@TOME V2.3
(Nov 2016)

Ref. - - Doc.
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Score:

Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : ROS1_HUMAN: (2013-07-24 )
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD

Atome Classification :

(83 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940.....-.1950......1960......1970.-.-....1980.....-.1990-......2000.-.....2010......2020----.......2030......2040--..---......---.------2050--........2060......2070......2080......2090......2100......2110.......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340....
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLR-LLLGSGAFGEVYEGTAVDILGVGSGE-I-KVAVKTLKKGSTD-QEKIE-FLKEAHLMSKF-NHPNILKQLGVCLLNEPQ-----YIILELMEGGDLLTYLRK-----AR---MATFYG---P------L-L---TLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKN-DYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD
47 PsiBlast_CBE 80.8842% -53 - C2 -2IVS RET_HUMAN A:[20-307] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPRKNLVLG-KTLGEGEFGKVVKATAFHLKGR-AGY-T-TVAVKMLKENASP-SELRD-LLSEFNVLKQV-NHPHVIKLYGACSQDGPL-----LLIVEYAKYGSLRGFLRE-----SR---KV---G---PGYLR--A-L---TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-----EGRKMKISDFGLSRDVYEE-DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE-----------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 78.4950% -46 - C2 -3LW0 IGF1R_HUMAN A:[14-280] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE-T-RVAIKTVNEAASM-RERIE-FLNEASVMKEF-NCHHVVRLLGVVSQGQPT-----LVIMELMTRGDLKSYLRS-----LR---P------------------PP-SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI----------------------------------------------------------------------------------------------------------------------------------------
42 PsiBlast_CBE 78.4149% -39 - C2 -3ETA INSR_HUMAN A:[15-286] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITLL-RELGQGSFGMVYEGNARDIIK-GEAE-T-RVAVKTVNESASL-RERIE-FLNEASVMKGF-TCHHVVRLLGVVSKGQPT-----LVVMELMAHGDLKSYLRS-----LR---PEAENN---P------G-RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFT----VKIGDFGMTRDIYET-DYYRKG-KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK-----------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 77.9050% -46 - C2 -3LW0 IGF1R_HUMAN B:[14-280] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE-T-RVAIKTVNEAASM-RERIE-FLNEASVMKEF-NCHHVVRLLGVVSQGQPT-----LVIMELMTRGDLKSYLRS-----LR---P------------------PP-SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI----------------------------------------------------------------------------------------------------------------------------------------
24 PsiBlast_CBE 77.9049% -55 - C2 -4FNW A:[22-301] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISDLKEVPRKNITLI-RGLG----GEVYEGQ-VS------SP-L-QVAVKTLPEVCSE-QDELD-FLMEALIISKL-NHQNIVRCIGVSLQSLPR-----FILLELMAGGDLKSFLRE-----TR---PRPSQP---S------S-L---AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG--PGRVAKIGDFGMARDIYR---------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE-----------------------------------------------------------------------------------------------------------------------------------
25 PsiBlast_CBE 77.1550% -44 - C2 -3LW0 D:[14-280] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE-T-RVAIKTVNEAASM-RERIE-FLNEASVMKEF-NCHHVVRLLGVVSQGQPT-----LVIMELMTRGDLKSYLRS-----LR---P------------------PP-SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI----------------------------------------------------------------------------------------------------------------------------------------
40 PsiBlast_CBE 77.1049% -44 - C2 -3QQU IGF1R_HUMAN A:[11-277] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE-T-RVAIKTVNEAASM-RERIE-FLNEASVMKEF-NCHHVVRLLGVVSQGQPT-----LVIMELMTRGDLKSYLRS-----LR----------------------PP-SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI----------------------------------------------------------------------------------------------------------------------------------------
26 PsiBlast_CBE 77.0450% -44 - C2 -3LW0 IGF1R_HUMAN C:[14-280] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE-T-RVAIKTVNEAASM-RERIE-FLNEASVMKEF-NCHHVVRLLGVVSQGQPT-----LVIMELMTRGDLKSYLRS-----LR---P------------------PP-SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI----------------------------------------------------------------------------------------------------------------------------------------
50 PsiBlast_CBE 76.9842% -46 - C2 -3CBL A:[114-374] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDLVLG-EQIGRGNFGEVFSGR------LRADN-T-LVAVKSCRETLPP-DLKAK-FLQEARILKQY-SHPNIVRLIGVCTQKQPI-----YIVMELVQGGDFLTFLRT-----E---------G---A------R-L---RVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADG-VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK-------------------------------------------------------------------------------------------------------------------------------
41 PsiBlast_CBE 76.6449% -40 - C2 -3ETA B:[15-286] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITLL-RELGQGSFGMVYEGNARDIIK-GEAE-T-RVAVKTVNESASL-RERIE-FLNEASVMKGF-TCHHVVRLLGVVSKGQPT-----LVVMELMAHGDLKSYLRS-----LR---PEAENN---P------G-RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFT----VKIGDFGMTRDIYET-DYYRK--KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK-----------------------------------------------------------------------------------------------------------------------------------
127 HHSearch 76.5144% -50 - C2 -1QCF HCK_HUMAN A:[180-442] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDAWEIPRESLKLE-KKLGAGQFGEVWMATYNK-------H-T-KVAVKTMKPGSM---SVEA-FLAEANVMKTL-QHDKLVKLHAVVT-KEPI-----YIITEFMAKGSLLDFLKS-----DE---G--------S------K-Q---PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-----ASLVCKIADFGLARVIEDN-EYTAREGA-KFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYT-------------------------------------------------------------------------------------------------------------------------------
46 PsiBlast_CBE 76.2549% -40 - C2 -1I44 A:[16-287] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITLL-RELGQGSFGMVYEGNARDIIK-GEAE-T-RVAVKTVNESASL-RERIE-FLNEASVMKGF-TCHHVVRLLGVVSKGQPT-----LVVMELMAHGDLKSYLRS-----LR---PEAENN---P------G-RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFT----VKIGDFGMT-----------------LPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK-----------------------------------------------------------------------------------------------------------------------------------
45 PsiBlast_CBE 76.1849% -45 - C2 -3EKK A:[17-288] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITLL-RELGQGSFGMVYEGNARDIIK-GEAE-T-RVAVKTVNESASL-RERIE-FLNEASVMKGF-TCHHVVRLLGVVSKGQPT-----LVVMELMAHGDLKSYLRS-----LR---PEAENN---P------G-RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMVA-HDFT----VKIGDF-------------------LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLK-----------------------------------------------------------------------------------------------------------------------------------
133 HHSearch 76.1348% -48 - C2 -3L9P A:[60-349] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSISDLKEVPRKNITLI-RGLGHGAFGEVYEGQVSG------SP-L-QVAVKTLPEVCSE-QDELD-FLMEALIISKF-NHQNIVRCIGVSLQSLPR-----FILLELMAGGDLKSFLRE-----TR---PRPSQP---S------S-L---AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG--PGRVAKIGDFGMARDIYRA-GYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDV---------------------------------------------------------------------------------------------------------------------------
90 PsiBlast_CBE 76.0741% -53 - C2 -3RHX FGFR1_HUMAN A:[14-295] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPLGEGAFGQVVLAEAIGLDKDKPNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RRPP-----------EE----Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
120 HHSearch 76.0041% -53 * C2 *4I4E A:[10-275] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YEIQRERIELG-RCIGEGQFGDVHQGIYMSP----NPA-L-AVAIKTCKNCTSD-SVREK-FLQEALTMRQF-DHPHIVKLIGVITE-NPV-----WIIMELCTLGELRSFLQV-----RK------------Y------S-L---DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS-----SNDCVKLGDF--------------------LPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTIL--------------------------------------------------------------------------------------------------------------------------------
107 PsiBlast_CBE 75.8242% -48 - C2 -2H8H SRC_HUMAN A:[264-519] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPRESLRLE-VKLGQGCFGEVW-------MGTWNGT-T-RVAIKTLKPGTMS-PEA---FLQEAQVMKKL-RHEKLV-QLYAVVSEEPI-----YIVTEYMSKGSLLDFLKG-----ET--------G---K------Y-L---RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGEN-----LVCKVADFGLARLIEDN-EYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY---------------------------------------------------------------------------------------------------------------------------------
119 HHSearch 75.6240% -58 - C2 -4AOJ NTRK1_HUMAN A:[33-319] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVHHIKRRDIVLK-WELGEGAFGKVFLAECHNLLP----K-M-LVAVKALKE-ASE-SARQD-FQREAELLTML-QHQHIVRFFGVCTEGRPL-----LMVFEYMRHGDLNRFLRS-----HG---PD---P---G------P-L---GLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-----QGLVVKIGDFG-----------------TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ-------------------------------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 75.3348% -50 - C2 -3LCS A:[30-318] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YCFAGKT----SSISDLKEVPRKNITLI-RGLGHGAFGEVYEGQ-VSGMPNDPSP-L-QVAVKTLPEVCSE-QDELD-FLMEALIISKF-NHQNIVRCIGVSLQSLPR-----FILLELMAGGDLKSFLRE-----TR---PRPSQP---S------S-L---AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG--PGRVAKIGDFGMARDIYRA-GYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE-----------------------------------------------------------------------------------------------------------------------------------
98 PsiBlast_CBE 75.2742% -50 - C2 -4AT3 A:[12-285] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHNIVLK-RELGEGAFGKVFLAECYN-LC----K-I-LVAVKTL--AS-D-NARKD-FHREAELLTNL-QHEHIVKFYGVCVEGDPL-----IMVFEYMKHGDLNKFLRAHGPDAVL---MA--NP---P------TEL---TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-----ENLLVKIGDFGMSR--YST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ-----------------------------------------------------------------------------------------------------------------------------------
74 PsiBlast_CBE 75.1941% -51 - C2 -1FGI FGFR1_HUMAN A:[18-299] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPLGEGAFGQVVLAEAIGL----PNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RRPP-----------EE----Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
68 PsiBlast_CBE 75.1742% -54 - C2 -2PY3 FGFR2_HUMAN A:[32-313] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPRDKLTLG-KPL----FGQVVMAEAVGIDKDKPKEAV-TVAVKMLKDDATE-KDLSD-LVSEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVGYASKGNLREYLRA-----RRP--------E--E------Q-M---TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
64 PsiBlast_CBE 74.9342% -54 - C2 -3RI1 ? A:[21-302] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPRDKLTLG-KPLGEGCFGQVVMAEAVGIDKDKPKEAV-TVAVKMLKDDATE-KDLSD-LVSEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLRA-----RRPP----------E------Q-M---TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
5 PsiBlast_PDB 74.6348% -47 - C2 -3LCT A:[29-318] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYCFAGKT----SSISDLKEVPRKNITLI-RGLGHGAFGEVYEGQ-VSGMPNDPSP-L-QVAVKTLPEVCSE-QDELD-FLMEALIISKF-NHQNIVRCIGVSLQSLPR-----FILLELMAGGDLKSFLRE-----TR---PRPSQP---S------S-L---AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG--PGRVAKIGDFGMARDIYRA-GYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE-----------------------------------------------------------------------------------------------------------------------------------
80 PsiBlast_CBE 74.5841% -56 - C2 -4F64 FGFR1_HUMAN A:[17-298] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPL-----GQVVLAEAIGL----PNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RRPP-----------EE----Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
88 PsiBlast_CBE 74.4541% -52 - C2 -3JS2 FGFR1_HUMAN A:[25-306] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPLGEGAFGQVVLAEAIGLDKDKPNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RRPPGL---------HNPEE-Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
39 PsiBlast_CBE 74.4549% -39 - C2 -3QQU IGF1R_HUMAN B:[11-277] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE-T-RVAIKTVNEAASM-RERIE-FLNEASVMKEF-NCHHVVRLLGVVSQGQPT-----LVIMELMTRGDLKSYLRS-----LR----------------------P--SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI----------------------------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 74.4341% -55 - C2 -2FGI B:[18-299] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPLGEGAFGQVVLAEAIGL----PNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RR-------------------Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLA-------DYYKK---GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
63 PsiBlast_CBE 74.4342% -52 - C2 -3RI1 FGFR2_HUMAN B:[21-302] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPRDKLTLG-KPLGEGCFGQVVMAEAVGID---PKEAV-TVAVKMLKDDATE-KDLSD-LVSEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLRA-----RRPP----------E------Q-M---TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
32 PsiBlast_CBE 74.4049% -45 - C2 -3NW6 A:[17-283] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE-T-RVAIKTVNEAASM-RERIE-FLNEASVMKEF-NCHHVVRLLGVVSQGQPT-----LVIMELMTRGDLKSYLRS-----LR---PEMENN---P------V-LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI----------------------------------------------------------------------------------------------------------------------------------------
93 PsiBlast_CBE 74.2940% -58 - C2 -3GQL C:[25-318] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPLGEGAFGQVVLAEAIGLDKDKPNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RRPP-----------E-----Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLAR-----------------PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEY------------------------------------------------------------------------------------------------------------------------
121 HHSearch 74.2537% -53 - C2 -4FYO A:[11-277] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYLDRKLLTLEDKELGSGNFGTVKKGYYQM----KKVV-K-TVAVKIL------PALKDE-LLAEANVMQQL-DNPYIVRMIGICE-AESW-----MLVMEMAELGPLNKYLQQ-----NR-------------------H-V---KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-----TQHYAKISDFGLSKALRADENYYKA----KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY---------------------------------------------------------------------------------------------------------------------------------
87 PsiBlast_CBE 74.1841% -46 - C2 -3JS2 B:[25-306] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPLGEGAFGQVVLAEAIGLDKDKPNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RRPP-----------E-----Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
92 PsiBlast_CBE 74.1041% -52 - C2 -3C4F FGFR1_HUMAN A:[10-291] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPLGEGAFGQVVLAEAIGLDKDKPNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RRPP-----------EE----Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
62 PsiBlast_CBE 74.0842% -60 - C2 -2PVY ? D:[32-313] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPRDKLTLG-KPL------QVVMAEAVGIDKDKPKEAV-TVAVKMLKDDATE-KDLSD-LVSEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLRA-----RRPPG------VPEE------Q-M---TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-----TENNVMKIADFGLARDINNI-DYYKNTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
91 PsiBlast_CBE 73.9541% -53 - C2 -3C4F B:[10-291] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPRDRLVLG-KPLGEGAFGQVVLAEAIGLDKDKPNR-VTKVAVKMLKSDATE-KDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQA-----RRPP-----------EE----Q-L---SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL------------------------------------------------------------------------------------------------------------------------------------
44 PsiBlast_CBE 73.8549% -42 - C2 -3EKN A:[17-288] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REKITLL-RELGQGSFGMVYEGNARDIIK-GEAE-T-RVAVKTVNESASL-RERIE-FLNEASVMKGF-TCHHVVRLLGVVSKGQPT-----LVVMELMAHGDLKSYLRS-----LR---PE