@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PIM1_HUMAN: (2013-07-24 )
MPHEPHEPLTPPFSALPDPAGAPSRRQSRQRPQLSSDSPSAFRASRSHSRNATRSHSHSHSPRHSLRHSPGSGSCGSSSGHRPCADILEVGMLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
Atome Classification :
(62 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160--.......170.......180.......190--.......200.......210.......220.......230.......240.......250.......260.......270---........280...-...-.290.......300.......310.......320.......330....------...340---------.......350.......360.......370.......380........390.......400..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPHEPHEPLTPPFSALPDPAGAPSRRQSRQRPQLSSDSPSAFRASRSHSRNATRSHSHSHSPRHSLRHSPGSGSCGSSSGHRPCADILEVGMLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEK--DRISDWGELPNGTRVPMEVVLLKKVSSGFS--GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG----ELKLIDFGSGALLK-DTV-YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRG---------QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQETAEIHLHSLSPGPSK
4
PsiBlast_PDB
94.01
98%
-127
- C1 -
3DCV
1
PIM1_HUMAN
A:
[47-320]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
16
PsiBlast_PDB
93.75
99%
-121
- C1 -
2OI4
5
PIM1_HUMAN
X:
[32-306]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
8
PsiBlast_PDB
93.74
99%
-127
- C1 -
3BGQ
1
PIM1_HUMAN
A:
[53-325]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
19
PsiBlast_PDB
93.40
99%
-127
- C1 -
3JPV
1
PIM1_HUMAN
A:
[34-306]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
22
PsiBlast_CBE
93.24
99%
-127
- C1 -
2J2I
1
PIM1_HUMAN
B:
[33-305]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
20
PsiBlast_PDB
93.23
99%
-128
- C1 -
3QF9
1
PIM1_HUMAN
A:
[33-306]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
36
PsiBlast_CBE
93.18
100%
-129
- C1 -
3R02
4
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
12
PsiBlast_PDB
93.16
99%
-127
- C1 -
2BZJ
1
PIM1_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
15
PsiBlast_PDB
93.15
99%
-126
- C1 -
2BZH
2
PIM1_HUMAN
B:
[32-306]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
57
PsiBlast_CBE
93.11
100%
-127
- C1 -
4K0Y
1
PIM1_HUMAN
A:
[1-274]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
10
PsiBlast_PDB
92.86
99%
-129
- C1 -
3CY2
2
PIM1_HUMAN
A:
[34-306]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
--
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
42
PsiBlast_CBE
92.76
100%
-124
- C1 -
2O65
2
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
17
PsiBlast_PDB
92.73
99%
-125
- C1 -
3BWF
1
PIM1_HUMAN
A:
[33-305]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
2
PsiBlast_PDB
92.57
99%
-126
- C1 -
4ALV
2
PIM1_HUMAN
A:
[48-321]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
5
PsiBlast_PDB
92.49
98%
-129
- C1 -
3T9I
1
PIM1_HUMAN
A:
[48-321]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
63
PsiBlast_CBE
92.44
99%
-127
- C1 -
4AS0
1
PIM1_HUMAN
A:
[1-273]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
59
PsiBlast_CBE
92.32
100%
-124
- C1 -
3C4E
2
PIM1_HUMAN
D:
[1-273]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
43
PsiBlast_CBE
92.30
100%
-125
- C1 -
2O64
3
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
60
PsiBlast_CBE
92.29
100%
-123
- C1 -
3C4E
2
PIM1_HUMAN
C:
[2-273]
----------------------------------------------------------------------------------------------------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
58
PsiBlast_CBE
92.13
100%
-124
- C1 -
4K1B
1
PIM1_HUMAN
A:
[1-273]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
55
PsiBlast_CBE
92.11
100%
-126
- C1 -
4K18
1
PIM1_HUMAN
A:
[1-277]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
-----
38
PsiBlast_CBE
92.04
100%
-125
- C1 -
3R00
2
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
13
PsiBlast_PDB
92.00
99%
-131
- C1 -
2BZK
1
PIM1_HUMAN
B:
[33-305]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
-----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
45
PsiBlast_CBE
91.96
100%
-127
- C1 -
2O3P
3
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
9
PsiBlast_PDB
91.76
99%
-127
- C1 -
3CXW
1
PIM1_HUMAN
A:
[34-307]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
--
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
21
PsiBlast_CBE
91.65
99%
-126
- C1 -
4GW8
2
PIM1_HUMAN
A:
[34-306]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
44
PsiBlast_CBE
91.64
100%
-124
- C1 -
2O63
4
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
47
PsiBlast_CBE
91.46
100%
-126
- C1 -
1YXV
2
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
6
PsiBlast_PDB
91.38
99%
-123
- C1 -
2OBJ
1
PIM1_HUMAN
A:
[53-325]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
46
PsiBlast_CBE
91.35
100%
-125
- C1 -
1YXX
2
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
51
PsiBlast_CBE
91.32
100%
-125
- C1 -
1YXU
2
PIM1_HUMAN
A:
[5-277]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
102
HHSearch
91.30
100%
-126
- C1 -
3A99
1
PIM1_HUMAN
A:
[40-312]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
39
PsiBlast_CBE
91.22
100%
-122
- C1 -
3JYA
1
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
29
PsiBlast_CBE
91.22
100%
-128
- C1 -
3UIX
2
PIM1_HUMAN
A:
[10-278]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
23
PsiBlast_CBE
91.15
100%
-127
- C1 -
1XR1
1
PIM1_HUMAN
A:
[19-295]
--------------------------------------------------------------------------------------------------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
-----
18
PsiBlast_PDB
91.07
99%
-120
- C1 -
4ALU
2
PIM1_HUMAN
A:
[48-321]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
S
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
41
PsiBlast_CBE
90.93
100%
-124
- C1 -
3JXW
1
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
49
PsiBlast_CBE
90.92
100%
-126
- C1 -
1YXU
2
PIM1_HUMAN
C:
[6-277]
----------------------------------------------------------------------------------------------------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
35
PsiBlast_CBE
90.91
100%
-125
- C1 -
3R04
4
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
7
PsiBlast_PDB
90.86
99%
-127
- C1 -
3BGP
1
PIM1_HUMAN
A:
[53-325]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
33
PsiBlast_CBE
90.82
100%
-126
- C1 -
3VBV
1
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
62
PsiBlast_CBE
90.80
100%
-124
- C1 -
3C4E
2
PIM1_HUMAN
A:
[1-273]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
31
PsiBlast_CBE
90.73
100%
-126
- C1 -
3VBX
1
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
48
PsiBlast_CBE
90.61
100%
-127
- C1 -
1YXU
2
PIM1_HUMAN
D:
[5-277]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
61
PsiBlast_CBE
90.41
100%
-121
- C1 -
3C4E
2
PIM1_HUMAN
B:
[1-273]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
27
PsiBlast_CBE
90.26
100%
-127
- C1 -
4ENX
1
PIM1_HUMAN
A:
[10-278]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
32
PsiBlast_CBE
90.14
100%
-126
- C1 -
3VBW
1
PIM1_HUMAN
A:
[8-278]
-----------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
---
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
14
PsiBlast_PDB
90.04
99%
-124
- C1 -
2C3I
1
PIM1_HUMAN
B:
[37-305]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
---
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
50
PsiBlast_CBE
89.76
100%
-126
- C1 -
1YXU
2
PIM1_HUMAN
B:
[5-277]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
26
PsiBlast_CBE
89.73
100%
-128
- C1 -
4ENY
3
PIM1_HUMAN
A:
[10-278]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
-
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
------
R
V
P
M
E
V
V
L
L
K
K
V
S
S
-
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
--------
28
PsiBlast_CBE
89.68
100%
-130
- C1 -
3UMW
2
PIM1_HUMAN
A:
[10-277]
-------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
----
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
---------
40
PsiBlast_CBE
89.49
100%
-125
- C1 -
3JY0
1
PIM1_HUMAN
A:
[6-280]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
------
30
PsiBlast_CBE
89.33
100%
-124
- C1 -
3VC4
2
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
52
PsiBlast_CBE
89.30
100%
-120
- C1 -
1YXT
1
PIM1_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
3
PsiBlast_PDB
88.87
99%
-123
- C1 -
4ALW
3
PIM1_HUMAN
A:
[49-321]
----------------------------------------------------------------------------------------------------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
37
PsiBlast_CBE
88.29
100%
-124
- C1 -
3R01
3
PIM1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
--
D
R
I
S
D
W
G
E
L
P
N
G
T
R
V
P
M
E
V
V
L
L
K
K
V
S
S
G
F
S
--
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
G
----
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
---------
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
-
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
-------
64
PsiBlast_CBE
74.14
58%
-130
- C1 -
2IWI
1
PIM2_HUMAN
B:
[24-288]
-----------------------------------------------------------------------------------------------------------------------
K
D
R
E
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
---------------
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
HP
G
V
I
R
L
L
D
W
F
E
----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
----
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
E
I
L
E
A
---------
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
-
M
Q
----------------------
65
PsiBlast_CBE
73.74
58%
-135
- C1 -
2IWI
1
PIM2_HUMAN
A:
[33-289]
--------------------------------------------------------------------------------------------------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
--
N
R
V
L
--------
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
HP
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
----
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
-
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
E
I
L
E
A
---------
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
-
M
Q
T
---------------------
115
HHSearch
58.10
30%
-122
- C1 -
2Y94
1
AAPK1_RAT
A:
[10-272]
------------------------------------------------------------------------------------------------------------------------
D
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
--
Q
K
I
R
S
---
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
--
H
P
--
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
-
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
-
M
----
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
-
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
---------
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
-
F
K
Q
---------------------
70
PsiBlast_CBE
56.65
33%
-118
- C1 -
4BL1
1
MELK_HUMAN
A:
[3-273]
-----------------------------------------------------------------------------------------------------------------------
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
--
N
T
L
-----
L
P
---
R
I
K
T
E
I
E
A
L
K
N
L
R
H
--
Q
--
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
-
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
-
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
A
K
-------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
---------
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
---------------
83
PsiBlast_CBE
54.77
31%
-106
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[6-279]
------------------------------------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
RQ
S
R
A
S
R
R
G
V
C
R
E
--
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
--
P
--
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
-
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
-
L
D
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
----
Q
E
T
L
A
N
I
T
A
VSYDFD
E
E
F
F
S
Q
-
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-
I
T
P
V
--------------------
84
PsiBlast_CBE
52.92
31%
-103
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[6-279]
------------------------------------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
C
R
E
--
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
--
P
--
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
-
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
-
L
D
K
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
----
Q
E
T
L
A
N
I
T
A
VSYDFD
E
E
F
F
S
Q
-
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-
I
T
P
V
--------------------