@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ST17A_HUMAN: (2013-07-25 )
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
Atome Classification :
(46 SA)
.........10........20........30.....---...40........50....-----....60-........70........80........90..------..-----.-..-------.100--....-.....110-.-......120.......130.......140.......150.......160.......170......-.180.......190......-.200.......210...-.....-220.......230...------....240.......250.......260.......-------270.......280.--......290.......300.......310----........320-----.-----.....-------..330--------.-........340.......350.......360.......370.......380.......390.......400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPP---PQARGLLTEIRAVVRTEPF-----QDGYSL-CPGRELGRGKFAVVRKCIKKDSGKEFAAKFMR------KR-----R-KG-------QD----CRME-IIHEIAVL-E-LAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLH-TRDVVHLDLKPQNILLTSES-PLGDIKIVDFGLS-RIL-KNSEE-LREIMGTPEYVAPEIL------SYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQ-------ETFLNISQMNLSYS--EEEFDVLSESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL------T-----QSSIQ-------EPS----------F-RMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
1
PsiBlast_PDB
84.73
60%
-115
- C1 -
3LM0
2
ST17B_HUMAN
A:
[24-302]
-------------------------------------------------------
E
N
F
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N
N
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--
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----------
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-
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P
---------------------------------------------------------------------------------
2
PsiBlast_PDB
82.98
60%
-118
- C1 -
3LM5
1
ST17B_HUMAN
A:
[24-299]
-------------------------------------------------------
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N
L
-----------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.13
45%
-114
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[2-278]
--------------------------------------------------
T
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------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.69
46%
-107
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[2-275]
--------------------------------------------------
T
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--------------------------------------------------------------------------------------------------------------------------
132
HHSearch
77.77
47%
-105
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[3-283]
---------------------------------------------------
V
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------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.28
46%
-114
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[4-275]
----------------------------------------------------
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6
PsiBlast_PDB
77.09
45%
-101
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[2-291]
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-----------------------------------------------------------------------------
26
PsiBlast_CBE
75.30
45%
-120
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[5-276]
-----------------------------------------------------
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-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-
D
------------
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.05
44%
-98
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[2-291]
--------------------------------------------------
T
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
---
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
------
K
R
-----
R
-
T
K
-------
S
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-
D
F
G
N
E
-
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-----
P
K
D
T
Q
-------
Q
A
L
----------
S
-
R
K
A
S
A
V
-----------------------------------------------------------------------------
22
PsiBlast_CBE
70.98
43%
-94
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[6-296]
-----------------------------------------------------
K
Q
Q
K
V
-----
E
D
F
Y
D
I
---
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
------
K
R
QSRAS
R
-
R
G
-------
V
-----
C
R
E
E
-
I
E
R
E
V
S
I
L
-
R
-
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
--
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
--
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
-----
P
V
D
T
Q
-------
Q
A
M
----------
V
-
R
R
E
S
V
V
N
L
E
N
-------------------------------------------------------------------------
36
PsiBlast_CBE
70.87
44%
-96
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[3-296]
-------------------------------------------------------
E
P
F
KQQKV
E
D
F
Y
D
I
---
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
------
K
R
QSRAS
R
-
R
G
-------
V
-----
S
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
-
V
L
H
H
N
--
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
--
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
-----
P
V
D
N
Q
-------
Q
A
M
----------
V
-
R
R
E
S
V
V
N
L
E
N
-------------------------------------------------------------------------
38
PsiBlast_CBE
70.81
44%
-97
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[3-296]
-------------------------------------------------------
E
P
F
KQQK
V
E
D
F
Y
D
I
---
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
------
K
R
QSRAS
R
-
R
G
-------
V
-----
S
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
-
V
L
H
H
N
--
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
--
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
-----
P
V
D
N
Q
-------
Q
A
M
----------
V
-
R
R
E
S
V
V
N
L
E
N
-------------------------------------------------------------------------
88
PsiBlast_CBE
69.58
35%
-108
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-291]
---------------------------------------------------------
F
-----
Y
E
N
Y
E
---
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
------
V
T
-----
G
-
G
G
SFS
A
E
E
V
Q
E
----
L
R
E
A
-
T
L
K
E
V
D
I
L
-
R
-
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
--
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
M
----
N
I
K
L
T
D
F
G
F
S
-
C
Q
L
-
D
P
G
E
K
-
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
-------
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
--
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
E
E
A
L
A
H
P
F
F
------
Q
-----
Q
Y
V
-----------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
69.07
45%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
-------------------------------------------------------
E
N
V
-----
D
D
Y
Y
D
---
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
------
K
R
-----
R
-
T
K
-------
S
-RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-
D
-----------
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.00
43%
-94
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[6-296]
-----------------------------------------------------
K
Q
Q
K
V
-----
E
D
F
Y
D
I
---
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
------
K
R
QSRAS
R
-
R
G
-------
V
-----
C
R
E
E
-
I
E
R
E
V
S
I
L
-
R
-
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
--
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
--
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
-----
P
V
D
T
Q
-------
Q
A
M
----------
V
-
R
R
E
S
V
V
N
L
E
N
-------------------------------------------------------------------------
35
PsiBlast_CBE
68.83
44%
-94
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[3-296]
-------------------------------------------------------
E
P
F
KQQKV
E
D
F
Y
D
I
---
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
------
K
R
QSRAS
R
-
R
G
-------
V
-----
S
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
-
V
L
H
H
N
--
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
--
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
-----
P
V
D
N
Q
-------
Q
A
M
----------
V
-
R
R
E
S
V
V
N
L
E
N
-------------------------------------------------------------------------
133
HHSearch
68.65
34%
-109
- C1 -
3Q5I
1
?
A:
[29-310]
----------------------------------------------------
K
K
E
G
K
I
-----
G
E
S
Y
F
K
---
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
------
K
------------------
K
----
F
H
E
E
-
I
Y
N
E
I
S
L
L
-
K
-
S
L
-
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
--
N
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
-
S
L
L
N
I
K
I
V
D
F
G
L
S
-
S
F
F
-
S
K
D
Y
K
-
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
------
K
-
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
-------
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
--
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
E
E
A
L
N
S
R
W
I
------
K
-----
K
Y
A
N
----------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
68.16
35%
-111
- C1 -
2PHK
2
PHKG1_RABIT
A:
[2-276]
---------------------------------------------------------
F
-----
Y
E
N
Y
E
---
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
------
V
T
-----
G
-
G
G
SFS
A
E
E
V
Q
E
----
L
R
E
A
-
T
L
K
E
V
D
I
L
-
R
-
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
--
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
M
----
N
I
K
L
T
D
F
G
F
S
-
C
Q
L
-
D
P
G
E
K
-
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
-------
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
--
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
E
E
A
L
A
H
P
F
F
------
Q
-----
Q
-------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.90
45%
-124
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
-------------------------------------------------------
E
N
V
-----
D
D
Y
Y
D
---
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---------------------------V---
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
-----
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-
D
-----------
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
66.85
34%
-101
- C1 -
1QL6
1
PHKG1_RABIT
A:
[12-291]
------------------------------------------------------
T
H
G
F
-----
Y
E
N
Y
E
---
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
------
V
T
-----
G
-
G
G
SFS
A
E
E
V
Q
E
----
L
R
E
A
-
T
L
K
E
V
D
I
L
-
R
-
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
--
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
M
----
N
I
K
L
T
D
F
G
F
S
-
C
Q
L
-
D
P
G
E
K
-
L
R
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
-------
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
--
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
E
E
A
L
A
H
P
F
F
------
Q
-----
Q
Y
V
-----------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
66.44
44%
-97
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[3-296]
-------------------------------------------------------
E
P
F
KQQK
V
E
D
F
Y
D
I
---
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
------
K
R
QSRAS
R
-
R
G
-------
V
-----
S
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
-
V
L
H
H
N
--
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
-
E
D
G
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
--
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
-----
P
V
D
N
Q
-------
Q
A
M
----------
V
-
R
R
E
S
V
V
N
L
E
N
-------------------------------------------------------------------------
43
PsiBlast_CBE
65.78
38%
-100
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[69-352]
---------------------------------
P
P
A
---
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
----------
F
Y
T
V
-
S
K
T
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
------
T
R
--------
G
-------
M
K
----
D
K
E
E
-
V
K
N
E
I
S
V
M
-
N
--
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
-
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
-
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
-
K
P
R
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
------
N
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
-------
E
T
L
N
N
I
L
A
C
R
W
D
L
E
--
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
-----
A
S
E
A
L
K
H
P
W
L
------
S
-----
D
H
K
L
H
---------------------------------------------------------------------------------------------------------
130
HHSearch
65.53
39%
-96
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-353]
-----------------------------
D
I
P
A
P
P
A
---
P
F
D
H
R
I
V
T
A
-----
K
Q
G
A
V
-----
N
S
F
Y
T
V
-
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
------
T
R
--------
G
-------
M
K
----
D
K
E
E
-
V
K
N
E
I
S
V
M
-
N
-
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
-
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
-
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
-
K
P
R
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
------
N
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
-------
E
T
L
N
N
I
L
A
C
R
W
D
L
E
--
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
-----
A
S
E
A
L
K
H
P
W
L
------
S
-----
D
H
K
L
H
-------
S
-------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
64.43
31%
-105
- C1 -
3LIJ
1
?
A:
[15-329]
-------------------------
Y
F
Q
G
D
L
Q
A
T
P
G
M
F
I
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
K
--------------------
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
------
K
------------------
S
----
S
N
S
K
-
L
L
E
E
V
A
V
L
-
K
-
L
L
-
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
--
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
S
-
A
V
F
-
E
N
Q
K
K
-
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K----
K
Y
D
E
---
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
-------
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
--
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
-----
E
S
----------
L
P
S
-------------
L
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
---------------------------------------------------------------
11
PsiBlast_PDB
62.58
45%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
-------------------------------------------------------
E
N
V
-----
D
D
Y
Y
D
---
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
------
K
R
-----
R
-
T
---------------
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
-
D
-------------
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-------
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
62.13
34%
-101
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[29-295]
---------------------------------------------------------
F
-----
T
D
D
Y
Q
L
-
F
--
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
------
T
K
-----
K
-
L
S
-------
A
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
-
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
E
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-------
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
D
Q
A
L
K
H
P
W
V
------
C
-----
Q
R
S
-----------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
60.20
35%
-115
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[98-363]
-----------------------------------------------------------------------
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VRL---
S
P
-----
E
-
Q
L
-------
E
E
----
V
R
E
A
-
T
R
R
E
T
H
I
L
-
R
-
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
--
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
----
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-
E
P
G
E
K
-
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
-------
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
--
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
E
Q
A
L
Q
H
P
F
F
--------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
58.14
33%
-81
- C1 -
3N51
3
?
A:
[22-336]
-------------------------------------------------------
A
I
F
-----
S
D
R
Y
K
---
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
------
K
R
-----
Q
-
V
K
-------
Q
K
----
T
D
K
E
S
L
L
R
E
V
Q
L
L
-
K
--
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-
E
A
S
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G----
T
Y
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
--
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
------
Q
T
Y
T
KE
Q
I
S
V
D
-------
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
-
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
------
T
S
Q
D
E
T
K
E
---------------------------------------------------
102
PsiBlast_CBE
57.75
35%
-114
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[98-363]
-----------------------------------------------------------------------
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTA
E
R
L
S
P
-----
E
-
Q
L
-------
E
E
----
V
R
E
A
-
T
R
R
E
T
H
I
L
-
R
-
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
--
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
----
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-
E
P
G
E
K
-
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
-------
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
--
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
E
Q
A
L
Q
H
P
F
F
--------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
56.22
35%
-98
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[11-268]
--------------------------------------------------------------------------
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
------
T
K
-----
K
-
L
S
-------
A
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
------
C
-----
Q
R
S
-----------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
55.96
35%
-114
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[98-363]
-----------------------------------------------------------------------
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTAERL
S
P
-----
E
-
Q
L
-------
E
E
----
V
R
E
A
-
T
R
R
E
T
H
I
L
-
R
-
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
--
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
----
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
-
E
P
G
E
K
-
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
-------
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
--
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
E
Q
A
L
Q
H
P
F
F
--------------------------------------------------------------------------------------------------------------------------
131
HHSearch
55.72
32%
-87
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-302]
-------------------------------------------------------
T
R
F
-----
T
E
E
Y
Q
L
---
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
------
T
K
-----
K
-
L
S
-------
A
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
-
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
V
-
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
-----
A
A
E
A
L
K
H
P
W
I
------
S
-----
H
R
S
T
V
ASCMHR
Q
E
T
V
----------
D
-
C
L
K
K
F
N
A
R
R
K
L
K
G
A
---------------------------------------------------------------------
60
PsiBlast_CBE
54.66
35%
-100
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[11-268]
--------------------------------------------------------------------------
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
------
T
K
-----
K
-
L
S
-------
A
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
------
C
-----
Q
R
S
-----------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
54.59
33%
-82
- C1 -
3I7B
4
?
A:
[23-336]
--------------------------------------------------------
I
F
-----
S
D
R
Y
K
---
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
------
K
R
-----
Q
-
V
K
-------
Q
K
----
T
D
K
E
S
L
L
R
E
V
Q
L
L
-
K
--
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
-
E
A
S
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G----
T
Y
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
-------
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
--
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
------
Q
T
Y
T
KE
Q
I
S
V
D
-------
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
-
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
------
T
S
Q
D
E
T
K
E
---------------------------------------------------
58
PsiBlast_CBE
54.49
35%
-101
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[11-268]
--------------------------------------------------------------------------
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
------
T
K
-----
K
-
L
S
-------
A
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-------
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
------
C
-----
Q
R
S
-----------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
52.78
32%
-102
- C1 -
3KN5
1
KS6A5_HUMAN
A:
[2-278]
-----------------------------------------------------
K
D
S
P
F
-----
Y
Q
H
Y
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
S
------
K
R
-----
M
-
E
A
-------
N
T
----
Q
K
------
E
I
T
A
L
-
K
-
L
C
E
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
--
I
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
-
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-----
L
E
I
K
I
I
D
F
G
F
A
-
R
L
K
P
P
-----------------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
-----CTS
A
V
--
E
I
M
K
K
I
K
K
G
D
F
S
F
E
--
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
S
G
L
R
Y
N
E
W
L
------
Q
-----
D
G
S
-----------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
52.74
32%
-103
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[11-268]
--------------------------------------------------------------------------
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
------
T
K
-----
K
-
L
S
-------
A
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
K
H
S
N
-
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
Q
A
-
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-------
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
H
E
A
L
K
H
P
W
V
------
C
-----
Q
R
S
-----------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
51.45
37%
-104
- C1 -
2W4O
1
KCC4_HUMAN
A:
[60-331]
--------------------------------------------------------------------------
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
------
K
----------------------------
I
----
G
V
L
---
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
--
E
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
-------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
-
D
E
R
G
-------
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
FI
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
F
Q
A
L
Q
H
P
W
V
------
T
-----
G
K
A
A
N
-------
F
V
H
----------
M
D
T
A
Q
K
K
L
Q
E
F
N
A
------------------------------------------------------------------------
57
PsiBlast_CBE
51.09
34%
-91
- C1 -
2WEI
1
?
A:
[30-286]
---------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
------
K
A
-----
S
-
A
K
-------
N
K
----
D
T
S
T
-
I
L
R
E
V
E
L
L
-
K
--
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
-
Q
Q
N
T
K
-
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G----
T
Y
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
--
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
------
Q
-----
K
Y
S
S
E
---------------------------------------------------------------------------------------------------------
136
HHSearch
50.93
33%
-92
- C1 -
3MWU
1
?
A:
[15-286]
----------------------------------------------------
Y
F
Q
G
T
F
-----
A
E
R
Y
N
I
---
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
------
K
A
-----
S
-
A
K
-------
N
K
----
D
T
S
T
-
I
L
R
E
V
E
L
L
-
K
-
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
-
Q
Q
N
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
--
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
------
Q
-----
K
Y
S
S
E
---------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
50.26
34%
-90
- C1 -
3IGO
8
?
A:
[30-299]
---------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
------
K
A
-----
S
-
A
K
-------
N
K
-----
T
S
T
-
I
L
R
E
V
E
L
L
-
K
--
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
-
Q
Q
N
T
--------
T
A
Y
Y
I
A
P
E
V
L
R
G----
T
Y
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
--
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
------
Q
-----
K
Y
S
S
E
-------
T
P
T
----------
I
-
S
D
L
P
S
L
E
S
A
--------------------------------------------------------------------------
81
PsiBlast_CBE
48.68
38%
-104
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[17-265]
---------------------------------------------------------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
------
K
S
-----------------------
S
L
E
---
N
E
I
A
V
L
-
K
K
I
K
H
E
N
--
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
--
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
-
Q
N
G
I
--
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
-------
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
--
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------
122
HHSearch
47.47
31%
-109
- C1 -
4GV1
5
AKT1_HUMAN
A:
[8-272]
----------------------------------------------------------------
N
E
F
E
Y
---
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
------
K
E
-----
V
I
V
A
-------
K
D
----
E
V
A
H
-
T
L
T
E
N
R
V
L
-
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
--
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
----
D
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
I
K
D
G
A
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
------
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
-------
K
L
F
E
L
I
L
M
E
E
I
R
F
P
--
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
------
A
-----
G
I
V
-----------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
47.18
34%
-90
- C1 -
3NCG
1
?
A:
[30-299]
---------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
------
K
A
-----
S
-
A
K
-------
N
K
----
D
T
S
T
-
I
L
R
E
V
E
L
L
-
K
--
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
-
Q
Q
N
T
------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G----
T
Y
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
--
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
------
Q
-----
K
Y
S
S
E
-------
T
P
T
----------
I
-
S
D
L
P
S
L
E
S
A
--------------------------------------------------------------------------
80
PsiBlast_CBE
46.79
38%
-103
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[17-265]
---------------------------------------------------------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
------
K
S
-----------------------
S
L
E
---
N
E
I
A
V
L
-
K
K
I
K
H
E
N
--
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
--
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
-
Q
N
G
I
--
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
-------
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
--
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
46.34
32%
-98
- C1 -
3KN5
1
B:
[2-278]
-----------------------------------------------------
K
D
S
P
F
-----
Y
Q
H
Y
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
S
------
K
R
-----
M
-
E
A
-------
N
T
----
Q
K
------
E
I
T
A
L
-
K
-
L
C
E
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
--
I
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
-
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-----
L
E
I
K
I
I
D
F
G
F
A
-
R
L
K
P
P
-----------------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
H
D
R
S
LTCTS
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
--
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
S
G
L
R
Y
N
E
W
L
------
Q
-----
D
G
S
-----------------------------------------------------------------------------------------------------------