@TOME V2.3
(Nov 2016)

Ref. - - Doc.
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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : RET_HUMAN: (2015-06-18 )
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS

Atome Classification :

(16 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.....-..730.......740....-...750.-........760.......-770.......780-.......790....-...800.......810.......820----.........830.......840...-....850.......860.......870.......880.......890.......900...-...-.910.......920.......930.......940.......950.......960........970.......980.......990.......1000.....--.1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110.
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLG-KTLGEGEFGKVVKATAFHL-KGRA--G-YTTVAVKMLKENASPSEL-RDLLSEFNVLKQV-NHPHVIKLYGACSQ-DGPLLLIVEYAKYGSLRGFLRESR------KVGPGYLGSGGSRNSSSLDHPDERA-LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKR-SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
2 PsiBlast_PDB 89.8899% -99 - C1 -2IVU A:[5-313] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSVDAFKIL-DPKWEFPRKNLVLG-KTLGEGEFGKVVKATAFHL-KGRA--G-YTTVAVKMLKENASPSEL-RDLLSEFNVLKQV-NHPHVIKLYGACSQ-DGPLLLIVEYAKYGSLRGFLRESR-----------------------------RA-LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKR-SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKR------------------------------------------------------------------------------------------------------
4 PsiBlast_PDB 89.0599%-104 - C1 -2X2M RET_HUMAN A:[5-314] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSVDAFKIL-DPKWEFPRKNLVLG-KTLG--EFGKVVKATAFHL-KGRA--G-YTTVAVKMLKENASPSEL-RDLLSEFNVLKQV-NHPHVIKLYGACSQ-DGPLLLIVEYAKYGSLRGFLRESR------------------------------A-LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKR-SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRR-----------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 87.7099% -99 - C1 -2IVV A:[5-312] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSVDAFKI----KWEFPRKNLVLG-KTLGEGEFGKVVKATAFHL-KGRA--G-YTTVAVKMLKENASPSEL-RDLLSEFNVLKQV-NHPHVIKLYGACSQ-DGPLLLIVEYAKYGSLRGFLRESR--------------------------------LTMGDLISFAWQISQGMQYLAEMSLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKR-SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVK-------------------------------------------------------------------------------------------------------
3 PsiBlast_PDB 87.3799%-103 - C1 -2X2L A:[5-311] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSVDAFKIL--PKWEFPRKNLVLG-KTLGEGEFGKVVKATAFHL-KGRA--G-YTTVAVKMLKENASPSEL-RDLLSEFNVLKQV-NHPHVIKLYGACSQ-DGPLLLIVEYAKYGSLRGFLRESR------KV---------------------RA-LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKR-SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MV--------------------------------------------------------------------------------------------------------
124 HHSearch 86.97100% -98 - C1 -2IVS RET_HUMAN A:[14-313] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDPKWEFPRKNLVLG-KTLGEGEFGKVVKATAFHL-KGRA--G-YTTVAVKMLKENASPSEL-RDLLSEFNVLKQV-NHPHVIKLYGACSQ-DGPLLLIVEYAKYGSLRGFLRESR------KVGPGYL----------------RA-LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKR-SQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKR------------------------------------------------------------------------------------------------------
40 PsiBlast_CBE 72.3353%-101 - C1 -4F64 FGFR1_HUMAN A:[8-302] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPEDPRWELPRDRLVLG-KPL-----GQVVLAEAIGL-----PNR-VTKVAVKMLKSDATEKDL-SDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLQARR------PP--------------------EEQ-LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY-KKT-TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI--VALTS-----------------------------------------------------------------------------------------------------
108 PsiBlast_CBE 70.4043%-102 - C1 -1Y6B A:[21-359] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KWEFPRDRLKLG-KPLGRG--GQVIEADAFGI-DKTA--T-CRTVAVKMLK--ATHSEH-RALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPY-------------------------FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDF----------------------PLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNL--LQANA-----------------------------------------------------------------------------------------------------
60 PsiBlast_CBE 70.3851%-102 - C1 -4J95 ? D:[23-317] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPEDPKWEFPRDKLTLG-KPLGEGAFGQVVMAEAVGI-DKDKPKE-AVTVAVKMLKDDATEKDL-SDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLRARR------------------------------Q-MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-------------GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI--LTLT------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 70.3753% -99 - C1 -1FGI B:[6-303] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEYELPEDPRWELPRDRLVLG-KPLGEGAFGQVVLAEAIGL-----PNR-VTKVAVKMLKSDATEKDL-SDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLQARR------------------------------Q-LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA------DYY-KK----GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI--VALT------------------------------------------------------------------------------------------------------
34 PsiBlast_CBE 70.3253% -97 - C1 -4NKA FGFR1_HUMAN A:[8-302] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPEDPRWELPRDRLVLG-KPLGE----QVVLAEAIGL-DKDKPNR-VTKVAVKMLKSDATEKDL-SDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLQARR------PP--------------------EEQ-LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG-------IDYY-KKT-TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI--VALTSNQE--------------------------------------------------------------------------------------------------
21 PsiBlast_CBE 69.3852% -99 - C1 -3GQL C:[15-318] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YELPEDPRWELPRDRLVLG-KPLGEGAFGQVVLAEAIGLDKDKP--NRVTKVAVKMLKSDATEKDL-SDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLQARR------PP---------------------EQ-LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR------------------PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEY---------------------------------------------------------------------------------------------------
29 PsiBlast_CBE 69.2853% -98 - C1 -1AGW B:[6-303] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEYELPEDPRWELPRDRLVLG-KPLGEGAFGQVVLAEAIGL-----PNR-VTKVAVKMLKSDATEKDL-SDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLQARR------------------------------Q-LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA------DYY-KK----GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI--VALT------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 68.3253% -98 - C1 -2FGI B:[6-303] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEYELPEDPRWELPRDRLVLG-KPLGEGAFGQVVLAEAIGL-----PNR-VTKVAVKMLKSDATEKDL-SDLISEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGNLREYLQARR------------------------------Q-LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA------DYY-KK----GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI--VALT------------------------------------------------------------------------------------------------------
130 HHSearch 65.3438% -87 - C1 -3CBL A:[106-376] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDKWVLNHEDLVLG-EQIGRGNFGEVFSGRLR------A--D-NTLVAVKSCRETLPPDLK-AKFLQEARILKQY-SHPNIVRLIGVCTQ-KQPIYIVMELVQGGDFLTFLRTEG-----------------------------AR-LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG-VY-AASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI--RKRH------------------------------------------------------------------------------------------------------
122 HHSearch 63.6538% -94 - C1 -4AOJ NTRK1_HUMAN A:[33-322] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVHHIKRRDIVLK-WELGEGAFGKVFLAECHNL-LP------KMLVAVKALKE-ASESAR-QDFQREAELLTML-QHQHIVRFFGVCTE-GRPLLMVFEYMRHGDLNRFLRSHG------PD--------------------PGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG------------------TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI-DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL--AQAPP-----------------------------------------------------------------------------------------------------
125 HHSearch 62.7839% -94 - C1 -4FYO A:[11-280] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYLDRKLLTLEDKELGSGNFGTVKKGY---Y-QMKK--V-VKTVAVKIL------PALKDELLAEANVMQQL-DNPYIVRMIGICE--AESWMLVMEMAELGPLNKYLQQNR------H-------------------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA-----KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT-AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY--YYDVVNEGHH------------------------------------------------------------------------------------------------