@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SRMS_HUMAN: (2013-07-25 )
MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHP
Atome Classification :
(104 SA)
.........10........20........30........40........50........60........70........80--...-.....90...-.....100.......110.......120.......130.......140.......150.......160-----..-----.---....170.......180.......190.......200.......210.---...--------..----------------.220--.........230..-.....240.......250-.----.--.......260...---.--...270.......280.......290.......300.......310......-----.320.......330.......340.......350.......---360.......370.......--380........390.......--400.......410.......420.......-430.......440.....---..450.......460.......470.......480......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCAL--EEG-GGYIFARRLS-GQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRA-----QA-----K---VCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM---PQK--------AP----------------RQ----DVWERPHSEFALGR-KLGEGYFGEVWEGLWL---G----S--LPVAIKVIKSANM---K--LTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPE-----GRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVD---DGLACKVADFGLARLLKDDI--YS-PSSSSKIPVKWTAPEAAN--YRVFSQKSDVWSFGVLLHEVFTYGQCPYEG-MTNHETLQQIMRGYRLPR---PAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHP
2
PsiBlast_PDB
93.69
42%
-117
- C3 -
2C0I
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
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-----
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PRQ
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T
---
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E
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Y
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D
F
Y
----
12
PsiBlast_PDB
93.59
42%
-118
- C3 -
3VS5
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
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-----
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PRQ
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---
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---
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A
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---
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F
Y
----
13
PsiBlast_PDB
93.48
42%
-115
- C3 -
3VS6
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
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PRQ
G
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T
---
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Y
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31
PsiBlast_CBE
93.08
42%
-116
- C3 -
2C0O
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
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D
PRQGD
T
---
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L
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F
Y
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29
PsiBlast_CBE
92.95
42%
-117
- C3 -
3VRY
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
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PRQ
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---
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A
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G
-
M
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G
Y
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M
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R
---
P
E
N
C
P
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E
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V
L
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D
F
Y
----
23
PsiBlast_CBE
92.72
42%
-118
- C3 -
3VS5
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
17
PsiBlast_PDB
92.57
44%
-115
- C3 -
2SRC
1
SRC_HUMAN
A:
[5-430]
-------------------------------------------------------
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
--
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
---
N
A
-----
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
---
T
S
K
--------
P
Q
----------------
T
Q
GLAK
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
--
Y
T
-
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
-----------
25
PsiBlast_CBE
92.50
42%
-118
- C3 -
3VS2
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
112
HHSearch
92.37
44%
-109
- C3 -
2H8H
1
SRC_HUMAN
A:
[87-522]
------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
N
T
-
E
G
D
W
W
L
A
H
S
L
-
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
NAK
G
L
-----
N
---
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
---
T
S
K
--------
P
Q
TQGL------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
--
Y
T
-
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
28
PsiBlast_CBE
92.30
42%
-119
- C3 -
3VRZ
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
32
PsiBlast_CBE
92.05
42%
-115
- C3 -
2C0I
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQGD
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
113
HHSearch
91.49
43%
-112
- C3 -
1QCF
1
HCK_HUMAN
A:
[7-443]
---------------------------------------------------
I
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
--
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
-----
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
---
S
S
K
PQK-----
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
--
Y
T
-
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
--
11
PsiBlast_PDB
91.48
42%
-113
- C3 -
3VS4
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
--------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
3
PsiBlast_PDB
91.43
42%
-114
- C3 -
2C0O
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
34
PsiBlast_CBE
91.35
42%
-114
- C3 -
1AD5
1
HCK_HUMAN
B:
[4-425]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQGD
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-------------
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
9
PsiBlast_PDB
91.30
42%
-115
- C3 -
3VS2
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
L
---
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
30
PsiBlast_CBE
91.26
42%
-113
- C3 -
2C0T
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
4
PsiBlast_PDB
91.20
42%
-113
- C3 -
2C0T
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
5
PsiBlast_PDB
91.07
42%
-116
- C3 -
3VRY
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
6
PsiBlast_PDB
90.99
42%
-115
- C3 -
3VRZ
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
22
PsiBlast_CBE
90.98
42%
-114
- C3 -
3VS6
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQGD
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
21
PsiBlast_CBE
90.94
42%
-114
- C3 -
3VS7
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
27
PsiBlast_CBE
90.74
42%
-114
- C3 -
3VS0
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
24
PsiBlast_CBE
90.41
42%
-112
- C3 -
3VS4
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
33
PsiBlast_CBE
90.30
42%
-113
- C3 -
2HCK
1
HCK_HUMAN
B:
[4-425]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQGD
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-------------
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
10
PsiBlast_PDB
90.29
42%
-112
- C3 -
3VS3
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
7
PsiBlast_PDB
89.14
42%
-113
- C3 -
3VS0
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
19
PsiBlast_PDB
89.01
44%
-111
- C3 -
1KSW
1
SRC_HUMAN
A:
[5-430]
-------------------------------------------------------
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
--
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
---
N
A
-----
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
---
T
S
K
--------
P
Q
----------------
T
Q
GLAK
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
--
Y
T
-
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
-----------
26
PsiBlast_CBE
88.77
42%
-115
- C3 -
3VS1
1
HCK_HUMAN
B:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
15
PsiBlast_PDB
88.59
44%
-110
- C3 -
1Y57
1
SRC_HUMAN
A:
[5-432]
-------------------------------------------------------
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
--
T
G
Y
I
P
S
N
Y
V
A
P
S
--
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
---
N
A
-----
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
---
T
S
K
--------
P
Q
----------------
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
--
Y
T
-
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
-----------
115
HHSearch
88.17
39%
-111
- C3 -
1OPK
3
ABL1_MOUSE
A:
[44-479]
-----------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
--
G
Y
N
H
N
G
E
W
C
E
A
Q
T
K
-
N
G
--
Q
G
W
V
P
S
N
Y
I
T
P
V
--
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
-----
R
---
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
---
K
R
N
--------
K
P
TIYGVSP---------
N
Y
----
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y---
S
--
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-----
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--
37
PsiBlast_CBE
87.11
38%
-109
- C3 -
2FO0
4
ABL1_HUMAN
A:
[30-473]
------------------------------------------
N
L
L
A
G
P
S
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
H
N
-
G
E
W
C
E
A
Q
T
K
N
-
G
Q
---
G
W
V
P
S
N
Y
I
T
P
V
N
--
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
-----
R
---
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
----
P
K
R
NKPTVYGV
S
P
----------------
N
Y
----
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y---
S
--
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-----
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
36
PsiBlast_CBE
86.82
38%
-113
- C3 -
1OPL
2
ABL1_HUMAN
A:
[81-515]
---------------------------------------------------
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
H
N
-
G
E
W
C
E
A
Q
T
K
N
-
G
Q
---
G
W
V
P
S
N
Y
I
T
P
V
N
--
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
-----
R
---
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
----
P
K
R
NKPTVYGV
S
P
----------------
N
Y
----
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y---
S
--
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-----
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
8
PsiBlast_PDB
86.78
42%
-110
- C3 -
3VS1
1
HCK_HUMAN
A:
[10-441]
------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
-
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
-----
Y
D
PRQ
G
D
T
---
V
K
H
Y
K
I
R
---------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
SSK
P
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
----
118
HHSearch
85.08
36%
-116
- C3 -
2OZO
1
ZAP70_HUMAN
A:
[156-599]
--------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
E
Q
G
T
Y
A
L
S
L
I
Y
-----
G
K
-----
T
---
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
---
N
------------MDTSVFESPFSDPEEL
K
D
----
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
RK
K
----
Q
--
I
D
V
A
I
K
V
L
K
Q
G
T
E
KA-
D
--
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-----
R
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
---
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
---------------
P
L
K
W
Y
A
P
E
C
I
N
--
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
-
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
---
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
--
35
PsiBlast_CBE
79.00
38%
-108
- C3 -
1OPL
1
ABL1_HUMAN
B:
[140-515]
---------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
-----
R
---
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
----
P
----------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y---
S
--
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-----
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-----
121
HHSearch
71.12
40%
-111
- C3 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
---
N
LLP-
K
--
M
L
V
A
V
K
A
L
K
E
A
S
E
---
S
A
-
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
PD---
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
--
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
---
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
97
PsiBlast_CBE
71.00
52%
-121
- C3 -
2QLQ
2
SRC_CHICK
A:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
69
PsiBlast_CBE
71.00
52%
-107
- C3 -
3EN4
1
SRC_CHICK
B:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
60
PsiBlast_CBE
70.57
52%
-108
- C3 -
3UQF
1
SRC_CHICK
A:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
77
PsiBlast_CBE
70.32
52%
-106
- C3 -
1YOL
1
SRC_HUMAN
B:
[9-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
-----------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
-----------
66
PsiBlast_CBE
70.27
52%
-117
- C3 -
3EN7
1
SRC_CHICK
A:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-----------
T
R
V
A
I
K
T
L
K
P
------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
42
PsiBlast_CBE
70.11
50%
-113
- C3 -
2OFV
1
LCK_HUMAN
A:
[6-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------
P
W
----------------
W
E
----
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
----
H
--
T
K
V
A
V
K
S
L
K
Q
G
------------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------------
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
-
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
---
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
-------
73
PsiBlast_CBE
70.06
52%
-104
- C3 -
3DQX
1
SRC_CHICK
B:
[12-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
67
PsiBlast_CBE
70.06
52%
-121
- C3 -
3EN6
1
SRC_CHICK
B:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
-----------------------
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
62
PsiBlast_CBE
69.89
52%
-102
- C3 -
3G6G
2
SRC_CHICK
A:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
90
PsiBlast_CBE
69.56
52%
-109
- C3 -
3G5D
2
SRC_CHICK
B:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
---
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
53
PsiBlast_CBE
69.52
52%
-107
- C3 -
4DGG
1
SRC_CHICK
B:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
-----------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
57
PsiBlast_CBE
69.45
52%
-106
- C3 -
3UQG
1
SRC_CHICK
B:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
----
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
-------
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
87
PsiBlast_CBE
69.36
52%
-105
- C3 -
3TZ8
1
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
58
PsiBlast_CBE
69.09
52%
-105
- C3 -
3UQG
1
SRC_CHICK
A:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
59
PsiBlast_CBE
68.96
52%
-109
- C3 -
3UQF
1
SRC_CHICK
B:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
------------
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
80
PsiBlast_CBE
68.95
51%
-109
- C3 -
3QLG
1
SRC_CHICK
A:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
45
PsiBlast_CBE
68.89
47%
-107
- C3 -
2HK5
1
HCK_HUMAN
A:
[2-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--------
P
W
----------------
E
K
----
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
----
H
--
T
K
V
A
V
K
T
M
K
P
G
S
M
---
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
--
Y
T
-
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
54
PsiBlast_CBE
68.73
52%
-104
- C3 -
4DGG
1
SRC_CHICK
A:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
43
PsiBlast_CBE
68.60
52%
-103
- C3 -
3GEQ
1
SRC_CHICK
B:
[3-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
Q
T
Q
--------
G
L
----------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
68
PsiBlast_CBE
68.37
52%
-108
- C3 -
3EN5
1
SRC_CHICK
A:
[13-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
-------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
------------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
71
PsiBlast_CBE
68.36
52%
-104
- C3 -
3EL8
1
SRC_CHICK
A:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
40
PsiBlast_CBE
68.36
50%
-104
- C3 -
3B2W
1
LCK_HUMAN
A:
[13-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
----
H
--
T
K
V
A
V
K
S
L
K
Q
G
S
M
---
S
--
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
--
Y
T
-
A
--
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
-
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
---
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
-------
70
PsiBlast_CBE
68.35
52%
-105
- C3 -
3EN4
1
SRC_CHICK
A:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
--
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
39
PsiBlast_CBE
68.31
50%
-105
- C3 -
3BYU
1
LCK_HUMAN
A:
[7-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------
P
W
----------------
W
E
----
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
----
H
--
T
K
V
A
V
K
S
L
K
Q
G
S
M
---
S
--
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
D
T
L
S
C
K
I
A
D
F
G
L
------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
-
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
---
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
-------
51
PsiBlast_CBE
68.24
52%
-110
- C3 -
4FIC
1
SRC_CHICK
B:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
-------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
56
PsiBlast_CBE
68.23
52%
-105
- C3 -
4AGW
3
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
79
PsiBlast_CBE
68.16
51%
-107
- C3 -
3QLG
1
SRC_CHICK
B:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
-----
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
44
PsiBlast_CBE
68.08
50%
-105
- C3 -
2OG8
1
?
B:
[1-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
----
H
--
T
K
V
A
V
K
S
L
K
Q
G
S
M
---
S
--
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
-
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
---
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
-------
72
PsiBlast_CBE
68.07
52%
-105
- C3 -
3EL7
1
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
-
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
---
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
85
PsiBlast_CBE
68.00
52%
-107
- C3 -
3TZ9
1
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
74
PsiBlast_CBE
67.78
52%
-102
- C3 -
3DQX
1
SRC_CHICK
A:
[12-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
55
PsiBlast_CBE
67.65
52%
-104
- C3 -
4AGW
2
SRC_CHICK
B:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
83
PsiBlast_CBE
67.63
51%
-101
- C3 -
3OEZ
1
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
49
PsiBlast_CBE
67.59
53%
-103
- C3 -
2BDF
1
SRC_HUMAN
B:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
-----------
46
PsiBlast_CBE
67.59
50%
-105
- C3 -
2OF4
1
LCK_HUMAN
A:
[5-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
----
H
--
T
K
V
A
V
K
S
L
K
Q
G
S
M
---
S
--
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
--
Y
T
-
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
-
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
---
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
-------
94
PsiBlast_CBE
67.58
52%
-105
- C3 -
3F3U
2
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
47
PsiBlast_CBE
67.48
50%
-105
- C3 -
2OF2
1
LCK_HUMAN
A:
[5-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
----
H
--
T
K
V
A
V
K
S
L
K
Q
G
S
M
---
S
--
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
--
Y
T
-
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
-
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
---
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
-------
100
PsiBlast_CBE
67.47
52%
-113
- C3 -
2HWO
2
SRC_CHICK
A:
[8-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
65
PsiBlast_CBE
67.43
52%
-103
- C3 -
3F6X
1
SRC_CHICK
B:
[8-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
95
PsiBlast_CBE
67.39
52%
-105
- C3 -
3F3T
2
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
52
PsiBlast_CBE
67.31
52%
-112
- C3 -
4FIC
1
SRC_CHICK
A:
[8-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
-------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
50
PsiBlast_CBE
67.23
53%
-104
- C3 -
2BDF
1
SRC_HUMAN
A:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
-----------
96
PsiBlast_CBE
67.22
52%
-108
- C3 -
2QLQ
1
SRC_CHICK
B:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
-------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
86
PsiBlast_CBE
67.17
52%
-104
- C3 -
3TZ8
1
SRC_CHICK
B:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
82
PsiBlast_CBE
67.04
51%
-102
- C3 -
3OEZ
1
SRC_CHICK
B:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
84
PsiBlast_CBE
66.94
52%
-104
- C3 -
3TZ9
1
SRC_CHICK
B:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
98
PsiBlast_CBE
66.83
52%
-109
- C3 -
2HWP
1
SRC_CHICK
B:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
-------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
63
PsiBlast_CBE
66.68
52%
-101
- C3 -
3F6X
1
SRC_CHICK
D:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
99
PsiBlast_CBE
66.66
52%
-108
- C3 -
2HWO
2
SRC_CHICK
B:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
----------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
61
PsiBlast_CBE
66.65
52%
-102
- C3 -
3G6G
2
SRC_CHICK
B:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
------------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
91
PsiBlast_CBE
66.36
52%
-103
- C3 -
3F3V
1
SRC_CHICK
B:
[9-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
48
PsiBlast_CBE
66.30
53%
-101
- C3 -
2BDJ
1
SRC_HUMAN
A:
[3-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
-----------
41
PsiBlast_CBE
66.11
50%
-108
- C3 -
2OFV
1
?
B:
[7-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
----------------
W
E
----
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
----
H
--
T
K
V
A
V
K
S
L
K
Q
G
----------
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
--------------
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
--------
I
Q
N
L
E
-
G
Y
R
M
V
R
---
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
-------
81
PsiBlast_CBE
66.03
51%
-110
- C3 -
3QLF
1
SRC_CHICK
A:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
--------------
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
38
PsiBlast_CBE
65.96
49%
-97
- C3 -
2PL0
1
LCK_HUMAN
A:
[11-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------
P
W
----------------
W
E
----
D
E
W
E
V
P
R
E
T
L
K
L
V
E
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
G
----
H
--
T
K
V
A
V
K
S
L
K
Q
G
S
M
---
S
--
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
-----
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
--
Y
T
-
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
-
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
---
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
-------
123
HHSearch
65.87
39%
-111
* C3 *
4I4E
1
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
-
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
---
S
PNP-
A
--
L
A
V
A
I
K
T
C
K
N
C
T
S
---
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-----
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
--
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
---
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
----
88
PsiBlast_CBE
65.87
52%
-103
- C3 -
3TZ7
1
SRC_CHICK
B:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
64
PsiBlast_CBE
65.44
52%
-106
- C3 -
3F6X
1
SRC_CHICK
C:
[8-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------
A
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
---------
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
130
HHSearch
65.14
38%
-103
- C3 -
2J0J
1
FAK1_CHICK
A:
[378-651]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--------
M
P
----------------
S
T
----
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
-
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
---
S
PEN
P
A
--
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
-
V
--
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-----
K
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
-------------
L
P
I
K
W
M
A
P
E
S
I
N
--
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
---
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
---
78
PsiBlast_CBE
65.11
52%
-104
- C3 -
1YOL
1
SRC_HUMAN
A:
[7-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
-----------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
-----------
93
PsiBlast_CBE
65.02
52%
-104
- C3 -
3F3U
1
SRC_CHICK
B:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
-----
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
92
PsiBlast_CBE
64.30
52%
-102
- C3 -
3F3V
1
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
89
PsiBlast_CBE
64.15
52%
-103
- C3 -
3TZ7
1
SRC_CHICK
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
75
PsiBlast_CBE
62.63
52%
-103
- C3 -
3D7T
1
SRC_CHICK
B:
[11-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
----
T
--
T
R
V
A
I
K
T
L
K
P
G
T
M
---
S
--
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
-----
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------
K
F
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
-----------
133
HHSearch
61.70
38%
-90
- C3 -
3L9P
4
A:
[62-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
----
D
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---
G
-----S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
-
D
--
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
PRPSQ
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
--
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
--
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
---
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
---
101
PsiBlast_CBE
58.79
46%
-97
- C3 -
3A4O
1
LYN_HUMAN
X:
[6-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
I
K
L
V
K
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
---
N
----
S
--
T
K
V
A
V
K
T
L
K
P
G
T
M
---
S
--
V
Q
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
-----
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
---
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
------------
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
-
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
---
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
----
127
HHSearch
51.74
30%
-103
- C3 -
4ITJ
1
RIPK1_HUMAN
A:
[8-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
I
K
M
K
S
S
D
F
L
E
---------
F
G
K
V
S
L
A
F
H
R
---
T
----
Q
--
G
L
M
I
M
K
T
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Y
K
G
P
N
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H
--
N
E
A
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
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I
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G
K
Y
S
L
V
M
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Y
M
E
K
G
N
L
M
H
V
L
K
A
-
E
------
M
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
---
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N---------
G
T
L
Y
Y
M
A
P
E
H
L
N
DV
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
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A
-
N
K
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P
Y
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N
A
I
A
E
Q
Q
L
I
M
A
I
K
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G
N
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DDI
T
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Y
C
P
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I
I
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L
M
K
L
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W
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A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
---
Add PDB User Result:
(9 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHP
135
-
99%
-126
- C3 -
U135
1
B:
[55-482]
------------------------------------------------------
L
F
L
A
L
Y
D
F
T
A
R
C
G
G
E
L
S
V
R
R
G
D
R
L
C
A
L
E
E
G
G
G
Y
I
F
A
R
R
L
S
G
Q
P
-
S
G
L
V
P
I
T
H
V
A
K
A
--
E
T
L
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G
V
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A
Q
Q
L
L
L
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N
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P
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A
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G
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Y
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L
S
V
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A
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A
K
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C
H
Y
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V
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M
A
A
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G
S
L
Y
L
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L
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L
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L
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Y
Y
K
A
N
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L
L
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A
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W
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P
H
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A
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L
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A
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N
L
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L
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A
L
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L
L
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F
A
C
Q
V
A
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G
M
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Y
L
E
E
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R
V
V
H
R
D
L
A
A
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N
V
L
V
D
D
G
L
A
C
K
V
A
D
F
G
L
A
R
L
L
------------
I
P
V
K
W
T
A
P
E
A
A
N
Y
R
V
F
S
Q
K
S
D
V
W
S
F
G
V
L
L
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V
F
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Y
G
Q
C
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Y
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G
M
T
N
H
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L
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M
R
G
Y
R
L
P
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A
A
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A
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V
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L
M
L
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C
W
R
S
S
P
E
E
R
P
S
F
A
T
L
R
E
K
L
H
A
------
136
-
99%
-127
- C3 -
U136
1
B:
[55-482]
------------------------------------------------------
L
F
L
A
L
Y
D
F
T
A
R
C
G
G
E
L
S
V
R
R
G
D
R
L
C
A
L
E
E
G
G
G
Y
I
F
A
R
R
L
S
G
Q
P
-
S
G
L
V
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I
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H
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A
K
A
--
E
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L
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Q
L
L
L
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P
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P
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L
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S
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S
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L
G
G
Y
S
L
S
V
R
A
Q
A
K
V
C
H
Y
R
V
S
M
A
A
D
G
S
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Y
L
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L
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L
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L
L
T
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Y
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A
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L
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A
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L
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L
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L
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A
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L
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A
V
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-
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P
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L
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A
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L
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A
L
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L
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P
L
L
G
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A
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Q
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A
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Y
L
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Q
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V
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A
A
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N
V
L
V
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D
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L
A
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V
A
D
F
G
L
A
R
L
L
-------------
P
V
K
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A
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A
A
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Y
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V
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Q
K
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L
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G
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Y
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Y
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L
P
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A
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L
M
L
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C
W
R
S
S
P
E
E
R
P
S
F
A
T
L
R
E
K
L
H
A
------
137
-
99%
-126
- C3 -
U137
1
B:
[55-482]
------------------------------------------------------
L
F
L
A
L
Y
D
F
T
A
R
C
G
G
E
L
S
V
R
R
G
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L
C
A
L
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G
G
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P
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A
K
A
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L
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G
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A
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A
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L
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A
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L
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K
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L
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L
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A
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A
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N
V
L
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D
D
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L
A
C
K
V
A
D
F
G
L
A
R
L
L
------------
I
P
V
K
W
T
A
P
E
A
A
N
Y
R
V
F
S
Q
K
S
D
V
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L
L
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F
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G
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Y
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A
A
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A
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L
M
L
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C
W
R
S
S
P
E
E
R
P
S
F
A
T
L
R
E
K
L
H
A
------
138
-
99%
-124
- C3 -
U138
1
B:
[55-482]
------------------------------------------------------
L
F
L
A
L
Y
D
F
T
A
R
C
G
G
E
L
S
V
R
R
G
D
R
L
C
A
L
E
E
G
G
G
Y
I
F
A
R
R
L
S
G
Q
P
-
S
G
L
V
P
I
T
H
V
A
K
A
--
E
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A
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L
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A
A
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N
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L
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D
D
G
L
A
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V
A
D
F
G
L
A
R
L
L
-------------
P
V
K
W
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A
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R
V
F
S
Q
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L
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A
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L
M
L
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C
W
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S
S
P
E
E
R
P
S
F
A
T
L
R
E
K
L
H
A
------
139
-
99%
-125
- C3 -
U139
1
A:
[55-482]
------------------------------------------------------
L
F
L
A
L
Y
D
F
T
A
R
C
G
G
E
L
S
V
R
R
G
D
R
L
C
A
L
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E
G
G
G
Y
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F
A
R
R
L
S
G
Q
P
-
S
G
L
V
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I
T
H
V
A
K
A
--
E
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L
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L
L
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P
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N
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P
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A
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S
S
L
G
G
Y
S
L
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V
R
A
Q
A
K
V
C
H
Y
R
V
------
S
L
Y
L
Q
K
G
R
L
F
P
G
L
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L
L
T
Y
Y
K
A
N
W
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L
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P
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C
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L
A
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L
L
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-----------
I
P
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L
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C
W
R
S
S
P
E
E
R
P
S
F
A
T
L
R
E
K
L
H
A
------
140
-
99%
-127
- C3 -
U140
1
B:
[55-482]
------------------------------------------------------
L
F
L
A
L
Y
D
F
T
A
R
C
G
G
E
L
S
V
R
R
G
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R
L
C
A
L
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G
G
G
Y
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A
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R
L
S
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-
S
G
L
V
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I
T
H
V
A
K
A
--
E
T
L
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F
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A
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L
L
L
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-------------
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A
------
141
-
100%
-113
- C3 -
U141
1
A:
[216-481]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
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---------------
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-------
142
-
100%
-114
- C3 -
U142
1
A:
[220-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
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------------------
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-----------
143
-
99%
-130
- C3 -
U143
1
A:
[55-482]
------------------------------------------------------
L
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-------------
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A
------