@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NTRK2_HUMAN: (2013-07-24 )
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Atome Classification :
(86 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520......--.530.......540.-.......550.......-560...--------------.----...570..-.-.-.-.-.--580.......590...-....600.......610.......620.......630---.......640---..----...--..650.......660.......670.......680..---.---..-----..690.......--700...-....710.......720....--...730.......740.......750.....-...760....-----...770...---......780.......790.......800.......810--.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDT--FVQHIKRHNIVLK-R-ELGEGAFGKVFLAECYN-LCPEQD--------------K----ILVAVKTL-K-D-A-S-D--NARKDFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAH---GPDAVLMAEG---NP----PTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---G---EN-----LLVKIGDFGMSR--DVYSTD-YYRVGGHTMLPIRWMPPESIM--YRKFTTESDVWSLGVVLWEIFTYGK-QPWYQ-LSNNEVIECI-----TQGR--VLQ---RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAK--ASPVYLDILG
1
PsiBlast_PDB
97.21
100%
-126
- C2 -
4AT3
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
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--
F
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2
PsiBlast_PDB
95.91
100%
-129
- C2 -
4AT4
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
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--
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3
PsiBlast_PDB
94.62
100%
-124
- C2 -
4AT5
2
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
--
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21
PsiBlast_CBE
89.57
73%
-124
- C2 -
4AOJ
1
C:
[33-322]
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A
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C
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-------
4
PsiBlast_PDB
88.97
82%
-127
- C2 -
3V5Q
1
NTRK3_HUMAN
A:
[9-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
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------
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22
PsiBlast_CBE
88.09
73%
-125
- C2 -
4AOJ
1
NTRK1_HUMAN
B:
[33-324]
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121
HHSearch
88.02
73%
-128
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
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T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
-----
T
Q
G
R
--
E
L
E
---
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
P
P
-------
75
PsiBlast_CBE
79.27
37%
-120
- C2 -
1MQB
1
B:
[35-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LK
F
T
T
E
I
H
P
S
C
V
T
R
Q
-
K
-
V
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
L
K
-
T
----
K
--------------
E
----
V
P
V
A
I
K
T
L
-
K
-
A
-
G
Y
T
-
E
--
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
---
D
-------------------
G
E
--
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
---
S
N
-----
L
V
C
K
V
S
D
F
G
L
S
R
VL-------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
--
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
-
R
P
Y
W
E
-
L
S
N
H
E
V
M
K
A
I
-----
N
D
G
F
--
R
L
P
---
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
--
A
---------
68
PsiBlast_CBE
78.88
38%
-122
- C2 -
3DZQ
1
A:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
---
L
P
S
K
K
--------------
E
----
I
S
V
A
I
K
T
L
-
K
-
V
-
G
Y
T
-
E
--
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
-----
D
A
-----------------
Q
--
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
---
S
N
-----
L
V
C
K
V
S
D
F
G
L
---------------------
P
I
R
W
T
S
P
E
A
I
A
--
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
-
R
P
Y
W
E
-
M
S
N
Q
D
V
I
K
A
V
-----
D
E
G
Y
--
R
L
P
---
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
---
N
P
--
L
K
I
I
-
67
PsiBlast_CBE
78.06
38%
-119
- C2 -
4G2F
1
A:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
---
L
P
S
K
K
--------------
E
----
I
S
V
A
I
K
T
L
-
K
-
V
-
G
Y
T
-
E
--
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
-----
D
A
-----------------
Q
--
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
---
S
N
-----
L
V
C
K
V
S
D
F
G
L
S
R
VL-----------------
P
I
R
W
T
S
P
E
A
I
A
--
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
-
R
P
Y
W
E
-
M
S
N
Q
D
V
I
K
A
V
-----
D
E
G
Y
--
R
L
P
---
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
---
N
P
G
S
L
K
I
I
-
10
PsiBlast_PDB
77.56
47%
-117
- C2 -
4BKJ
10
?
A:
[9-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
-
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----
P
Q
D
LVSLDFPLNVRKG
H
P
----
L
L
V
A
V
K
I
L
-
R
P
D
-
A
-
T
-
K
--
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
---
Q
L
E
D
---------------
P
T
---
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
---
E
N
-----
F
T
I
K
I
A
D
F
G
M
S
R
--
N
L
Y
A
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
--
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
---
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------
23
PsiBlast_CBE
77.47
47%
-113
- C2 -
4BKJ
10
?
B:
[9-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
-
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----
P
Q
D
LVSLDFPLNVRKG
H
P
----
L
L
V
A
V
K
I
L
-
R
P
D
-
A
-
T
-
K
--
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
---
Q
L
E
D
K
----------G---
P
T
---
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
---
E
N
-----
F
T
I
K
I
A
D
F
G
M
S
R
--
N
L
Y
A
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
--
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
---
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------
24
PsiBlast_CBE
77.34
47%
-107
- C2 -
3ZOS
3
B:
[9-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
-
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----
P
Q
D
LVSLDFPLNVRKG
H
P
----
L
L
V
A
V
K
I
L
-
R
P
D
-
A
-
T
-
K
--
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
---
Q
L
E
D
K
----------Q
G
--
P
T
---
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
---
E
N
-----
F
T
I
K
I
A
D
F
G
M
S
R
--
N
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
--
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
---
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------
102
PsiBlast_CBE
77.32
36%
-114
- C2 -
3GQL
1
FGFR1_HUMAN
B:
[15-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
-----------
P
----
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
-------------------
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
------
139
HHSearch
76.70
34%
-108
- C2 -
4FL3
1
KSYK_HUMAN
A:
[365-630]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
R
K
L
L
T
L
E
-
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
----
K
K
V
--------------
V
----
K
T
V
A
V
K
I
L
-
K
-
N
-
E
-
A
-
N
DP
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
---
R
--------------------
H
--
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
---
T
Q
-----
H
Y
A
K
I
S
D
F
G
L
S
K
--
A
L
R
A
-------------
P
V
K
W
Y
A
P
E
C
I
N
--
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
-
K
P
Y
R
G
-
M
K
G
S
E
V
T
A
M
L
-----
E
K
G
E
--
R
M
G
---
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
-------------
9
PsiBlast_PDB
76.62
47%
-111
- C2 -
3ZOS
4
DDR1_HUMAN
A:
[9-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
-
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----
P
Q
D
LVSLDFP
L
N
V
R
KG
H
P
----
L
L
V
A
V
K
I
L
-
R
P
D
-
A
-
T
-
K
--
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
---
Q
L
E
D
-----------AAQ
G
P
T
---
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
---
E
N
-----
F
T
I
K
I
A
D
F
G
M
S
R
--
N
L
Y
A
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
--
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
---
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------
76
PsiBlast_CBE
75.58
37%
-120
- C2 -
1MQB
1
EPHA2_HUMAN
A:
[38-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
-
K
-
V
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
L
K
-
T
---
K
K
--------------
E
----
V
P
V
A
I
K
T
L
-
K
-
A
-
G
Y
T
-
E
--
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
---
D
-------------------
G
E
--
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
---
S
N
-----
L
V
C
K
V
S
D
F
G
L
-----------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
--
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
-
R
P
Y
W
E
-
L
S
N
H
E
V
M
K
A
I
-----
N
D
G
F
--
R
L
P
---
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
--
A
---------
103
PsiBlast_CBE
75.31
36%
-114
- C2 -
3GQL
1
FGFR1_HUMAN
A:
[15-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
-----------------
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
---------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
L
D
L
--
14
PsiBlast_PDB
75.28
44%
-111
- C2 -
3ETA
1
INSR_HUMAN
A:
[12-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
-
I
I
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
-
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
A
E
-
N
N
P
G
---
R
P
----
P
P
T
--
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
--
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
---
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
---------------
80
PsiBlast_CBE
74.62
39%
-111
- C2 -
2IVS
5
RET_HUMAN
A:
[22-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
G
-
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
-
L
K
G
R
A
G
--------------
Y
----
T
T
V
A
V
K
M
L
-
K
-
E
N
A
-
S
-
P
--
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
G
P
G
Y
L
-----------------RA
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
-----
R
K
M
K
I
S
D
F
G
L
S
R
--
D
V
Y
E
E
D
-
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
--
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
-
N
P
Y
P
G
-
I
P
P
E
R
L
F
N
L
L
-----
K
T
G
H
--
R
M
E
---
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
--------------
34
PsiBlast_CBE
74.48
43%
-114
- C2 -
1I44
1
A:
[9-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
-
I
I
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
-
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
A
E
-
N
N
P
G
---
R
P
----
P
P
T
--
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
-----
F
T
V
K
I
G
D
F
G
M
T
-------------------
L
P
V
R
W
M
A
P
E
S
L
K
--
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
---
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
---------------
33
PsiBlast_CBE
74.48
44%
-122
- C2 -
3EKK
1
A:
[14-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
-
I
I
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
-
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
A
E
-
N
N
P
G
---
R
P
----
P
P
T
--
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
---
H
D
-----
F
T
V
K
I
G
D
F
---------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
--
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
---
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
---------------
25
PsiBlast_CBE
74.10
44%
-111
- C2 -
3ETA
1
B:
[12-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
-
I
I
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
-
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
A
E
-
N
N
P
G
---
R
P
----
P
P
T
--
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
--
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
---
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
---------------
101
PsiBlast_CBE
73.93
36%
-120
- C2 -
3GQL
1
C:
[15-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
-----------------
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
-------------------
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
-----
125
HHSearch
73.76
40%
-121
* C2 *
4I4E
1
A:
[11-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
-
R
-
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
---
M
S
P
-
N
P
--------------
A
----
L
A
V
A
I
K
T
C
-
K
-
N
C
T
-
S
-
D
--
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
---
K
-------------------
Y
S
--
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
---
S
N
-----
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
--
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
-
K
P
F
Q
G
-
V
K
N
N
D
V
I
G
R
I
-----
E
N
G
E
--
R
L
P
---
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
------------
133
HHSearch
73.53
35%
-111
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[331-598]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
R
D
N
L
L
I
A
-
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
----
R
K
K
--------------
Q
----
I
D
V
A
I
K
V
L
-
K
-
Q
-
G
-
T
E
K
--
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
---
R
-------------------
E
E
--
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
---
V
---
N
R
-----
H
Y
A
K
I
S
D
F
G
L
S
K
--
A
L
G
--------------
P
L
K
W
Y
A
P
E
C
I
N
--
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
-
K
P
Y
K
K
-
M
K
G
P
E
V
M
A
F
I
-----
E
Q
G
K
--
R
M
E
---
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
------------
38
PsiBlast_CBE
73.43
43%
-111
- C2 -
3LW0
2
IGF1R_HUMAN
A:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
------------
P
----
P
S
-----
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
46
PsiBlast_CBE
73.30
42%
-120
- C2 -
4DCE
1
B:
[31-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
----
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
83
PsiBlast_CBE
73.23
37%
-120
- C2 -
1FGI
1
B:
[6-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
--------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
--------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
37
PsiBlast_CBE
73.14
43%
-111
- C2 -
3LW0
3
IGF1R_HUMAN
B:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
------------
P
----
P
S
-----
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
35
PsiBlast_CBE
73.10
43%
-109
- C2 -
3LW0
2
D:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
------------
P
----
P
S
-----
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
19
PsiBlast_PDB
73.05
44%
-115
- C2 -
3NW5
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
M
----
E
N
---
N
P
V
L
A
-
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
140
HHSearch
72.96
42%
-107
- C2 -
3L9P
4
A:
[66-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
------
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
------
P
---
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
R
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
--------
108
PsiBlast_CBE
72.83
38%
-121
- C2 -
3RHX
4
FGFR1_HUMAN
A:
[13-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
----------------
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
129
HHSearch
72.81
40%
-115
- C2 -
3CBL
3
A:
[110-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
-
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
------
A
D
--------------
N
----
T
L
V
A
V
K
S
C
-
R
-
E
-
T
L
P
-
P
--
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
---
G
A
-------------------
R
--
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
---
E
K
-----
N
V
L
K
I
S
D
F
G
M
S
R
--
E
E
A
D
G
V
-
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
--
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
-
S
P
Y
P
N
-
L
S
N
Q
Q
T
R
E
F
V
-----
E
K
G
G
--
R
L
P
---
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
--
R
---------
16
PsiBlast_PDB
72.71
44%
-114
- C2 -
3I81
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
-----
E
N
---
N
P
V
L
A
-
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
36
PsiBlast_CBE
72.55
43%
-111
- C2 -
3LW0
3
IGF1R_HUMAN
C:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
------------
P
----
P
S
-----
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
27
PsiBlast_CBE
72.08
44%
-112
- C2 -
3NW7
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
M
----
E
N
---
N
P
V
L
A
-
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
92
PsiBlast_CBE
72.07
37%
-122
- C2 -
4F63
3
FGFR1_HUMAN
A:
[8-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
-----
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
----------------
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
20
PsiBlast_PDB
71.82
44%
-113
- C2 -
3NW6
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
M
----
E
N
---
N
P
VLA-
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
47
PsiBlast_CBE
71.78
42%
-115
- C2 -
4DCE
1
ALK_HUMAN
A:
[31-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
------
P
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
-----------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
49
PsiBlast_CBE
71.71
42%
-118
- C2 -
2XB7
1
A:
[16-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
----------------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
-----------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
86
PsiBlast_CBE
71.70
37%
-121
- C2 -
1AGW
1
FGFR1_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
-----
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
----------------
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
32
PsiBlast_CBE
71.69
44%
-111
- C2 -
3EKN
1
A:
[14-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
-
I
I
K
G
E
A
--------------
E
----
T
R
V
A
V
K
T
V
-
N
-
E
S
A
-
S
-
L
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
A
E
-
N
N
P
G
---
R
P
----
P
P
T
--
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
---
H
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
--
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
---
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
---------------
30
PsiBlast_CBE
71.69
44%
-115
- C2 -
3QQU
1
IGF1R_HUMAN
B:
[4-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
-------------------
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
56
PsiBlast_CBE
71.37
42%
-114
- C2 -
4FOC
1
A:
[51-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
78
PsiBlast_CBE
71.33
37%
-116
- C2 -
3TT0
4
B:
[52-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
--------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
--------------------
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
87
PsiBlast_CBE
71.32
37%
-120
- C2 -
4F65
4
B:
[4-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
-----------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
-------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
---------
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
45
PsiBlast_CBE
71.26
42%
-110
- C2 -
4FOD
2
A:
[31-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
84
PsiBlast_CBE
71.20
37%
-117
- C2 -
1FGI
1
FGFR1_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
----------------
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
130
HHSearch
71.00
39%
-110
- C2 -
1OPK
3
ABL1_MOUSE
A:
[215-481]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
-
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
--------------
S
----
L
T
V
A
V
K
T
L
-
K
-
E
-
D
-
T
-
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
---
N
R
------------------
Q
E
--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
---
E
N
-----
H
L
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
-
D
-
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
-
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
-----
E
K
D
Y
--
R
M
E
---
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--
E
S
S
-------
57
PsiBlast_CBE
70.84
42%
-113
- C2 -
4FOB
1
A:
[51-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
----------------
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
R
A
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
107
PsiBlast_CBE
70.75
38%
-123
- C2 -
3RHX
2
B:
[13-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
--------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
--------
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
61
PsiBlast_CBE
70.62
41%
-114
- C2 -
4ANS
1
A:
[39-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
-----------------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
A
D
F
G
M
A
R
--
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
58
PsiBlast_CBE
70.51
41%
-119
- C2 -
4FNY
1
A:
[25-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
---------------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
----------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
-------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
18
PsiBlast_PDB
70.50
44%
-113
- C2 -
2OJ9
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
A
S
-
M
--
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
----------------
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
89
PsiBlast_CBE
70.47
37%
-122
- C2 -
4F64
3
B:
[5-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PNRV
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
--------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
--------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
99
PsiBlast_CBE
70.42
36%
-114
- C2 -
2PZP
1
B:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
P
E
D
--
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
-
P
L
------
Q
V
V
M
A
E
A
V
G
-
I
D
K
D
K
P
--------------
K
E
A
--
V
T
V
A
V
K
M
L
-
K
-
D
D
A
-
T
-
E
--
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
---
R
P
P
G
---------------
E
E
Q
--
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
N
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
95
PsiBlast_CBE
70.29
37%
-113
- C2 -
3JS2
1
B:
[11-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
K
D
--------------
K
PNR
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
-----------------
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
48
PsiBlast_CBE
70.28
42%
-122
- C2 -
2XBA
1
A:
[16-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
-------
V
Y
E
G
Q
V
S
----------------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
-----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
44
PsiBlast_CBE
70.27
42%
-114
- C2 -
4FNZ
1
A:
[25-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
------
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
82
PsiBlast_CBE
70.24
37%
-121
- C2 -
2FGI
1
FGFR1_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
-----
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
---
D
I
H
H
I
D
-
Y
Y
K
K
T
-
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
96
PsiBlast_CBE
70.13
37%
-116
- C2 -
3JS2
1
FGFR1_HUMAN
A:
[16-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
G
L
-----H--
N
P
----
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
91
PsiBlast_CBE
70.05
37%
-119
- C2 -
4F63
3
B:
[5-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
--------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
--------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
60
PsiBlast_CBE
70.01
41%
-113
- C2 -
4ANQ
1
A:
[39-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
-----------------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
A
D
F
G
M
A
R
--
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
97
PsiBlast_CBE
69.95
36%
-117
- C2 -
2PZ5
1
B:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
P
E
D
--
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
-
P
L
------
Q
V
V
M
A
E
A
V
G
-
I
D
K
D
K
P
--------------
K
EA--
V
T
V
A
V
K
M
L
-
K
-
D
D
A
-
T
-
E
--
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
---
R
P
P
-----------------
E
Q
--
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
N
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
104
PsiBlast_CBE
69.89
36%
-111
- C2 -
2PWL
1
FGFR2_HUMAN
B:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
P
E
D
--
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
-
I
D
K
D
K
P
--------------
K
E
A
--
V
T
V
A
V
K
M
L
-
K
-
D
D
A
-
T
-
E
--
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
---
R
P
P
G
----------------
E
Q
--
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
N
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
55
PsiBlast_CBE
69.69
42%
-114
- C2 -
2YFX
1
A:
[24-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
-----------------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
98
PsiBlast_CBE
69.51
36%
-116
- C2 -
2PZ5
1
FGFR2_HUMAN
A:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
P
E
D
--
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
-
P
L
------
Q
V
V
M
A
E
A
V
G
-
I
D
K
D
K
P
--------------
K
E
A
--
V
T
V
A
V
K
M
L
-
K
-
D
D
A
-
T
-
E
--
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
---
R
P
-----------------
E
E
Q
--
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
N
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
88
PsiBlast_CBE
69.45
37%
-123
- C2 -
4F65
6
FGFR1_HUMAN
A:
[8-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
----------------
K
PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
-----------
P
----
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
-------------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
54
PsiBlast_CBE
69.23
42%
-105
- C2 -
3LCS
3
A:
[42-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
-
M
P
N
D
P
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
R
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
------------------------
52
PsiBlast_CBE
69.07
42%
-110
- C2 -
3AOX
5
A:
[41-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
S
----------------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---------------------
28
PsiBlast_CBE
68.98
44%
-113
- C2 -
3QQU
1
D:
[4-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
M
-----------LA--
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
105
PsiBlast_CBE
68.83
36%
-110
- C2 -
2PWL
1
FGFR2_HUMAN
A:
[23-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
-
P
E
D
--
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
-
I
D
K
D
K
P
--------------
K
E
A
--
V
T
V
A
V
K
M
L
-
K
-
D
D
A
-
T
-
E
--
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
---
R
P
------------------
E
Q
--
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
N
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
100
PsiBlast_CBE
68.80
36%
-115
- C2 -
2PZP
1
FGFR2_HUMAN
A:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
P
E
D
--
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
-
P
L
------
Q
V
V
M
A
E
A
V
G
-
I
D
K
D
K
P
--------------
K
E
A
--
V
T
V
A
V
K
M
L
-
K
-
D
D
A
-
T
-
E
--
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
---
R
P
-----------------
E
E
Q
--
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
N
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
N
N
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
I
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
26
PsiBlast_CBE
68.76
44%
-114
- C2 -
1JQH
1
IGF1R_HUMAN
B:
[11-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
-----------------
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
----------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
53
PsiBlast_CBE
68.43
42%
-101
- C2 -
3LCT
3
A:
[42-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
-
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
-
M
P
N
D
P
S
--------------
P
----
L
Q
V
A
V
K
T
L
-
P
-
E
-
V
C
S
-
E
--
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
---
R
P
R
P
---------
S
Q
----
P
S
S
--
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
-----
R
V
A
K
I
G
D
F
G
M
A
R
--
D
I
Y
R
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
-
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
-----
T
S
G
G
--
R
M
D
---
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
------------------------
85
PsiBlast_CBE
68.35
37%
-120
- C2 -
1AGW
1
B:
[6-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
--------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
--------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
31
PsiBlast_CBE
68.29
44%
-117
- C2 -
3QQU
1
IGF1R_HUMAN
A:
[6-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
------------------
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
81
PsiBlast_CBE
67.96
37%
-117
- C2 -
2FGI
1
B:
[6-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--------------------PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
--------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
--------
D
-
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
79
PsiBlast_CBE
67.77
37%
-110
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[54-343]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
-
P
E
D
--
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
-
L
--
D
K
D
--------------
K
PN
R
V
T
K
V
A
V
K
M
L
-
K
S
D
-
A
-
T
-
E
--
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
---
R
P
P
G
L
E
Y
S
Y
N
PSH
N
P
----
E
E
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
-----
N
V
M
K
I
A
D
F
G
L
A
R
--
D
I
H
H
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
-
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
-----
K
E
G
H
--
R
M
D
---
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------
123
HHSearch
67.45
35%
-117
- C2 -
4FYO
1
A:
[12-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
-
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
----
K
K
V
--------------
V
----
K
T
V
A
V
K
I
L
----------P-
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
---
R
H
----------------------
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
---
T
Q
-----
H
Y
A
K
I
S
D
F
G
L
S
K
--
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
--
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
-
K
P
Y
R
G
-
M
K
G
S
E
V
T
A
M
L
-----
E
K
G
E
--
R
M
G
---
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
--------------
29
PsiBlast_CBE
67.33
44%
-112
- C2 -
3QQU
1
IGF1R_HUMAN
C:
[4-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
M
-----------VLA-
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
E
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
12
PsiBlast_PDB
67.07
43%
-116
- C2 -
3LVP
2
IGF1R_HUMAN
A:
[39-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
--
E
V
A
R
E
K
I
T
M
S
-
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
-
V
V
K
D
E
P
--------------
E
----
T
R
V
A
I
K
T
V
-
N
-
E
-
A
-
A
-
S
M-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
---
R
P
E
M
----
E
-----
P
VLA-
P
P
S
--
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
-----
F
T
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
--
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
---
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
---------------------------
77
PsiBlast_CBE
65.85
41%
-106
- C2 -
3ZBF
1
?
A:
[32-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
L
T
L
R
-
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
L
G
V
G
S
G
--------------
E
----
I
K
V
A
V
K
T
L
-
K
-
K
-
G
-
S
T
D
--
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
--------
A
R
M
A
T
F
---
Y
G
----
P
L
L
--
T
L
V
D
L
V
D
L
C
V
D
-
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
---
V
K
DYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
--
D
I
Y
-------------
L
P
V
R
W
M
A
P
E
S
L
M
--
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
-
Q
P
Y
P
A
-
H
S
N
L
D
V
L
N
Y
V
-----
Q
T
G
G
--
R
L
E
---
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
----------------
131
HHSearch
59.73
32%
-106
- C2 -
4ITJ
1
RIPK1_HUMAN
A:
[12-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
S
S
D
F
L
E
----------
F
G
K
V
S
L
A
F
H
R
------
T
Q
--------------
G
-----
L
M
I
M
K
T
V
Y
K
-
G
-
P
N
C
-
I
--
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
---
M
S
----------------------
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
---
D
---
N
D
-----
F
H
I
K
I
A
D
L
G
L
A
S
--
F
K
M
W
S
K
-
L
N
-------
G
T
L
Y
Y
M
A
P
E
H
L
N
DV
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
K
-
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
-----
K
S
G
N
--
R
P
D
VDD
I
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
---------------
Add PDB User Result:
(92 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
142
-
99%
-125
- C2 -
U142
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
------
I
L
V
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N
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F
H
R
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A
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L
L
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L
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M
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---------
P
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L
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L
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V
V
L
W
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P
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N
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L
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L
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C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
143
-
100%
-120
- C2 -
U143
1
A:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
F
--
H
I
K
R
H
N
I
V
L
K
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L
G
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G
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M
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A
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----
A
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G
N
P
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L
--
S
Q
M
L
H
I
A
Q
Q
I
A
A
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M
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Y
L
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T
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N
C
L
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N
L
L
V
K
I
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F
G
M
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V
Y
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T
D
Y
Y
R
V
G
---
M
L
P
I
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W
M
P
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M
Y
R
K
F
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V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
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Y
Q
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Q
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V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
144
-
100%
-129
- C2 -
U144
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
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F
L
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C
Y
N
L
C
----
K
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A
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A
---
P
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A
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L
L
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N
L
A
K
A
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P
V
Y
L
D
I
L
G
145
-
100%
-129
- C2 -
U145
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
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L
G
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Y
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----
K
I
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N
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H
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L
L
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L
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G
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M
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A
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A
V
L
M
A
---
P
P
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L
L
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N
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Y
L
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I
L
G
146
-
100%
-129
- C2 -
U146
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
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L
G
E
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N
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----
K
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L
L
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A
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A
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A
---
P
P
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L
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Y
L
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I
L
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147
-
100%
-129
- C2 -
U147
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
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L
G
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F
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Y
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----
K
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A
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A
---
P
P
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L
L
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Y
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L
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148
-
100%
-129
- C2 -
U148
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
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K
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H
N
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----
K
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A
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A
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A
---
P
P
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L
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N
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Y
L
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I
L
G
149
-
99%
-125
- C2 -
U149
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
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L
K
R
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L
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A
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C
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N
L
------
I
L
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---------
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C
W
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K
N
I
K
G
I
-------------------
150
-
100%
-130
- C2 -
U150
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
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H
N
I
V
L
K
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E
L
G
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G
A
F
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Y
-------
K
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A
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A
------
N
P
P
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L
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--------------
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T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
151
-
100%
-129
- C2 -
U151
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
152
-
99%
-125
- C2 -
U152
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
------
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
---------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
153
-
100%
-129
- C2 -
U153
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
154
-
100%
-130
- C2 -
U154
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
-------
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
------
N
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
--------------
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
155
-
100%
-129
- C2 -
U155
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
156
-
100%
-129
- C2 -
U156
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
157
-
100%
-133
- C2 -
U157
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
P
E
Q
D
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
-
M
A
E
G
N
P
P
T
E
L
--
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
------------------
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
-------------
158
-
100%
-129
- C2 -
U158
1
B:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
----
K
V
F
L
A
E
C
Y
------
D
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
------
N
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
---------------
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
159
-
100%
-129
- C2 -
U159
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
160
-
100%
-129
- C2 -
U160
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
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Y
L
A
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Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
161
-
100%
-129
- C2 -
U161
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
162
-
100%
-129
- C2 -
U162
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
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T
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V
W
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L
G
V
V
L
W
E
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F
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Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
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C
P
Q
E
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Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
163
-
100%
-130
- C2 -
U163
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
-------
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
------
N
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
--------------
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
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Y
G
K
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P
W
Y
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N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
164
-
99%
-125
- C2 -
U164
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
------
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
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H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
---------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
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H
F
V
H
R
D
L
A
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N
C
L
V
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N
L
L
V
K
I
G
D
F
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M
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D
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Y
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D
Y
Y
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G
G
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M
L
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W
M
P
P
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S
I
M
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F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
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L
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N
N
E
V
I
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C
I
T
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G
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V
L
Q
R
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R
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C
P
Q
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Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
165
-
100%
-129
- C2 -
U165
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
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V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
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H
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H
I
V
K
F
Y
G
V
C
V
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G
D
P
L
I
M
V
F
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Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
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M
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L
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L
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N
L
L
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I
G
D
F
G
M
S
R
D
V
Y
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D
Y
Y
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G
G
H
T
M
L
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W
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L
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V
L
W
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N
N
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V
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C
W
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G
I
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T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
166
-
100%
-130
- C2 -
U166
1
C:
[528-815]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
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F
L
A
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C
Y
N
L
C
P
-
Q
D
K
I
L
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A
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K
T
L
K
D
A
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A
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K
D
F
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A
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L
L
T
N
L
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H
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H
I
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K
F
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V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
----------
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
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H
F
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H
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D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
E
S
I
M
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R
K
F
T
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L
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N
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V
I
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C
I
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L
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R
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Y
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L
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L
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C
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H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
167
-
100%
-129
- C2 -
U167
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
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Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
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Y
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A
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A
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C
L
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N
L
L
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F
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M
L
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W
M
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N
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I
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I
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L
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L
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L
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C
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N
I
K
G
I
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T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
168
-
100%
-129
- C2 -
U168
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
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H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
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M
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Y
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A
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C
L
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N
L
L
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F
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Y
Y
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M
L
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P
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L
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V
L
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P
W
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N
N
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V
I
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C
I
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V
L
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L
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L
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C
W
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N
I
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G
I
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T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
169
-
100%
-124
- C2 -
U169
1
D:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
F
--
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
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V
F
L
A
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C
Y
N
L
C
P
E
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D
K
I
L
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A
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K
T
L
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D
A
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N
A
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D
F
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A
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L
L
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L
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H
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F
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P
L
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M
K
H
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D
L
N
K
F
L
R
A
H
G
P
D
A
--------
P
T
E
L
--
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
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N
L
L
V
K
I
G
D
F
G
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V
Y
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Y
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V
G
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M
L
P
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M
P
P
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I
M
Y
R
K
F
T
T
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S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
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N
N
E
V
I
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C
I
T
Q
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V
L
Q
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P
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C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
170
-
99%
-125
- C2 -
U170
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
------
I
L
V
A
V
K
T
L
K
D
A
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N
A
R
K
D
F
H
R
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L
L
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L
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M
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H
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D
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F
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A
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---------
P
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L
T
Q
S
Q
M
L
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A
Q
Q
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A
A
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L
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G
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M
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W
S
L
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V
V
L
W
E
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F
T
Y
G
K
Q
P
W
Y
Q
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N
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I
T
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Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
171
-
100%
-129
- C2 -
U171
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
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K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
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L
K
D
A
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K
D
F
H
R
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A
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L
L
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L
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L
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A
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A
---
P
P
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L
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A
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L
L
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Y
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Y
Y
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M
L
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N
N
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T
Q
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L
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L
M
L
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W
Q
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R
K
N
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G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
172
-
100%
-129
- C2 -
U172
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
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N
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----
K
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K
D
A
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F
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L
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A
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A
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L
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A
---
P
P
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L
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L
L
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N
L
A
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A
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P
V
Y
L
D
I
L
G
173
-
99%
-125
- C2 -
U173
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
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F
V
Q
H
I
K
R
H
N
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L
K
R
E
L
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F
L
A
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L
------
I
L
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L
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A
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P
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---------
P
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Q
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M
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K
N
I
K
G
I
-------------------
174
-
100%
-120
- C2 -
U174
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
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H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
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F
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A
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C
Y
-----
Q
D
K
I
L
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A
V
K
T
L
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-
A
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L
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F
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A
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-----------
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N
L
A
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A
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P
-------
175
-
100%
-130
- C2 -
U175
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
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N
I
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L
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-------
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A
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A
------
N
P
P
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A
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F
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--------------
T
M
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M
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K
N
I
K
G
I
-------------------
176
-
100%
-120
- C2 -
U176
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
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H
N
I
V
L
K
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L
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G
A
F
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F
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-----
Q
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A
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-
A
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F
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A
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-----------
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L
L
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N
L
A
K
A
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P
-------
177
-
100%
-120
- C2 -
U177
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
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K
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H
N
I
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L
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A
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F
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-----
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A
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-----------
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L
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N
L
A
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A
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P
-------
178
-
100%
-124
- C2 -
U178
1
D:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
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--
H
I
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N
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--------
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P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
179
-
99%
-125
- C2 -
U179
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
------
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
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H
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V
K
F
Y
G
V
C
V
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G
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P
L
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M
V
F
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Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
---------
P
T
E
L
T
Q
S
Q
M
L
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I
A
Q
Q
I
A
A
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M
V
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A
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H
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V
H
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D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
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V
V
L
W
E
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F
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Y
G
K
Q
P
W
Y
Q
L
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N
N
E
V
I
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C
I
T
Q
G
R
V
L
Q
R
P
R
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C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
180
-
100%
-120
- C2 -
U180
1
A:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
F
--
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
P
E
Q
D
K
I
L
V
A
V
K
T
L
K
D
A
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D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
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H
I
V
K
F
Y
G
V
C
V
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G
D
P
L
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V
F
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Y
M
K
H
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L
N
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F
L
R
A
H
G
P
D
----
A
E
G
N
P
P
T
E
L
--
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
---
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
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S
D
V
W
S
L
G
V
V
L
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I
F
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Y
G
K
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P
W
Y
Q
L
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N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
181
-
100%
-120
- C2 -
U181
1
A:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
F
--
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
Y
N
L
C
P
E
Q
D
K
I
L
V
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V
K
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L
K
D
A
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N
A
R
K
D
F
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A
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L
L
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N
L
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H
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V
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F
Y
G
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C
V
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G
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P
L
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M
V
F
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Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
----
A
E
G
N
P
P
T
E
L
--
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
---
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
182
-
99%
-125
- C2 -
U182
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
------
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
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A
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L
L
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L
Q
H
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V
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F
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G
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V
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G
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P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
---------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
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R
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L
A
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C
L
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N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
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T
D
Y
Y
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G
G
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M
L
P
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W
M
P
P
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S
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M
Y
R
K
F
T
T
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D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
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N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
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R
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P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
183
-
100%
-129
- C2 -
U183
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
I
L
V
A
V
K
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L
K
D
A
S
D
N
A
R
K
D
F
H
R
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A
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L
L
T
N
L
Q
H
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H
I
V
K
F
Y
G
V
C
V
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G
D
P
L
I
M
V
F
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Y
M
K
H
G
D
L
N
K
F
L
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A
H
G
P
D
A
V
L
M
A
---
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
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C
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N
L
L
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Y
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G
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M
L
P
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W
M
P
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M
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L
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V
V
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Q
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N
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I
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C
I
T
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L
M
L
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W
Q
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M
R
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N
I
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G
I
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T
L
L
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N
L
A
K
A
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P
V
Y
L
D
I
L
G
184
-
100%
-129
- C2 -
U184
1
A:
[527-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
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G
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F
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A
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C
Y
N
L
C
----
K
I
L
V
A
V
K
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L
K
D
A
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D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
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H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
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F
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M
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H
G
D
L
N
K
F
L
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A
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G
P
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A
V
L
M
A
---
P
P
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L
T
Q
S
Q
M
L
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A
Q
Q
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A
A
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M
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Y
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A
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L
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N
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I
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L
L
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N
L
A
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A
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V
Y
L
D
I
L
G
185
-
100%
-120
- C2 -
U185
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
-----
Q
D
K
I
L
V
A
V
K
T
L
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D
-
A
R
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A
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L
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M
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D
L
N
K
F
L
R
A
H
G
-----------
P
T
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L
T
Q
S
Q
M
L
H
I
A
Q
Q
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A
A
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M
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L
L
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N
L
A
K
A
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P
-------
186
-
100%
-130
- C2 -
U186
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
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A
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C
Y
-------
K
I
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V
K
T
L
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D
A
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N
A
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D
F
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A
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L
L
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N
L
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F
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P
L
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V
F
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Y
M
K
H
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D
L
N
K
F
L
R
A
H
G
P
D
A
------
N
P
P
T
E
L
T
Q
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Q
M
L
H
I
A
Q
Q
I
A
A
G
M
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Y
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A
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C
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L
L
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K
I
G
D
F
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M
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--------------
T
M
L
P
I
R
W
M
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P
E
S
I
M
Y
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K
F
T
T
E
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D
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L
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V
V
L
W
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G
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P
W
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N
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I
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V
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L
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C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
187
-
100%
-126
- C2 -
U187
1
B:
[518-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
T
N
S
Q
L
-
P
D
T
F
V
Q
H
I
K
R
H
N
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L
G
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G
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F
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A
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--
E
Q
D
K
I
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A
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T
L
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D
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A
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D
F
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L
L
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L
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F
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P
L
I
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F
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M
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H
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D
L
N
K
F
L
R
A
H
G
-------------
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
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Y
L
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A
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C
L
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N
L
L
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K
I
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D
F
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M
S
-----------------
P
I
R
W
M
P
P
E
S
I
M
Y
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K
F
T
T
E
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D
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W
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L
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V
V
L
W
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G
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N
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Y
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L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
188
-
99%
-119
- C2 -
U188
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
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A
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N
L
C
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L
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A
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L
L
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L
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H
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H
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V
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F
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G
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C
V
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L
I
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V
F
E
Y
M
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H
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D
L
N
K
F
L
R
A
H
G
-----------
P
T
E
L
T
Q
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M
L
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A
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Q
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A
A
G
M
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Y
L
A
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H
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V
H
R
D
L
A
T
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N
C
L
V
G
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N
L
L
V
K
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G
D
F
G
M
S
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V
Y
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Y
Y
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G
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M
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W
M
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P
E
S
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M
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F
T
T
E
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D
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W
S
L
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V
V
L
W
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F
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Y
G
K
Q
P
W
Y
Q
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N
N
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C
P
Q
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V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
189
-
100%
-120
- C2 -
U189
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
-----
Q
D
K
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L
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A
V
K
T
L
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A
S
D
-
A
R
K
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L
L
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L
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V
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M
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L
N
K
F
L
R
A
H
G
-----------
P
T
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L
T
Q
S
Q
M
L
H
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A
Q
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A
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L
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N
L
L
V
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S
R
D
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Y
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-
D
Y
Y
R
V
G
G
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L
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W
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Q
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N
N
E
V
I
E
C
I
T
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G
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Q
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M
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W
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H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
190
-
100%
-130
- C2 -
U190
1
C:
[528-815]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
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-
Q
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A
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F
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L
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V
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M
K
H
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D
L
N
K
F
L
R
A
H
G
P
D
----------
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
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M
V
Y
L
A
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H
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V
H
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L
A
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R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
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S
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V
W
S
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H
M
R
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N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
191
-
100%
-130
- C2 -
U191
1
C:
[528-815]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
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L
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C
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-
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L
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M
V
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Y
M
K
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L
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K
F
L
R
A
H
G
P
D
----------
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
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L
A
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N
C
L
V
G
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N
L
L
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K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
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G
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Q
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W
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N
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M
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K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
192
-
100%
-127
- C2 -
U192
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
---
G
K
V
F
L
A
E
C
Y
N
-----
D
K
I
L
V
A
V
K
T
L
K
D
A
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A
R
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F
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L
L
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L
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M
K
H
G
D
L
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K
F
L
R
A
H
G
P
D
A
------
N
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
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A
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N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
---------------
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
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F
T
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L
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L
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L
G
C
W
Q
R
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P
H
M
R
K
N
I
K
G
I
-------------------
193
-
99%
-119
- C2 -
U193
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
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F
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A
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-----------
P
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L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
194
-
100%
-120
- C2 -
U194
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
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F
L
A
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C
Y
-----
Q
D
K
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A
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L
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-
A
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A
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-----------
P
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I
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H
T
L
L
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N
L
A
K
A
S
P
-------
195
-
100%
-120
- C2 -
U195
1
A:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
F
--
H
I
K
R
H
N
I
V
L
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E
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----
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--
S
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---
M
L
P
I
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V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
196
-
100%
-122
- C2 -
U196
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
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L
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E
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A
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C
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P
H
M
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N
I
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G
I
H
T
L
L
Q
N
-------------
197
-
100%
-122
- C2 -
U197
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
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L
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L
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V
V
L
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F
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Y
G
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N
N
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Q
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C
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L
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C
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P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
-------------
198
-
100%
-120
- C2 -
U198
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
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F
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A
E
C
Y
-----
Q
D
K
I
L
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A
V
K
T
L
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-
A
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A
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-----------
P
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M
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L
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-
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N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
199
-
100%
-120
- C2 -
U199
1
A:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
F
--
H
I
K
R
H
N
I
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L
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L
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M
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----
A
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G
N
P
P
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--
S
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Y
Y
R
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---
M
L
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V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
200
-
100%
-122
- C2 -
U200
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
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Y
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P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
-------------
201
-
100%
-133
- C2 -
U201
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
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--
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L
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N
L
L
V
K
I
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D
F
------------------
M
L
P
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W
M
P
P
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S
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M
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P
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M
R
K
N
I
K
G
I
H
T
L
L
Q
N
-------------
202
-
99%
-118
- C2 -
U202
1
B:
[535-807]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
R
E
L
G
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G
A
F
G
K
V
F
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---
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--------
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P
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M
R
K
N
I
K
G
I
H
T
L
L
---------------
203
-
100%
-122
- C2 -
U203
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
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H
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L
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R
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N
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G
I
H
T
L
L
Q
N
-------------
204
-
100%
-130
- C2 -
U204
1
C:
[528-815]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
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H
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H
N
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A
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----------
T
E
L
T
Q
S
Q
M
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H
I
A
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Q
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A
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L
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D
F
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----------------
M
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M
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H
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L
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Q
N
L
A
K
A
S
P
-------
205
-
100%
-124
- C2 -
U205
1
D:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
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--
H
I
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R
H
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--------
P
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--
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M
L
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W
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P
H
M
R
-------------------------
206
-
100%
-132
- C2 -
U206
1
A:
[532-812]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
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L
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R
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E
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------------
T
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-------------------
L
P
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L
L
Q
N
L
A
K
----------
207
-
100%
-120
- C2 -
U207
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
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H
N
I
V
L
K
R
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L
G
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A
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-----
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-----------
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I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
208
-
100%
-122
- C2 -
U208
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
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Y
N
L
C
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A
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L
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-
M
A
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--
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M
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Y
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L
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N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
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V
Y
S
T
D
Y
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G
-
H
T
M
L
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W
M
P
P
E
S
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K
F
T
T
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D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
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N
N
E
V
I
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C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
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V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
-------------
209
-
100%
-120
- C2 -
U209
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
-----
Q
D
K
I
L
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A
V
K
T
L
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-
A
R
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L
L
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M
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L
N
K
F
L
R
A
H
G
-----------
P
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L
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S
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I
A
Q
Q
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A
A
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M
V
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L
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L
L
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F
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-
D
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P
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M
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L
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V
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L
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F
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G
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P
W
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Q
L
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N
N
E
V
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C
I
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L
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K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
210
-
100%
-122
- C2 -
U210
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
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C
Y
N
L
C
P
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L
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L
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D
A
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F
H
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A
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L
L
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L
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H
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H
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F
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G
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C
V
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G
D
P
L
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F
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Y
M
K
H
G
D
L
N
K
F
L
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A
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P
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A
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-
M
A
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G
N
P
P
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E
L
--
S
Q
M
L
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A
Q
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Y
L
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L
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C
L
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N
L
L
V
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I
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Y
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Y
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V
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-
H
T
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L
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F
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W
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L
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V
V
L
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G
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N
N
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L
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Y
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M
L
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C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
-------------
211
-
100%
-130
- C2 -
U211
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
Y
-------
K
I
L
V
A
V
K
T
L
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D
A
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N
A
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D
F
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A
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L
L
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L
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V
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M
K
H
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D
L
N
K
F
L
R
A
H
G
P
D
A
------
N
P
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
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H
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L
A
T
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N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
--------------
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
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L
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V
L
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N
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L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
212
-
100%
-124
- C2 -
U212
1
D:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
F
--
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
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A
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F
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A
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A
--------
P
T
E
L
--
S
Q
M
L
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I
A
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I
A
A
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Y
L
A
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V
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R
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L
A
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N
C
L
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N
L
L
V
K
I
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D
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D
V
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Y
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W
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F
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V
W
S
L
G
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V
L
W
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F
T
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L
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N
N
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C
I
T
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G
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L
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V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
213
-
100%
-120
- C2 -
U213
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
-----
Q
D
K
I
L
V
A
V
K
T
L
K
D
A
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D
-
A
R
K
D
F
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R
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A
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L
L
T
N
L
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H
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H
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V
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L
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M
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D
L
N
K
F
L
R
A
H
G
-----------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
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M
V
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V
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L
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N
C
L
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N
L
L
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I
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F
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Y
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-
D
Y
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G
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L
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N
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C
I
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N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
214
-
98%
-131
- C2 -
U214
1
A:
[529-821]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
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--
C
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L
L
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L
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H
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V
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P
L
I
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V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
D
------------
A
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
------------------
P
I
R
W
M
P
P
E
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I
M
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F
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V
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L
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V
V
L
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N
N
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C
I
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G
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L
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L
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L
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C
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R
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N
I
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G
I
H
T
L
L
Q
N
L
A
K
S
P
---
L
D
I
L
-
215
-
100%
-120
- C2 -
U215
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
-----
Q
D
K
I
L
V
A
V
K
T
L
K
D
A
S
D
-
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
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H
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H
I
V
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F
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G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
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D
L
N
K
F
L
R
A
H
G
-----------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
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M
V
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L
A
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C
L
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N
L
L
V
K
I
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F
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M
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R
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V
Y
S
-
D
Y
Y
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V
G
G
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M
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P
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M
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P
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S
I
M
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F
T
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S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
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N
N
E
V
I
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C
I
T
Q
G
R
V
L
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R
P
R
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C
P
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Y
E
L
M
L
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C
W
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E
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H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
216
-
99%
-125
- C2 -
U216
1
A:
[523-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
------
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
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M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
---------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
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L
A
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H
F
V
H
R
D
L
A
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N
C
L
V
G
E
N
L
L
V
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I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
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K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
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G
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Q
P
W
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Q
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N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
217
-
100%
-129
- C2 -
U217
1
B:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
----
K
V
F
L
A
E
C
Y
------
D
K
I
L
V
A
V
K
T
L
K
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
------
N
P
P
T
E
L
T
Q
S
Q
M
L
H
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A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
---------------
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
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Q
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N
N
E
V
I
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G
R
V
L
Q
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R
T
C
P
Q
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Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
218
-
100%
-120
- C2 -
U218
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
Y
-----
Q
D
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A
V
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T
L
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D
-
A
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L
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K
F
L
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A
H
G
-----------
P
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L
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L
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A
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L
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-
D
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L
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F
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G
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Q
P
W
Y
Q
L
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N
N
E
V
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C
I
T
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R
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R
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P
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L
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H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
219
-
100%
-122
- C2 -
U219
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
Y
------
D
K
I
L
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A
V
K
T
L
K
D
A
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D
N
A
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F
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L
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M
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L
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K
F
L
R
A
H
G
P
D
---------
P
T
E
L
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Q
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Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
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C
L
V
G
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N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
------
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
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L
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L
G
C
W
Q
R
E
P
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M
R
K
N
I
K
G
I
-------------------
220
-
100%
-129
- C2 -
U220
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
-------
V
F
L
A
E
C
Y
-------
K
I
L
V
A
V
K
T
L
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D
A
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M
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L
N
K
F
L
R
A
H
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P
D
A
------
N
P
P
T
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L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
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C
L
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N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
----------
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
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T
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V
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L
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V
V
L
W
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F
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Y
G
K
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P
W
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N
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V
I
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L
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L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
221
-
100%
-122
- C2 -
U221
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
Y
------
D
K
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A
V
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A
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L
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K
F
L
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A
H
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P
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---------
P
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L
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Q
M
L
H
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A
Q
Q
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A
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V
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V
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L
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N
C
L
V
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N
L
L
V
K
I
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D
F
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M
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R
D
V
Y
S
T
------
G
H
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M
L
P
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M
P
P
E
S
I
M
Y
R
K
F
T
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D
V
W
S
L
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V
V
L
W
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L
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C
W
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R
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P
H
M
R
K
N
I
K
G
I
-------------------
222
-
100%
-122
- C2 -
U222
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
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R
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L
G
E
G
A
F
G
K
V
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--
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-
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N
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L
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C
W
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P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
-------------
223
-
100%
-120
- C2 -
U223
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
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A
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C
Y
-----
Q
D
K
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A
V
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L
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-
A
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L
L
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L
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M
K
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D
L
N
K
F
L
R
A
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-----------
P
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L
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M
L
H
I
A
Q
Q
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A
A
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M
V
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L
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L
L
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-
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G
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N
I
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G
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H
T
L
L
Q
N
L
A
K
A
S
P
-------
224
-
99%
-118
- C2 -
U224
1
B:
[535-807]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
R
E
L
G
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A
F
G
K
V
F
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A
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C
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N
---
E
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L
V
A
V
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A
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L
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A
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A
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--------
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A
A
G
M
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A
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L
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V
L
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F
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Q
P
W
Y
Q
L
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N
N
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I
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L
M
L
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C
W
Q
R
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P
H
M
R
K
N
I
K
G
I
H
T
L
L
---------------
225
-
100%
-120
- C2 -
U225
1
A:
[531-815]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
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K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
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A
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C
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-----
Q
D
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A
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L
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-
A
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F
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A
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-----------
P
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Q
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A
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-
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N
I
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I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
226
-
100%
-122
- C2 -
U226
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
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------
D
K
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V
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A
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D
N
A
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D
F
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A
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L
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N
L
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H
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H
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F
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V
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D
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V
F
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Y
M
K
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D
L
N
K
F
L
R
A
H
G
P
D
---------
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
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L
A
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H
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V
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C
L
V
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N
L
L
V
K
I
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D
F
G
M
S
R
D
V
Y
S
T
------
G
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M
L
P
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W
M
P
P
E
S
I
M
Y
R
K
F
T
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E
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D
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W
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L
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V
V
L
W
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Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
-------------------
227
-
100%
-130
- C2 -
U227
1
A:
[530-815]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
------
K
V
F
L
A
E
C
Y
N
L
C
P
E
Q
D
K
I
L
V
A
V
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--
A
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A
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A
E
L
L
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L
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K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------------
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
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H
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R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
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Y
G
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P
W
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L
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N
N
E
V
I
E
C
I
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P
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V
Y
E
L
M
L
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C
W
Q
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H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
-------
228
-
100%
-122
- C2 -
U228
1
A:
[526-797]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
T
F
--
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
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G
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N
L
C
P
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D
K
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L
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D
A
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N
A
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D
F
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A
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L
L
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N
L
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H
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H
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K
F
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Y
M
K
H
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D
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N
K
F
L
R
A
H
G
P
D
---------
P
T
E
L
--
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
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H
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L
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N
C
L
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N
L
L
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L
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N
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V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
-------------------------
229
-
100%
-122
- C2 -
U229
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
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M
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L
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Y
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D
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-
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V
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N
N
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R
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N
I
K
G
I
H
T
L
L
Q
N
-------------
230
-
99%
-134
- C2 -
U230
1
A:
[530-803]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
---
G
K
V
F
L
A
E
C
Y
N
------
K
I
L
V
A
V
K
T
L
K
D
A
S
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A
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H
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L
N
K
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R
A
H
G
P
D
A
N
----------
L
T
Q
S
Q
M
L
H
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A
Q
Q
I
A
A
G
M
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Y
L
A
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N
C
L
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N
L
L
V
K
I
G
D
F
----------------
H
T
M
L
P
I
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W
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P
P
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G
C
W
Q
R
E
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H
M
R
K
N
I
K
G
I
-------------------
231
-
99%
-118
- C2 -
U231
1
B:
[535-807]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
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C
Y
N
---
E
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L
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A
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P
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A
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P
T
--------
L
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A
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M
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F
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V
W
S
L
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V
V
L
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F
T
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W
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Q
L
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N
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I
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P
R
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P
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L
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P
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M
R
K
N
I
K
G
I
H
T
L
L
---------------
232
-
100%
-122
- C2 -
U232
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
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L
K
R
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A
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P
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Y
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-
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C
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K
N
I
K
G
I
H
T
L
L
Q
N
-------------
233
-
100%
-122
- C2 -
U233
1
A:
[532-809]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
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L
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G
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G
A
F
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A
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--
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L
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L
L
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Y
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Y
Y
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-
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L
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L
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F
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N
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C
I
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Q
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R
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L
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R
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R
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L
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L
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C
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I
K
G
I
H
T
L
L
Q
N
-------------