182
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
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I
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L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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L
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A
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-------
P
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A
R
L
Q
A
L
A
-----------
183
-
99%
-129
- C3 -
U183
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
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A
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--
Q
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------------
G
P
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A
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A
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H
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I
K
D
V
-------------------
184
-
98%
-122
- C3 -
U184
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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-------
P
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H
A
R
L
Q
A
L
A
-----------
185
-
100%
-123
- C3 -
U185
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
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R
R
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I
V
L
K
W
E
L
G
E
G
A
F
G
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V
F
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A
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C
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-----
Q
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A
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L
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-
A
R
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M
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H
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L
N
R
F
L
R
S
H
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-------------
P
G
P
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A
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A
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A
L
A
Q
A
P
P
-------
186
-
100%
-122
- C3 -
U186
1
A:
[504-782]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
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-----
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L
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V
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I
G
D
F
G
M
S
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D
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Y
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Y
Y
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V
G
G
R
T
M
L
P
I
R
W
M
P
P
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S
I
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Y
R
K
F
T
T
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S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
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A
I
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C
I
T
Q
G
R
E
L
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R
P
R
A
C
P
P
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V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
--------------
187
-
98%
-122
- C3 -
U187
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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L
L
P
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D
K
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L
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A
V
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L
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R
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-
D
A
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-------
P
L
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L
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A
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Q
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A
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Y
L
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A
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C
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Q
G
L
V
V
K
I
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F
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M
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T
D
Y
Y
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M
L
P
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W
M
P
P
E
S
I
L
Y
R
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F
T
T
E
S
D
V
W
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F
G
V
V
L
W
E
I
F
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Y
G
K
Q
P
W
Y
Q
L
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N
T
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A
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G
R
E
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A
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P
P
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Y
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C
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Q
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Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
188
-
100%
-123
- C3 -
U188
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
H
-----
Q
D
K
M
L
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A
V
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A
L
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E
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-
A
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L
L
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Y
M
R
H
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D
L
N
R
F
L
R
S
H
G
-------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
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Q
V
A
A
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M
V
Y
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A
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G
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V
K
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F
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-
D
Y
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R
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G
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M
P
P
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A
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S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
189
-
100%
-125
- C3 -
U189
1
D:
[504-782]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
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A
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C
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N
L
L
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M
L
V
A
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A
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F
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V
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M
R
H
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D
L
N
R
F
L
R
S
H
G
P
D
A
----------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
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C
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V
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I
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W
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F
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P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
--------------
190
-
98%
-122
- C3 -
U190
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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L
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H
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-
D
A
K
L
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-------
P
L
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L
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A
A
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M
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Y
L
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S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
191
-
100%
-131
- C3 -
U191
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
------
M
L
V
A
V
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A
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H
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------------
G
P
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H
S
I
K
D
V
-------------------
192
-
100%
-123
- C3 -
U192
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
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A
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C
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-----
Q
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A
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A
L
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-
A
R
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A
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L
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E
Y
M
R
H
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D
L
N
R
F
L
R
S
H
G
-------------
P
G
P
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G
L
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L
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A
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A
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Q
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A
A
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V
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A
R
L
Q
A
L
A
Q
A
P
P
-------
193
-
100%
-135
- C3 -
U193
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
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-------
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A
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--------
A
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L
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A
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A
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A
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A
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N
C
L
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G
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V
V
K
I
G
D
F
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M
S
--------------
T
M
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R
W
M
P
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E
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I
L
Y
R
K
F
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D
V
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A
R
L
Q
A
L
A
Q
A
P
P
V
------
194
-
98%
-122
- C3 -
U194
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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N
L
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F
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-
D
A
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-------
P
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I
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D
V
H
A
R
L
Q
A
L
A
-----------
195
-
100%
-123
- C3 -
U195
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
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A
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C
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-----
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A
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-
A
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D
L
N
R
F
L
R
S
H
G
-------------
P
G
P
L
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A
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A
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A
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M
V
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-
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I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
196
-
98%
-122
- C3 -
U196
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
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L
L
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K
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V
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A
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S
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L
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H
Q
H
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-
D
A
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-------
P
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A
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A
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Y
L
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C
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Y
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M
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M
P
P
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S
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L
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R
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F
T
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V
W
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F
G
V
V
L
W
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Y
G
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N
T
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A
I
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C
I
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R
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A
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P
P
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Y
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C
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Q
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Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
197
-
100%
-131
- C3 -
U197
1
C:
[500-789]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
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N
L
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-
Q
D
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L
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F
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Y
M
R
H
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L
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L
R
S
H
G
P
D
------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
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A
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R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
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T
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S
D
V
W
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F
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V
V
L
W
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F
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Q
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S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
198
-
98%
-122
- C3 -
U198
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
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L
L
P
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V
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-
D
A
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-------
P
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L
G
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I
K
D
V
H
A
R
L
Q
A
L
A
-----------
199
-
100%
-131
- C3 -
U199
1
C:
[500-789]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
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L
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-
Q
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M
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F
L
R
S
H
G
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D
------------
G
P
L
G
L
G
Q
L
L
A
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A
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A
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V
Y
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A
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R
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C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
----------------
M
L
P
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R
W
M
P
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I
L
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R
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D
V
H
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Q
A
L
A
Q
A
P
P
-------
200
-
98%
-122
- C3 -
U200
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
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D
A
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-------
P
L
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L
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L
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L
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A
R
L
Q
A
L
A
-----------
201
-
100%
-124
- C3 -
U201
1
A:
[504-777]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
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W
E
L
G
E
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F
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-------
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H
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I
K
D
V
-------------------
202
-
100%
-135
- C3 -
U202
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
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K
R
R
D
I
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L
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W
E
L
G
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G
A
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-------
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M
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F
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H
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P
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A
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--------
A
P
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L
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L
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Q
L
L
A
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A
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A
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G
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V
V
K
I
G
D
F
G
M
S
--------------
T
M
L
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W
M
P
P
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I
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Y
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K
D
V
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A
R
L
Q
A
L
A
Q
A
P
P
V
------
203
-
98%
-122
- C3 -
U203
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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-------
P
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D
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H
A
R
L
Q
A
L
A
-----------
204
-
100%
-125
- C3 -
U204
1
D:
[504-782]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
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L
G
E
G
A
F
G
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A
----------
P
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V
H
A
R
L
Q
--------------
205
-
100%
-129
- C3 -
U205
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
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R
D
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V
L
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W
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--
G
A
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--------
K
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H
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--------
A
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L
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A
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A
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L
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V
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I
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G
M
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R
D
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------
G
G
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W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
------
206
-
100%
-119
- C3 -
U206
1
A:
[493-790]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
F
S
D
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
--------
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
------
207
-
98%
-122
- C3 -
U207
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
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R
E
A
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L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-
D
A
K
L
G
E
D
-------
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
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V
Y
A
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M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
-----------
208
-
100%
-131
- C3 -
U208
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
------
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
-------------------
209
-
100%
-124
- C3 -
U209
1
A:
[504-777]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
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S
A
R
Q
D
F
Q
R
E
A
E
L
L
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M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
-------
D
V
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
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Y
S
T
D
Y
Y
R
V
G
-
R
T
M
L
P
I
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W
M
P
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F
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D
V
W
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F
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V
V
L
W
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G
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P
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L
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N
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A
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R
P
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A
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P
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Y
A
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M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
-------------------
210
-
100%
-124
- C3 -
U210
1
A:
[504-777]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
H
N
L
L
P
E
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D
K
M
L
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A
V
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A
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E
A
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A
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A
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L
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L
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M
V
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R
H
G
D
L
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R
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L
R
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H
G
P
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A
-------
D
V
A
P
G
P
L
G
L
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Q
L
L
A
V
A
S
Q
V
A
A
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M
V
Y
L
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G
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H
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A
T
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N
C
L
V
G
Q
G
L
V
V
K
I
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F
G
M
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T
D
Y
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R
V
G
-
R
T
M
L
P
I
R
W
M
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P
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L
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F
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D
V
W
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F
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V
V
L
W
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P
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A
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R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
-------------------
211
-
100%
-135
- C3 -
U211
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
-------
V
F
L
A
E
C
H
-------
K
M
L
V
A
V
K
A
L
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E
A
S
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S
A
R
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A
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L
L
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M
L
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C
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G
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P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
--------
A
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
----------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
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V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
------
212
-
100%
-131
- C3 -
U212
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
------
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
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D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
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M
L
P
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M
P
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E
S
I
L
Y
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F
T
T
E
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D
V
W
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F
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V
V
L
W
E
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F
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Y
G
K
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P
W
Y
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N
T
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A
I
D
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R
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L
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P
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A
C
P
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V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
-------------------
213
-
100%
-123
- C3 -
U213
1
A:
[503-789]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
-----
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
-
A
R
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D
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E
A
E
L
L
T
M
L
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H
Q
H
I
V
R
F
F
G
V
C
T
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G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
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N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
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M
S
R
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Y
S
-
D
Y
Y
R
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G
G
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M
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P
E
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I
L
Y
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F
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D
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W
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F
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V
V
L
W
E
I
F
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Y
G
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P
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Q
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A
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C
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A
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Y
A
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M
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S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
214
-
100%
-117
- C3 -
U214
1
B:
[507-778]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
---------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
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D
Y
Y
R
V
G
G
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M
L
P
I
R
W
M
P
P
E
S
I
L
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R
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F
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T
E
S
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V
W
S
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V
V
L
W
E
I
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Y
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K
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P
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Y
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R
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L
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V
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A
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R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
------------------
215
-
98%
-122
- C3 -
U215
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
E
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D
K
M
L
V
A
V
K
A
L
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E
A
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E
S
A
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D
F
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R
E
A
E
L
L
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L
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H
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H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
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D
L
N
R
F
L
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-
D
A
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-------
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D
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A
R
L
Q
A
L
A
-----------
216
-
100%
-131
- C3 -
U216
1
A:
[507-777]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
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N
L
------
M
L
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A
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------------
G
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I
K
D
V
-------------------
217
-
100%
-129
- C3 -
U217
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
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R
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L
K
W
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L
--
G
A
F
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--------
K
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--------
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------
G
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A
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A
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P
V
------
218
-
100%
-124
- C3 -
U218
1
A:
[504-777]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
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L
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I
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D
V
-------------------
219
-
100%
-132
- C3 -
U219
1
A:
[502-789]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
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V
L
K
W
E
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------
K
V
F
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--------------
P
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--
D
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----
R
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A
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A
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P
-------
220
-
98%
-122
- C3 -
U220
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
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K
W
E
L
G
E
G
A
F
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-
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-------
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I
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A
R
L
Q
A
L
A
-----------
221
-
98%
-122
- C3 -
U221
1
A:
[507-785]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
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L
K
W
E
L
G
E
G
A
F
G
K
V
F
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H
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-
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A
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-------
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A
R
L
Q
A
L
A
-----------
222
-
100%
-135
- C3 -
U222
1
A:
[502-790]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
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C
H
N
------
K
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A
V
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A
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A
S
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A
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L
N
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F
L
R
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H
G
P
D
A
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------------
L
G
L
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L
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A
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A
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A
A
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L
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G
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V
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K
I
G
D
F
----------------
R
T
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I
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W
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P
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I
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V
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V
L
W
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A
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A
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A
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P
V
------