@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PASK_HUMAN: (2013-07-24 )
MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
Atome Classification :
(71 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050........1060-.........1070......1080......1090......1100......1110......1120.......1130...---...1140.......1150-......1160......1170......1180......1190......1200-----..------....1210--...----..--..-1220......1230......1240---........1250......1260......1270......1280......1290......1300......1310......1320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVT--LEIAILSRVE----HANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRL-KDIIHRDIKDENIVI---AEDF-TIKLIDFGSAAYL-ERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF-----CE------LEETVEA---AIH----PP--YL-VSKELMSLVSGLLQPVPERRTT-----LEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
102
PsiBlast_CBE
68.24
31%
-93
- C1 -
3LIJ
1
?
A:
[15-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
G
D
L
Q
A
T
P
G
M
F
I
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
-----------
S
S
N
S
K
L
L
--
E
E
V
A
V
L
K
L
L
D
----
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
-
E
L
F
D
E
I
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
E
K
D
A
-
L
I
K
I
V
D
F
G
L
S
A
V
F
-
E
N
Q
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
--
R
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
GGQT
D
Q
E
------
I
L
R
K
V
E
K
---
G
K
Y
TFDS
P
E
--
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
Q
Q
A
L
E
H
P
W
I
K
E
----------------------------------------------------------------------
45
PsiBlast_CBE
68.07
34%
-98
- C1 -
3R02
4
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
49
PsiBlast_CBE
66.79
34%
-99
- C1 -
3CXW
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
--
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
101
PsiBlast_CBE
66.48
33%
-86
- C1 -
3HZT
9
?
A:
[3-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
-----
T
T
T
S
N
S
G
A
L
L
--
D
E
V
A
V
L
K
Q
L
D
----
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
-
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
R
D
A
-
L
I
K
I
V
D
F
G
L
S
A
H
F
-
E
V
G
--------
T
A
Y
Y
I
A
P
E
V
L
--
R
K
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
GGQT
D
Q
E
------
I
L
K
R
V
E
K
GKF
S
F
D
----
P
P
DW
T
Q
-
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
E
E
A
L
N
H
P
W
I
V
K
----------------------------------------------------------------------
20
PsiBlast_PDB
66.15
34%
-99
- C1 -
2XIY
3
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
126
HHSearch
66.13
31%
-92
- C1 -
4GV1
5
AKT1_HUMAN
A:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-----
K
D
E
V
A
H
T
L
--
T
E
N
R
V
L
Q
N
S
R
----
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
-
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
K
D
G
-
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
---
E
I
R
----
F
P
--
R
T
-
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
------
G
I
V
W
Q
H
V
Y
---------------------------------------------------------
69
PsiBlast_CBE
65.90
34%
-93
- C1 -
2J2I
1
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
57
PsiBlast_CBE
65.54
34%
-97
- C1 -
1YXU
2
PIM1_HUMAN
C:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
76
PsiBlast_CBE
65.44
34%
-98
- C1 -
3C4E
2
PIM1_HUMAN
D:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
28
PsiBlast_CBE
65.27
34%
-93
- C1 -
4ALW
3
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
67
PsiBlast_CBE
65.21
34%
-96
- C1 -
2BZH
2
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
60
PsiBlast_CBE
65.18
34%
-95
- C1 -
1YXT
1
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
35
PsiBlast_CBE
65.06
34%
-100
- C1 -
4ENY
3
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
-
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
------
R
V
P
--
M
E
V
V
L
L
K
K
V
S
S---
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
81
PsiBlast_CBE
64.90
34%
-95
- C1 -
4AS0
1
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
74
PsiBlast_CBE
64.90
34%
-94
- C1 -
4K0Y
1
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
47
PsiBlast_CBE
64.89
34%
-95
- C1 -
3R00
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
36
PsiBlast_CBE
64.83
34%
-97
- C1 -
4ENX
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
39
PsiBlast_CBE
64.80
34%
-95
- C1 -
3VC4
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
37
PsiBlast_CBE
64.76
34%
-100
- C1 -
3UMW
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
----
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
42
PsiBlast_CBE
64.75
34%
-97
- C1 -
3VBV
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
59
PsiBlast_CBE
64.69
34%
-95
- C1 -
1YXU
2
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
56
PsiBlast_CBE
64.60
34%
-93
- C1 -
1YXU
2
PIM1_HUMAN
D:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
70
PsiBlast_CBE
64.58
34%
-92
- C1 -
3JYA
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
48
PsiBlast_CBE
64.56
34%
-98
- C1 -
3CY2
2
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
--
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
44
PsiBlast_CBE
64.53
34%
-94
- C1 -
3R04
4
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
19
PsiBlast_PDB
64.35
34%
-91
- C1 -
1XR1
1
PIM1_HUMAN
A:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
54
PsiBlast_CBE
64.06
34%
-97
- C1 -
1YXX
2
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
55
PsiBlast_CBE
63.80
34%
-96
- C1 -
1YXV
2
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
136
HHSearch
63.74
31%
-91
- C1 -
2Y94
1
AAPK1_RAT
A:
[12-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
-----
L
D
V
V
G
K
I
R
--
R
E
I
Q
N
L
K
L
F
R
----
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
M
-
N
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
---
I
F
Y
----
T
P
--
Q
Y
-
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
-----
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
--------------------------------------------------------------------
73
PsiBlast_CBE
63.73
34%
-90
- C1 -
4K18
1
PIM1_HUMAN
A:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
17
PsiBlast_PDB
63.54
34%
-93
- C1 -
2XJ0
1
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
63
PsiBlast_CBE
63.28
34%
-92
- C1 -
2OI4
5
PIM1_HUMAN
X:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
77
PsiBlast_CBE
63.21
34%
-93
- C1 -
3C4E
2
PIM1_HUMAN
C:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
51
PsiBlast_CBE
63.20
34%
-96
- C1 -
2O64
3
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
46
PsiBlast_CBE
63.20
34%
-93
- C1 -
3R01
3
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
34
PsiBlast_CBE
63.08
34%
-91
- C1 -
3JPV
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
64
PsiBlast_CBE
62.92
34%
-96
- C1 -
2C3I
1
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
---
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
40
PsiBlast_CBE
62.83
34%
-95
- C1 -
3VBX
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
53
PsiBlast_CBE
62.80
34%
-95
- C1 -
2O3P
3
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
58
PsiBlast_CBE
62.76
34%
-95
- C1 -
1YXU
2
PIM1_HUMAN
B:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
71
PsiBlast_CBE
62.64
34%
-95
- C1 -
3JY0
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
33
PsiBlast_CBE
62.56
34%
-92
- C1 -
3QF9
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
32
PsiBlast_CBE
62.37
34%
-92
- C1 -
4GW8
2
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
27
PsiBlast_CBE
62.37
35%
-95
- C1 -
2IWI
1
PIM2_HUMAN
B:
[29-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
-----------------
T
CP
L
E
V
A
L
L
W
K
V
G
AGGG
H
P
G
V
I
R
L
L
D
W
F
E
----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
-
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D--
L
R
R
G
-
C
A
K
L
I
D
F
G
S
G
A
L
L
-
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
R
------
D
Q
E
I
L
E
A
---
E
L
H
----
F
P
--
A
H
-
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
-----
L
E
E
I
L
L
D
P
W
M
Q
-----------------------------------------------------------------------
38
PsiBlast_CBE
62.35
34%
-95
- C1 -
3UIX
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
16
PsiBlast_PDB
62.34
34%
-93
- C1 -
3A99
1
PIM1_HUMAN
A:
[44-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
66
PsiBlast_CBE
62.31
34%
-92
- C1 -
2BZJ
1
PIM1_HUMAN
A:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
79
PsiBlast_CBE
62.13
34%
-96
- C1 -
3C4E
2
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
72
PsiBlast_CBE
62.09
34%
-93
- C1 -
3JXW
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
62
PsiBlast_CBE
61.99
34%
-93
- C1 -
3BWF
1
PIM1_HUMAN
A:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
50
PsiBlast_CBE
61.98
34%
-86
- C1 -
2O65
2
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
29
PsiBlast_CBE
61.86
34%
-93
- C1 -
4ALV
2
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
52
PsiBlast_CBE
61.71
34%
-94
- C1 -
2O63
4
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
75
PsiBlast_CBE
61.69
34%
-93
- C1 -
4K1B
1
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
78
PsiBlast_CBE
60.96
34%
-95
- C1 -
3C4E
2
PIM1_HUMAN
B:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
41
PsiBlast_CBE
60.73
34%
-97
- C1 -
3VBW
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
88
PsiBlast_CBE
60.61
34%
-86
- C1 -
3F2A
1
PIM1_HUMAN
A:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
65
PsiBlast_CBE
60.41
34%
-90
- C1 -
2BZK
1
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
-----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
96
PsiBlast_CBE
60.31
34%
-87
- C1 -
4A7C
2
PIM1_HUMAN
A:
[32-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
92
PsiBlast_CBE
60.22
34%
-86
- C1 -
3CY3
2
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
--
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
14
PsiBlast_PDB
59.97
35%
-96
- C1 -
2IWI
1
PIM2_HUMAN
A:
[33-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
------------
V
T
CP
L
E
V
A
L
L
W
K
V
G
AGGG
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
-
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D--
L
R
R
G
-
C
A
K
L
I
D
F
G
S
G
A
L
L
-
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
R
------
D
Q
E
I
L
E
A
---
E
L
H
----
F
P
--
A
H
-
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
-----
L
E
E
I
L
L
D
P
W
M
Q
T
----------------------------------------------------------------------
82
PsiBlast_CBE
59.90
34%
-88
- C1 -
2XJ2
1
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
108
PsiBlast_CBE
59.76
34%
-91
- C1 -
4ALU
2
PIM1_HUMAN
A:
[76-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
84
PsiBlast_CBE
59.40
34%
-90
- C1 -
2XIZ
1
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
90
PsiBlast_CBE
59.33
34%
-84
- C1 -
3DCV
1
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
85
PsiBlast_CBE
58.73
34%
-85
- C1 -
3BGQ
1
PIM1_HUMAN
A:
[57-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
83
PsiBlast_CBE
58.40
34%
-86
- C1 -
2XJ1
1
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
87
PsiBlast_CBE
57.94
34%
-83
- C1 -
2OBJ
1
PIM1_HUMAN
A:
[57-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
94
PsiBlast_CBE
56.93
34%
-85
- C1 -
2BZI
1
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
86
PsiBlast_CBE
56.60
34%
-83
- C1 -
3BGP
1
PIM1_HUMAN
A:
[57-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
R
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------
93
PsiBlast_CBE
54.03
34%
-83
- C1 -
3MA3
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
--
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
-
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
-----
E
H
------
D
E
E
I
I
G
G
---
Q
V
F
----
F
R
--
Q
R
-
V
S
-
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
-----
F
E
E
I
Q
N
H
P
W
M
------------------------------------------------------------------------