@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SRPK1_HUMAN: (2015-06-18 )
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60......-..70...---.....80..-......90.......--.-100-.......110.------......120.......130.......140.......150...--.-...160.......170.......180-.--........190.......200...-....210.......220.......230.......240.......250...------....260..-------------.....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500...---.--.--..510.......520....-.-..530.......540.......550.......560.......570.......580.-...--...590...-------------....--------600------.---...--.---------.--.---..610..-----------.....620--.........630.......640.......650...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MER
K
V
L
A
L
Q
A
R
K
K
R
TKA
K
K
D
K
A
Q
R
KS
E
T
QHRGSAPHSESDL
P
E
Q
E
E
E
ILGSDDDEQEDPNDYCKG
G
Y
-
H
L
V
K
I
G
D
---LFN
G
R
Y
H
V
I
-
R
K
LGWGH
F
S
T
V
W
L
S
W
--D-IQG-
K
K
F
V
A
M
K
V
V
K
S
------
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
RNSDPNDP
N
R
E
M
V
V
Q
L
L
D
D
F
K
ISG--V-NG
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
KSN---Y--QGL
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T-K
C
R
I
I
HTDIKPE
N
I
L
L
SV
N
E
Q
Y
I
R
R
L
A
A
E
A
T
E
W
QRSGAPPPSGSAVSTAP------QPK
P
A
D
K
M
S
-------------
K
N
K
K
K
K
L
K
K
K
Q
K
R
Q
A
E
L
L
E
K
R
M
Q
E
I
E
E
M
E
KESGPGQKRPNKQEESESPVERPLKENPP
N
K
M
T
Q
E
K
L
E
ESSTIGQD
Q
T
L
M
ERDTEGG
A
A
E
I
NCN
G
V
I
E
V
I
N
YTQNSNNET
L
R
H
K
E
DLHNANDCDVQNLN
Q
E
S
S
FLSSQNGDSSTSQETDSCTPITSEVS
D
T
M
V
CQSSST
V
G
Q
S
F
S
E
Q
H
I
S
Q
L
Q
E
S
I
RAEIPCEDEQEQEHNGPLDNKGKSTAG
N
F
L
VNPLEPKNA
E
K
L
K
V
K
I
ADLG
N
A
C
W
V
H---
K
--
H
--
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
GS-G-YN
T
P
A
D
I
W
S
T
A
C
M
A
F
E
LATG
D
Y
L
FEPHSGEEYTRD
E
D
H
I
A
L
I
I
E
L
L
GKV
P
R
K
L
I
V
A-GKY--
S
K
E
F
FTKKG-------------
D
L
K
H
--------
I
--------T---KLK--
P
---------
W
--
G
---
L
F
E
V
L
V
E
-----------
K
YEW
S
Q
----
E
EAAG
F
T
D
F
L
L
P
M
L
E
LIPEKRA
T
A
A
E
C
L
RHPWLNS
117
HHSearch
99.60
100%
-128
- C1 -
1WAK
5
SRPK1_HUMAN
A:
[22-397]
--------------------------------------------------------------
C
K
--
Y
-
H
L
V
K
I
G
D
---
L
F
N
G
R
Y
H
V
I
-
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
--
D
-
I
Q
G
-
K
K
F
V
A
M
K
V
V
K
S
------
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
P
N
D
P
N
R
E
M
V
V
Q
L
L
D
D
F
K
I
S
G
--
V
-
N
G
T
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
---
Y
--
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
-
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
Q
Y
I
R
R
L
A
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
G
N
F
L
V
N
P
L
E
P
K
N
A
E
K
L
K
V
K
I
A
D
L
G
N
A
C
W
V
H
---
K
--
H
--
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
-
G
-
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
E
Y
T
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
-
G
K
Y
--
S
K
E
F
F
T
K
K
G
-------------
D
L
K
H
--------
I
--------
T
---
K
L
K
--
P
---------
W
--
G
---
L
F
E
V
L
V
E
-----------
K
Y
E
W
S
Q
----
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
S
119
HHSearch
72.36
31%
-112
- C1 -
2VX3
4
DYR1A_HUMAN
A:
[34-378]
----------------------------------------------------------
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
---
K
W
M
D
R
Y
E
I
D
-
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
--
D
-
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
------
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
-------
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
---
F
--
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
---
Q
--
R
--
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
-
P
-
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
------
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
-
A
P
K
--
A
R
K
F
F
E
K
L
P
-------------
D
G
T
W
NLKKTKDG
K
--------
R
---
E
Y
K
--
P
---------
P
--
G
TR
K
L
H
N
I
L
G
V
ETGGPGGRRAG
E
S
G
H
T
V
----
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
121
HHSearch
70.66
39%
-103
- C1 -
3KVW
1
DYRK2_HUMAN
A:
[90-413]
-----------------------------------------------------------------------
V
P
H
D
---
H
V
A
Y
R
Y
E
V
L
-
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
--
D
-
H
K
V
-
H
Q
H
V
A
L
K
M
V
R
N
------
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
--
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
-------
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
---
F
--
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
-
N
-
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
-----------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
---
Q
--
R
--
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
---
G
E
---
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
-
S
K
R
--
A
K
N
F
V
S
S
K
G
-------------
Y
P
R
Y
--------
C
--------
T
---
V
T
T
LS
D
V
V
L
N
G
G
RSR
R
--
G
---
K
L
R
G
P
P
E
-----------
S
R
E
W
G
N
ALKG
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-
120
HHSearch
67.88
32%
-93
- C1 -
2EU9
1
CLK3_HUMAN
A:
[5-338]
---------------------------------------------------------------
K
E
G
H
-
L
V
C
R
I
G
D
---
W
L
Q
E
R
Y
E
I
V
-
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
--
D
-
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
------
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
--
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
-------
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
---
F
--
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
-
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
T
L
-----------------------------------
Y
N
-----------------------
E
H
-
S
C
E
--------------------------------------------------------
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
---
E
--
H
--
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
--
Q
K
Y
F
Y
K
G
G
L
-------------
V
W
D
E
--------
N
S
S
D
G
R
Y
V
K
E
---
N
C
K
--
P
---------
L
--
K
---------
S
-----------
Y
M
L
Q
D
S
----
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
123
HHSearch
63.21
34%
-98
- C1 -
3LLT
1
?
A:
[26-360]
---------------------------------------------------------------------
S
W
K
K
G
M
---
L
L
N
N
A
F
L
V
I
-
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
--
H
-
I
D
N
-
K
K
Y
Y
A
V
K
V
V
R
N
------
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
N
---
I
V
K
Y
H
G
K
F
M
Y
-------
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
---
Y
--
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
--
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
---------------------------------------------------------------------------------------------
F
---
E
-----------------------------------
K
S
--------------
L
I
T
V
R
R
V
---------------
T
D
------------------------------------------------------
G
K
K
I
--------------
Q
I
--------------------------------
Y
R
T
K
S
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
---
D
--
Y
--
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
-
G
-
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
------
E
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
-
A
T
K
T
N
G
S
K
Y
V
N
K
D
E
LKLAWPENASS
I
N
S
I
K
H
--------
V
--------
K
---
K
C
L
--
P
----------------
L
Y
--------------------
K
I
----
I
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
-
122
HHSearch
62.35
31%
-88
- C1 -
1Z57
1
CLK1_HUMAN
A:
[2-334]
-----------------------------------------------------------------
M
H
-
L
I
C
Q
S
G
D
---
V
L
S
A
R
Y
E
I
V
-
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
--
D
H
K
A
G
-
G
R
H
V
A
V
K
I
V
K
N
------
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
--
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
-------
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
---
F
--
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
-
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
E
A
------------------
Y
N
------------------------------------------------------------------------
R
-
D
--
E
R
-------------------------
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
---
E
--
H
--
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
-
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
------
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
-
T
R
K
--
R
K
Y
F
H
H
D
R
L
-------------
D
W
D
E
--------
H
--------
S
---
S
A
G
--
R
---------
Y
V
S
R
---
A
C
K
P
L
K
E
-----------
F
M
L
S
Q
D
----
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
132
HHSearch
61.14
30%
-107
* C1 *
3NIZ
1
?
A:
[15-306]
------------------------------------------------------------------------
Y
F
Q
---
G
L
M
E
K
Y
Q
K
L
-
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
--
D
-
S
Q
--
G
R
I
V
A
L
K
R
I
R
---------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
-----
H
P
N
---
I
V
S
L
I
D
V
I
H
-------
S
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
-
N
---
K
--
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
-
H
-
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
IPV
R
-------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
-
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
K
P
L
F
P
G
V
------
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
-
V
Q
E
--
L
P
L
W
K
Q
R
T
---------------
F
-
Q
--------
V
--------
F
---
E
K
K
--
P
---------
W
--
S
---
S
I
---
I
P
-----------
G
----------
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
127
HHSearch
60.92
28%
-106
- C1 -
3TTJ
1
MK10_HUMAN
A:
[46-360]
----------------------------------------------------------------
N
Q
F
-
Y
S
V
E
V
--S
T
F
T
V
L
K
R
Y
Q
N
L
-
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
--
D
-
A
V
L
-
D
R
N
V
A
I
K
K
L
S
R
PFQ---
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
-----
H
K
N
---
I
I
S
L
L
N
V
F
T
P
Q
K
TL
E
-
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
M
---------
E
L
D
H
E
R
M
S
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
-
A
-
G
I
I
H
R
D
L
K
P
S
N
I
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
S
D
C
T
L
K
I
L
D
F
G
L
A
----------
S
FM
M
----
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
-
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
---
G
R
D
---
Y
I
D
Q
W
N
K
V
I
E
Q
L
G
T
P
C
P
E
F
M
K
K
L
Q
P
T
--
V
R
N
Y
V
E
N
R
P
-------------
K
Y
A
G
--------
L
TF------
P
---
K
L
F
--
P
---------
D
--
S
---
L
F
P
A
D
--------------
S
E
H
N
K
----
L
K
A
S
Q
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
133
HHSearch
60.65
29%
-105
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-300]
------------------------------------------------------------------------------
V
M
-
N
K
F
E
I
L
-
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
--
H
-
K
E
T
-
H
E
I
V
A
I
K
K
F
K
----------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
-----
E
N
---
I
V
E
L
K
E
A
F
R
-------
R
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
------
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
-
N
-
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
-----------------------
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
L
C
D
F
G
F
A
R
N
L
S
---
E
-----------
T
R
W
Y
R
S
P
E
L
L
L
G
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
------
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
--
L
F
Y
--
S
N
P
R
F
H
G
-
L
-------------
R
F
P
A
--------
V
--------
N
-----
H
--
P
---------
Q
--
S
-------
L
E
R
-----------
R
--
Y
L
G
----
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
128
HHSearch
60.40
29%
-99
- C1 -
4AU8
2
CDK5_HUMAN
A:
[4-292]
-------------------------------------------------------------------------------
G
S
Q
K
Y
E
K
L
-
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
--
N
-
R
E
T
-
H
E
I
V
A
L
K
R
V
------------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
-----
K
N
---
I
V
R
L
H
D
V
L
H
----------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
------
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
-
R
-
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
IPV
R
------
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
-----
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
-----------------------------
M
T
K
--------
L
--------
P
---
D
Y
K
--
P
---------
Y
--
P
---
M
Y
P
A
T
T
S
-----------
L
V
N
V
V
P
----
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
1
PsiBlast_PDB
59.94
71%
-106
- C2 -
2X7G
3
SRPK2_HUMAN
A:
[22-257]
---------------------------------------------------------------------
P
V
K
I
G
D
---
L
F
N
G
R
Y
H
V
I
-
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
--
D
-
M
Q
G
-
K
R
F
V
A
M
K
V
V
K
S
------
A
Q
H
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
D
P
S
D
P
N
K
D
M
V
V
Q
L
I
D
D
F
K
I
S
G
--
M
-
N
G
I
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
---
Y
--
Q
G
L
P
V
R
C
V
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
-
K
C
K
I
I
H
T
D
I
K
P
E
N
I
L
M
C
V
D
D
A
Y
V
R
R
M
A
A
E
---------------------LLVNPL
D
P
R
N
A
D
K
I
R
V
K
I
A
DLGNACWVH
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
A
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
D
Y
S
R
D
E
D
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
F
A
L
S
G
K
Y
S
R
E
F
F
N
R
R
G
E
L
R
H
I
T
K
L
K
P
W
S
L
F
D
V
L
V
E
K
Y
G
W
P
H
E
D
A
A
Q
F
T
D
F
L
I
P
M
L
E
M
V
P
E
K
R
A
S
A
G
E
C
L
R
H
P
W
L
N
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
59.86
29%
-106
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[4-288]
----------------------------------------------------------------------------------
M
Y
E
T
L
-
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
--
H
-
K
N
T
-
G
Q
I
V
A
I
K
I
F
Y
-----------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
-----
H
E
N
---
L
V
N
L
I
E
V
F
R
-------
Q
K
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
H
Y
C
------
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
--
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------
I
T
K
L
C
D
F
G
F
A
R
T
---------DI
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
-
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
L
P
S
S
------
S
D
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
P
H
L
Q
----------
N
I
F
S
K
S
P
-------------
I
F
A
G
--------
V
--------
V
L
P
Q
V
Q
H
--
P
---------
K
--
N
---
A
R
K
K
Y
-
P
-------------
K
L
N
G
--------
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
126
HHSearch
58.13
32%
-103
- C1 -
3G33
-
CDK4_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------
R
Y
E
P
V
-
A
E
I
G
V
G
A
Y
G
T
V
Y
K
A
R
--
D
-
P
H
S
-
G
H
F
V
A
L
K
S
V
R
V
P
N
G
GGG
G
G
G
L
P
I
S
T
V
R
E
V
A
L
L
R
R
L
E
A
F
E
--
H
P
---
N
V
V
R
L
M
D
V
C
A
T
S
R
--
T
D
R
E
I
K
V
T
L
V
F
E
H
V
D
Q
D
L
R
T
Y
L
D
K
A
P
---
P
--
P
G
L
P
A
E
T
I
K
D
L
M
R
Q
F
L
R
G
L
D
F
L
H
A
-
N
C
-
I
V
H
R
D
L
K
P
E
N
I
L
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
T
V
K
L
A
D
F
G
L
A
R
I
Y
S
---
Y
QM
A
--
L
T
P
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
T
-
Y
A
T
P
V
D
M
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
C
G
N
------
S
E
A
D
Q
L
G
K
I
F
D
L
I
G
L
P
P
E
D
D
W
P
R
D
V
S
L
--
P
R
G
A
F
P
P
R
G
-------------------------------------------
P
---------
R
--
P
---
V
Q
S
V
------------------
V
P
----
E
M
E
E
S
G
A
Q
L
L
L
E
M
L
T
F
N
P
H
K
R
I
S
A
F
R
A
L
Q
H
S
Y
L
--
131
HHSearch
57.43
29%
-91
- C1 -
3O0G
-
CDK5_HUMAN
A:
[2-288]
---------------------------------------------------------------------------------
Q
K
Y
E
K
L
-
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
--
N
-
R
E
T
-
H
E
I
V
A
L
K
R
V
R
L
DDD---
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
-----
K
N
---
I
V
R
L
H
D
V
L
H
-------
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
N
------
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
-
R
-
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
IPV
R
--
C
--
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
-----
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
-------------
S
M
T
-------------
K
-----------
L
--------
P
---
D
Y
K
--
P
---------
Y
--
P
---
M
Y
P
A
T
T
S
-----------
L
V
N
V
V
P
----
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
135
HHSearch
57.24
25%
-95
- C1 -
4F6U
10
CDK8_HUMAN
A:
[15-338]
-------------------------------------------------------------------------
R
E
---
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
RK
D
-
G
K
D
-
D
K
D
Y
A
L
K
Q
I
E
G
------
T
-
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
-----
H
P
---
N
V
I
S
L
Q
K
V
F
L
S
----
H
-
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
---
A
S
K
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
-
N
W
-
V
L
H
R
D
L
K
P
A
N
I
L
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
-
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
--
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
-
I
K
K
--
M
P
E
H
S
T
L
M
K
-------------
D
F
R
R
--------
N
------------
T
Y
T
--
N
---------
C
--
S
---
L
I
K
Y
M
E
K
-----------
H
K
V
-------
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
138
HHSearch
55.73
25%
-100
- C1 -
3RGF
5
CDK8_HUMAN
A:
[15-338]
-------------------------------------------------------------------------
R
E
---
R
V
E
D
L
F
E
Y
E
G
C
K
V
G
-----
H
V
Y
K
A
K
R
K
D
-
G
K
D
-
D
K
D
Y
A
L
K
Q
I
E
G
------
T
-
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
-----
H
P
---
N
V
I
S
L
Q
K
V
F
L
S
----
H
-
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K-----
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
-
N
W
-
V
L
H
R
D
L
K
P
A
N
I
L
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
-----------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
-
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
---
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
-
I
K
K
--
M
P
E
H
S
T
L
M
K
-------------
D
F
R
R
--------
N
------------
T
Y
T
--
N
---------
C
--
S
---
L
I
K
Y
M
E
K
-----------
H
K
V
-------
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
36
PsiBlast_CBE
52.10
32%
-121
- C2 -
2WO6
1
DYR1A_HUMAN
B:
[45-192]
---------------------------------------------------------------------
I
V
K
N
G
E
---
K
W
M
D
R
Y
E
I
D
-
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
--
D
-
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
------
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
--
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
-------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
---
F
--
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
------
P
E
V
L
L
G
M
P
Y
-------------
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
K
K
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
52.03
32%
-128
- C2 -
4MQ2
2
DYR1A_HUMAN
D:
[24-171]
---------------------------------------------------------------------
I
V
K
N
G
E
---
K
W
M
D
R
Y
E
I
D
-
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
--
D
-
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
------
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
--
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
-------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
---
F
--
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
------
P
E
V
L
L
G
M
P
Y
-------------
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
W
N
L
K
K
T
K
K
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
51.55
32%
-116
- C2 -
4AZE
1
DYR1A_HUMAN
B:
[45-192]
---------------------------------------------------------------------
I
V
K
N
G
E
---
K
W
M
D
R
Y
E
I
D
-
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
--
D
-
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
------
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
--
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
-------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
---
F
--
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
------
P
E
V
L
L
G
M
P
Y
-------------
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
K
K
T
K
D
G
K
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
51.50
32%
-130
- C2 -
4MQ2
2
DYR1A_HUMAN
C:
[24-171]
---------------------------------------------------------------------
I
V
K
N
G
E
---
K
W
M
D
R
Y
E
I
D
-
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
--
D
-
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
------
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
--
E
--
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
-------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
---
F
--
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
------
P
E
V
L
L
G
M
P
Y
-------------
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
F
E
K
L
P
D
G
T
W
N
L
K
K
T
K
D
G
K
R
E
Y
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------