@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PAK1_HUMAN: (2013-07-24 )
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
Atome Classification :
(46 SA)
.........10........20........30........40........50........60........70........80........90........100...----....110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290--........300...-....310..-.....320.......330.......340.......350-.......360-------.----........370.......380.......390......-.400.......410...----....420.......430.....-----.--.440.......450.......460....-...470.......480......-------..490.......500.......-----510.......520-..--......530.......540...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWAR----LLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVA---TGQEVAIKQMNLQQ-QPKKELIIN-EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL-TDVVTETC---------M----DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLG-MDGSVKLTDFGFCAQIT----PEQSKRSTMVGTPYWMAPEVVT-----R--KAYGPKVDIWSLGIMAIEMIEGEPPYLN-ENPLRALYLIATNGT-PELQNP-------EKLSAIFRDFLNRCLEMDVEKR-----GSAKELLQHQF-L-KI--AKPLSSLTPLIAAAKEATKNNH
8
PsiBlast_PDB
92.98
98%
-115
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[4-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
I
I
V
S
V
G
D
P
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-------
Q
E
V
A
I
R
Q
M
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
C
---------
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
-
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
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M
V
G
T
P
Y
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M
A
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V
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-----
R
--
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L
G
I
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Y
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N
-
E
N
P
L
R
A
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Y
L
I
A
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N
G
T
-
P
E
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Q
N
P
-------
E
K
L
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A
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N
R
C
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E
M
D
V
E
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-----
G
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A
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E
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I
Q
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Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
125
HHSearch
92.93
100%
-110
- C1 -
3FXZ
1
?
A:
[1-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
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S
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A
---
T
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I
R
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N
L
Q
Q
-
Q
P
K
K
E
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I
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N
-
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
C
---------
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
-
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
2
PsiBlast_PDB
91.74
98%
-106
- C1 -
3Q53
1
PAK1_HUMAN
A:
[3-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
---
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
C
---------
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
-
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
I
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
6
PsiBlast_PDB
89.55
99%
-108
- C1 -
3FY0
1
PAK1_HUMAN
A:
[1-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
---
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
-
T
D
V
V
T
E
T
C
---------
M
----
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
-
M
D
G
S
V
K
L
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F
G
F
C
A
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I
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----
P
E
Q
S
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R
S
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M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
-
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
-
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
-----
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
123
HHSearch
80.01
45%
-99
- C1 -
4FIE
1
PAK4_HUMAN
A:
[46-418]
---------------------------------------------------------------------------------------------------------------------------
R
P
K
P
L
V
D
-----------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
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I
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E
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S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
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K
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D
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-
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G
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C
A
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V
S
----
K
E
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T
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M
A
P
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I
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-----
R
--
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W
S
L
G
I
M
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I
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P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
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D
N
L
P
-
P
R
L
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N
L
-------
H
K
V
S
P
S
L
K
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F
L
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V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
----------
19
PsiBlast_PDB
76.98
53%
-104
- C1 -
2X4Z
3
A:
[4-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
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G
D
P
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Y
L
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N
F
I
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E
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T
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C
I
A
T
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R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
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F
N
-
E
V
V
I
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D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
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A
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-
T
D
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---------
M
----
N
E
E
Q
I
A
A
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C
L
A
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Q
A
L
S
V
L
H
A
Q
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I
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-
H
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F
G
F
C
A
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V
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----
K
E
V
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R
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T
P
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M
A
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E
L
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-----
R
--
L
P
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G
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E
V
D
I
W
S
L
G
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M
V
I
E
M
V
D
G
E
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P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
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P
-
P
R
L
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L
-------
H
K
V
S
P
S
L
K
G
F
L
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R
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-----
A
T
A
A
E
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L
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H
P
F
-
L
-
A
K
--
A
G
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P
A
S
I
V
P
L
M
-----------
11
PsiBlast_PDB
76.34
52%
-108
- C1 -
2CDZ
1
PAK4_HUMAN
A:
[11-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
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F
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K
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G
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C
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-----
G
K
L
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A
V
K
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M
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L
R
K
-
Q
Q
R
R
E
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L
F
N
-
E
V
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I
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R
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Y
Q
H
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V
E
M
Y
N
S
Y
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V
G
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E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
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I
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-
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G
F
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----
K
E
V
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R
R
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G
T
P
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W
M
A
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E
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I
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-----
R
--
L
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Y
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V
D
I
W
S
L
G
I
M
V
I
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M
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G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
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V
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D
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A
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-----
A
T
A
A
E
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F
-
L
-
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--
A
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-----------
12
PsiBlast_PDB
74.38
52%
-104
- C1 -
2J0I
4
PAK4_HUMAN
A:
[12-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
-----------
18
PsiBlast_PDB
73.98
52%
-102
- C1 -
2Q0N
7
PAK4_HUMAN
A:
[8-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
-----------
20
PsiBlast_PDB
72.72
53%
-101
- C1 -
4APP
2
A:
[4-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
-----------
14
PsiBlast_PDB
72.58
52%
-103
- C1 -
4FIG
1
?
A:
[53-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
-----------
13
PsiBlast_PDB
72.31
52%
-96
- C1 -
4FIF
1
PAK4_HUMAN
A:
[51-340]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
-----------
30
PsiBlast_CBE
63.00
44%
-99
- C1 -
3GGF
1
MST4_HUMAN
A:
[18-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
A
G
P
---------
F
----
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
Q
G
D
V
K
L
A
D
F
G
V
A
-------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
-
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
-
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
32
PsiBlast_CBE
61.31
44%
-104
- C1 -
4FZD
1
MST4_HUMAN
B:
[3-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
A
G
P
---------
F
----
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
----------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
-
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
-
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
-----------
33
PsiBlast_CBE
60.57
44%
-95
- C1 -
4FZA
3
MST4_HUMAN
B:
[3-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
A
G
P
---------
F
----
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
-
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
-
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
-----------
31
PsiBlast_CBE
60.35
44%
-94
- C1 -
4FZF
1
?
B:
[3-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
---
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
A
G
P
---------
F
----
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
-
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
-
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
-----------
29
PsiBlast_CBE
59.84
44%
-95
- C1 -
3GGF
1
MST4_HUMAN
B:
[19-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
R
A
G
P
---------
F
----
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
Q
G
D
V
K
L
A
D
F
G
V
A
--------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
-
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
-
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
23
PsiBlast_CBE
58.59
40%
-72
- C1 -
4FIE
1
PAK4_HUMAN
B:
[46-417]
---------------------------------------------------------------------------------------------------------RPKP
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
-----------
50
PsiBlast_CBE
58.40
41%
-103
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[12-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
---
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
H
I
V
A
K
GEHKSGV
L
----
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
-
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG----------
V
G
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V
-
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
-
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
-
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
-----
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
--------------------
48
PsiBlast_CBE
57.22
41%
-103
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[12-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
---
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
H
I
V
A
K
GEHKSGV
L
----
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
-
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD-------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V
-
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
-
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
-
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
-----
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
--------------------
43
PsiBlast_CBE
56.73
41%
-105
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[17-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
---
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
H
I
V
A
K
GEHKSGV
L
----
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
-
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG--------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V-
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
-
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
-
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
-----
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
--------------------
49
PsiBlast_CBE
56.38
41%
-103
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[12-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
---
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
-
L
D
I
I
K
H
I
V
A
K
GEHKSGV
L
----
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
-
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD-----------
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V
-
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
-
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
-
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
-----
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
--------------------
27
PsiBlast_CBE
56.14
52%
-74
- C1 -
2F57
1
PAK7_HUMAN
A:
[24-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
---
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
-
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
-
P
R
V
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
-----
A
T
A
Q
E
L
L
G
H
P
F
-
L
-
K
L
--
A
G
P
P
S
C
I
V
P
L
M
-----------
42
PsiBlast_CBE
55.92
40%
-95
- C1 -
2J51
5
SLK_HUMAN
A:
[34-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
---
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
-
D
A
V
M
L
E
L
E
RP-------
L
----
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
-
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
----
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETSK
D
--
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
-
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
-
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
-----
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
---
L
I
A
E
A
K
-------
73
PsiBlast_CBE
55.19
32%
-112
- C1 -
4BIE
2
?
A:
[27-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
---------
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
------------------------
78
PsiBlast_CBE
53.81
32%
-107
- C1 -
4BIB
1
?
B:
[27-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
------------------------
79
PsiBlast_CBE
53.72
32%
-109
- C1 -
4BIB
3
?
A:
[27-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
---------
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
-------------------------
75
PsiBlast_CBE
53.20
32%
-112
- C1 -
4BID
1
?
A:
[27-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
---------
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
-------------------------
25
PsiBlast_CBE
52.97
52%
-70
- C1 -
4FIF
1
PAK4_HUMAN
B:
[52-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
-----------
26
PsiBlast_CBE
52.77
52%
-68
- C1 -
2F57
1
B:
[24-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
---
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
-
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
-
P
R
V
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
-----
A
T
A
Q
E
L
L
G
H
P
F
-
L
-
K
L
--
A
G
P
P
S
C
I
V
P
L
M
-----------
70
PsiBlast_CBE
52.32
32%
-108
- C1 -
4BF2
1
?
B:
[43-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
R
----------
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
------------------------
77
PsiBlast_CBE
52.21
32%
-110
- C1 -
4BIC
2
?
A:
[27-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
------
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
------------------------
74
PsiBlast_CBE
51.66
32%
-108
- C1 -
4BID
1
?
B:
[27-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
------------------------
72
PsiBlast_CBE
51.57
32%
-111
- C1 -
4BIE
2
?
B:
[27-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
R
--------
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
--
S
---------------------
76
PsiBlast_CBE
51.17
32%
-106
- C1 -
4BIC
2
?
B:
[27-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
--
S
---------------------
68
PsiBlast_CBE
51.10
33%
-111
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[30-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
R
D
-
S
---
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
------------------------
67
PsiBlast_CBE
51.09
33%
-107
- C1 -
2CLQ
1
B:
[30-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
V
------------------------
71
PsiBlast_CBE
50.70
32%
-111
- C1 -
4BF2
2
?
A:
[43-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
---
N
Q
V
R
I
A
I
K
E
I
P
E
-----------
E
-
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
-
S
A
L
L
R
S
K
W
---------
G
PLKD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
-----
K
GP
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
--
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
-----
A
C
A
N
D
L
L
V
D
E
F
-
L
-
K
-------------------------
24
PsiBlast_CBE
50.59
52%
-67
- C1 -
4FIG
1
?
B:
[53-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
-
T
D
I
V
T
H
T
R
---------
M
----
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
-
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
----
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
-
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
-----------
112
PsiBlast_CBE
50.56
31%
-106
- C1 -
3A61
1
KS6B1_HUMAN
A:
[25-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
GAN
T
G
K
I
F
A
M
K
V
L
-------
K
------A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
---------
F
----
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
--------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
--
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
-
E
N
R
K
K
T
I
D
K
I
L
K
C
----
K
L
N
L
P
-------
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
LGAGP
G
D
A
G
E
V
Q
A
H
P
F
-
F
-
R
-------------------------
39
PsiBlast_CBE
41.79
44%
-62
- C1 -
2XIK
2
STK25_HUMAN
A:
[16-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
---
T
K
E
V
V
A
I
K
I
I
D
L
E
E
-
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
K
P
G
P
---------
L
----
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
-
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
-
P
T
L
E
G
Q
-------
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
--
T
K
K
T
S
F
L
T
E
L
I
-----------
35
PsiBlast_CBE
40.76
45%
-61
- C1 -
3A7J
1
STK24_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
E
P
G
P
---------
L
----
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
-
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
-
P
T
L
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
-----------
36
PsiBlast_CBE
40.72
45%
-62
- C1 -
3A7I
1
STK24_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
E
P
G
P
---------
L
----
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
-
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
-
P
T
L
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
-----------
40
PsiBlast_CBE
40.02
45%
-63
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
E
P
G
P
---------
L
----
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
-
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
-
P
T
L
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
-----------
37
PsiBlast_CBE
38.06
45%
-57
- C1 -
3A7H
1
STK24_HUMAN
B:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
E
P
G
P
---------
L
----
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
-
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
-
P
T
L
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
-----------
38
PsiBlast_CBE
37.48
45%
-55
- C1 -
3A7H
1
STK24_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
---
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
D
L
L
E
P
G
P
---------
L
----
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
-
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
----
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
-
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
-
P
T
L
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
-----
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
-----------