@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PHKG2_HUMAN: (2013-07-24 )
MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
Atome Classification :
(43 SA)
.........-10........20........30........40........50.....---...60.........70...-.....80........90........100.......110.......120.----......130.......140....-...150.......-160-.---..---..----.---...170......-.-180..-.--..-..190.......200........210.......220.......230.....-..240-.........250.......260.......270.......280----........290-----...------....------------..--300-----.........310.......320.......330.......340.......350.......360.......370.......380.......390.......400....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTLDVGPED-ELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIME---VTAE-RLSPEQLEEVREAT-RRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV----ALSEKETRSIMRSLLEAVSFLHA-NNIVHRDLKPENI-L---L---DD---NM----Q---IRLSDFGFSCHL-E-PGEKL-R--EL-CGTPGYLAPEILK-CSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRR-QIL---MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLT-----AEQALQHPF-------FER------CEGS------------QP--W-------NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
22
PsiBlast_CBE
94.73
99%
-133
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
---
V
T
A
E
-
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
-
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
N
M
----
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
-
E
-
P
G
E
K
L
-
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
L
---
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
--------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.02
99%
-130
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
---
V
----
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
-
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
N
M
----
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
-
E
-
P
G
E
K
L
-
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
L
---
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
--------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
92.62
100%
-132
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
---
V
T
A
E
-
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
-
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
N
M
----
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
-
E
-
P
G
E
K
L
-
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
L
---
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
--------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.92
69%
-134
- C1 -
2PHK
2
PHKG1_RABIT
A:
[2-276]
--------------------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
---
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
D
M
----
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
-
P
G
E
K
L
-
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
L
---
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.62
67%
-124
- C1 -
1QL6
1
PHKG1_RABIT
A:
[11-289]
----------------
S
T
H
G
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
---
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
D
M
----
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
-
P
G
E
K
L
-
R
--
S
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
L
---
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.13
67%
-127
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-289]
--------------------
F
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
---
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
D
M
----
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
-
P
G
E
K
L
-
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
L
---
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
64.12
36%
-124
- C1 -
3LIJ
1
?
A:
[33-338]
------------------
G
H
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
---
K
--------
S
S
N
S
----
K
L
-
L
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
----
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
E
S
---
K
E
----
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
-
E
-
N
Q
K
K
M
-
K
--
E
R
-
L
G
T
A
Y
Y
I
A
P
E
V
L
R
--------
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
-
D
Q
E
---
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
Q
Q
A
L
E
H
P
W
-------
I
K
E
------
M
C
S
K
K
E
SL
P
S
L
A
N
A
I
E
N
M
--
R
-------
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
K
---------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.54
38%
-109
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[15-304]
------
T
E
N
L
Y
F
Q
S
M
A
T
C
T
R
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
-----
I
N
T
K
-
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
-
H
D
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
C
----
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
--
G
E
Q
Q
-
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
K
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
D
Q
A
L
K
H
P
W
-------
V
--------
C
Q
R
S
------------
T
V
--
A
-------
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.29
40%
-128
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[12-277]
------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-----
I
N
T
K
-
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
S
----
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
-
G
D
Q
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
-------
I
--------
C
Q
R
-------------------------
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
57.74
40%
-121
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-277]
---------------------
Y
Q
L
Y
E
D
---
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
-----
I
N
T
K
-
K
L
S
A
R
D
H
Q
K
L
-----
E
R
E
A
R
I
C
R
-
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
C
----
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
-
G
D
Q
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
K
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
H
E
A
L
K
H
P
W
-------
V
--------
C
Q
R
S
------------
T
V
--
A
-------
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.12
37%
-118
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[14-283]
------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
R
Q
S
-
R
A
S
R
R
G
V
S
--
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
I
PIP-
H
---
I
K
L
I
D
F
G
L
A
H
E
I
-
E
-
D
G
V
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
-------
I
T
P
------
V
D
N
Q
------------
Q
---------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
56.77
40%
-117
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[12-277]
------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-----
I
N
T
K
-
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
-
G
D
Q
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
-------
I
--------
C
Q
R
S
------------
T
V
--
A
-------
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
56.62
40%
-134
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-276]
--------------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
-----------
I
A
K
E
----------
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
YYS
L
---
D
E
---
D
S
----
K
---
I
M
I
S
D
F
------------------------
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
-------
I
----------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
56.50
40%
-121
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-277]
---------------------
Y
Q
L
Y
E
D
---
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
-----
I
N
T
K
-
K
L
S
A
R
D
H
Q
K
L
-----
E
R
E
A
R
I
C
R
-
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
C
----
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
-
G
D
Q
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
K
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
H
E
A
L
K
H
P
W
-------
V
--------
C
Q
R
S
------------
T
V
--
A
-------
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
55.98
35%
-115
- C1 -
3I7B
4
?
A:
[24-286]
--------------------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
------
S
K
-
R
Q
V
K
Q
K
T
D
--
K
E
S
L
-
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
E
S
KSK
D
A
----
N
---
I
R
I
I
D
F
G
L
S
T
H
F
-
E
-
A
S
K
K
M
-
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
---
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
-------
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
55.43
35%
-116
- C1 -
3N51
3
?
A:
[24-286]
--------------------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
------
S
K
-
R
Q
V
K
Q
K
T
D
--
K
E
S
L
-
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
E
S
KSK
D
A
----
N
---
I
R
I
I
D
F
G
L
S
T
H
F
-
E
-
A
S
K
K
M
-
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
---
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
-------
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.00
40%
-119
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[12-277]
------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
-----
I
N
T
K
-
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
S
----
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
-
G
D
Q
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
-------
I
--------
C
Q
R
S
------------
T
V
--
A
-------
S
M
M
H
R
Q
----------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
54.93
38%
-114
- C1 -
3MFR
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
A
K
F
-
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
ASK
E
N
---
S
A
----
P
---
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
-
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
-------
L
K
---------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
54.43
36%
-108
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[14-302]
------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
R
Q
S
-
R
A
S
R
R
G
V
--
C
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
I
P
I
P
-
H
---
I
K
L
I
D
F
G
L
A
H
E
I
-
E
-
D
G
V
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
-------
I
T
P
------
V
D
T
Q
------------
Q
A
--
M
V
R
R
E
SVV
N
L
E
N
F
K
K
Q
Y
V
------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
54.43
38%
-113
- C1 -
3MFU
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
A
K
F
-
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
ASK
E
N
---
S
A
----
P
---
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
-
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
-------
L
K
---------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
54.28
35%
-118
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[13-278]
------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
K
K
R
-
R
T
K
S
S
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
V
P
K
P
-
R
---
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-
F
G
N
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
-------
I
K
P
------
K
-------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
54.10
36%
-109
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[14-302]
------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
R
Q
S
-
R
A
S
R
R
G
V
--
C
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
I
P
I
P
-
H
---
I
K
L
I
D
F
G
L
A
H
E
I
-
E
-
D
G
V
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
-------
I
T
P
------
V
D
T
Q
------------
Q
A
--
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
53.86
35%
-120
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[13-282]
------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
K
K
R
-
R
T
K
S
S
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
V
P
K
P
-
R
---
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-
F
G
N
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
-------
I
K
P
------
K
D
T
Q
------------
Q
---------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
53.70
37%
-113
- C1 -
3C0H
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
A
K
F
-
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
ASK
E
N
---
S
A
----
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
-
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
-------
L
K
---------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
53.58
38%
-115
- C1 -
3MFS
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
A
K
F
-
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
ASK
E
N
---
S
A
----
P
---
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
-
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
-------
L
K
---------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
53.18
33%
-104
- C1 -
3IGO
8
?
A:
[20-288]
--------------------
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
---
K
A
S
A
-
K
------
N
K
-
T
S
T
I
-
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
E
S
KEK
D
C
----
D
---
I
K
I
I
D
F
G
L
S
T
C
F
-
Q
-
Q
N
T
-----------
T
A
Y
Y
I
A
P
E
V
L
R
-
G
T
Y
D
E
-------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
D
---
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
-------
I
Q
K
------
Y
S
S
E
------------
T
P
--------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
52.72
35%
-114
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
K
K
R
-
R
T
K
S
S
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
V
P
K
P
-
R
---
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-
F
G
N
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
-------
I
K
---------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
52.67
37%
-114
- C1 -
3C0G
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
A
K
F
-
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
ASK
E
N
---
S
A
----
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
-
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
-------
L
K
---------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
52.57
37%
-110
- C1 -
3C0I
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
A
K
F
-
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
ASK
E
N
---
S
A
----
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
-
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
-------
L
K
---------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
51.75
37%
-117
- C1 -
3C0G
1
CSKP_HUMAN
B:
[22-291]
--------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
A
K
F
-
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
ASK
E
N
---
S
A
----
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
-
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
-------
L
K
---------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
51.25
37%
-115
- C1 -
3C0H
1
CSKP_HUMAN
B:
[22-291]
--------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
A
K
F
-
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
DAGF
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
ASK
E
N
---
S
A
----
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
-
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
-------
L
K
---------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
51.20
37%
-104
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[9-311]
--------------------
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
-----
I
N
T
K
-
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
N
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
L
----
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
-
E
--
G
E
Q
Q
-
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
-----
A
A
E
A
L
K
H
P
W
-------
I
S
H
RSTVAS
C
M
H
R
------------
Q
E
--
T
V
D
C
L
K
--
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
--------------------------------------------------------------------------------------
83
PsiBlast_CBE
49.79
37%
-124
- C1 -
3HZT
9
?
A:
[12-263]
------------------------------
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
KSS
V
T
T
T
-
S
N
S
G
A
L
L
D
E
V
A
---------
V
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
----
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
E
S
---
K
S
----
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
F
-
E
-
V
G
------------
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
E
-------
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
-
D
Q
E
---
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
E
E
A
L
N
H
P
W
-------
I
----------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
49.26
31%
-112
- C1 -
4GV1
5
AKT1_HUMAN
A:
[8-273]
----------------------
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
---
K
E
V
I
-
V
-
A
K
D
E
V
----
A
H
T
-
L
T
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
---
L
---
D
K
---
D
G
----
H
---
I
K
I
T
D
F
G
L
C
K
E
G
-
I
K
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-------
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
-
H
E
K
---
L
F
E
L
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
-------
F
A
G
------
I
V
W
-----------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
49.24
37%
-116
- C1 -
4D9U
1
A:
[19-281]
-------------------
Q
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
----
K
S
K
-
R
D
P
T
E
E
I
E
------------
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
----
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
-
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
---
Y
---
V
D
---
E
S
GNPE
S
---
I
R
I
C
D
F
G
F
A
K
Q
L
-
R
-
A
E
N
G
L
-
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
-
D
D
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
-----
A
A
L
V
L
R
H
P
W
-------
I
----------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
47.83
35%
-106
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
K
K
R
-
R
T
K
S
S
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
V
P
K
P
-
R
---
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-
F
G
N
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
-------
I
K
---------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
46.79
37%
-113
- C1 -
4D9T
1
A:
[19-281]
-------------------
Q
F
T
D
G
Y
E
V
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
----
K
S
K
-
R
D
P
T
E
E
I
E
------------
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
K
----
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
-
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
---
Y
---
V
D
---
E
S
GNPE
S
---
I
R
I
C
D
F
G
F
A
K
Q
L
-
R
-
A
E
N
G
L
-
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
-
D
D
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
-----
A
A
L
V
L
R
H
P
W
-------
I
----------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
46.54
35%
-125
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
K
K
R
-
R
T
--------
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
----
V
PK
P
-
R
---
I
K
I
I
D
F
G
L
A
H
K
I
-
D
-----------------
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
-------
I
K
---------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
45.92
40%
-117
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-266]
----------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---------
K
K
S
----------
S
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
LTP
E
E
---
N
S
----
K
---
I
M
I
T
D
F
G
L
S
-
K
M
-
E
-
Q
N
G
I
M
-
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
S
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
-------
I
D
---------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
45.02
35%
-120
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[13-276]
------------------------
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
K
K
R
-
R
T
K
S
S
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
V
P
K
P
-
R
---
I
K
I
I
D
F
G
L
A
H
K
I
-
D
----------------
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
-------
I
K
---------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
44.90
40%
-118
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-266]
----------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---------
K
K
S
----------
S
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
LTP
E
E
---
N
S
----
K
---
I
M
I
T
D
F
G
L
S
-
K
M
-
E
-
Q
N
G
I
M
-
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
S
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
-------
I
D
---------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
44.81
37%
-112
- C1 -
2W4O
1
KCC4_HUMAN
A:
[61-346]
------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
---
K
----------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
---
A
T
PAP
D
A
----
P
---
L
K
I
A
D
F
----------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
-------
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
---
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
F
Q
A
L
Q
H
P
W
VTGKAAN
F
V
H
------
M
D
T
A
------------
Q
K
K
L
Q
-------
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
---------------------------------------------------------------------------------------
99
PsiBlast_CBE
44.06
35%
-114
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[13-276]
------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
-----
I
K
K
R
-
R
T
K
S
-
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
V
P
K
P
-
R
---
I
K
I
I
D
F
G
L
A
H
K
I
-
D
---------------
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
-------
I
K
---------------------------------------------------------------------------------------------------------------------------------------------