@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK33_HUMAN: (2014-03-06 )
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90........100.......110-.......120.......130.......140.......150.-.....-.160------.-------.-----......170........180.......190.......200........210.......220.......230........240....--...250.......260.......270.......280.......290...--....----300.......310.......320.-------......330.......340.......350.......360.......370----........380-------.-....--...390.........400.......410.......-420.......430.......440.......450.......460.......470.......480.......490.......500.......510..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAI-EEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAG-SSAVK-LLE-------R-------E-----VNILKSVK-HEHIIHLEQVFETPKKMYLVMELCEDGEL-KEILDRKGHFSENETRWIIQSLASAIAYLHN-NDIVHRDLKLENIMV--KSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVI--SAHD----YSQQCDIWSIGVVMYMLLRGEPPF-------LASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL--------T-GNKL--SSVR--PTNVLEMMKEWKNNPESVEENTTEEKNKP-STEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
33
PsiBlast_CBE
68.40
32%
-105
- C1 -
3LIJ
1
?
A:
[35-346]
---------------------------------------------------------------------------------------------------------------
L
-
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
------
S
S
N
S
-
K
L
L
-------
E
-------
E
-----
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
-
F
D
E
I
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
------
K
E
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
K
--
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
--
R
K
K
-----
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
-------
G
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
E
S
----
L
--
P
S
L
----
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
-
T
S
Q
E
E
T
K
----------------------------------------------------------------------------------------
36
PsiBlast_CBE
67.43
36%
-120
- C1 -
3Q5I
1
?
A:
[26-305]
------------------------------------------------------------------------------------------------------
Y
V
R
K
K
E
G
K
-
I
-
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
---------------------
K
F
H
E
E
I
Y
N
E
-----
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
-
F
E
Q
I
I
N
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
-
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
EN
K
N
S
L
--------
L
N
I
K
I
V
D
F
G
L
S
--
S
F
F
S
K
D
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
--
K
K
K
-----
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
-------
G
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
E
E
A
L
N
S
R
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
65.75
39%
-114
- C1 -
4GV1
5
AKT1_HUMAN
A:
[8-270]
------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
-
H
T
L
-------
T
-------
E
-----
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
-
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
K
D
---------
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
-
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-------
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
--------
A
-
G
----------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.59
37%
-112
- C1 -
3HX4
3
?
A:
[37-309]
-----------------------------------------------------------------------------------------------------
P
G
M
F
V
Q
H
S
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
--------
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
65.56
35%
-110
- C1 -
1PHK
1
PHKG1_RABIT
A:
[24-291]
-------------------------------------------------------------------------------------------------------------------------
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
-
S
F
S
A
E
-
E
V
Q
E
L
R
E
A
T
L
K
-------
E
-----
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
T
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
-------
L
L
D
D
----
D
M
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
K
--
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPG
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
-------
W
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
E
E
A
L
A
H
P
F
F
--------
Q
-
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.08
36%
-95
- C1 -
3MWU
1
?
A:
[18-289]
-------------------------------------------------------------------------------------------------------------
G
T
F
-
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
K
D
T
S
-
T
I
L
-------
R
-------
E
-----
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
------
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-------
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
-----------
Q
K
Y
--
S
S
E
T
--
P
T
---------------------------------------------------------------------------------------------------------------------------
139
HHSearch
60.13
31%
-75
- C1 -
3NYV
1
?
A:
[19-361]
----------------------------------------------------------------------------------------------------------
H
S
T
A
I
F
-
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
T
D
K
E
-
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
------
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
--------
Q
-
T
Y
T
K
----
D
V
PS
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
---------------------------------------------------------------
61
PsiBlast_CBE
60.03
35%
-105
- C1 -
1QL6
1
PHKG1_RABIT
A:
[24-291]
-------------------------------------------------------------------------------------------------------------------------
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
-
S
F
S
A
E
-
E
V
Q
E
L
R
E
A
T
L
K
-------
E
-----
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
T
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
-------
L
L
D
D
----
D
M
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
K
--
L
R
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPG
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
-------
W
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
E
E
A
L
A
H
P
F
F
--------
Q
-
Q
Y
V
--------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
59.68
37%
-85
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[7-287]
---------------------------------------------------------------------------------------------------------------
I
-
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-------
S
---
L
E
-------
N
-------
E
-----
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
L
T
P
------
E
E
N
S
K
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
---
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
----
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-------
Y
E
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------
D
-
G
N
T
A
LH
R
D
I
Y
--
P
S
V
S
L
Q
I
Q
K
N
F
------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.63
36%
-97
- C1 -
3NCG
1
?
A:
[18-289]
-------------------------------------------------------------------------------------------------------------
G
T
F
-
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
K
D
T
S
-
T
I
L
-------
R
-------
E
-----
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
------
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
-------
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-------
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
-----------
Q
K
Y
--
S
S
E
T
--
P
T
---------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.54
36%
-93
- C1 -
3IGO
8
?
A:
[18-289]
-------------------------------------------------------------------------------------------------------------
G
T
F
-
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
K
-
T
S
-
T
I
L
-------
R
-------
E
-----
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
------
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
---------
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-------
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
-----------
Q
K
Y
--
S
S
E
T
--
P
T
---------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.24
37%
-86
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[7-287]
---------------------------------------------------------------------------------------------------------------
I
-
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-------
S
---
L
E
-------
N
-------
E
-----
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
L
T
P
------
E
E
N
S
K
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
---
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
----
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-------
Y
E
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------
D
-
G
N
T
A
LH
R
D
I
Y
--
P
S
V
S
L
Q
I
Q
K
N
F
------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
59.05
33%
-103
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[12-264]
--------------------------------------------------------------------------------------------------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
-
A
R
D
H
Q
-
K
L
E
-------
R
-------
E
-----
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
------
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
----
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-------
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
58.29
36%
-99
- C1 -
2WEI
1
?
A:
[18-280]
-------------------------------------------------------------------------------------------------------------
G
T
F
-
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
K
D
T
S
-
T
I
L
-------
R
-------
E
-----
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
------
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
K
--
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-------
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
57.22
37%
-99
- C1 -
3MA6
1
?
A:
[29-291]
---------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
56.81
37%
-102
- C1 -
3V5P
1
?
A:
[20-285]
------------------------------------------------------------------------------------------------------------
S
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
56.37
33%
-105
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[39-291]
--------------------------------------------------------------------------------------------------------------------------
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
-
A
R
D
H
Q
-
K
L
E
-------
R
-------
E
-----
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
-
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
S
K
C
K
------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
E
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
----
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-------
W
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
D
Q
A
L
K
H
P
W
V
---------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
55.20
37%
-97
- C1 -
3UPX
1
?
A:
[21-285]
-------------------------------------------------------------------------------------------------------------
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
54.77
37%
-97
- C1 -
3V5T
1
?
A:
[20-285]
------------------------------------------------------------------------------------------------------------
S
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
54.43
35%
-97
- C1 -
3KN5
1
KS6A5_HUMAN
A:
[19-282]
--------------------------------------------------------------------------------------------------------------------------
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
S
K
R
M
E
A
-
N
T
------
Q
-------
K
-------
E
-----
I
T
A
L
K
L
C
E
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
-
F
E
R
I
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
-
V
G
V
V
H
R
D
L
K
P
E
N
L
L
------
F
T
D
------
L
E
I
K
I
I
D
F
G
F
A
R
L
K
P
P
-------------------------
N
G
----
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q-------
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
S
G
L
R
Y
N
E
W
L
--------
Q
D
G
S
Q
L
--
S
S
---------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
54.26
37%
-98
- C1 -
3T3V
2
?
A:
[22-285]
--------------------------------------------------------------------------------------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
53.96
37%
-100
- C1 -
3SX9
1
?
A:
[19-285]
-----------------------------------------------------------------------------------------------------------
H
S
T
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
53.73
37%
-99
- C1 -
3I7B
4
?
A:
[23-285]
---------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
53.26
35%
-95
- C1 -
3KN5
1
B:
[19-282]
--------------------------------------------------------------------------------------------------------------------------
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
S
K
R
M
E
A
-
N
T
------
Q
-------
K
-------
E
-----
I
T
A
L
K
L
C
E
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
-
F
E
R
I
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
-
V
G
V
V
H
R
D
L
K
P
E
N
L
L
------
F
T
D
------
L
E
I
K
I
I
D
F
G
F
A
R
L
K
P
P
-------------------------
N
G
----
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
QSHDRSL
T
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
S
G
L
R
Y
N
E
W
L
--------
Q
D
G
S
Q
L
--
S
S
---------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
52.56
37%
-95
- C1 -
3SXF
3
?
A:
[22-285]
--------------------------------------------------------------------------------------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
52.26
32%
-94
- C1 -
2OU7
1
PLK1_HUMAN
A:
[48-318]
-------------------------------------------------------------------------------------------------------------------------
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
-----
S
L
L
L
K
-
P
H
Q
-------
R
-------
E
K
M
S
M
E
I
S
I
H
R
S
L
A
-
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
-
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
----------
N
E
-
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
-
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
--
S
K
K
G
----
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
-------
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
----
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
-----
I
N
E
L
L
N
D
E
F
F
--------
T
-
S
G
Y
I
--
P
A
R
L
--
P
I
T
C
L
T
I
P
P
R
F
S
I
A
---------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.26
37%
-99
- C1 -
3T3U
5
?
A:
[22-285]
--------------------------------------------------------------------------------------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
51.89
32%
-92
- C1 -
3FC2
7
PLK1_HUMAN
A:
[48-319]
-------------------------------------------------------------------------------------------------------------------------
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
-----
S
L
L
L
K
-
P
H
Q
-------
R
-------
E
K
M
S
M
E
I
S
I
H
R
S
L
A
-
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
-
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
----------
N
E
-
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
-
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
--
S
K
K
G
----
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
-------
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
----
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
-----
I
N
E
L
L
N
D
E
F
F
--------
T
-
S
G
Y
I
--
P
A
R
L
--
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
--------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
51.29
37%
-99
- C1 -
3N51
3
?
A:
[22-285]
--------------------------------------------------------------------------------------------------------------
A
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
D
K
E
S
L
L
-------
R
-------
E
-----
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
S
K
D
------
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
--
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
-
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-------
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
---------------------------------------------------------------------------------------------------------------------------------------------------