@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PKN2_HUMAN: (2013-07-24 )
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADWC
Atome Classification :
(50 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670....---.---..680.......690.......700.......710.......720.......730.......740.......750-----.-.-......760.......770..-.-..-..780.......790.......800.......810..-......820.......830---...----......840.......850.......860-.----.----.......870.--.....--.---880.......890.......900-..-.....910.......920.......930......-----.940.......950.......960..---.....970.......980..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY---K---NTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-T-----D-V-FSEPRAVFYAACVVLGLQYLH-E-HK-IVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYG-DR-TSTFCGTPEFLAPEVLT-----ETS----YTRAVDWWGLGVLIYEMLVGESPFPGD---D----E----EEVFDSIVNDE--VRYPR--F---LSTEAISIMRRLLRRNPERRLGA-SE-KDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIR-----GREDVSNFDDEFTSEAPILTPPREPR---ILSEEEQEMFRDFDYIADWC
2
PsiBlast_PDB
91.63
48%
-113
- C2 -
2JDR
1
AKT2_HUMAN
A:
[8-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
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-----
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S
I
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-----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
-
90
HHSearch
91.39
51%
-116
- C2 -
1O6L
1
AKT2_HUMAN
A:
[2-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
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---
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A
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I
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-----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
-
4
PsiBlast_PDB
90.42
48%
-113
- C2 -
2X39
1
AKT2_HUMAN
A:
[8-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
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L
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A
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Q
E
M
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A
D
W
-
3
PsiBlast_PDB
89.59
48%
-112
- C2 -
2UW9
1
AKT2_HUMAN
A:
[8-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
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87
HHSearch
89.46
48%
-111
- C2 -
4GV1
5
AKT1_HUMAN
A:
[4-337]
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--
1
PsiBlast_PDB
89.16
48%
-114
- C2 -
2JDO
2
AKT2_HUMAN
A:
[8-342]
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T
M
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---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
M
F
E
D
F
D
Y
I
A
D
W
-
5
PsiBlast_PDB
88.31
48%
-116
- C2 -
2XH5
1
AKT2_HUMAN
A:
[8-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
-----
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
-
89
HHSearch
87.82
46%
-112
- C2 -
4DC2
1
KPCI_MOUSE
A:
[49-387]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
--
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
-
R
Q
----
R
-
K
-
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
-
D
T
-
T
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
-----
G
E
D
----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
GSN
T
----
E
----
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
R
--
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
-----
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
-
D
---
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
--
14
PsiBlast_PDB
87.26
46%
-113
- C2 -
3E87
1
AKT2_HUMAN
A:
[3-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
-----
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
---
16
PsiBlast_PDB
86.68
46%
-115
- C2 -
3E8D
1
AKT2_HUMAN
A:
[3-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
-----
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
H
F
P
Q
F
D
Y
S
A
---
15
PsiBlast_PDB
85.95
46%
-112
- C2 -
3E88
1
AKT2_HUMAN
A:
[3-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
-----
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
--------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
---
17
PsiBlast_PDB
85.76
46%
-110
- C2 -
3D0E
1
AKT2_HUMAN
A:
[3-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
-----
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
D
-----------
Q
R
T
H
F
P
Q
F
D
Y
S
A
---
13
PsiBlast_PDB
85.70
46%
-111
- C2 -
1O6K
1
AKT2_HUMAN
A:
[3-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
---
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
-----
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
---
104
HHSearch
85.61
50%
-118
- C2 -
4EJN
3
AKT1_HUMAN
A:
[144-438]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-------------
V
L
---
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
E
----
R
-
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
E
K
N
-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-------
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
-----
S
E
T
D
T
R
Y
F
-----------------------------------------
94
HHSearch
85.46
50%
-120
- C2 -
1XJD
1
A:
[16-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
--
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
-
S
C
----
H
-
K
-
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
-
A
K
-
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
-----
G
Q
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
---
D
----
E
----
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
R
--
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
-----------------------------------------------
Q
N
M
F
R
N
F
S
F
-----
19
PsiBlast_PDB
84.58
47%
-105
- C2 -
3OCB
1
AKT1_HUMAN
A:
[7-337]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
-----
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
-
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
-----
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
-------------------
R
P
H
F
P
Q
F
D
Y
S
A
---
20
PsiBlast_PDB
84.01
47%
-106
- C2 -
3OW4
1
AKT1_HUMAN
A:
[7-337]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
-
R
-----
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
-
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
---
D
----
H
----
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
--
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
-----
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
-----------------
R
P
H
F
P
Q
F
D
Y
S
A
---
92
HHSearch
83.70
49%
-108
- C2 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
---
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
--
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
-
K
S
----
R
-
R
-
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
-----------
G
T
P
D
Y
I
A
P
E
I
L
Q
-----
E
M
L
----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
---
N
----
E
----
D
D
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
T
--
W
---
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
-
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
-----
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
----
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
--
100
HHSearch
78.60
40%
-98
- C2 -
1RDQ
3
KAPCA_MOUSE
E:
[36-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
-
R
I----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
-
G
R
-
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
----------
C
G
K
E
F
T
E
F
-------
98
HHSearch
78.19
37%
-108
- C2 -
3C4Z
1
RK_BOVIN
A:
[180-510]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
---
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
-
N
VDED
N
P
-
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-----
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
---
G
E
K
V
E
N
----
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
D
--
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
TVYAK
N
----
G
A
F
S
---------------
G
V
---
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
---
33
PsiBlast_CBE
76.91
41%
-105
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[40-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
29
PsiBlast_CBE
75.99
41%
-103
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[40-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
30
PsiBlast_CBE
75.63
41%
-104
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[40-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
34
PsiBlast_CBE
75.54
41%
-106
- C2 -
2UZW
1
KAPCA_BOVIN
E:
[25-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
32
PsiBlast_CBE
75.48
41%
-101
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[40-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
37
PsiBlast_CBE
75.43
41%
-109
- C2 -
2UZT
1
KAPCA_BOVIN
A:
[25-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
31
PsiBlast_CBE
75.18
41%
-113
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[40-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
99
HHSearch
73.90
35%
-102
- C2 -
4AW2
3
MRCKA_RAT
A:
[70-406]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
---
K
---
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
---
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
-
K
F
E---
D
-
R
-
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
-
Q
-
L
H
-
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
-
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GG
K
G
R
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
---
S
----
L
----
V
E
T
Y
G
K
I
M
N
H
K
ER
F
Q
F
P
T
--
Q
VTD
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
-
R
L
G
Q
----
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
-----
S
P
T
D
T
S
N
F
D
V
D
---------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
--
36
PsiBlast_CBE
73.76
41%
-105
- C2 -
2UZU
1
KAPCA_BOVIN
E:
[25-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
24
PsiBlast_CBE
73.67
44%
-123
- C2 -
2R5T
1
SGK1_HUMAN
A:
[39-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
-
R
-----
E
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
T
-
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
---
N
----
T
----
A
E
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
P
--
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
--
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
-----
G
------------------------------------------------
35
PsiBlast_CBE
72.30
41%
-103
- C2 -
2UZV
1
KAPCA_BOVIN
A:
[25-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-----
G
-
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
-
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
---
Q
----
P
----
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
--
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
---------------------------------------
23
PsiBlast_CBE
71.65
44%
-116
- C2 -
3HDM
1
SGK1_HUMAN
A:
[39-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
-
R
-----
E
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
T
-
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
---
N
----
T
----
A
E
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
P
--
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
--
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
-----
G
------------------------------------------------
39
PsiBlast_CBE
71.41
41%
-116
- C2 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
---
D
S
G
H
L
Y
A
M
K
V
L
K
------------------
I
L
A
D
V
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
-
K
-----
E
-
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
---
D
----
R
----
K
E
T
M
T
L
I
L
K
A
K
--
L
G
M
P
Q
--
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------
106
HHSearch
70.50
43%
-112
* C2 *
3A62
1
KS6B1_HUMAN
A:
[13-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
---
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
-------------
K
A
E
R
N
I
L
E
E
V
---
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
-
R
E
----
G
-
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
------------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
---
N
----
R
----
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
P
--
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
--------------------------------------------------------
41
PsiBlast_CBE
69.97
41%
-116
- C2 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
---
D
S
G
H
L
Y
A
M
K
V
L
-------------------
I
L
A
D
V
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
-
K
-----
E
-
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
---
D
----
R
----
K
E
T
M
T
L
I
L
K
A
K
--
L
G
M
P
Q
--
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------
53
PsiBlast_CBE
68.90
38%
-104
- C2 -
3C4W
1
RK_BOVIN
B:
[189-474]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
---
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
-
N
V
DED
N
P
-
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-----
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
---
G
----
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
D
--
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
------------------------------------------------------
46
PsiBlast_CBE
68.75
38%
-103
- C2 -
3T8O
2
RK_BOVIN
A:
[189-474]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
---
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
-
N
VDED
N
P
-
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-----
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
---
G
----
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
D
--
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
------------------------------------------------------
22
PsiBlast_CBE
68.59
44%
-121
- C2 -
3HDN
1
SGK1_HUMAN
A:
[39-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
-
R
-----
E
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
T
-
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
---
N
----
T
----
A
E
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
P
--
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
--
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
---------------------------------------------------------
25
PsiBlast_CBE
68.40
43%
-116
- C2 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
---
N
T
G
K
I
F
A
M
K
V
L
K
--------------
A
E
R
N
I
L
E
---
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
-
R
-----
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
---
N
----
R
----
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
P
--
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
---------------------------------------------------------
50
PsiBlast_CBE
68.34
38%
-103
- C2 -
3C50
1
RK_BOVIN
A:
[189-474]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
---
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
-
N
VDEDN
P
-
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-----
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
---
G
----
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
D
--
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
------------------------------------------------------
38
PsiBlast_CBE
67.81
41%
-110
- C2 -
3G51
1
KS6A3_MOUSE
A:
[26-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
---
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
----------
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
-
K
-----
E
-
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-------------
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
---
D
----
R
----
K
E
T
M
T
M
I
L
K
A
K
--
L
G
M
P
Q
--
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------------------------------------------
49
PsiBlast_CBE
67.55
38%
-102
- C2 -
3C50
1
RK_BOVIN
B:
[189-474]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
---
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
-
N
VDEDN
P
-
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-----
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
---
G
----
E
KVEN
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
D
--
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
------------------------------------------------------
48
PsiBlast_CBE
67.55
38%
-103
- C2 -
3C51
1
RK_BOVIN
A:
[189-474]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
---
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
-
N
VDEDN
P
-
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-----
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
---
G
----
E
KVE
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
D
--
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
------------------------------------------------------
40
PsiBlast_CBE
67.55
41%
-109
- C2 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
---
D
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
------------
I
L
A
D
V
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
-
K
-----
E
-
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
---
D
----
R
----
K
E
T
M
T
L
I
L
K
A
K
--
L
G
M
P
Q
--
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
---------------------------------------------------------
75
PsiBlast_CBE
67.37
33%
-86
- C2 -
3D9V
1
ROCK1_HUMAN
A:
[67-402]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
---
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-
N
-----
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
G
-
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
-
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
---
S
----
L
----
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
D
DN
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
-----
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
---
F
V
G
N
--
Q
L
P
F
V
G
F
T
Y
Y
S
N
--
27
PsiBlast_CBE
67.28
43%
-108
- C2 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
----------
K
A
E
R
N
I
L
E
---
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
-
R
-----
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
---------------
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
---
N
----
R
----
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
P
--
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
---------------------------------------------------------
74
PsiBlast_CBE
67.19
33%
-86
- C2 -
3D9V
1
ROCK1_HUMAN
B:
[67-402]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
---
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-
N
-----
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
G
-
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
-
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
---
S
----
L
----
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
D
DN
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
-----
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
---
F
V
G
N
--
Q
L
P
F
V
G
F
T
Y
Y
S
N
--
52
PsiBlast_CBE
66.66
38%
-103
- C2 -
3C4X
1
RK_BOVIN
B:
[189-474]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
---
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
-
N
VDEDN
P
-
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-----
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
---
G
----
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
D
--
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
------------------------------------------------------
26
PsiBlast_CBE
65.67
43%
-105
- C2 -
3A60
1
KS6B1_HUMAN
B:
[19-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
-
R
-----
E
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
---
N
----
R
----
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
P
--
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
--------------------------------------------------------
47
PsiBlast_CBE
65.32
38%
-100
- C2 -
3C51
1
RK_BOVIN
B:
[189-474]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
---
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
--
D
I
R
Y
H
I
Y
------------
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
-
T
K
-
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
-----
G
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
---
G
----
E
E
N
--
K
E
L
K
Q
R
V
---------
P
D
--
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
------------------------------------------------------