@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TYK2_HUMAN: (2015-06-18 )
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....-..-.920.......930.......940.......950.......960.......970.......980.......990--...-----.....1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110.-.-....1120......1130......1140......1150......1160......1170......1180....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCY-DP-TNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP---RHS-----IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGI-A-QGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
6
PsiBlast_PDB
62.27
98%
-118
- C2 -
4GFO
4
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
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-
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T
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N
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T
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Y
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H
---------
4
PsiBlast_PDB
61.68
99%
-112
- C2 -
3NZ0
1
A:
[7-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
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--------
T
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Y
R
H
---------
15
PsiBlast_PDB
60.99
91%
-109
- C2 -
4E1Z
1
A:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
T
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---
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---
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-----
V
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12
PsiBlast_PDB
60.38
97%
-104
- C2 -
4GJ2
1
A:
[9-296]
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T
V
F
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7
PsiBlast_PDB
59.84
97%
-108
- C2 -
3LXN
1
A:
[24-314]
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D
P
T
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13
PsiBlast_PDB
59.66
97%
-104
- C2 -
4GJ3
1
A:
[9-296]
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T
V
F
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14
PsiBlast_PDB
59.46
97%
-105
- C2 -
4GIH
1
A:
[9-296]
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T
V
F
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G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
-
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
16
PsiBlast_PDB
58.92
91%
-114
- C2 -
4E20
1
A:
[1-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
E
G
C
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
----
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
C
-----
V
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
P
H
T
K
F
T
E
L
I
G
------
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
Q
T
A
Q
E
K
Y
Q
----------
11
PsiBlast_PDB
58.57
97%
-104
- C2 -
4GII
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
-----
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
-
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
---------
5
PsiBlast_PDB
58.08
98%
-112
- C2 -
3NYX
3
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
-
T
N
D
--
G
E
M
V
A
V
K
A
L
K
A
D
C
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
-
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
-----
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
-
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
---------
10
PsiBlast_PDB
57.93
97%
-104
- C2 -
4GVJ
1
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
-
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
-----
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
-
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
---------
65
PsiBlast_CBE
54.23
50%
-105
- C2 -
4E4M
1
JAK2_HUMAN
B:
[10-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER---
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
-
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
62
PsiBlast_CBE
53.69
50%
-100
- C2 -
4F08
1
JAK2_HUMAN
A:
[13-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER---
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
-
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
76
PsiBlast_CBE
53.66
50%
-103
- C2 -
4JIA
2
A:
[8-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER---
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
-
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
23
PsiBlast_CBE
50.97
57%
-103
- C2 -
4K6Z
1
A:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
-
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK---
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
-
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
28
PsiBlast_CBE
50.65
57%
-99
- C2 -
4IVB
1
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
-
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK---
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
-
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
25
PsiBlast_CBE
50.47
57%
-100
- C2 -
4IVD
1
JAK1_HUMAN
A:
[1-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
-
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK---
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
-
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
22
PsiBlast_CBE
50.37
57%
-100
- C2 -
4K77
1
JAK1_HUMAN
A:
[12-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
-
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
---
G
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK---
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
-
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
30
PsiBlast_CBE
50.19
57%
-100
- C2 -
4I5C
5
B:
[1-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
-
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK---
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
-
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
26
PsiBlast_CBE
49.78
57%
-98
- C2 -
4IVC
1
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
-
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK---
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
-
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
121
HHSearch
48.18
51%
-94
- C2 -
3UGC
1
A:
[6-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
-
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
-
T
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER---
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
-------------
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
-
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
------------
118
HHSearch
39.68
37%
-97
- C2 -
4I4E
1
A:
[17-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
S
--
P
-
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
---
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
---
V
R
K
YS---
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
---
K
P
F
Q
-------------
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
--------
114
HHSearch
39.27
38%
-95
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[40-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
-
H
N
L
L
P
---
K
M
L
V
A
V
K
A
L
K
E
A
-
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
--
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
PDPGP
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
---
P
W
-------------
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
----------
102
Fugue
37.28
38%
-82
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
--------
N
K
V
A
V
K
C
I
K
-----
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--
E
E
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
S
V
-----
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
---
G
R
V
P
Y
------------
P
R
I
P
L
-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
-
E
L
---------