@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TOPK_HUMAN: (2015-06-18 )
MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV
Atome Classification :
(20 SA)
----------------------------.........10........20.......------.30.....---...40..----......50...--.....60........70........80........90--........-100-...---.--...110.......120.......130-.------......---140.......150......--.-------160.......170.......180.......190.......-200.......210.......--220-----.......230.......240-.----------......250.......260.......270...--....280-...--.-..-...290...-....300.......310.......320--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------MEGISNFK
T
P
S
K
L
S
E
K
K
K
S
VLCSTPTIN------IP
A
S
P
F
M
Q
---
K
LGFGTG----
V
N
V
Y
L
M
KRSPR--GLSHSPWA
V
K
KI
N
P
I
C
N
D
H
Y
R
S
V
Y
Q
K
R
L
M
D
E
A
K
I
L
K
S
--LHHPNI
V
G
-
Y
R
A
-
F
TE---A--NDG
S
L
C
L
A
M
EYGGE
K
S
L
N
D
L
I
E
E
R
Y
K-A------SQDPF
P
---
A
A
I
I
L
K
V
A
L
N
M
A
R
G
L
K
Y
L
H
--
Q
-------
E
K
K
L
L
HGDIKSS
N
V
V
I
K
GD
F
E
T
I
K
I
C
DVGVSLPLDENMTV-TDPE
A
C
Y
IGTEPWK
P
K
E
A
V
E--ENG-----VITDK
A
D
I
F
A
F
G
L
T
L
W
E
M
M
T-L----------SIPHINLSNDDDDEDKTFDESDFDD
E
A
Y
Y
A
AL--GTRPP---I
N
M
--
E
-
E
L
-
D
E
S
Y
Q
K
V
I
E
-
L
F
S
V
CTNEDPKDRP
S
A
A
H
I
V
E
A
L
ETDV--------------------
41
HHSearch
75.73
23%
-84
- C1 -
4G3F
1
A:
[62-313]
-------------------------------------------------------------------
H
Q
P
---
R
V
G
R
G
S
F
----
G
E
V
H
R
M
K
D
K
Q
T
--
G
---
F
Q
C
A
V
K
K
V
R
L
E
V
F
----------
R
V
E
E
L
V
A
C
A
G
--
L
S
S
P
R
I
V
P
-
L
Y
G
-
A
V
R
------
E
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
------------
G
C
L
P
---
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
--
T
--------
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
-----------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
--
G
-
K
-----
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
----------
C
H
P
W
T
Q
Y
F
R
G
P
-----------
L
----
C
L
K
I
A
--
S
E
P
P
P
IRE
I
P
---
P
-
S
C
-
A
P
L
T
A
Q
----
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
--------------------
50
HHSearch
75.11
25%
-59
- C1 -
3Q4U
7
ACVR1_HUMAN
A:
[12-300]
-------------------------------------------------------------------
L
L
E
---
C
V
G
K
G
R
Y
----
G
E
V
W
R
G
S
W
Q
G
-------
E
N
V
A
V
K
I
F
S
S
R
--------
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
VM
L
R
H
E
N
I
L
G
-
F
I
A
-
S
D
M
T
S
R
H
--
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
-------------
T
T
L
D
---
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
--
I
E
I
F
G
TQ
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
-
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
--
E
T
I
QVDC
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
-
R
MVSNG
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
--------
P
S
F
E
D
M
R
K
V
V
C
V
D
--
Q
Q
R
P
N
---
I
P
N
--
R
-
W
F
S
D
P
T
L
T
S
L
A
K
-
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
--------------------
31
HHSearch
75.06
22%
-73
- C1 -
4GT4
-
ROR2_HUMAN
A:
[22-304]
-----------------------------------------------------
E
I
S
------
L
S
A
V
R
F
M
E
---
E
L
G
E
D
R
F
----
G
K
V
Y
K
G
H
L
F
-------
T
Q
A
V
A
I
K
T
L
K
D
-
A
E
----
G
-
L
R
E
E
F
R
H
E
A
M
L
R
A
R
--
L
Q
H
P
N
V
V
C
-
L
L
G
-
V
V
----
T
--
K
D
Q
P
L
S
M
I
F
S
Y
C
S
H
G
D
L
H
E
F
L
V
M
R
S
P
-
H
SDVGR
T
V
K
S
A
L
E
---
P
P
D
F
V
H
L
V
A
Q
I
A
A
G
M
E
Y
L
S
--
S
--------
H
H
V
V
H
K
D
L
A
T
R
N
V
L
V
Y
D
K
-
L
N
V
K
I
S
D
L
G
L
F
R
E
V
Y
A
A
D
Y
Y
-
K
-
L
L
G
N
S
L
L
P
I
R
W
M
A
P
E
A
I
M
--
Y
-
G
-----
K
F
S
I
D
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
Y
G
----------
L
Q
P
Y
C
G
Y
S
N
--------------
Q
D
V
V
E
M
I
R
N
--
R
Q
V
L
P
---
C
P
---
D
-
D
C
-
P
A
W
V
Y
---
A
-
L
M
I
E
C
W
N
E
F
P
S
R
R
P
R
F
K
D
I
H
S
R
L
R
A
W
G
--------------------
46
HHSearch
74.76
22%
-71
- C1 -
4FIE
1
PAK4_HUMAN
A:
[155-400]
-------------------------------------------------------------------
N
F
I
---
K
I
G
E
G
S
T
----
G
I
V
C
I
A
T
V
R
S
S
--
G
---
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
-----
R
R
E
L
L
F
N
E
V
V
I
M
R
D
--
Y
Q
H
E
N
V
V
E
-
M
Y
N
-
S
Y
L
---
V
---
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-------------
T
R
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
--
A
--------
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
-
R
---
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
----------
E
P
P
Y
F
N
E
P
P
--------------
L
K
A
M
K
M
I
R
D
--
N
L
P
P
R
---
L
K
N
--
L
H
K
V
-
S
P
S
L
K
---
G
-
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
--------------------
33
HHSearch
73.65
22%
-77
* C1 *
4AOJ
1
NTRK1_HUMAN
A:
[45-317]
-------------------------------------------------------------------
L
K
W
---
E
L
G
E
G
A
F
----
G
K
V
F
L
A
E
C
H
N
L
LP---
K
M
L
V
A
V
K
A
L
K
E
A
-----
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
--
L
Q
H
Q
H
I
V
R
-
F
F
G
-
V
C
T
------
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D--------
P
G
P
L
G
---
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
--
G
--------
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
-
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
--
Y
-
R
-----
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
----------
K
Q
P
W
Y
Q
L
S
N
--------------
T
E
A
I
D
C
I
T
Q
--
G
R
E
L
E
---
R
P
---
R
-
A
C
-
P
P
E
V
Y
A
I
M
----
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
--------------------
22
Fugue
72.73
24%
-86
- C1 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------
G
W
A
------
L
N
M
K
E
L
K
L
---
L
Q
T
I
G
K
G
EF
G
D
V
M
L
G
D
Y
R
G
---------
N
K
V
A
V
K
C
I
K
---------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
--
L
R
H
S
N
L
V
Q
-
L
L
G
-
V
I
V
-------
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
----------
R
S
V
L
G
---
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
--
G
--------
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
-
N
V
A
K
V
S
D
F
G
-------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
--
E
-
K
-----
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
-
F
G---------
R
V
P
Y
P
R
I
P
L
-
K
D
V
V
P
R
V
E
K
G
Y
----------------------
K
M
--
D
-
A
P
-
D
G
C
P
P
A
V
Y
E
-
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
EL----------------
35
HHSearch
72.45
23%
-75
- C1 -
4HZS
-
ACK1_HUMAN
A:
[127-387]
------------------------------------------------------------------
R
L
L
E
---
K
L
G
D
G
S
F
----
G
V
V
R
R
G
E
W
D
A
P
--
S
G
K
T
V
S
V
A
V
K
C
L
K
P
D
V
L
S
Q
--
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
--
L
D
H
R
N
L
I
R
-
L
Y
G
-
V
V
L
---
T
----
P
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
-----------
Q
G
H
F
L
---
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
--
S
--------
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
-
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
--------------
V
P
F
A
W
C
A
P
E
S
L
K
--
T
-
R
-----
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
----------
Q
E
P
W
I
G
L
N
G
-------------
S
Q
I
L
H
K
I
D
K
E
--
G
E
R
L
P
---
R
P
---
E
-
D
C
-
P
Q
D
---
I
Y
N
-
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
--------------------
34
HHSearch
72.43
23%
-79
- C1 -
4HZR
1
ACK1_HUMAN
A:
[15-275]
------------------------------------------------------------------
R
L
L
E
---
K
L
G
D
G
-------
V
V
R
R
G
E
W
D
A
P
S-
G
K
T
-
V
S
V
A
V
K
C
L
-----------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
--
L
D
H
R
N
L
I
R
-
L
Y
G
-
V
V
L
---
T
----
P
P
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
H
Q
-----------
G
H
F
L
---
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
--
S
--------
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
-
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
N
D
D
H
-
Y
V
M
Q
E
H
R
K
V
P
F
A
W
C
A
P
E
S
L
K
--
T
-
R
-----
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
----------
Q
E
P
W
I
G
L
N
G
-------------
S
Q
I
L
H
K
I
D
K
E
--
G
E
R
L
P
---
R
P
---
E
-
D
C
-
P
Q
D
---
I
Y
N
-
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
--------------------
12
PsiBlast_PDB
72.22
24%
-78
- C1 -
2WQM
-
NEK7_HUMAN
A:
[38-291]
---------------------------------------------------------------------
K
---
K
I
G
R
G
------
S
E
V
Y
---
R
A
A
C
--
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
--
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
--
L
N
H
P
N
V
I
K
-
Y
Y
A
S
F
I
E
---
D
--
N
E
L
N
I
V
L
E
L
A
D
A
G
D
--
L
S
R
M
I
K
H
-
F
K
-
K
------
Q
K
R
L
I
P
---
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
----------
S
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
T
-
G
V
V
K
L
G
D
L
----------------------
T
P
Y
Y
M
S
P
E
R
I
H
--
E
N
G
-----
Y
-
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
-
L
----------
Q
S
P
F
Y
---
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
Y
--------------
P
P
---
L
P
S
--
D
-
H
Y
-
S
E
E
L
R
Q
L
V
N
-
M
---
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
--------------------
25
Fugue
72.05
21%
-69
- C1 -
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
P
V
DY
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
----
G
E
V
H
R
M
E
D
K
Q
T
--
G
---
F
Q
C
A
V
K
K
V
R
L
----------
E
V
F
R
A
E
E
L
M
A
C
A
G
--
L
T
S
P
R
I
V
P
-
L
Y
G
-
A
V
R
---
E
--
G
P
-
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
------------
G
C
L
P
---
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
--
S
-------
R
R
I
L
-
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
------------
I
P
G
T
E
T
H
M
A
P
E
V
V
L
--
G
R
S
-----
C
-
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
-
G
----------
C
H
P
W
----------------
T
Q
F
F
R
G
P
L
C
L
K
I
--
A
S
E
P
P
---
P
V
R
--
E
-
I
P
-
P
S
C
A
P
L
T
A
Q
-
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
GGLKSPWR
G
E
Y
K
E
P
RHP
32
HHSearch
71.51
22%
-77
- C1 -
3OMV
1
RAF1_HUMAN
A:
[29-297]
--------------------------------------------------
Y
Y
W
E
I
E
------
A
S
E
V
M
L
S
T
---
R
I
G
S
G
S
F
----
G
T
V
Y
K
G
K
W
--------
H
G
D
V
A
V
K
I
L
K
V
V
---
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
--
T
R
H
V
N
I
L
L
-
F
M
G
-
Y
M
T
-------
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
Q
-----------
E
T
K
F
Q
---
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
--------
K
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
-
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
MQ
D
N
N
-----
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
----------
E
L
P
Y
S
H
I
N
N
-------------
R
D
Q
I
I
F
M
V
G
R
--
G
Y
A
S
P
D--
L
S
K
LY
K
-
N
C
-
P
K
A
M
K
---
R
-
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
--------------------
42
HHSearch
71.41
25%
-88
- C1 -
4G31
2
A:
[10-279]
--------------------------------------------------------------------
I
Q
---
C
L
G
R
G
------
G
V
V
F
E
A
K
N
K
V
D
--
D
---
C
N
Y
A
I
K
R
I
R
L
P
----
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
--
L
E
H
P
G
I
V
R
-
Y
F
N
-
A
W
L
---
E
K
N-
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
T
---------
I
E
E
R
E
---
R
S
V
C
L
H
I
F
L
Q
I
A
E
A
V
E
F
L
H
--
S
--------
K
G
L
M
H
R
D
L
K
P
S
N
I
F
F
T
M
D
-
D
V
V
K
V
G
D
F
G
L
V
------------------
G
T
K
L
Y
M
S
P
E
Q
I
H
--
G
-
N
-----
S
Y
S
H
K
V
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
--------------
P
F
S
T
-------------
Q
M
E
R
V
R
T
L
T
D
V
R
N
--
L
K
F
P
P
---
L
F
--------
T
Q
K
Y
P
C
E
Y
V
-
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
E
A
I
N
I
I
E
N
A
V
F
E
D
--------------------
13
PsiBlast_PDB
71.37
24%
-74
- C1 -
2WQN
1
NEK7_HUMAN
A:
[38-291]
---------------------------------------------------------------------
K
---
K
I
G
R
G
Q
F
----
S
E
V
Y
---
R
A
A
C
--
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
--
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
--
L
N
H
P
N
V
I
K
-
Y
Y
A
S
F
I
E
---
D
--
N
E
L
N
I
V
L
E
L
A
D
A
G
D
--
L
S
R
M
I
K
H
-
F
K
-
K
------
Q
K
R
L
I
P
---
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
----------
S
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
T
-
G
V
V
K
L
G
D
L
----------------------
T
P
Y
Y
M
S
P
E
R
I
H
--
E
N
G
-----
Y
-
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
-
L
----------
Q
S
P
F
Y
---
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
Y
--------------
P
P
---
L
P
S
--
D
-
H
Y
-
S
E
E
L
R
Q
L
V
N
-
M
---
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
--------------------
36
HHSearch
70.02
22%
-69
- C1 -
4FYO
1
A:
[23-277]
---------------------------------------------------------------------
K
---
E
L
G
S
G
N
F
----
G
T
V
K
K
G
Y
Y
Q
M
K
--
K
V
-
V
K
T
V
A
V
K
I
L
---------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
--
L
D
N
P
Y
I
V
R
-
M
I
G
-
I
C
E
---
A
----
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
------------
R
H
V
K
---
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
--
E
--------
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
-
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
-
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
--
Y
-
Y
-----
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
----------
Q
K
P
Y
R
G
M
K
G
--------------
S
E
V
T
A
M
L
E
K
--
G
E
R
M
G
---
C
P
A
----
G
C
-
P
R
E
M
Y
---
D
-
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
--------------------
6
PsiBlast_PDB
69.14
29%
-92
- C1 -
2EVA
1
M3K7_HUMAN
A:
[45-258]
-------------------------------------------------------------------------------------------------------------------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
--
V
N
H
P
N
I
V
----
K
-
L
Y
G
---
A
--
C
L
N
P
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
------------
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
-------
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
T
-------------
G
S
A
A
W
M
A
P
E
-------
V
F
--
E
G
S
-----
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-------------------------
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
P
-----------
L
-
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
--------------------
9
PsiBlast_PDB
68.72
26%
-92
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[11-241]
--------------------------------------------------------------------
I
S
---
E
L
G
A
G
N
G
----
G
V
V
F
---------
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
--
C
N
S
P
Y
I
V
G
F
Y
G
A
-
F
Y
-------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
---
K
-
A
------
G
R
--
I
P
---
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
--
E
-------
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
-
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-----
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
--
G
T
H
-----
Y
-
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
-
G
----------
R
Y
P
---
I
P
----------------------------------
M
--------------
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
V
F
S
L
E
F
Q
D
F
V
N
--------------------
43
HHSearch
68.32
21%
-84
- C1 -
3HYH
-
SNF1_YEAST
A:
[57-302]
-------------------------------------------------------------------
I
V
K
---
T
L
G
E
G
-------
K
V
K
L
A
Y
H
T
T
T
--
G
---
Q
K
V
A
L
K
I
I
N
K
K
--------
M
Q
G
R
I
E
R
E
I
S
Y
L
R
L
--
L
R
H
P
H
I
I
K
-
L
Y
D
-
V
I
K
---
S
---
K
D
E
I
I
M
V
I
E
Y
A
-
G
N
E
L
F
D
Y
I
V
Q
R
------------
D
K
M
S
---
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
--
R
--------
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
E
H
-
L
N
V
K
I
A
D
F
G
L
S
--------------------
P
N
Y
A
A
P
E
V
I
S
--
G
K
L
-----
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
-
R
----------
R
L
P
F
D
D
E
S
---------------
I
P
V
L
F
K
N
I
S
--
N
G
V
Y
T
---
L
P
---
K
-
F
L
-
S
P
G
A
A
---
G
-
L
I
K
R
M
L
I
V
N
P
L
N
R
I
S
I
H
E
I
M
Q
D
D
W
F
K
V
--------------------
3
PsiBlast_PDB
67.43
29%
-99
- C1 -
4L3P
1
M3K7_HUMAN
A:
[46-259]
-------------------------------------------------------------------------------------------------------------------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
--
V
N
H
P
N
I
V
----
K
-
L
Y
G
---
A
--
C
L
N
P
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
------------
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
-------
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
--------------
G
S
A
A
W
M
A
P
E
-------
V
F
--
E
G
S
-----
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-------------------------
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
P
-----------
L
-
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
--------------------
8
PsiBlast_PDB
65.47
26%
-83
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[11-241]
--------------------------------------------------------------------
I
S
---
E
L
G
A
G
N
G
----
G
V
V
F
---------
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
--
C
N
S
P
Y
I
V
G
F
Y
G
A
-
F
Y
-------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
---
K
-
A
------
G
R
--
I
P
---
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
--
E
-------
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
-
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-----
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
--
G
T
H
-----
Y
-
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
-
G
----------
R
Y
P
---
I
P
P
P
----------------------------
P
---
M
--------------
A
I
F
E
-
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
--------------------
4
PsiBlast_PDB
64.85
29%
-98
- C1 -
4L52
1
M3K7_HUMAN
A:
[46-259]
-------------------------------------------------------------------------------------------------------------------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
--
V
N
H
P
N
I
V
----
K
-
L
Y
G
---
A
--
C
L
N
P
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
------------
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
-------
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
T
-------------
G
S
A
A
W
M
A
P
E
-------
V
F
--
E
G
S
-----
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-------------------------
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
P
-----------
L
-
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
--------------------