@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TSSK1_HUMAN: (2013-07-25 )
MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ
Atome Classification :
(39 SA)
.........10........20........30........40........50........-----.---60........70........80.-.....-...90........100.......110.......120......-.130.......140.---.---.....150.......160.......170.......180.....--..190-........200.......210......-.220..-.-.--..-.-230...--...-.240.........250.......260.......270-...-....--280.......290.......300.......310.......320.......330.......340.......350.......360.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPA-DFLEKFLP-----R---EIEILAMLNHCSIIKTYEIFE-T-SHGKV-YIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCH-DLDVVHRDLKCDNLL---L---DKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVL--QGIP--YQPKVYDIWSLGVILYIMVCGSMPYDD-SNIKKM-L-R--IQ-K-EHRVNF--PRS-KH--LTGECKDLIYHMLQPDVNRRLHIDEILSHCWM-QPK-ARGS--PSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ
135
HHSearch
77.58
39%
-115
- C1 -
2Y94
1
AAPK1_RAT
A:
[13-273]
------
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
V
V
G
K
I
R
------
R
---
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
-
T
-
P
-
S
D
I
-
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
-----
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
L
--
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
-
D
H
V
P
T
L
-
F
-
K
--
K
I
-
C
-
D
G
I
F
Y
T
--
P
Q
---
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-
K
Q
D
-----------------------------------------------------------------------------------------------
81
PsiBlast_CBE
75.14
31%
-117
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[15-296]
-----------
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
--------
E
Q
V
Y
------
Q
---
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
-
D
P
N
E
D
H
L
-
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
-
V
P
T
L
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
-
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
---
V
---
G
E
D
G
H
I
K
I
A
D
F
G
V
S
N
E
F
----
K
G
S
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
--
S
E
T
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
-
E
R
I
M
C
L
-
H
-
S
--
K
I
-
K
-
S
Q
A
L
E
F
--
P
D
Q
-
P
D
--
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
K
L
H
P
W
V
---------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
73.33
32%
-111
- C1 -
4BDI
6
?
A:
[15-313]
--------
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
A
Q
P
-----------------------------------------------------------------
31
PsiBlast_CBE
72.05
32%
-105
- C1 -
2YCR
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
K
P
Q
----------------------------------------------------------------------
62
PsiBlast_CBE
70.09
32%
-109
- C1 -
2W0J
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
-
T
--
A
L
P
Q
----------------------------------------------------------------------
99
PsiBlast_CBE
70.02
33%
-120
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[6-264]
-----------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
-
R
D
H
Q
K
-
L
E
-----
R
---
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
--
S
-
E
E
G
F
H
-
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
ASK
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
----
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
P
--
Y
G
K
P
V
-
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
H
R
L
-
Y
-
Q
--
Q
I
-
K
-
A
G
A
Y
D
F
--
P
S
P
-
E
W
DT
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
---------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
69.90
32%
-107
- C1 -
4BDK
4
?
A:
[15-311]
--------
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
A
-------------------------------------------------------------------
78
PsiBlast_CBE
69.21
33%
-127
- C1 -
3IGO
8
?
A:
[30-291]
-----------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
-
K
-
T
S
T
I
L
------
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
-
S
-
S
S
F
-
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
ESK
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
Q
N
T
-----------
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
--
Y
D
E
K
C
-
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
Y
D
I
-
L
K
R
--
V
E
-
T
G
K
Y
A
F
D
L
--
P
Q
W
-
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-
Q
K
Y
-
S
S
E
T
--
P
T
I
S
------------------------------------------------------------------------------------
36
PsiBlast_CBE
69.21
32%
-115
- C1 -
4BDJ
1
?
A:
[15-311]
--------
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
A
-------------------------------------------------------------------
76
PsiBlast_CBE
68.55
33%
-127
- C1 -
3NCG
1
?
A:
[30-291]
-----------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
-
K
D
T
S
T
I
L
------
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
-
S
-
S
S
F
-
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
ESK
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
Q
N
T
---------
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
-
T
--
Y
D
E
K
C
-
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
Y
D
I
-
L
K
R
--
V
E
-
T
G
K
Y
A
F
D
L
--
P
Q
W
-
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-
Q
K
Y
-
S
S
E
T
--
P
T
I
S
------------------------------------------------------------------------------------
40
PsiBlast_CBE
68.12
32%
-109
- C1 -
4BDF
3
?
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
60
PsiBlast_CBE
67.88
32%
-109
- C1 -
2YCS
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------NV
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
18
PsiBlast_PDB
67.37
36%
-125
- C1 -
4BL1
1
MELK_HUMAN
A:
[12-264]
-----------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
---------
L
P
-----
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
-
T
-
A
N
-
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
-
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
Y
H
K
L
K
L
I
D
F
G
L
---
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
-
D
N
V
--
M
-
A
-
L
--
Y
K
-
K
-
I
M
R
G
K
Y
--
D
V
P
-
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
---------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
67.36
32%
-105
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------V
E
---
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
52
PsiBlast_CBE
67.17
32%
-110
- C1 -
2WTI
3
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
101
PsiBlast_CBE
67.13
33%
-117
- C1 -
4EJN
3
AKT1_HUMAN
A:
[156-392]
-----------------
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
----------------------
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
-
T
--
H
D
R
L
-
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
---
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
---------
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
D
--
Y
G
R
A
V
-
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
-
Q
D
H
E
K
L
-
F
-
E
--
L
I
-
L
-
M
E
E
I
R
F
--
P
R
T
-----
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
--------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
67.09
32%
-112
- C1 -
4BDC
2
?
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
27
PsiBlast_CBE
67.06
36%
-142
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
------------------
N
---
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
---
S
G
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
S
K
I
M
I
S
D
F
----------------------
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
--
Y
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
A
K
L
-
F
-
E
Q
I
L
K
-
A
-
E
Y
E
F
D
S
--
P
Y
W
-
D
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
66.79
32%
-111
- C1 -
2YIR
1
CHK2_HUMAN
A:
[9-301]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------LN
V
E
-
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
-----------------------------------------------------------------------
63
PsiBlast_CBE
66.63
32%
-102
- C1 -
2YCF
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
53
PsiBlast_CBE
66.51
32%
-112
- C1 -
2WTD
4
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
42
PsiBlast_CBE
66.49
32%
-113
- C1 -
4BDD
3
?
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
56
PsiBlast_CBE
66.13
32%
-109
- C1 -
2CN5
1
CHK2_HUMAN
A:
[15-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
-------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
------------------------------------------------------------------------------
50
PsiBlast_CBE
66.01
32%
-106
- C1 -
2XM9
1
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
61
PsiBlast_CBE
65.67
32%
-107
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
51
PsiBlast_CBE
65.41
32%
-108
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
39
PsiBlast_CBE
65.02
32%
-108
- C1 -
4BDG
2
?
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
45
PsiBlast_CBE
64.84
32%
-109
- C1 -
4BDA
8
?
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
54
PsiBlast_CBE
63.03
32%
-107
- C1 -
2WTC
1
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
R
T
Q
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
30
PsiBlast_CBE
62.70
35%
-117
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[8-265]
--------
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
S
--------
S
L
E
-----
N
---
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
-
T
H
--
Y
-
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
E
N
S
K
I
M
I
T
D
F
G
L
S
K
---
M
E
Q
N
G
I
M
S
---
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
--
Y
S
-
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
S
K
L
-
F
-
E
--
K
I
-
K
-
E
G
Y
Y
E
F
ES
P
F
W
-
D
D
--
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
---------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.63
35%
-114
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[8-265]
--------
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
S
--------
S
L
E
-----
N
---
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
-
T
H
--
Y
-
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
E
N
S
K
I
M
I
T
D
F
G
L
S
K
---
M
E
Q
N
G
I
M
S
---
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
P
--
Y
S
-
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
S
K
L
-
F
-
E
--
K
I
-
K
-
E
G
Y
Y
E
F
ES
P
F
W
-
D
D
--
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
---------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
60.24
34%
-117
- C1 -
2RKU
6
PLK1_HUMAN
A:
[23-265]
-----------------
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
-
P
H
Q
R
E
K
M
S
-----
M
---
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
---
D
N
D
F
V
-
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
-
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
---
L
---
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
----
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
--
S
K
K
G
--
H
S
F
E
V
-
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
-
S
C
L
K
E
T
Y
L
-
R
--
I
K
-
K
-
N
---
E
Y
--
S
I
P
-
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
-------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
60.04
34%
-121
- C1 -
3FC2
7
PLK1_HUMAN
A:
[49-291]
-----------------
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
-
P
H
Q
R
E
K
M
S
-----
M
---
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
---
D
N
D
F
V
-
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
-
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
---
L
---
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
----
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
--
S
K
K
G
--
H
S
F
E
V
-
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
-
S
C
L
K
E
T
Y
L
-
R
--
I
K
-
K
-
N
---
E
Y
--
S
I
P
-
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
-------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
59.41
32%
-114
- C1 -
2CN8
1
CHK2_HUMAN
A:
[15-301]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
D
--
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
-
H
---
V
S
-
L
-
K
--
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
--
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-
Q
D
E
D
M
K
R
K
--
F
Q
D
L
L
S
E
E
N
-------------------------------------------------------------------------------
106
PsiBlast_CBE
55.84
31%
-96
- C1 -
2HXL
1
CHK1_HUMAN
A:
[14-275]
-----------------
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-----
C
P
E
N
-
I
K
-----
K
---
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
-
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
-
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
N
R
E
R
L
L
N
K
-
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
--
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
-
Y
-
S
--
D
W
-
K
-
E
K
K
T
Y
L
--
N
P
W
-
K
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
-
K
K
G
A
KR
P
---------------------------------------------------------------------------------------
105
PsiBlast_CBE
55.56
31%
-97
- C1 -
2HXQ
1
CHK1_HUMAN
A:
[14-275]
-----------------
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-----
C
P
E
N
-
I
K
-----
K
---
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
-
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
-
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
N
R
E
R
L
L
N
K
-
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
--
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
-
Y
-
S
--
D
W
-
K
-
E
K
K
T
Y
L
--
N
P
W
-
K
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
-
K
K
G
A
KR
P
---------------------------------------------------------------------------------------
102
PsiBlast_CBE
54.37
31%
-96
- C1 -
3TKI
1
CHK1_HUMAN
A:
[15-280]
-----------------
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------
N
-
I
K
-----
K
---
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
-
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
-
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
N
R
E
R
L
L
N
K
-
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
--
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
-
Y
-
S
--
D
W
-
K
-
E
K
K
T
Y
L
--
N
P
W
-
K
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
-
K
K
G
A
K
R
P
R
V
T
S
-----------------------------------------------------------------------------------
107
PsiBlast_CBE
52.63
31%
-98
- C1 -
2HOG
1
CHK1_HUMAN
A:
[14-279]
-----------------
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------
N
-
I
K
-----
K
---
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
-
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
-
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
N
R
E
R
L
L
N
K
-
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
--
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
-
Y
-
S
--
D
W
-
K
-
E
K
K
T
Y
L
--
N
P
W
-
K
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
-
K
K
G
A
K
R
P
R
V
T
S
-----------------------------------------------------------------------------------
104
PsiBlast_CBE
51.08
31%
-97
- C1 -
2HY0
1
CHK1_HUMAN
A:
[14-279]
-----------------
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---------
N
-
I
K
-----
K
---
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
--
H
-
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
-
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
N
R
E
R
L
L
N
K
-
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
E
--
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
-
Y
-
S
--
D
W
-
K
-
E
K
K
T
Y
L
--
N
P
W
-
K
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
-
K
K
G
A
KR
P
R
V
T
S
-----------------------------------------------------------------------------------