@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SIK2_HUMAN: (2013-07-25 )
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN
Atome Classification :
(59 SA)
.........10........20........30......--------..40........50..----...-.-.----.-60-.-.----......70........80........90........100.......110.-......120.......130...-....140.....-.-.---150---.---.---.---....160.---....-..170---........180.......190..--.....200.......210.....-..220--.......230...--...--..-----.-----240...---....250.......260----........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLG--------RHRITKTEVAIKIIDK----SQL-D-A----V-NL-E-K----IYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGR-LNESEARRKFWQILSAVDYCHG-RKIVHRDLKAEN-L-L---LDN---N---M---N---IKIADFGF---GNFF-KSG-E---LLATWCGSPPYAAPEVFEGQQYE--GPQLDIWSMGVVLYVLVCGALPF-DGPTL--PILRQRVL--EGR--FRI--PY-----F-----MSEDCE---HLIRRMLVLDPSKRLT-----IAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN
13
PsiBlast_PDB
79.49
49%
-112
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[4-276]
--------
H
--
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
--------
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
----
Q
K
I
-
R
-
S
----
L
-
D
V
V
G
-
K
----
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
-
V
-
L
---
L
D
A
---
H
---
M
---
N
---
A
K
I
A
D
F
G
L
---
S
N
M
M
-
S
D
G
-
E
---
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
--
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
E
H
V
--
P
T
L
F
K
K
I
R
--
G
G
V
--
F
Y
I
--
P
E
-----
Y
-----
L
N
R
S
V
A
---
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
-----
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
---
S
Y
L
F
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
70.74
40%
-110
- C1 -
3KU2
1
?
A:
[56-308]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.26
42%
-114
- C1 -
4BL1
1
MELK_HUMAN
A:
[11-265]
------------------
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
--------
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
----
N
T
L
-----------
L
-
P
-
R
----
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
-
L
---
F
D
E
---
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
CAK--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
D
D
N
V
--
M
A
L
Y
K
K
I
M
--
R
G
K
--
Y
D
V
--
P
K
-----
W
-----
L
S
P
S
S
I
---
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
-----
M
K
N
L
L
N
H
P
W
I
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
70.11
39%
-113
- C1 -
3NCG
1
?
A:
[24-280]
-------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
--------
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
----
A
S
A
-
K
-
N
----
K
-
D
T
-
S
-
T
----
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
-
I
-
L
---
L
E
S
KEK
D
---
C
---
D
---
I
K
I
I
D
F
G
L
---
S
T
C
F
-
Q
Q
N
-
T
--------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
----
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
--
Y
D
I
L
K
R
V
E
--
T
G
K
YA
F
D
L
--
P
Q
-----
W
R
T
---
I
S
D
D
A
K
---
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.11
40%
-107
- C1 -
3SXF
3
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
69.96
40%
-108
- C1 -
3V5P
1
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
69.90
34%
-113
- C1 -
2WTW
1
AURKA_HUMAN
A:
[15-265]
-------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
A
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
A
---
G
---
E
---
L
K
I
A
D
F
G
W
---
S
V
H
A
-
P
S
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
---
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
-
E
A
N
T
Y
--
Q
E
T
Y
K
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
-----
L
R
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
69.52
39%
-112
- C1 -
3IGO
8
?
A:
[24-280]
-------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
--------
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
----
A
S
A
-
K
-
N
----
K
--
T
-
S
-
T
----
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
-
I
-
L
---
L
E
S
KEK
D
---
C
---
D
---
I
K
I
I
D
F
G
L
---
S
T
C
F
-
Q
Q
N
-
T
----------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
----
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
--
Y
D
I
L
K
R
V
E
--
T
G
K
YA
F
D
L
--
P
Q
-----
W
R
T
---
I
S
D
D
A
K
---
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
69.20
40%
-108
- C1 -
3T3U
5
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
69.17
40%
-107
- C1 -
3UPX
1
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
KK---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
69.06
36%
-107
- C1 -
3D14
1
AURKA_MOUSE
A:
[14-264]
-------------------
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
T
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
N
---
G
---
E
---
L
K
I
A
D
F
G
W
---
S
V
H
A
-
P
S
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
---
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
-
E
A
H
T
Y
--
Q
E
T
Y
R
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
-----
L
A
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
68.94
40%
-108
- C1 -
3N51
3
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
KK---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
68.88
37%
-114
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
-------
R
W
K
Q
A
E
D
I
R
-
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
--------
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
-----------------------
S
----
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
-
L
-
L
YYS
L
D
E
---
D
---
S
---
K
---
I
M
I
S
D
F
G
L
---
S
K
M
E
-
D
P
G
------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
---
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
--
A
K
L
F
E
Q
I
L
K
A
E
Y
E
--
F
D
S
--
P
Y
-----
W
DD---
I
S
D
S
A
K
---
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
68.82
37%
-110
- C1 -
3Q5I
1
?
A:
[31-305]
----------------------
E
G
K
I
G
E
S
Y
F
K
V
R
K
L
G
SY
G
E
V
L
LC
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
----------------------
K
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
K
-
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
-
H
N
I
V
H
R
D
I
K
P
E
N
-
I
-
L
---
L
E
N
---
K
NSL
L
---
N
---
I
K
I
V
D
F
G
L
---
S
S
F
F
-
S
K
D
-
Y
---
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
K
Y
N
E
----
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
-
G
G
Q
N
D
--
Q
D
I
I
K
K
V
E
--
K
G
K
--
Y
Y
F
--
D
F
NDWK-
N
-----
I
S
D
E
A
K
---
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
E
E
A
L
N
S
R
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
68.78
35%
-111
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-286]
------------
E
D
I
R
-
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
--------
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
-
L
-
L
YYS
L
D
E
---
D
---
S
---
K
---
I
M
I
S
D
F
G
-----------
G
-
S
---
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
--
A
K
L
F
E
Q
I
L
K
A
E
Y
E
--
F
D
S
--
P
Y
-----
W
DD---
I
S
D
S
A
K
---
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
68.70
40%
-106
- C1 -
3MA6
1
?
A:
[34-291]
-------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
K
Q
-
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
-
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
68.50
36%
-108
- C1 -
3DJ7
1
AURKA_MOUSE
A:
[14-264]
-------------------
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
T
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
N
---
G
---
E
---
L
K
I
A
D
F
G
W
---
S
V
H
A
-
P
S
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
---
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
-
E
A
H
T
Y
--
Q
E
T
Y
R
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
-----
L
A
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
68.49
39%
-109
- C1 -
3MWU
1
?
A:
[24-280]
-------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
--------
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
----
A
S
A
-
K
-
N
----
K
-
D
T
-
S
-
T
----
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
-
I
-
L
---
L
E
S
KEK
D
---
C
---
D
---
I
K
I
I
D
F
G
L
---
S
T
C
F
-
Q
Q
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
----
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
--
Y
D
I
L
K
R
V
E
--
T
G
K
YA
F
D
L
--
P
Q
-----
W
R
T
---
I
S
D
D
A
K
---
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
68.20
36%
-112
- C1 -
3D2I
1
AURKA_MOUSE
A:
[14-264]
-------------------
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
T
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
N
---
G
---
E
---
L
K
I
A
D
F
G
W
---
S
V
H
A
-
P
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
---
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
-
E
A
H
T
Y
--
Q
E
T
Y
R
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
-----
L
A
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
67.95
38%
-118
- C1 -
3HZT
9
?
A:
[12-264]
-------------------------
L
G
S
G
A
Y
G
E
V
L
L
C
--------
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
----
S
S
V
-
T
-
T
----
T
S
N
S
-
G
-
A
----
L
L
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
---
K
---
S
---
R
D
A
L
I
K
I
V
D
F
G
L
---
S
A
H
F
-
E
V
G
------------
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
---
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
-
G
G
Q
T
D
--
Q
E
I
L
K
R
V
E
--
K
G
K
--
F
S
F
DP
P
D
-----
W
TQ---
V
S
D
E
A
K
---
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
E
E
A
L
N
H
P
W
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
67.81
39%
-103
- C1 -
2WEI
1
?
A:
[24-280]
-------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
--------
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
----
A
S
A
-
K
-
N
----
K
-
D
T
-
S
-
T
----
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
-
I
-
L
---
L
E
S
KEK
D
---
C
---
D
---
I
K
I
I
D
F
G
L
---
S
T
C
F
-
Q
Q
N
-
T
---
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
----
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
--
Y
D
I
L
K
R
V
E
--
T
G
K
YA
F
D
L
--
P
Q
-----
W
RT---
I
S
D
D
A
K
---
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
67.71
40%
-104
- C1 -
3V51
1
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
67.59
34%
-120
- C1 -
3EFW
1
AURKA_HUMAN
A:
[133-383]
-------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
A
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
A
---
G
---
E
---
L
K
I
A
D
F
--------------------------
L
D
Y
L
P
P
E
M
I
E
---------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
-
E
A
N
T
Y
--
Q
E
T
Y
K
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
-----
L
R
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
67.47
40%
-112
- C1 -
3HX4
3
?
A:
[57-309]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----------------
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
KK---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.30
40%
-108
- C1 -
3SX9
1
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
67.20
34%
-112
- C1 -
4GV1
5
AKT1_HUMAN
A:
[5-270]
--------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
--------
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
----
E
V
I
-
V
A
K
----
D
-
E
V
-
A
-
H
----
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
-
L
-
M
---
L
D
K
---
D
---
G
---
H
---
I
K
I
T
D
F
G
L
---
C
K
E
G
I
K
D
G
-
A
---
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
---
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-
Y
N
Q
D
H
--
E
K
L
F
E
L
I
L
--
M
E
E
--
I
R
F
--
P
R
-----
T
-----
L
G
P
E
A
K
---
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
67.19
40%
-105
- C1 -
3V5T
1
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.18
35%
-112
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-286]
------------
E
D
I
R
-
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
--------
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
-
L
-
L
YYS
L
D
E
---
D
---
S
---
K
---
I
M
I
S
D
F
------------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
--
A
K
L
F
E
Q
I
L
K
A
E
Y
E
--
F
D
S
--
P
Y
-----
W
DD---
I
S
D
S
A
K
---
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.11
40%
-111
- C1 -
3I7B
4
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
67.08
35%
-116
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-286]
--------
W
K
Q
A
E
D
I
R
-
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
--------
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
----
E
------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
-
L
-
L
YYS
L
D
E
---
D
---
S
---
K
---
I
M
I
S
D
F
-------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
--
A
K
L
F
E
Q
I
L
K
A
E
Y
E
--
F
D
S
--
P
Y
-----
W
DD---
I
S
D
S
A
K
---
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
66.84
40%
-104
- C1 -
3UPZ
1
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
66.68
39%
-102
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[12-275]
------------------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
--------
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTK
S
S
R
-
R
-
G
----
V
-
S
R
-
E
-
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
-
L
---
L
D
R
---
N
---
V
P
K
P
R
---
I
K
I
I
D
F
G
L
---
A
H
K
I
-
D
F
G
-
N
---
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
---
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
--
N
Y
E
--
F
E
D
--
E
Y
-----
F
SN---
T
S
A
L
A
K
---
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
66.42
35%
-116
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-286]
--------
W
K
Q
A
E
D
I
R
-
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
--------
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
----
E
-----------------------
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
-
L
-
L
YYS
L
D
E
---
D
---
S
---
K
---
I
M
I
S
D
F
--------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
--
A
K
L
F
E
Q
I
L
K
A
E
Y
E
--
F
D
S
--
P
Y
-----
W
DD---
I
S
D
S
A
K
---
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
65.99
40%
-105
- C1 -
3MA6
1
?
B:
[34-291]
-------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
K
Q
------
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
KK---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
65.73
40%
-106
- C1 -
3T3V
2
?
A:
[33-285]
------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
--------
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----
R
Q
V
-
K
Q
K
----
T
-
D
K
-
E
-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
L
E
S
KSK
D
---
A
---
N
---
I
R
I
I
D
F
G
L
---
S
T
H
F
-
E
A
S
-
K
---
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
----
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
--
Y
D
I
L
K
K
V
E
--
K
G
K
YT
F
E
L
--
P
Q
-----
W
K
K
---
V
S
E
S
A
K
---
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
65.68
36%
-108
- C1 -
3D15
1
AURKA_MOUSE
A:
[14-264]
-------------------
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
T
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
N
---
G
---
E
---
L
K
I
A
D
F
G
W
---
S
V
H
A
-
P
S
------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
---
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
-
E
A
H
T
Y
--
Q
E
T
Y
R
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
-----
L
A
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
65.09
34%
-119
- C1 -
3EFW
1
AURKA_HUMAN
B:
[133-383]
-------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
A
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
A
---
G
---
E
---
L
K
I
A
D
F
--------------------------
L
D
Y
L
P
P
E
M
I
E
--------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
-
E
A
N
T
Y
--
Q
E
T
Y
K
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
-----
L
R
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
64.79
35%
-113
- C1 -
4B8L
1
?
A:
[17-267]
-------------------
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
----
S
Q
L
-
E
-
K
----
E
-
G
V
-
E
H
Q
----
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
M
G
Y
---
K
---
G
---
E
---
L
K
I
A
D
F
-------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
---
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
-
D
S
P
S
H
--
T
E
T
H
R
R
I
V
--
N
V
D
--
L
K
F
--
P
P
-----
F
-----
L
S
D
G
S
K
---
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
P
-----
L
K
G
V
M
E
H
P
W
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.62
39%
-104
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[13-276]
------------------
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
--------
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
----
R
Q
S
-
R
-
A
SRRG
V
-
C
R
-
E
-
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
-
L
---
L
D
K
---
N
---
I
P
I
P
H
---
I
K
L
I
D
F
G
L
---
A
H
E
I
-
E
D
G
-
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
------
K
Q
E
T
L
--
A
N
I
--
T
A
V
--
S
Y
DFDEE
F
-----
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.60
36%
-115
- C1 -
3DJ6
1
AURKA_MOUSE
A:
[14-264]
-------------------
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
T
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
N
---
G
---
E
---
L
K
I
A
D
F
G
W
------------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
---
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
-
E
A
H
T
Y
--
Q
E
T
Y
R
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
-----
L
A
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
63.95
39%
-105
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[12-275]
------------------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
--------
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTK
S
S
R
-
R
-
G
----
V
-
S
R
-
E
-
D
----
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
-
L
---
L
D
R
---
N
---
V
P
K
P
R
---
I
K
I
I
D
F
G
L
---
A
H
K
I
-
D
F
G
-
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
--
N
Y
E
--
F
E
D
--
E
Y
-----
F
SN---
T
S
A
L
A
K
---
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
63.87
39%
-109
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[13-276]
------------------
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
--------
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
----
R
Q
S
-
R
-
A
SRRG
V
-
S
R
-
E
-
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
---
L
D
K
---
N
---
I
PIP
H
---
I
K
L
I
D
F
G
L
---
A
H
E
I
-
E
D
G
-
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
------
K
Q
E
T
L
--
A
N
I
--
T
S
V
--
S
Y
DFDEE
F
-----
F
S
H
T
S
E
LAK
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
63.65
39%
-107
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[13-276]
------------------
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
--------
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
----
R
Q
S
-
R
-
A
SRRG
V
-
S
R
-
E
-
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
---
L
D
K
---
N
---
I
PIP
H
---
I
K
L
I
D
F
G
L
---
A
H
E
I
-
E
D
G
-
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
------
K
Q
E
T
L
--
A
N
I
--
T
S
V
--
S
Y
DFDEE
F
-----
F
S
H
T
S
E
LAK
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
63.13
36%
-114
- C1 -
3DJ5
1
AURKA_MOUSE
A:
[14-264]
-------------------
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
--------
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
----
T
Q
L
-
E
-
K
----
A
-
G
V
-
E
H
Q
----
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
-
L
-
L
---
L
G
S
---
N
---
G
---
E
---
L
K
I
A
D
F
G
W
------------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
---
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
-
E
A
H
T
Y
--
Q
E
T
Y
R
R
I
S
--
R
V
E
--
F
T
F
--
P
D
-----
F
-----
V
T
E
G
A
R
---
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
-----
L
A
E
V
L
E
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
63.07
39%
-106
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[13-276]
------------------
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
--------
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
----
R
Q
S
-
R
-
A
SRRG
V
-
C
R
-
E
-
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
-
L
---
L
D
K
---
N
---
I
P
I
P
H
---
I
K
L
I
D
F
G
L
---
A
H
E
I
-
E
D
G
-
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
------
K
Q
E
T
L
--
A
N
I
--
T
A
V
--
S
Y
DFDEE
F
-----
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
62.88
39%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[13-276]
------------------
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
--------
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
----
R
Q
S
-
R
-
A
SR
R
G
V
-
S
R
-
E
-
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
---
L
D
K
---
N
---
I
P
I
P
H
---
I
K
L
I
D
F
G
L
---
A
H
E
I
-
E
D
G
-
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
------
K
Q
E
T
L
--
A
N
I
--
T
S
V
--
S
Y
DFDEE
F
-----
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
62.17
39%
-108
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[13-276]
------------------
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
--------
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
----
R
Q
S
-
R
-
A
SR
R
G
V
-
S
R
-
E
-
E
----
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
---
L
D
K
---
N
---
I
P
I
P
H
---
I
K
L
I
D
F
G
L
---
A
H
E
I
-
E
D
G
-
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
PL
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
D
T
------
K
Q
E
T
L
--
A
N
I
--
T
S
V
--
S
Y
DFDEE
F
-----
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
61.00
38%
-119
- C1 -
3COK
1
PLK4_HUMAN
A:
[13-266]
-------------------
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
--------
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
----
K
A
M
Y
K
-
A
----
G
-
M
V
-
Q
-
R
----
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
-
L
-
L
---
L
T
R
---
N
---
M
---
N
---
I
K
I
A
D
F
G
L
---
A
T
Q
L
-
K
----------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-
D
T
D
T
V
--
K
-----
V
V
--
L
A
D
--
Y
E
M
--
P
S
-----
F
-----
L
S
I
E
A
K
---
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
-----
L
S
S
V
L
D
H
P
F
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
60.76
37%
-111
- C1 -
2W4O
1
KCC4_HUMAN
A:
[54-309]
------------------
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
--------
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
-------------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
-
L
-
L
---
Y
A
T
PAP
D
---
A
---
P
---
L
K
I
A
D
F
------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
---
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
--
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
--
F
I
S
--
P
W
-----
W
DE---
V
S
L
N
A
K
---
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
F
Q
A
L
Q
H
P
W
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
HHSearch
59.94
34%
-97
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[10-273]
----------------
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
--------
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
----
K
K
L
-
S
-
A
----
R
-
D
H
-
Q
-
K
----
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
N
L
K
P
E
N
-
L
-
L
---
L
A
S
KLK
G
---
A
---
A
---
V
K
L
A
D
F
G
L
---
A
I
E
V
-
E
G
E
Q
Q
---
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
---
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
E
D
Q
--
H
R
L
Y
Q
Q
I
K
--
A
G
A
--
Y
D
F
--
P
S
PEWD-
T
-----
V
T
P
E
A
K
---
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
-----
A
A
E
A
L
K
H
P
W
I
S
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
59.21
36%
-99
- C1 -
2QHN
1
CHK1_HUMAN
A:
[9-264]
-------------------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----
K
-----------------
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
NPWKK
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
58.60
36%
-99
- C1 -
2HY0
1
CHK1_HUMAN
A:
[8-263]
-------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----
K
-----------------
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
NPWKK
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
58.42
36%
-97
- C1 -
2QHM
1
CHK1_HUMAN
A:
[9-264]
-------------------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----
K
-----------------
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
NPWKK
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
58.01
36%
-100
- C1 -
2HOG
1
CHK1_HUMAN
A:
[8-263]
-------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----
K
-----------------
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
N
P
W
K
K
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
57.78
36%
-98
- C1 -
2HXL
1
CHK1_HUMAN
A:
[8-263]
-------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----
K
R
------------
C
P
E
-
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
N
P
W
K
K
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
57.00
36%
-97
- C1 -
2HXQ
1
CHK1_HUMAN
A:
[8-263]
-------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----
K
R
------------
C
P
E
-
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
NPWKK
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
56.93
36%
-100
- C1 -
3TKI
1
CHK1_HUMAN
A:
[9-264]
-------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----
K
-----------------
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
NPWKK
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
56.56
36%
-97
- C1 -
2R0U
1
CHK1_HUMAN
A:
[9-264]
-------------------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
----
K
-----------------
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
NPWKK
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
54.39
36%
-102
- C1 -
3TKH
1
CHK1_HUMAN
A:
[9-264]
-------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
--------
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------------------------
N
----
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
-
L
-
L
---
L
D
E
---
R
---
D
---
N
---
L
K
I
S
D
F
G
L
---
A
T
V
F
-
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
--
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
Q
P
S
D
--
S
C
--
Q
E
Y
S
--
D
W
K
--
E
K
K
--
T
Y
-----
L
NPWKK
I
D
S
A
P
L
---
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
-----
I
P
D
I
K
K
D
R
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------