@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
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Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : NTRK2_HUMAN: (2013-07-24 )
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG

Atome Classification :

(86 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520......--.530.......540.-.......550.......-560...--------------.----...570..-.-.-.-.-.--580.......590...-....600.......610.......620.......630---.......640---..----...--..650.......660.......670.......680..---.---..-----..690.......--700...-....710.......720....--...730.......740.......750.....-...760....-----...770...---......780.......790.......800.......810--.......820
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDT--FVQHIKRHNIVLK-R-ELGEGAFGKVFLAECYN-LCPEQD--------------K----ILVAVKTL-K-D-A-S-D--NARKDFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAH---GPDAVLMAEG---NP----PTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---G---EN-----LLVKIGDFGMSR--DVYSTD-YYRVGGHTMLPIRWMPPESIM--YRKFTTESDVWSLGVVLWEIFTYGK-QPWYQ-LSNNEVIECI-----TQGR--VLQ---RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAK--ASPVYLDILG
1 PsiBlast_PDB 97.21100%-126 - C2 -4AT3 A:[4-299] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DT--FVQHIKRHNIVLK-R-ELGEGAFGKVFLAECYN-LC------------------K----ILVAVKTL-----A-S-D--NARKDFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAH---GPDAVLMA-----NP----PTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---G---EN-----LLVKIGDFGMSR----YSTD-YYRVGGHTMLPIRWMPPESIM--YRKFTTESDVWSLGVVLWEIFTYGK-QPWYQ-LSNNEVIECI-----TQGR--VLQ---RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAK--ASPVYLDILG
2 PsiBlast_PDB 95.91100%-129 - C2 -4AT4 A:[4-299] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DT--FVQHIKRHNIVLK-R-ELGEGAFGKVFLAECYN-LC------------------K----ILVAVKTL-K-D-A-S-D--NARKDFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAH---GPDAVLMA------P----PTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---G---EN-----LLVKIGDFGMSR--DVYSTD-YYRVGGHTMLPIRWMPPESIM--YRKFTTESDVWSLGVVLWEIFTYGK-QPWYQ-LSNNEVIECI-----TQGR--VLQ---RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAK--ASPVYLDILG
3 PsiBlast_PDB 94.62100%-124 - C2 -4AT5 A:[4-299] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DT--FVQHIKRHNIVLK-R-ELGEGAFGKVFLAECYN-L-------------------K----ILVAVKTL-K-D-A-S-D--NARKDFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAH---GPDAVLMAEG---NP----PTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---G---EN-----LLVKIGDFGMSR--DVYSTD-YYRVGGHTMLPIRWMPPESIM--YRKFTTESDVWSLGVVLWEIFTYGK-QPWYQ-LSNNEVIECI-----TQGR--VLQ---RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAK--ASPVYLDILG
21 PsiBlast_CBE 89.5773%-124 - C2 -4AOJ C:[33-322] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A--CVHHIKRRDIVLK-W-ELGEGAFGKVFLAECHN-LLP-QD--------------K----MLVAVKAL-K-E-A-S-E--SARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH---GPD-----------------GP--LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G---QG-----LVVKIGDFGM-------------------MLPIRWMPPESIL--YRKFTTESDVWSFGVVLWEIFTYGK-QPWYQ-LSNTEAIDCI-----TQGR--ELE---RPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ--APP-------
4 PsiBlast_PDB 88.9782%-127 - C2 -3V5Q NTRK3_HUMAN A:[9-297] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQHIKRRDIVLK-R-EL------KVFLAECYN-LSPTKD--------------K----MLVAVKAL-----P-T-L--AARKDFQREAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAH---GP-------------------E--LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV---G---AN-----LLVKIGDFGM----DVYSTD-YYR----TMLPIRWMPPESIM--YRKFTTESDVWSFGVILWEIFTYGK-QPWFQ-LSNTEVIECI-----TQGR--VLE---RPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGK--ATP-------
22 PsiBlast_CBE 88.0973%-125 - C2 -4AOJ NTRK1_HUMAN B:[33-324] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A--CVHHIKRRDIVLK-W-ELGEGAFGKVFLAECHN-LLP-----------------K----MLVAVKAL-K-E-A-S-E--SARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH---GPD-----------------GP--LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G---QG-----LVVKIGDF----------------------LPIRWMPPESIL--YRKFTTESDVWSFGVVLWEIFTYGK-QPWYQ-LSNTEAIDCI-----TQGR--ELE---RPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ--APPVY-----
121 HHSearch 88.0273%-128 - C2 -4AOJ NTRK1_HUMAN A:[33-322] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A--CVHHIKRRDIVLK-W-ELGEGAFGKVFLAECHN-LLP-----------------K----MLVAVKAL-K-E-A-S-E--SARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSH---GPD----------------PGP--LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G---QG-----LVVKIGDFG-------------------TMLPIRWMPPESIL--YRKFTTESDVWSFGVVLWEIFTYGK-QPWYQ-LSNTEAIDCI-----TQGR--ELE---RPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ--APP-------
75 PsiBlast_CBE 79.2737%-120 - C2 -1MQB B:[35-310] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKFTTEIHPSCVTRQ-K-VIGAGEFGEVYKG-MLK-T----K--------------E----VPVAIKTL-K-A-GYT-E--KQRVDFLGEAGIMGQF-SHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREK---D-------------------GE--FSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILV---N---SN-----LVCKVSDFGLSRVL-------------K--IPIRWTAPEAIS--YRKFTSASDVWSFGIVMWEVMTYGE-RPYWE-LSNHEVMKAI-----NDGF--RLP---TPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIR--A---------
68 PsiBlast_CBE 78.8838%-122 - C2 -3DZQ A:[26-305] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FAKELDATNISID-K-VVGAGEFGEVCSGRLK---LPSKK--------------E----ISVAIKTL-K-V-GYT-E--KQRRDFLGEASIMGQF-DHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH-----DA-----------------Q--FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILI---N---SN-----LVCKVSDFGL---------------------PIRWTSPEAIA--YRKFTSASDVWSYGIVLWEVMSYGE-RPYWE-MSNQDVIKAV-----DEGY--RLP---PPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIR---NP--LKII-
67 PsiBlast_CBE 78.0638%-119 - C2 -4G2F A:[26-305] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FAKELDATNISID-K-VVGAGEFGEVCSGRLK---LPSKK--------------E----ISVAIKTL-K-V-GYT-E--KQRRDFLGEASIMGQF-DHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH-----DA-----------------Q--FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILI---N---SN-----LVCKVSDFGLSRVL-----------------PIRWTSPEAIA--YRKFTSASDVWSYGIVLWEVMSYGE-RPYWE-MSNQDVIKAV-----DEGY--RLP---PPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIR---NPGSLKII-
10 PsiBlast_PDB 77.5647%-117 - C2 -4BKJ ? A:[9-307] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSRLRFK-E-KLGEGQFGEVHLCEVDS----PQDLVSLDFPLNVRKGHP----LLVAVKIL-RPD-A-T-K--NARNDFLKEVKIMSRL-KDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH---QLED---------------PT---ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV---G---EN-----FTIKIADFGMSR--NLYAGD-YY----RAVLPIRWMAWECIL--MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ-LTDEQVIENAGEFFRDQGRQVYLS---RPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL-----------------
23 PsiBlast_CBE 77.4747%-113 - C2 -4BKJ ? B:[9-307] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSRLRFK-E-KLGEGQFGEVHLCEVDS----PQDLVSLDFPLNVRKGHP----LLVAVKIL-RPD-A-T-K--NARNDFLKEVKIMSRL-KDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH---QLEDK----------G---PT---ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV---G---EN-----FTIKIADFGMSR--NLYAGD-YY----RAVLPIRWMAWECIL--MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ-LTDEQVIENAGEFFRDQGRQVYLS---RPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL-----------------
24 PsiBlast_CBE 77.3447%-107 - C2 -3ZOS B:[9-307] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSRLRFK-E-KLGEGQFGEVHLCEVDS----PQDLVSLDFPLNVRKGHP----LLVAVKIL-RPD-A-T-K--NARNDFLKEVKIMSRL-KDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH---QLEDK----------QG--PT---ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV---G---EN-----FTIKIADFGMSR--NLYAGD-YYRVQGRAVLPIRWMAWECIL--MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ-LTDEQVIENAGEFFRDQGRQVYLS---RPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL-----------------
102 PsiBlast_CBE 77.3236%-114 - C2 -3GQL FGFR1_HUMAN B:[15-317] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YEL-PED--PRWELPRDRLVLG-K-PLGEGAFGQVVLAEAIG-L--DKD--------------KPNRVTKVAVKML-KSD-A-T-E--KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR---RPP-----------P----EEQ--LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T---ED-----NVMKIADFGLAR-------------------PVKWMAPEALF--DRIYTHQSDVWSFGVLLWEIFTLGG-SPYPG-VPVEELFKLL-----KEGH--RMD---KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE------
139 HHSearch 76.7034%-108 - C2 -4FL3 KSYK_HUMAN A:[365-630] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDRKLLTLE-DKELGSGNFGTVKKGYYQM----KKV--------------V----KTVAVKIL-K-N-E-A-NDPALKDELLAEANVMQQL-DNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQN---R--------------------H--VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL---V---TQ-----HYAKISDFGLSK--ALRA-------------PVKWYAPECIN--YYKFSSKSDVWSFGVLMWEAFSYGQ-KPYRG-MKGSEVTAML-----EKGE--RMG---CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY-------------
9 PsiBlast_PDB 76.6247%-111 - C2 -3ZOS DDR1_HUMAN A:[9-307] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSRLRFK-E-KLGEGQFGEVHLCEVDS----PQDLVSLDFPLNVRKGHP----LLVAVKIL-RPD-A-T-K--NARNDFLKEVKIMSRL-KDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH---QLED-----------AAQGPT---ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLV---G---EN-----FTIKIADFGMSR--NLYAGD-YYRVQGRAVLPIRWMAWECIL--MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ-LTDEQVIENAGEFFRDQGRQVYLS---RPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL-----------------
76 PsiBlast_CBE 75.5837%-120 - C2 -1MQB EPHA2_HUMAN A:[38-310] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTEIHPSCVTRQ-K-VIGAGEFGEVYKG-MLK-T---KK--------------E----VPVAIKTL-K-A-GYT-E--KQRVDFLGEAGIMGQF-SHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREK---D-------------------GE--FSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILV---N---SN-----LVCKVSDFGL-----------------K--IPIRWTAPEAIS--YRKFTSASDVWSFGIVMWEVMTYGE-RPYWE-LSNHEVMKAI-----NDGF--RLP---TPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIR--A---------
103 PsiBlast_CBE 75.3136%-114 - C2 -3GQL FGFR1_HUMAN A:[15-321] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YEL-PED--PRWELPRDRLVLG-K-PLGEGAFGQVVLAEAIG-L--DKD--------------KPNRVTKVAVKML-KSD-A-T-E--KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR---RPP-----------------EQ--LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T---ED-----NVMKIADFGLAR---------------NGRLPVKWMAPEALF--DRIYTHQSDVWSFGVLLWEIFTLGG-SPYPG-VPVEELFKLL-----KEGH--RMD---KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDL--
14 PsiBlast_PDB 75.2844%-111 - C2 -3ETA INSR_HUMAN A:[12-287] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-R-ELGQGSFGMVYEGNARD-IIKGEA--------------E----TRVAVKTV-N-ESA-S-L--RERIEFLNEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSL---RPEAE-NNPG---RP----PPT--L--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A---HD-----FTVKIGDFGMTR--DIYETD-YYRKG-KGLLPVRWMAPESLK--DGVFTTSSDMWSFGVVLWEITSLAE-QPYQG-LSNEQVLKFV-----MDGG--YLD---QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD---------------
80 PsiBlast_CBE 74.6239%-111 - C2 -2IVS RET_HUMAN A:[22-309] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKNLVLG-K-TLGEGEFGKVVKATAFH-LKGRAG--------------Y----TTVAVKML-K-ENA-S-P--SELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYL-----------------RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV---A---EG-----RKMKISDFGLSR--DVYEED-SYVKRSQGRIPVKWMAIESLF--DHIYTTQSDVWSFGVLLWEIVTLGG-NPYPG-IPPERLFNLL-----KTGH--RME---RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--------------
34 PsiBlast_CBE 74.4843%-114 - C2 -1I44 A:[9-288] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDE--W--EVSREKITLL-R-ELGQGSFGMVYEGNARD-IIKGEA--------------E----TRVAVKTV-N-ESA-S-L--RERIEFLNEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSL---RPEAE-NNPG---RP----PPT--L--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A---HD-----FTVKIGDFGMT-------------------LPVRWMAPESLK--DGVFTTSSDMWSFGVVLWEITSLAE-QPYQG-LSNEQVLKFV-----MDGG--YLD---QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD---------------
33 PsiBlast_CBE 74.4844%-122 - C2 -3EKK A:[14-289] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-R-ELGQGSFGMVYEGNARD-IIKGEA--------------E----TRVAVKTV-N-ESA-S-L--RERIEFLNEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSL---RPEAE-NNPG---RP----PPT--L--QEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMV---A---HD-----FTVKIGDF---------------------LLPVRWMAPESLK--DGVFTTSSDMWSFGVVLWEITSLAE-QPYQG-LSNEQVLKFV-----MDGG--YLD---QPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKD---------------
25 PsiBlast_CBE 74.1044%-111 - C2 -3ETA B:[12-287] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-R-ELGQGSFGMVYEGNARD-IIKGEA--------------E----TRVAVKTV-N-ESA-S-L--RERIEFLNEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSL---RPEAE-NNPG---RP----PPT--L--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A---HD-----FTVKIGDFGMTR--DIYETD-YYRK--KGLLPVRWMAPESLK--DGVFTTSSDMWSFGVVLWEITSLAE-QPYQG-LSNEQVLKFV-----MDGG--YLD---QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD---------------
101 PsiBlast_CBE 73.9336%-120 - C2 -3GQL C:[15-318] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YEL-PED--PRWELPRDRLVLG-K-PLGEGAFGQVVLAEAIG-L--DKD--------------KPNRVTKVAVKML-KSD-A-T-E--KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR---RPP-----------------EQ--LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T---ED-----NVMKIADFGLAR-------------------PVKWMAPEALF--DRIYTHQSDVWSFGVLLWEIFTLGG-SPYPG-VPVEELFKLL-----KEGH--RMD---KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEY-----
125 HHSearch 73.7640%-121 * C2 *4I4E A:[11-276] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIQRERIELG-R-CIGEGQFGDVHQGIY---MSP-NP--------------A----LAVAIKTC-K-NCT-S-D--SVREKFLQEALTMRQF-DHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVR---K-------------------YS--LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLV---S---SN-----DCVKLGDF----------------------LPIKWMAPESIN--FRRFTSASDVWMFGVCMWEILMHGV-KPFQG-VKNNDVIGRI-----ENGE--RLP---MPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE------------
133 HHSearch 73.5335%-111 - C2 -2OZO ZAP70_HUMAN A:[331-598] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLKRDNLLIA-DIELGCGNFGSVRQGVYRM----RKK--------------Q----IDVAIKVL-K-Q-G-TEK--ADTEEMMREAQIMHQL-DNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGK---R-------------------EE--IPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLL---V---NR-----HYAKISDFGLSK--ALG--------------PLKWYAPECIN--FRKFSSRSDVWSYGVTMWEALSYGQ-KPYKK-MKGPEVMAFI-----EQGK--RME---CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY------------
38 PsiBlast_CBE 73.4343%-111 - C2 -3LW0 IGF1R_HUMAN A:[7-274] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDE--W--EVAREKITMS-R-ELGQGSFGMVYEGVAKG-VVKDEP--------------E----TRVAIKTV-N-E-A-A-SM-RERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSL---RP------------P----PS-----LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A---ED-----FTVKIGDFGMTR--DIYETD-YYRKG---LLPVRWMSPESLK--DGVFTTYSDVWSFGVVLWEIATLAE-QPYQG-LSNEQVLRFV-----MEGG--LLD---KPDNCPDMLFELMRMCWQYNPKMR---------------------------
46 PsiBlast_CBE 73.3042%-120 - C2 -4DCE B:[31-302] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKEVPRKNITLI-R-GLGH----EVYEGQVS-------S--------------P----LQVAVKTL-P-E-VCS-E--QDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRET---RPRP---------SQ----PSS--LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG---PG-----RVAKIGDF------------------GCAMLPVKWMPPEAFM--EGIFTSKTDTWSFGVLLWEIFSLGY-MPYPS-KSNQEVLEFV-----TSGG--RMD---PPKNCPGPVYRIMTQCWQHQPEDRPNFAII---------------------
83 PsiBlast_CBE 73.2337%-120 - C2 -1FGI B:[6-295] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEYEL-PED--PRWELPRDRLVLG-K-PLGEGAFGQVVLAEAIG-L--------------------PNRVTKVAVKML-KSD-A-T-E--KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR---R--------------------Q--LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T---ED-----NVMKIADFGLA--------D-YYKK---GRLPVKWMAPEALF--DRIYTHQSDVWSFGVLLWEIFTLGG-SPYPG-VPVEELFKLL-----KEGH--RMD---KPSNCTNELYMMMRDCWHAVPSQRPTFKQL---------------------
37 PsiBlast_CBE 73.1443%-111 - C2 -3LW0 IGF1R_HUMAN B:[7-274] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDE--W--EVAREKITMS-R-ELGQGSFGMVYEGVAKG-VVKDEP--------------E----TRVAIKTV-N-E-A-A-SM-RERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSL---RP------------P----PS-----LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A---ED-----FTVKIGDFGMTR--DIYETD-YYRKG---LLPVRWMSPESLK--DGVFTTYSDVWSFGVVLWEIATLAE-QPYQG-LSNEQVLRFV-----MEGG--LLD---KPDNCPDMLFELMRMCWQYNPKMR---------------------------
35 PsiBlast_CBE 73.1043%-109 - C2 -3LW0 D:[7-274] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDE--W--EVAREKITMS-R-ELGQGSFGMVYEGVAKG-VVKDEP--------------E----TRVAIKTV-N-E-A-A-SM-RERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSL---RP------------P----PS-----LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A---ED-----FTVKIGDFGMTR--DIYETD-YYRKG---LLPVRWMSPESLK--DGVFTTYSDVWSFGVVLWEIATLAE-QPYQG-LSNEQVLRFV-----MEGG--LLD---KPDNCPDMLFELMRMCWQYNPKMR---------------------------
19 PsiBlast_PDB 73.0544%-115 - C2 -3NW5 A:[10-277] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDE--W--EVAREKITMS-R-ELGQGSFGMVYEGVAKG-VVKDEP--------------E----TRVAIKTV-N-E-AAS-M--RERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSL---RPEM----EN---NPVLA-PPS--L--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A---ED-----FTVKIGDFGMTR--DIYETD-YYRKGGKGLLPVRWMSPESLK--DGVFTTYSDVWSFGVVLWEIATLAE-QPYQG-LSNEQVLRFV-----MEGG--LLD---KPDNCPDMLFELMRMCWQYNPKMR---------------------------
140 HHSearch 72.9642%-107 - C2 -3L9P A:[66-347] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEVPRKNITLI-R-GLGHGAFGEVYEGQVSG------S--------------P----LQVAVKTL-P-E-VCS-E--QDELDFLMEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRET---RPR------P---SQ----PSS--LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLL---TCPGPG-----RVAKIGDFGMAR--DIYRAG-YYRKGGCAMLPVKWMPPEAFM--EGIFTSKTDTWSFGVLLWEIFSLGY-MPYPS-KSNQEVLEFV-----TSGG--RMD---PPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQ--DP--------
108 PsiBlast_CBE 72.8338%-121 - C2 -3RHX FGFR1_HUMAN A:[13-291] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPRDRLVLG-K-PLGEGAFGQVVLAEAIG-L--DKD--------------KPNRVTKVAVKML-KSD-A-T-E--KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR---RPP----------------EEQ--LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T---ED-----NVMKIADFGLAR--DIHHID-YYKKTTNGRLPVKWMAPEALF--DRIYTHQSDVWSFGVLLWEIFTLGG-SPYPG-VPVEELFKLL-----KEGH--RMD---KPSNCTNELYMMMRDCWHAVPSQRPTFKQL---------------------
129 HHSearch 72.8140%-115 - C2 -3CBL A:[110-375] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLNHEDLVLG-E-QIGRGNFGEVFSGRLR------AD--------------N----TLVAVKSC-R-E-TLP-P--DLKAKFLQEARILKQY-SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE---GA-------------------R--LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLV---T---EK-----NVLKISDFGMSR--EEADGV-YAASGGLRQVPVKWTAPEALN--YGRYSSESDVWSFGILLWETFSLGA-SPYPN-LSNQQTREFV-----EKGG--RLP---CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK--R---------
16 PsiBlast_PDB 72.7144%-114 - C2 -3I81 A:[10-277] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDE--W--EVAREKITMS-R-ELGQGSFGMVYEGVAKG-VVKDEP--------------E----TRVAIKTV-N-E-A-A-SM-RERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSL---RPE-----EN---NPVLA-PPS--L--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A---ED-----FTVKIGDFGMTR--DIYETD-YYR-----LLPVRWMSPESLK--DGVFTTYSDVWSFGVVLWEIATLAE-QPYQG-LSNEQVLRFV-----MEGG--LLD---KPDNCPDMLFELMRMCWQYNPKMR---------------------------
36 PsiBlast_CBE 72.5543%-111 - C2 -3LW0 IGF1R_HUMAN C:[7-274] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDE--W--EVAREKITMS-R-ELGQGSFGMVYEGVAKG-VVKDEP--------------E----TRVAIKTV-N-E-A-A-SM-RERIEFLNEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSL---RP------------P----PS-----LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A---ED-----FTVKIGDFGMTR--DIYETD-YYRKG---LLPVRWMSPESLK--DGVFTTYSDVWSFGVVLWEIATLAE-QPYQG-LSNEQVLRFV-----MEGG--LLD---KPDNCPDMLFELMRMCWQYNPKMR---------------------------
27 PsiBlast_CBE 72.0844%-112 - C2 -3NW7 A:[10-277] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDE--W--EVAREKITMS-R-ELGQGSFGMVYEGVAKG-VVKDEP--------------E----TRVAIKTV-N-E-AAS-M--RE