@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TSSK2_HUMAN: (2013-07-25 )
MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
Atome Classification :
(53 SA)
.........10........20........30........40........50-.......-----.---60........70........80........90........100.......110.......120.......-130.......140.---.---.---....150.......160.......170.......180.......190.--.--.....200.......210...-.---...220...-...-.-230...--...-.240.......250.......260-----.......270.......280.......290.......300.......310.......320.......330.......340.......350......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTD-FVERFLP-----R---EMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHD-LDIVHRDLKCENLL---L---D---KDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQ--P--KVYDIWSLGVILYIMVCGSMP-Y---DDSDIRKML-RIQ-K-EHRVDF--PRS-KNLTCECKDLIYRMLQPDVSQRLH-----IDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
45
PsiBlast_CBE
81.94
36%
-130
- C1 -
3IGO
8
?
A:
[30-281]
-----------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
--
T
S
T
I
L
------
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
-
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
ESK
E
---
K
D
C
D
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
-
Q
N
T
----------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
YGK
N
E
Y
D
I
L
K
R
V
-
E
T
G
-
K
--
Y
A
F
D
L
--
P
Q
W
-
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
-------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.75
38%
-121
- C1 -
2Y94
1
AAPK1_RAT
A:
[18-276]
-----------
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
-
D
V
V
G
K
I
R
-----
R
---
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
-
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
---
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
--
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
--
G
--
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
---
D
D
D
H
V
P
T
L
F
-
K
---
K
-
I
C
D
G
I
F
--
Y
T
P
-
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
-----
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
--------------------------------------------------------------------------------
16
PsiBlast_PDB
80.45
35%
-124
- C1 -
4BL1
1
MELK_HUMAN
A:
[10-264]
---------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
---------
L
P
-----
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
-
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
---
E
Y
H
K
L
K
L
I
D
F
G
L
---
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
-----
G
--
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
---
D
D
D
N
V
M
A
L
Y
-
K
K
I
-
M
-
R
G
K
Y
D
V
--
P
---
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
-----
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------
44
PsiBlast_CBE
80.02
36%
-128
- C1 -
3MWU
1
?
A:
[30-281]
-----------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
-
D
T
S
T
I
L
------
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
-
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
ESK
E
---
K
D
C
D
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
-
Q
N
-------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
YGK
N
E
Y
D
I
L
K
R
V
-
E
T
G
-
K
--
Y
A
F
D
L
--
P
Q
W
-
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
-------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.98
38%
-143
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
E
----------------
N
---
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
S
K
I
M
I
S
D
F
----------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
L
F
E
-
Q
I
L
-
K
A
E
Y
E
F
D
S
--
P
Y
W
-
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------
42
PsiBlast_CBE
79.72
35%
-135
- C1 -
3HX4
3
?
A:
[58-310]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
--------
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.47
38%
-140
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
E
----------
E
-----
N
---
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
S
K
I
M
I
S
D
F
-----------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
L
F
E
-
Q
I
L
-
K
A
E
Y
E
F
D
S
--
P
Y
W
-
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------
120
HHSearch
78.95
35%
-121
- C1 -
4GV1
5
AKT1_HUMAN
A:
[9-270]
----------
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
-
L
-----
T
---
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
---
D
---
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
----
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
--
R
---
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
-
E
L
I
-
L
-
M
E
E
I
R
F
--
P
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
------------------------------------------------------------------------------------
67
PsiBlast_CBE
78.85
34%
-130
- C1 -
4BDI
6
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.59
38%
-136
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
-----------------
N
---
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
S
K
I
M
I
S
D
F
G
----------
G
S
V
L
--
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
K
L
F
E
-
Q
I
L
-
K
A
E
Y
E
F
D
S
--
P
Y
W
-
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------
43
PsiBlast_CBE
78.47
36%
-131
- C1 -
3NCG
1
?
A:
[30-281]
-----------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
-
D
T
S
T
I
L
------
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
-
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
ESK
E
---
K
D
C
D
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
-
Q
N
T
--------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
YGK
N
E
Y
D
I
L
K
R
V
-
E
T
G
-
K
--
Y
A
F
D
L
--
P
Q
W
-
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
-------------------------------------------------------------------------------------
92
PsiBlast_CBE
78.41
34%
-128
- C1 -
2YCS
1
CHK2_HUMAN
A:
[12-279]
-----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------NV
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
GY
N
--
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
86
PsiBlast_CBE
77.90
34%
-124
- C1 -
2CN5
1
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
-------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
77
PsiBlast_CBE
77.61
34%
-125
- C1 -
4A9T
4
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
70
PsiBlast_CBE
77.27
34%
-133
- C1 -
4BDF
3
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
66
PsiBlast_CBE
77.20
34%
-136
- C1 -
4BDJ
1
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
90
PsiBlast_CBE
77.19
34%
-126
- C1 -
2YIR
1
CHK2_HUMAN
A:
[12-279]
-----------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------LN
V
E
-
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
GY
N
--
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
74
PsiBlast_CBE
76.87
34%
-134
- C1 -
4BDB
10
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------L
N
V
E
-
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
95
PsiBlast_CBE
76.64
34%
-120
- C1 -
2YCF
1
CHK2_HUMAN
A:
[12-279]
-----------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
GY
N
--
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
94
PsiBlast_CBE
76.63
34%
-126
- C1 -
2W0J
1
CHK2_HUMAN
A:
[12-279]
-----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
GY
N
--
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
73
PsiBlast_CBE
76.42
34%
-133
- C1 -
4BDC
2
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
65
PsiBlast_CBE
76.03
34%
-128
- C1 -
4BDK
4
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
93
PsiBlast_CBE
76.00
34%
-124
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[12-279]
-----------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
GY
N
--
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
75
PsiBlast_CBE
75.91
34%
-132
- C1 -
4BDA
8
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
60
PsiBlast_CBE
75.68
35%
-123
- C1 -
2WEI
1
?
A:
[24-281]
-----------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
K
-
D
T
S
T
I
L
------
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
-
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
ESK
E
---
K
D
C
D
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
Q
N
T
K
M
----
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
YGK
N
E
Y
D
I
L
K
R
V
-
E
T
G
-
K
--
Y
A
F
D
L
--
P
Q
W
-
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
-------------------------------------------------------------------------------------
80
PsiBlast_CBE
75.64
34%
-126
- C1 -
2XM9
1
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
91
PsiBlast_CBE
75.63
34%
-125
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[12-279]
-----------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------V
E
---
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
GY
N
--
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.09
35%
-120
- C1 -
3T3V
2
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
76
PsiBlast_CBE
74.99
34%
-129
- C1 -
4A9U
10
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
D
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
68
PsiBlast_CBE
74.87
34%
-137
- C1 -
4BDH
4
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
79
PsiBlast_CBE
74.82
34%
-130
- C1 -
4A9R
2
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
82
PsiBlast_CBE
74.77
34%
-130
- C1 -
2WTI
3
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
69
PsiBlast_CBE
74.76
34%
-132
- C1 -
4BDG
2
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
87
PsiBlast_CBE
74.72
34%
-123
- C1 -
2YCR
1
CHK2_HUMAN
A:
[12-279]
-----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
GY
N
--
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
72
PsiBlast_CBE
74.72
34%
-137
- C1 -
4BDD
3
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
81
PsiBlast_CBE
74.48
34%
-129
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
50
PsiBlast_CBE
74.44
35%
-121
- C1 -
3UPX
1
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
83
PsiBlast_CBE
74.10
34%
-133
- C1 -
2WTD
4
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
47
PsiBlast_CBE
73.97
35%
-122
- C1 -
3V5P
1
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
49
PsiBlast_CBE
73.62
35%
-122
- C1 -
3UPZ
1
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
71
PsiBlast_CBE
73.27
34%
-136
- C1 -
4BDE
5
?
A:
[18-285]
-----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.76
35%
-119
- C1 -
3I7B
4
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
78
PsiBlast_CBE
72.63
34%
-131
- C1 -
4A9S
1
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
46
PsiBlast_CBE
72.48
35%
-119
- C1 -
3V5T
1
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
84
PsiBlast_CBE
72.25
34%
-126
- C1 -
2WTC
1
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
R
T
Q
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------
38
PsiBlast_CBE
72.09
34%
-110
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[8-265]
--------
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
S
--------
S
L
E
-----
N
---
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
-
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
---
E
N
S
K
I
M
I
T
D
F
G
L
S
K
---
M
E
Q
N
G
---
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
-
F
---
Y
E
E
T
E
S
K
L
F
-
E
K
I
-
K
-
E
G
Y
Y
E
F
ES
P
F
W
-
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------------------------
39
PsiBlast_CBE
71.91
34%
-113
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[8-265]
--------
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
S
--------
S
L
E
-----
N
---
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
-
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
---
E
N
S
K
I
M
I
T
D
F
G
L
S
K
---
M
E
Q
N
G
---
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
-
F
---
Y
E
E
T
E
S
K
L
F
-
E
K
I
-
K
-
E
G
Y
Y
E
F
ES
P
F
W
-
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------------------------
53
PsiBlast_CBE
71.89
35%
-115
- C1 -
3SXF
3
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
58
PsiBlast_CBE
71.72
35%
-123
- C1 -
3MA6
1
?
B:
[40-292]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
--
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
52
PsiBlast_CBE
71.50
35%
-119
- C1 -
3T3U
5
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
55
PsiBlast_CBE
71.23
35%
-117
- C1 -
3N51
3
?
A:
[34-286]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
-----
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
--
E
--
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
Y
D
I
L
K
K
V
E
-
K
G
K
Y
T
F
E
L
--
P
Q
W
-
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.00
36%
-111
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[13-270]
-----------
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
-
D
V
V
G
K
I
K
-----
R
---
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
-
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
---
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
--------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
--
G
--
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
---
D
D
E
H
V
P
T
L
F
-
K
K
I
-
R
-
G
G
V
F
Y
I
--
P
E
Y
-
L
N
R
S
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
-----
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
---------------------------------------------------------------------------------
85
PsiBlast_CBE
69.41
34%
-129
- C1 -
2CN8
1
CHK2_HUMAN
A:
[18-285]
-----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
---
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
--
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
---
S
E
H
---
V
S
L
-
K
D
Q
I
T
-
S
G
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
-------------------------------------------------------------------------------------