@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK3_HUMAN: (2013-07-25 )
MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF
Atome Classification :
(77 SA)
.........10.--.......20.---------.......-------30........40........50.-.......60---..--.-..----..---.70..-......80........90........100....---...110-------.---......120--.......130.....-..-140.-......150....-..-.160......------.170.......180.......190.-----..-.--...200.......210......----.220---------.---.-.-..-..230---........240-----------------...-------.--....250.......260.......270......-.--280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEQPPAPKSKLK--KLSEDSLTKQ---------PEEVFDV-------LEKLGEGSYGSVFKAIHKESGQV-VAIKQVPVE---SD--L-QE----II---KEISI-MQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGS---VSDIIR-------L---RNKTLIEDE--IATILKSTLKGLEYL-HF-MRKI-HRDIKAGNILLNT-EG-HAKLADFGVA------GQLTDTMAKRNTVIGTPFWMAPEVI-----QE-I--GYNCVADIWSLGITSIEMAEGK----PPYA---------D---I-H-PM-RAIF----MIPTNPPPTF------------------RKP-------E--LWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI-K--NAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF
27
PsiBlast_CBE
78.18
44%
-100
- C4 -
4AOT
1
STK10_HUMAN
B:
[17-295]
---------------------------------
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
-
A
A
A
K
V
I
E
T
K
---
S
E
E
E
L
-
E
D
----
Y
I
---
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
---
V
D
A
I
M
L
-------
E
---
L
D
R
G
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
-
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
-
D
I
R
L
A
D
F
G
V
S
------
A
K
-----------
I
G
T
P
Y
W
M
A
P
E
V
V
M----------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
H
H
---------
E
---
L
-
N
-
P
M
-
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
------------------
L
T
P
-------
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
78.07
38%
-95
- C4 -
4FIE
1
PAK4_HUMAN
A:
[146-419]
---------------------
P
G
D
---------
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
KQ-
Q
R
--
R
-
E
L
----
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.03
54%
-91
- C4 -
3CKX
1
STK24_HUMAN
A:
[5-283]
---------------------------------
P
E
E
L
F
T
K
-------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
-
V
A
I
K
I
I
D
L
E
---
E
-----
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
E
P
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
-
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
---------
E
---
L
-
H
-
P
M
-
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
E
G
N
-----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
--
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.98
54%
-90
- C4 -
3A7I
1
STK24_HUMAN
A:
[15-298]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
-------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
-
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
E
P
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
-
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
---------
E
---
L
-
H
-
P
M
-
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
E
G
N
-----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
--
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.91
54%
-88
- C4 -
3A7H
1
STK24_HUMAN
A:
[15-298]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
-------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
-
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
E
P
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
-
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
---------
E
---
L
-
H
-
P
M
-
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
E
G
N
-----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
--
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.39
55%
-97
- C4 -
4FZD
1
MST4_HUMAN
B:
[6-282]
---------------------------------
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
-
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
R
A
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
-
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
---------
D
---
M
-
H
-
P
M
-
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
V
G
D
-----------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.34
54%
-91
- C4 -
3A7J
1
STK24_HUMAN
A:
[15-298]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
-------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
-
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
E
P
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
-
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
---------
E
---
L
-
H
-
P
M
-
K
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
E
G
N
-----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
--
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.95
44%
-103
- C4 -
4AOT
1
STK10_HUMAN
A:
[17-295]
---------------------------------
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
-
A
A
A
K
V
I
E
T
K
---
S
E
E
E
L
-
E
D
----
Y
I
---
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
---
V
D
A
I
M
L
-------
E
---
L
D
R
G
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
-
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
-
D
I
R
L
A
D
F
G
V
S
------
A
-------------
G
T
P
Y
W
M
A
P
E
V
V
M-----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
H
H
---------
E
---
L
-
N
-
P
M
-
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
------------------
L
T
P
-------
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
74.58
55%
-97
- C4 -
3GGF
1
MST4_HUMAN
B:
[21-298]
---------------------------------
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
-
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
R
A
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
-
D
V
K
L
A
D
F
G
V
A
----------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
---------
D
---
M
-
H
-
P
M
-
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
V
G
D
-----------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
74.49
43%
-96
- C4 -
3FXZ
1
?
A:
[7-293]
-----------
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
-------
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
-
V
A
I
R
Q
M
N
L
Q
QQ-
P
K
--
K
-
E
L
----
I
I
---
N
E
I
L
V
-
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
---
L
T
D
V
V
T
------------
E
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
-
H
S
-
N
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
Y
L
---------
N
---
E
-
N
-
P
L
-
R
A
L
Y
----
L
I
A
T
N
G
T
P
E
L
------------------
Q
N
P
-------
E
--
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
--
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.44
55%
-96
- C4 -
3GGF
1
MST4_HUMAN
A:
[21-300]
---------------------------------
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
-
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
R
A
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
-
D
V
K
L
A
D
F
G
V
A
---------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
---------
D
---
M
-
H
-
P
M
-
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
V
G
D
-----------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.33
55%
-86
- C4 -
4FZF
1
?
B:
[6-282]
---------------------------------
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
-
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
R
A
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
-
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
---------
D
---
M
-
H
-
P
M
-
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
V
G
D
-----------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.28
55%
-89
- C4 -
4FZA
3
MST4_HUMAN
B:
[6-282]
---------------------------------
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
-
D
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
R
A
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
-
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
-
S
--
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
---------
D
---
M
-
H
-
P
M
-
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
------------------
V
G
D
-----------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
--
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
73.72
41%
-94
- C4 -
3Q4Z
1
PAK1_HUMAN
A:
[7-299]
----------
L
E
--
K
L
R
I
I
V
S
V
G
D
---------
P
K
------------
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
-
V
A
I
R
Q
M
N
L
-----------
K
E
L
--
I
I
---
N
E
I
L
V
-
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
---
L
T
D
V
V
T
------------
E
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
-
H
S
-
N
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
-
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
Y
L
---------
N
---
E
-
N
-
P
L
-
R
A
L
Y
----
L
I
A
T
N
G
T
P
E
L
------------------
Q
N
P
-------
E
--
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
-
K
--
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.84
54%
-89
- C4 -
2XIK
2
STK25_HUMAN
A:
[17-285]
---------------------------------
P
E
E
L
F
T
K
-------
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
-
V
A
I
K
I
I
D
L
E
---
E
A
--
E
--
E
----
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
---------
L
---
K
P
G
P
L
E
E
T
Y
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
-
H
S
-
E
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
-
D
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
-
S
--
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
---------
D
---
L
-
H
-
P
M
-
R
V
L
F
----
L
I
P
K
N
S
P
P
T
L
------------------
E
G
Q
-------
H
----
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
--
Y
T
K
K
T
S
F
L
T
E
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.52
44%
-96
- C4 -
2J7T
1
STK10_HUMAN
A:
[17-295]
---------------------------------
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
-
A
A
A
K
V
I
E
-------EE
L
-
E
D
----
Y
I
---
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
---
V
D
A
I
M
L
-------
E
---
L
D
R
G
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
-
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
-
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
H
H
---------
E
---
L
-
N
-
P
M
-
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
------------------
L
T
P
-------
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.25
44%
-97
- C4 -
4BC6
2
STK10_HUMAN
A:
[9-287]
---------------------------------
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
-
A
A
A
K
V
I
E
T
K
---
S
E
E
E
L
-
E
D
----
Y
I
---
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
---
V
D
A
I
M
L
-------
E
---
L
D
R
G
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
-
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
-
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
H
H
---------
E
---
L
-
N
-
P
M
-
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
------------------
L
T
P
-------
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
71.97
35%
-107
- C4 -
4ARK
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
KELELMF-----------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
71.80
35%
-104
- C4 -
3EQH
2
MP2K1_HUMAN
A:
[35-331]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F
GC---------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
71.75
35%
-108
- C4 -
3EQG
2
MP2K1_HUMAN
A:
[35-331]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
I
K
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
FGC---------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.74
44%
-98
- C4 -
4EQU
2
STK10_HUMAN
A:
[17-295]
---------------------------------
P
N
E
V
W
E
I
-------
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
-
A
A
A
K
V
I
E
---------
L
-
E
D
----
Y
I
---
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
---
V
D
A
I
M
L
-------
E
---
L
D
R
G
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
-
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
-
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
H
H
---------
E
---
L
-
N
-
P
M
-
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
------------------
L
T
P
-------
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
71.71
35%
-109
- C4 -
2P55
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F----------
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
71.68
35%
-110
- C4 -
3ZLX
1
?
A:
[33-329]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
FGC---------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
71.54
35%
-115
- C4 -
3V04
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F----------
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.30
35%
-113
- C4 -
1S9J
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IKP
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F----------
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
71.17
44%
-98
- C4 -
4EQU
2
STK10_HUMAN
B:
[17-295]
---------------------------------
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
-
A
A
A
K
V
I
E
-------EE
L
-
E
D
----
Y
I
---
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
---
V
D
A
I
M
L
-------
E
---
L
D
R
G
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
-
H
S
-
K
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
-
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
H
H
---------
E
---
L
-
N
-
P
M
-
R
V
L
L
----
K
I
A
K
S
D
P
P
T
L
------------------
L
T
P
-------
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
--
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
70.97
35%
-111
- C4 -
3EQB
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F----------
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
70.86
35%
-107
- C4 -
3EQC
2
MP2K1_HUMAN
A:
[35-331]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
I
K
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F
GC---------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
70.75
35%
-114
- C4 -
3V01
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F----------
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
70.53
35%
-108
- C4 -
3ZLS
1
?
A:
[33-329]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
I
K
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
FGC---------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
70.50
35%
-107
- C4 -
3ZLY
1
?
A:
[33-329]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
I
K
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
FGC---------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
70.43
43%
-94
- C4 -
2UV2
6
SLK_HUMAN
A:
[35-312]
---------------------------------
P
E
D
F
W
E
I
-------
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
-
A
A
A
K
V
I
D
T
K
---
S
E
E
E
L
-
E
D
----
Y
M
---
V
E
I
D
I
-
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
---
V
D
A
V
M
L
-------
E
---
L
E
R
P
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
-
H
D
-
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
-
D
I
K
L
A
D
F
G
V
S
------
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
D
-
R
--
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
H
H
---------
E
---
L
-
N
-
P
M
-
R
V
L
L
----
K
I
A
K
S
E
P
P
T
L
------------------
A
Q
P
-------
S
--
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
VD
S
N
K
P
I
---
R
E
L
I
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
70.40
35%
-107
- C4 -
3DV3
3
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
---
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F-----------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
70.33
35%
-110
- C4 -
3E8N
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F----------
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
70.28
35%
-108
- C4 -
3EQF
1
MP2K1_HUMAN
A:
[35-331]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F
GC---------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.69
43%
-93
- C4 -
2J51
5
SLK_HUMAN
A:
[35-312]
---------------------------------
P
E
D
F
W
E
I
-------
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
-
A
A
A
K
V
I
D
T
K
---
S
E
EE
L
-
E
D
----
Y
M
---
V
E
I
D
I
-
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
---
V
D
A
V
M
L
-------
E
---
L
E
R
P
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
-
H
D
-
N
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
-
D
I
K
L
A
D
F
G
V
S
------
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
D
-
R
--
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
H
H
---------
E
---
L
-
N
-
P
M
-
R
V
L
L
----
K
I
A
K
S
E
P
P
T
L
------------------
A
Q
P
-------
S
--
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
VD
S
N
K
P
I
---
R
E
L
I
A
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
69.68
39%
-108
- C4 -
3SLS
2
MP2K1_HUMAN
A:
[27-285]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IKP
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
--------
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
I
G
---------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
69.48
35%
-110
- C4 -
3MBL
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
F-----------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
69.33
35%
-110
- C4 -
3DY7
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
---
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
--------------------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
69.05
39%
-105
- C4 -
4AN2
2
MP2K1_HUMAN
A:
[11-265]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
I
K
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
E
M
A
--
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
-----------------
R
-
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
A
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
68.94
35%
-101
- C4 -
3ZM4
1
?
A:
[33-329]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
I
K
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
------
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
D
A
K
E
L
E
L
M
FGC---------
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
68.43
39%
-104
- C4 -
4ANB
2
MP2K1_HUMAN
A:
[11-265]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
E
M
A
--
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
-----------------
R
-
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
A
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
67.99
40%
-107
- C4 -
3ORN
3
MP2K1_HUMAN
A:
[8-272]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
--------------------
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
S
--------
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
67.81
39%
-101
- C4 -
4AN9
2
MP2K1_HUMAN
A:
[11-265]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
I
K
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
E
M
A
--
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
-----------------
R
-
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
A
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
67.22
40%
-100
- C4 -
3DAK
1
OXSR1_HUMAN
A:
[12-290]
-------------------------------------
Y
E
L
-------
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
-
V
A
I
K
R
I
N
L
E
KCQ
T
S
--
M
-
D
E
----
L
L
---
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
---
V
L
D
I
I
K
H
I
V
A
K
GE
H
---
K
S
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
-
H
K
-
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
-
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
------------
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
Q
-
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
Y
H
---------
K
---
Y
-
P
-
P
M
-
K
V
L
M
----
L
T
L
Q
N
D
P
P
S
L
------------------
E
T
G
VQDKEML
K
--
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
--
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
67.07
40%
-114
- C4 -
3OS3
2
MP2K1_HUMAN
A:
[8-272]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
------------------
P
------------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
67.01
39%
-103
- C4 -
4AN3
2
MP2K1_HUMAN
A:
[11-265]
-------------------------------------
F
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
-
M
A
R
K
L
I
H
L
E
IK
P
A
I
--
R
-
N
Q
----
I
I
---
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
---
L
D
Q
V
L
K
-----------
K
A
G
R
I
P
E
Q
I
--
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
-
R
E
-
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
-
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
I
D
E
M
A
--
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
-
T
--
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
-----------------
R
-
P
P
-
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-------------------
P
S
-------
A
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
--
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
66.96
40%
-101
- C4 -
3DAK
1
OXSR1_HUMAN
D:
[12-290]
-------------------------------------
Y
E
L
-------
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
-
V
A
I
K
R
I
N
L
E
KCQ
T
S
--
M
-
D
E
----
L
L
---
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
---
V
L
D
I
I
K
H
I
V
A
K
GE
H
---
K
S
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
-
H
K
-
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
-
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
------
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
Q
-
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
Y
H
---------
K
---
Y
-
P
-
P
M
-
K
V
L
M
----
L
T
L
Q
N
D
P
P
S
L
------------------
E
T
G
VQDKEML
K
--
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
--
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
66.52
40%
-100
- C4 -
3DAK
1
OXSR1_HUMAN
B:
[12-290]
-------------------------------------
Y
E
L
-------
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
-
V
A
I
K
R
I
N
L
E
KCQ
T
S
--
M
-
D
E
----
L
L
---
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
---
V
L
D
I
I
K
H
I
V
A
K
GE
H
---
K
S
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
-
H
K
-
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
-
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
-------------
T
P
C
W
M
A
P
E
V
M
-----
E
Q
-
V
R
-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
Y
H
---------
K
---
Y
-
P
-
P
M
-
K
V
L
M
----
L
T
L
Q
N
D
P
P
S
L
------------------
E
T
G
VQDKEML
K
--
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
--
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
65.38
39%
-103
- C4 -
2VWI
1
OXSR1_HUMAN
D:
[17-298]
-------------------------------------
Y
E
L
-------
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
-
V
A
I
K
R
I
N
L
E
KCQ
T
S
--
M
-
D
E
----
L
L
---
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
---
V
L
D
I
I
K
H
I
V
A
K
GE
H
---
K
S
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
-
H
K
-
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
-
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
----------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
Q
-
V
R-
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
Y
H
---------
K
---
Y
-
P
-
P
M
-
K
V
L
M
----
L
T
L
Q
N
D
P
P
S
L
------------------
E
T
G
VQDKEML
K
--
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
--
K
A
K
N
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
63.72
37%
-116
- C4 -
3FME
1
MP2K6_HUMAN
A:
[15-270]
--------------------------------------------------
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
-
M
A
V
K
R
I
R
------
N
--
S
-
Q
E
Q
K
R
-
L
L
---
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
---
L
D
K
F
Y
K
-------
Q
V
I
D
K
G
Q
T
I
P
E
D
I
--
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
-
H
S
K
L
S
V
I
-
H
R
D
V
K
P
S
N
V
L
I
N
A
-
L
G
-
Q
V
K
M
C
D
F
----------------------
A
G
C
K
P
Y
M
A
P
E
R
I
N
PEL-
N
Q
-----
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
----
F
P
Y
D
---------
S
---
W
-
G
T
P
F
-
Q
Q
L
K
----
Q
V
V
E
E
P
S
P
Q
L
-------------------
P
A
-------
D
--
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
63.34
38%
-83
- C4 -
4BIB
1
?
B:
[27-280]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---
R
----S
Q
P
----
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
62.51
38%
-83
- C4 -
4BIC
2
?
B:
[27-280]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---
R
----S
Q
P
----
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
62.30
38%
-82
- C4 -
4BID
1
?
B:
[27-280]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---
R
----S
Q
P
----
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
62.25
38%
-85
- C4 -
4BIC
2
?
A:
[27-280]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
--------S
Q
P
----
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
62.23
38%
-82
- C4 -
4BHN
2
?
B:
[43-295]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---
R
----S
Q
P
----
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
61.71
38%
-84
- C4 -
2CLQ
1
B:
[30-283]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---
R
----S
Q
P
----
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
61.39
38%
-84
- C4 -
2CLQ
1
M3K5_HUMAN
A:
[30-283]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---
R
D
--
S
-
Q
P
----
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
61.29
38%
-84
- C4 -
4BIE
2
?
A:
[27-280]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---------------
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
60.30
38%
-81
- C4 -
4BF2
1
?
B:
[43-296]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---
R
----------------
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
---------
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
60.10
38%
-82
- C4 -
4BIE
2
?
B:
[27-280]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---
R
-----------
L
H
---
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
--------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
59.85
38%
-86
- C4 -
4BF2
2
?
A:
[43-296]
--------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
-
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
--------------------
E
E
I
A
L
-
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
---
L
S
A
L
L
R
-------
S
---
K
W
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
-
H
D
-
N
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
-
V
L
K
I
S
D
F
G
T
S
------
K
R
L
A
------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
-
G
PR
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
----
P
P
F
Y
---------
E
---
L
G
E
-
P
Q
-
A
A
M
F
K
V
G
-
M
F
K
V
H
P
----------------------
E
I
P
-------
E
--
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
58.45
34%
-93
- C4 -
3ALN
1
MP2K4_HUMAN
B:
[6-289]
-----------------
S
G
K
L
K
I
S
---------
P
E
Q
H
W
D
F
T
AEDLKD
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
-
M
A
V
K
R
I
R
S
T
---
V
D
--
E
-
K
E
Q
K
Q
L
L
M
---
D
L
D
V
V
-
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
Y
V
Y
S
-------
V
---
L
D
D
V
I
P
E
E
I
--
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
-
L
K
I
I
-
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
-
N
I
K
L
C
D
F
G
I
S
------
G
Q
L
----------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
----
F
P
Y
P
---------------------------------
D
P
P
Q
L
------------------
S
N
S
-------
E
ER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
57.93
31%
-82
- C4 -
4G3F
1
A:
[58-310]
-----------------------------------
H
W
M
T
H
-------
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
-
C
A
V
K
K
V
R
L
E
---
V
F
--
R
--------
V
---
E
E
L
V
A
-
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
---
L
G
Q
L
I
K
-----------
Q
M
G
C
L
P
E
D
R
--
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
-
H
T
-
R
R
I
L
-
H
G
D
V
K
A
D
N
V
L
L
S
S
-
D
G
S
R
A
A
L
C
D
F
G
H
A
------
L
C
L
-------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
-----
M
G
-
K
--
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
----
H
P
W
T
---------
Q
---
Y
-
F
-
R
G
-
P
L
C
L
----
K
I
A
S
E
P
P
P
I
R
------------------
E
I
P
-------
P
--
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
57.03
31%
-77
- C4 -
3ZDU
3
CDKL3_HUMAN
A:
[4-294]
------------------------------------
M
Y
E
T
-------
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
-
V
A
I
K
I
F
Y
---------
N
-
K
I
----
A
M
---
R
E
I
K
F
-
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
K
K
I
H
L
V
F
E
F
I
D
H
T
V
---
L
D
E
L
Q
H
-----------
Y
C
H
G
L
E
S
K
R
--
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
-
H
S
-
N
N
I
I
-
H
R
D
I
K
P
E
N
I
L
V
S
Q
-
S
G
-
I
T
K
L
C
D
F
G
F
A
------
R
T
-----
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
-----
L
K
D
T
--
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
----
P
Y
L
P
---------
S
SS
D
L
-
D
-
L
L
-
H
K
I
V
----
L
K
V
G
N
L
S
P
H
L
Q
N
I
F
S
K
SPIFAGVV
L
P
Q
V
Q
H
P
KN
A
R
K
K
Y
P
--
K
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
-
T
--
R
D
G
F
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.00
34%
-89
- C4 -
3ALO
1
MP2K4_HUMAN
A:
[17-289]
-------------------------------------
W
D
F
TAEDLKD
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
-
M
A
V
K
R
I
R
S
T
---
V
D
--
E
-
K
E
Q
K
Q
L
L
M
---
D
L
D
V
V
-
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
Y
V
Y
S
-------
V
---
L
D
D
V
I
P
E
E
I
--
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
-
L
K
I
I
-
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
-
N
I
K
L
C
D
F
G
I
S
------
G
Q
L
V
D
S
I
A
K
T
R
D
A
G
C
R
P
Y
-
M
A
P
E
R
I
DP----------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
----
F
P
Y
P
---------
K
---
W
-
N
-
S
V
F
D
Q
L
T
----
Q
V
V
K
G
D
P
P
Q
L
------------------
S
N
S
-------
E
E
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
53.70
39%
-58
- C4 -
2F57
1
B:
[43-313]
---------------------------------
P
R
E
Y
L
A
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
E
L
--
L
F
---
N
E
V
V
I
-
M
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
-
H
N
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
S
-
D
G
-
R
I
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
R
-
L
--
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
Q
A
M
R
----
R
I
R
D
S
L
P
P
R
V
------------------
K
D
L
-------
H
--
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
-
K
--
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
53.16
39%
-61
- C4 -
2F57
1
PAK7_HUMAN
A:
[43-313]
---------------------------------
P
R
E
Y
L
A
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
E
L
--
L
F
---
N
E
V
V
I
-
M
R
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
-
H
N
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
S
-
D
G
-
R
I
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
R
-
L
--
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
Q
A
M
R
----
R
I
R
D
S
L
P
P
R
V
------------------
K
D
L
-------
H
--
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
-
K
--
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
53.16
36%
-59
- C4 -
4FIF
1
PAK4_HUMAN
A:
[51-332]
------------P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
DPGD
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
EL--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
53.09
39%
-63
- C4 -
2X4Z
3
A:
[22-282]
---------------------------------
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
E
L
--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
53.04
36%
-61
- C4 -
4FIF
1
PAK4_HUMAN
B:
[52-332]
------------Q-
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
DPGD
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
EL--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
51.73
39%
-59
- C4 -
4APP
2
A:
[22-282]
---------------------------------
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
E
L
--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
51.34
39%
-59
- C4 -
2J0I
4
A:
[29-289]
---------------------------------
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
EL--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
51.26
36%
-63
- C4 -
4FIG
1
?
A:
[53-332]
--------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
DPGD
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
EL--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
51.11
36%
-59
- C4 -
4FIG
1
?
B:
[53-332]
--------------
R
V
S
H
E
Q
F
R
A
A
LQLVVDPGD
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
EL--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
50.72
39%
-60
- C4 -
2CDZ
1
A:
[29-289]
---------------------------------
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
E
L
--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
49.57
39%
-55
- C4 -
2Q0N
7
A:
[27-287]
---------------------------------
P
R
S
Y
L
D
N
-------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
-
V
A
V
K
K
M
D
L
R
---
K
Q
--
Q
-
R
R
E
L
--
L
F
---
N
E
V
V
I
-
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
---
L
T
D
I
V
T
------------
H
T
R
M
N
E
E
Q
--
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
-
H
A
-
Q
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
G
-
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
R
-
L
--
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
Y
F
---------
N
---
E
-
P
-
P
L
-
K
A
M
K
----
M
I
R
D
N
L
P
P
R
L
------------------
K
N
L
-------
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
--
K
A
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------