@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ROCK2_HUMAN: (2013-07-24 )
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS
Atome Classification :
(44 SA)
.........10........20........30......----..40.-----.......50........60........70........80........90........100.......110.---......120.......130.......140...-..-..150.......160.......170......-.180.-..--.-...190.......200....-...210.......220.......230...---.---...240.......250.......260..-.....270.......280.......290......---.300.......310....-...-320.......-330..-.-.....340-.---..--.....350.......360..--.....370.......380.......390.......400-...--......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDP----RSPIN-----VESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKA---SQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA-FA-NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSN-YD--V-PEKWAKFYTAEVVLALDAIH-SMGLIHRDVKPDNMLLDKHGHLKLADFGT---C---MKMDETGMVHCDTAVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADS---LVGTYSKIMDHKNSLCFP-EDA-EISKHAKNLI-CA-FL-T-DREVRLG--R---NG--VEEIRQHPFFKNDQWHWDNI--RETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIP---KAF--VGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS
1
PsiBlast_PDB
67.73
98%
-95
- C3 -
2F2U
1
ROCK2_BOVIN
A:
[12-402]
--------------------------
Q
R
K
L
E
A
L
I
R
D
P
----
R
S
P
I
N
-----
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
---
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
-
E
D
A
-
E
I
S
K
H
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
Q
H
P
F
F
K
N
D
Q
W
N
W
D
N
I
--
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
-----
V
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.56
98%
-85
- C3 -
2H9V
1
ROCK2_BOVIN
A:
[10-402]
------------------------
S
R
Q
R
K
L
E
A
L
I
R
D
P
----
R
S
P
I
N
-----
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
---
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
-
E
D
A
-
E
I
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K
H
A
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N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
Q
H
P
F
F
K
N
D
Q
W
N
W
D
N
I
--
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
----------
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
65.96
83%
-86
- C3 -
2ETR
1
ROCK1_HUMAN
B:
[9-402]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
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V
L
A
L
D
A
I
H
-
S
M
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F
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D
N
M
L
L
D
K
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G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
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M
V
R
C
D
T
A
V
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T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
65.90
98%
-90
- C3 -
2F2U
1
ROCK2_BOVIN
B:
[12-402]
--------------------------
Q
R
K
L
E
A
L
I
R
D
P
----
R
S
P
I
N
-----
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
---
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
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G
G
D
L
V
-
N
L
M
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N
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Y
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--
V
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A
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A
I
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N
M
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A
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---
C
---
M
K
M
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Y
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A
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---
N
G
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A
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V
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E
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I
D
S
S
N
F
D
D
I
--------
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.69
83%
-83
- C3 -
2ESM
1
ROCK1_HUMAN
A:
[9-405]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
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S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
65.68
83%
-86
- C3 -
3D9V
1
ROCK1_HUMAN
B:
[9-402]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.49
83%
-87
- C3 -
2ETK
1
ROCK1_HUMAN
A:
[9-405]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
65.45
83%
-87
- C3 -
2ETK
1
ROCK1_HUMAN
B:
[9-402]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.39
83%
-86
- C3 -
2ESM
1
ROCK1_HUMAN
B:
[9-402]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.36
83%
-86
- C3 -
3D9V
1
ROCK1_HUMAN
A:
[9-405]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.22
83%
-86
- C3 -
2ETR
1
ROCK1_HUMAN
A:
[9-405]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.39
85%
-88
- C3 -
2V55
1
ROCK1_HUMAN
A:
[9-400]
------------------------
T
R
F
E
K
M
D
N
L
L
R
D
P
----
K
S
E
V
N
-----
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
---
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
N
-
Y
D
--
V
-
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
---
C
---
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
---
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
-
D
D
N
-
D
I
S
K
E
A
K
N
L
I
-
C
A
-
F
L
-
T
-
D
R
E
V
R
L
G
--
R
---
N
G
--
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
--
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
P
---
K
A
F
--
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.75
48%
-76
- C3 -
4AW2
5
MRCKA_RAT
A:
[1-416]
---------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
----
P
A
Q
T
N
GQCFS
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
---
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
-
T
L
L
S
K
-
F
E
DR
L
-
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
---
C
---
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
G
K
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
---
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
Q
F
P
T
Q
V
T
-
D
V
S
E
N
A
K
D
L
I
-
R
R
-
L
I
-
C
-
S
R
E
H
R
L
G
--
Q
---
N
G
--
I
E
D
F
K
K
H
P
F
F
S
G
I
D
--
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
---------------------
S
G
H
H
L
P
F
V
G
F
T
-
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
60.49
47%
-85
- C3 -
3QFV
3
MRCKB_HUMAN
B:
[6-409]
-------------------------
R
L
K
K
L
E
Q
L
L
L
D
G
PWRN
E
S
A
L
S
-----
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
---
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
-
T
L
L
S
K
-
F
E
DK
L
-
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
---
C
---
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
---
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
-
S
H
V
T
D
V
S
E
E
A
K
D
L
I
-
Q
R
-
L
I
-
C
-
S
R
E
R
R
L
G
--
Q
---
N
G
--
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
-------------------
G
F
--
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.03
47%
-85
- C3 -
3QFV
2
MRCKB_HUMAN
A:
[6-409]
-------------------------
R
L
K
K
L
E
Q
L
L
L
D
G
PWRN
E
S
A
L
S
-----
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
---
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
-
T
L
L
S
K
-
F
E
DK
L
-
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
---
C
---
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
---
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
-
S
H
V
T
D
V
S
E
E
A
K
D
L
I
-
Q
R
-
L
I
-
C
-
S
R
E
R
R
L
G
--
Q
---
N
G
--
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
----------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.56
46%
-82
- C3 -
3TKU
3
MRCKB_HUMAN
A:
[18-425]
---------------------
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
G
PWRN
E
S
A
L
S
-----
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
---
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
-
T
L
L
S
K
-
F
E
DK
L
-
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
---
C
---
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
---
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
-
S
H
V
T
D
V
S
E
E
A
K
D
L
I
-
Q
R
-
L
I
-
C
-
S
R
E
R
R
L
G
--
Q
---
N
G
--
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
----------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
59.46
46%
-85
- C3 -
3TKU
3
MRCKB_HUMAN
B:
[18-425]
---------------------
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
G
PWRN
E
S
A
L
S
-----
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
---
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
-
T
L
L
S
K
-
F
E
DK
L
-
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
-
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
---
C
---
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
---
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
-
S
H
V
T
D
V
S
E
E
A
K
D
L
I
-
Q
R
-
L
I
-
C
-
S
R
E
R
R
L
G
--
Q
---
N
G
--
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
--------------------
F
--
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
52.21
37%
-74
- C3 -
1O6L
1
AKT2_HUMAN
A:
[1-336]
----------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
---
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
-
F
H
L
S
R
-
E
R
V-
F
-
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
---
K
E
G
I
S
D
G
A
-
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
--
E
I
R
F
P
-
R
---
T
L
S
P
E
A
K
S
L
L
-
A
G
-
L
L
-
K
K
D
P
K
Q
R
L
G
--
G
GP-
S
D
--
A
K
E
V
M
E
H
R
F
F
L
S
I
N
--
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
52.14
34%
-76
- C3 -
4GV1
5
AKT1_HUMAN
A:
[3-337]
---------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
-
F
H
L
S
R
-
E
R
V-
F
-
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
---
K
E
G
I
K
D
G
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-
N
----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
---
H
E
K
L
F
E
L
I
L
M
E
--
E
I
R
F
P
-
R
---
T
L
G
P
E
A
K
S
L
L
-
S
G
-
L
L
-
K
K
D
P
K
Q
R
L
G
--
G
---
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
--
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
-
I
T
P
--SME
C
V
D
--
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
50.71
35%
-56
- C3 -
2GNI
1
KAPCA_BOVIN
A:
[24-333]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
49.71
37%
-70
- C3 -
1RDQ
3
KAPCA_MOUSE
E:
[37-350]
----------------------------------------------------------------------------------------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
----
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
-
K
----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
-
S
H
---
F
S
S
D
L
K
D
L
L
-
R
N
-
L
L
-
Q
V
D
L
T
K
R
F
G
NL
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
--
W
I
A
I
YQ
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
---------
S
I
N
--
E
K
C
G
K
E
F
T
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
49.60
37%
-81
- C3 -
1XJD
1
A:
[16-335]
-------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
-
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
-
Y
H
I
Q
S
-
C
H
K-
F
-
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
---
K
E
N
M
L
-
G
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
---
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
-
R
---
W
L
E
K
E
A
K
D
L
L
-
V
K
-
L
F
-
V
R
E
P
E
K
R
L
G
--
V
---
R
G
----
D
I
R
Q
H
P
L
F
R
E
I
N
--
W
E
E
L
E
R
K
E
I
D
P
------------------------------------------
Q
N
M
F
R
N
F
S
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
HHSearch
49.06
36%
-60
- C3 -
4DC2
1
KPCI_MOUSE
A:
[49-387]
-----------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
----
I
D
W
V
Q
T
E
K
H
V
F
E
-
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
-
F
H
M
Q
R
-
Q
R
K-
L
-
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
---
K
E
G
L
R
P
G
D
-
T
T
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
SNT
E
D
Y
L
F
Q
V
I
L
E
--
K
Q
I
R
I
P
-
R
S
---
L
S
V
K
A
A
S
V
L
-
K
S
-
F
L
-
N
K
D
P
K
E
R
L
G
--
C
HPQ
T
G
--
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
--
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
---
D
I
V
R
-
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
49.01
35%
-56
- C3 -
2GNF
1
KAPCA_BOVIN
A:
[24-333]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.55
35%
-54
- C3 -
2GNH
2
KAPCA_BOVIN
A:
[24-333]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
48.37
34%
-61
- C3 -
2OH0
1
KAPCA_BOVIN
E:
[25-334]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
47.87
34%
-56
- C3 -
2F7X
1
KAPCA_BOVIN
E:
[25-334]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
47.83
34%
-57
- C3 -
2F7E
1
KAPCA_BOVIN
E:
[25-334]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
47.16
34%
-57
- C3 -
2OJF
1
KAPCA_BOVIN
E:
[25-334]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
46.88
34%
-58
- C3 -
2UZW
1
KAPCA_BOVIN
E:
[10-319]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
D
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
46.72
34%
-61
- C3 -
2UZT
1
KAPCA_BOVIN
A:
[10-319]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
D
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
46.67
34%
-56
- C3 -
2UZU
1
KAPCA_BOVIN
E:
[10-319]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
D
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
46.49
34%
-61
- C3 -
2F7Z
1
KAPCA_BOVIN
E:
[25-334]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
N
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
HHSearch
45.38
38%
-60
- C3 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
--------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
-
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
-
F
H
I
Q
K
-
S
R
R-
F
-
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
---
C
---
K
E
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-
M
----
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
---
E
D
D
L
F
E
A
I
L
N
D
--
E
V
V
Y
P
-
T
W
---
L
H
E
D
A
T
G
I
L
-
K
S
-
F
M
-
T
K
N
P
T
M
R
L
G
--
S
LTQ
G
G
--
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
--
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
-
P
I
D
---
E
G
H
LP
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
44.46
36%
-78
- C3 -
2R5T
1
SGK1_HUMAN
A:
[34-320]
----------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
C
--
F
-
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
KEN
I
E
H
N
S
T
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
K
-
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
---
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
-----
K
P
-
N
I
T
N
S
A
R
H
L
L
-
E
G
-
L
L
Q
K
-
D
R
T
K
R
L
G
A-
K
---
D
D
--
F
M
E
I
K
S
H
V
F
F
--
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
43.37
38%
-61
- C3 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
----------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD
S
G
H
L
Y
A
M
K
V
L
K
------------------
I
L
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
-
T
R
L
S
K
E
V
M
--
F
-
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
---
R
K
E
T
M
T
L
I
L
--
K
A
K
L
G
M
P
-
Q
---
F
L
S
T
E
A
Q
S
L
L
-
R
A
L
F
K
-
R
-
N
P
A
N
R
L
G
--
S
GP-
D
G
--
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
--
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
43.28
36%
-76
- C3 -
3HDN
1
SGK1_HUMAN
A:
[34-316]
----------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
C
--
F
-
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
KEN
I
E
H
N
S
T
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
K
-
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
---
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
-----
K
P
-
N
I
T
N
S
A
R
H
L
L
-
E
G
-
L
L
Q
K
-
D
R
T
K
R
L
G
A-
K
---
D
D
--
F
M
E
I
K
S
H
V
F
F
--
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
43.09
36%
-74
- C3 -
3HDM
1
SGK1_HUMAN
A:
[34-320]
----------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
C
--
F
-
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
---
C
KEN
I
E
H
N
S
T
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
K
-
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
---
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
-----
K
P
-
N
I
T
N
S
A
R
H
L
L
-
E
G
-
L
L
Q
K
-
D
R
T
K
R
L
G
A-
K
---
D
D
--
F
M
E
I
K
S
H
V
F
F
--
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
42.43
38%
-58
- C3 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
----------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD
S
G
H
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
-----------
I
L
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
-
T
R
L
S
K
E
V
M
--
F
-
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
---
R
K
E
T
M
T
L
I
L
--
K
A
K
L
G
M
P
-
Q
---
F
L
S
T
E
A
Q
S
L
L
-
R
A
L
F
K
-
R
-
N
P
A
N
R
L
G
--
S
GP-
D
G
--
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
--
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
41.10
37%
-65
- C3 -
3G51
1
KS6A3_MOUSE
A:
[26-304]
----------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
D
---------
I
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
-
T
R
L
S
K
E
V
M
--
F
-
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE
S
---
I
---------------
T
V
E
Y
M
A
P
E
V
V
N
R
-
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
---
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
-
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
-
F
K
-
R
-
N
P
A
N
R
L
G
--
A
GP-
D
G
--
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
--
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
40.39
37%
-58
- C3 -
4GUE
1
KS6A3_MOUSE
A:
[27-305]
----------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
R
D
R
V
--------
L
V
-
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
-
T
R
L
S
K
E
V
M
--
F
-
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E--------
K
K
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
-
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
---
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
-
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
-
F
K
-
R
-
N
P
A
N
R
L
G
--
A
GP-
D
G
--
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
--
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
40.06
38%
-60
- C3 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
----------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD
S
G
H
L
Y
A
M
K
V
L
-------------------
I
L
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
-
T
R
L
S
K
E
V
M
--
F
-
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
SKE-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
---
R
K
E
T
M
T
L
I
L
--
K
A
K
L
G
M
P
-
Q
---
F
L
S
T
E
A
Q
S
L
L
-
R
A
L
F
K
-
R
-
N
P
A
N
R
L
G
--
S
GP-
D
G
--
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
--
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
40.05
34%
-53
- C3 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
----------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
GAN
T
G
K
I
F
A
M
K
V
L
K
K
------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
-
M
Q
L
E
R
-
E
G
--
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
---
K
E
S
-----------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
---
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
-----
P
P
-
Y
L
T
Q
E
A
R
D
L
L
-
K
K
-
L
L
-
K
R
N
A
A
S
R
L
G
--
A
GP-
G
D
--
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
--
R
K
V
E
P
P
F
K
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
37.28
34%
22
- C3 -
2UZV
1
KAPCA_BOVIN
A:
[10-319]
-----------------------------------------------------------------------------
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
-
S
H
L
R
R
-
I
G
R-
F
-
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
---
K
R
V
K
G
R
T
W
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
---
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
-
F
S
S
-
D
L
K
D
L
L
R
N
L
L
-
Q
V
-
D
L
-
T
-
K
R
F
G
N
L
---
K
---
D
G
--
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
--
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------