@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PDPK1_HUMAN: (2013-07-24 )
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
Atome Classification :
(57 SA)
.........10........20........30........40........50........60........70........80........90........100---.......110.......120.......130....-...140.......150.......160.......170.......180.......190......-.200.......210---.......220.......230.......240.......250.......260.......270.......280.......290.......300----.......310.......320.......330......-----.340.......350.--.-----.....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLAREL---ATSREYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENIL---LNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFP----EKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKA-----HPFFESVTWENLHQQ--T-----PPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
6
PsiBlast_PDB
91.57
99%
-115
- C2 -
3QCX
6
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
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--
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-----
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------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.37
100%
-120
- C2 -
3ION
1
PDPK1_HUMAN
A:
[28-312]
--------------------------------------------------------------------------
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K
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-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
91.12
99%
-113
- C2 -
3QD3
3
PDPK1_HUMAN
A:
[24-311]
----------------------------------------------------------------------
P
P
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------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.07
100%
-116
- C2 -
2R7B
2
PDPK1_HUMAN
A:
[28-312]
--------------------------------------------------------------------------
R
K
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-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.01
99%
-118
- C2 -
3IOP
1
PDPK1_HUMAN
A:
[28-312]
--------------------------------------------------------------------------
R
K
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5
PsiBlast_PDB
90.93
99%
-115
- C2 -
3QCS
5
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
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------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.75
99%
-112
- C2 -
3QCY
5
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
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18
PsiBlast_PDB
90.67
99%
-113
- C2 -
3RWP
5
PDPK1_HUMAN
A:
[25-311]
------------------------------------------------------------------------
Q
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L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.59
99%
-112
- C2 -
3PWY
1
PDPK1_HUMAN
A:
[23-311]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
--------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.43
99%
-113
- C2 -
3QD4
1
PDPK1_HUMAN
A:
[24-311]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
90.22
99%
-114
- C2 -
3SC1
3
PDPK1_HUMAN
A:
[25-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
--------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
90.02
99%
-111
- C2 -
2XCH
7
PDPK1_HUMAN
A:
[23-309]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
--------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
89.98
99%
-115
- C2 -
2PE2
9
PDPK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
89.94
99%
-112
- C2 -
2PE0
4
PDPK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
89.92
99%
-113
- C2 -
1Z5M
4
PDPK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.77
99%
-116
- C2 -
3QCQ
5
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
89.58
99%
-114
- C2 -
2PE1
5
PDPK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
89.57
100%
-118
- C2 -
3NAX
1
PDPK1_HUMAN
A:
[25-309]
---------------------------------------------------------------------------
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
A
-------
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
89.44
99%
-107
- C2 -
3RWQ
4
PDPK1_HUMAN
A:
[24-311]
-----------------------------------------------------------------------
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.43
99%
-113
- C2 -
2XCK
5
PDPK1_HUMAN
A:
[26-309]
---------------------------------------------------------------------------
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
T
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
--------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.53
99%
-110
- C2 -
3QD0
6
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
76.02
99%
-67
- C2 -
1UVR
8
PDPK1_HUMAN
A:
[1-289]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A
N
-
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
75.96
99%
-65
- C2 -
3HRF
4
PDPK1_HUMAN
A:
[27-311]
--------------------------------------------------------------------------
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
A
N
-
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
75.30
99%
-66
- C2 -
1H1W
9
PDPK1_HUMAN
A:
[1-289]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A
N
-
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
73.70
99%
-67
- C2 -
3RCJ
1
PDPK1_HUMAN
A:
[29-310]
----------------------------------------------------------------------------
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
A
N
-
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.88
99%
-67
- C2 -
3HRC
1
PDPK1_HUMAN
A:
[28-311]
---------------------------------------------------------------------------
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
---
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A
N
-
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
D
F
P
----
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
-----
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-----
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.27
37%
-97
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
66.15
37%
-101
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
65.95
36%
-95
- C2 -
1RDQ
3
KAPCA_MOUSE
E:
[35-321]
-------------------------------------------------------------------------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
-----
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-----
V
E
A
--
P
F
I
P
K
F
K
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.52
37%
-98
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
65.47
37%
-102
- C2 -
2UZT
1
KAPCA_BOVIN
A:
[19-294]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
65.21
37%
-97
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
65.14
37%
-99
- C2 -
2UZU
1
KAPCA_BOVIN
E:
[19-294]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.95
37%
-103
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
63.90
37%
-96
- C2 -
2UZW
1
KAPCA_BOVIN
E:
[19-294]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
63.42
36%
-97
* C2 *
4GV1
5
AKT1_HUMAN
A:
[4-291]
---------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
-
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
--
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
I
M
Q
-----
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
--
K
-----
L
S
P
--
P
F
K
P
Q
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
63.25
38%
-95
- C2 -
1O6L
1
AKT2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
--
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
-
S
D
A
K
E
V
M
E
-----
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
-----
L
L
--
P
P
F
K
P
Q
V
T
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.91
40%
-101
- C2 -
2R5T
1
SGK1_HUMAN
A:
[29-313]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
-----
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
KI
T
-----
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
60.96
40%
-100
- C2 -
3HDN
1
SGK1_HUMAN
A:
[29-313]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
-----
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
KI
T
-----
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
60.90
40%
-97
- C2 -
3HDM
1
SGK1_HUMAN
A:
[29-313]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
----
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
-----
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
KI
T
-----
P
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
HHSearch
59.60
35%
-98
- C2 -
3UBD
1
KS6A3_MOUSE
A:
[19-304]
--------------------------------------------------------------------------
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
-
R
V
------
D
I
L
V
E
-
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
-
D
G
V
E
E
I
K
R
-----
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
--
E
-----
I
H
P
--
P
F
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
58.33
36%
-115
- C2 -
4FG7
1
KCC1A_HUMAN
A:
[18-277]
-------------------------------------------------------------------------------
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
-----------
S
M
E
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
M
E
D
P
G
-----------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
SPYW
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
------
A
L
Q
-----
H
P
W
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
52.33
37%
-64
- C2 -
3E88
1
AKT2_HUMAN
B:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
KEVME
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
52.31
37%
-66
- C2 -
3E87
1
AKT2_HUMAN
B:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
KEVME
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
52.16
37%
-66
- C2 -
3D0E
1
AKT2_HUMAN
A:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
52.06
37%
-66
- C2 -
3E87
1
AKT2_HUMAN
A:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
52.04
37%
-64
- C2 -
3E88
1
AKT2_HUMAN
A:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
51.32
37%
-64
- C2 -
3D0E
1
AKT2_HUMAN
B:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
KEVME
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
51.26
37%
-62
- C2 -
1O6K
1
AKT2_HUMAN
A:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
50.84
37%
-61
- C2 -
2JDR
1
AKT2_HUMAN
A:
[11-302]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPP
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
50.68
37%
-66
- C2 -
3E8D
1
AKT2_HUMAN
A:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
50.53
37%
-63
- C2 -
2UW9
1
AKT2_HUMAN
A:
[11-302]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
50.46
37%
-64
- C2 -
2XH5
1
AKT2_HUMAN
A:
[11-302]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
50.37
37%
-62
- C2 -
2JDO
2
AKT2_HUMAN
A:
[11-302]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
50.24
37%
-65
- C2 -
3E8D
1
AKT2_HUMAN
B:
[6-297]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
KEVME
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
49.94
37%
-64
- C2 -
2X39
1
AKT2_HUMAN
A:
[11-302]
--------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
-
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
------
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
--
K
LLPPF
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
27.88
37%
23
- C2 -
2UZV
1
KAPCA_BOVIN
A:
[19-294]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
-----
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------