@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TYRO3_HUMAN: (2013-07-25 )
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
Atome Classification :
(96 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510....------..--.--520.........530.......--540.......550.......560.......570.......580.......590.......600.......610.......--620......--.630.......640.......650.......660.......670.......680...--.--...690.......700.......710.......720.......730.......740.......750.......760.......770.......----780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQ------QF--T--L--GRMLGKGEFGSVREAQLKQ--EDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR--IGENPFNLP--LQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDY--Y--RQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSF----TCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
120
HHSearch
92.45
98%
-153
- C4 -
3QUP
1
A:
[16-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---------
F
--
T
--
L
--
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
---------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
--
I
---
P
F
N
L
P
--
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
---------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
----
T
C
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.51
97%
-141
- C4 -
4FEQ
1
A:
[22-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
------
Q
F
--
T
--
L
--
G
R
M
L
G
K
G
---
S
V
R
E
A
Q
L
K
----
D
G
S
F
V
K
V
A
V
K
M
L
------------
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
-----------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
--
I
-------
P
--
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
----
T
C
L
R
M
E
L
E
N
I
L
G
H
L
-------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.51
63%
-143
- C4 -
3TCP
1
MERTK_HUMAN
A:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
------
L
L
--
I
--
L
--
G
K
I
L
G
-----
S
V
M
E
G
N
L
K
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
--
L
E
T
G
P
K
H
I
P
--
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.79
63%
-139
- C4 -
2P0C
1
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
--
I
--
L
--
G
K
I
L
G
E
G
---
S
V
M
E
G
N
L
K
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
--------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
--
L
E
T
G
P
K
H
I
P
--
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
81.44
63%
-133
- C4 -
3BRB
2
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
--
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
--
L
E
T
G
P
K
H
I
P
--
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.35
63%
-141
- C4 -
2P0C
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
--
I
--
L
--
G
K
I
L
G
--
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
--------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
--
L
E
T
G
P
K
H
I
P
--
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.29
63%
-140
- C4 -
3BPR
1
MERTK_HUMAN
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
------
L
L
--
I
--
L
--
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
--------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
--
L
E
T
G
P
K
H
I
P
--
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.18
63%
-139
- C4 -
3BPR
1
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
--
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
--
L
E
T
G
P
K
H
I
P
--
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.74
41%
-142
- C4 -
2RFN
1
MET_HUMAN
A:
[11-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
----
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.53
63%
-138
- C4 -
3TCP
1
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
------
L
L
--
I
--
L
--
G
K
I
L
G
E
G
---
S
V
M
E
G
N
L
K
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
--
L
E
T
G
P
K
H
I
P
--
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
-----------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.49
63%
-138
- C4 -
3BPR
1
D:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
--
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
--
L
E
T
G
P
K
H
I
P
--
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.23
41%
-143
- C4 -
2RFN
1
B:
[10-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
----
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
78.77
41%
-132
- C4 -
3EFJ
1
MET_HUMAN
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
78.53
41%
-134
- C4 -
3EFJ
1
B:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
77.11
41%
-133
- C4 -
3EFK
1
MET_HUMAN
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
77.00
40%
-131
- C4 -
1R0P
1
A:
[5-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
DS
V
--
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
76.95
41%
-136
- C4 -
3EFK
1
B:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
76.39
42%
-129
- C4 -
2WD1
3
A:
[7-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
76.08
41%
-120
- C4 -
3PLS
1
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
------
R
V
--
V
--
T
HS
D
R
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
I
D
--
Q
A
Q
N
R
I
Q
C
A
I
K
S
L
-
S
R
I
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
N
H
P
N
V
L
A
L
I
G
I
M
L
P
P
E
G
-----
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
R
S
P
Q
----
R
N
P
---
T
--
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
E
Y
--
Y
SV
Q
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
----
R
V
L
V
G
E
V
E
Q
I
V
S
A
L
-------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.91
41%
-134
- C4 -
3U6I
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.31
41%
-131
- C4 -
3I5N
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-----
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
75.30
41%
-127
- C4 -
3F66
4
MET_HUMAN
A:
[2-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
75.26
40%
-133
- C4 -
3DKF
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
---------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
75.24
39%
-136
- C4 -
3DKG
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
------
C
V
Y
H
G
T
L
L
D
-----
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
-------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.21
41%
-130
- C4 -
4DEH
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
75.18
41%
-131
- C4 -
3CCN
1
A:
[9-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--------
K
I
H
C
A
V
K
S
L
N
R
------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.15
41%
-123
- C4 -
3RHK
1
B:
[25-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.10
41%
-124
- C4 -
3RHK
1
MET_HUMAN
A:
[25-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
75.03
41%
-132
- C4 -
3F66
3
B:
[11-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
------
K
K
I
H
C
A
V
K
S
L
N
-------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
75.03
41%
-127
- C4 -
2WGJ
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.01
41%
-131
- C4 -
4EEV
1
A:
[24-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
75.00
41%
-129
- C4 -
3CD8
1
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--------
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
-----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
74.87
41%
-123
- C4 -
3ZZE
1
A:
[10-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.81
41%
-130
- C4 -
4DEG
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.74
41%
-131
- C4 -
3U6H
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.33
41%
-127
- C4 -
4DEI
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
------
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
74.10
40%
-130
- C4 -
3F82
1
A:
[9-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-------
K
I
H
C
A
V
K
S
L
N
R
-----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
73.74
41%
-121
- C4 -
3LQ8
1
A:
[5-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
--
D
K
E
Y
--
Y
S------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
73.64
40%
-115
- C4 -
3DKC
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
D
S
V
--
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
73.55
41%
-121
- C4 -
2WKM
1
A:
[10-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
73.26
41%
-126
- C4 -
3ZXZ
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.10
41%
-130
- C4 -
2RFS
1
A:
[21-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
------
S
L
--
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--------
K
I
H
C
A
V
K
S
L
N
-----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
72.92
41%
-125
- C4 -
4AOI
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.60
41%
-127
- C4 -
4GG5
1
A:
[37-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
----
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
72.42
41%
-123
- C4 -
4AP7
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
72.20
40%
-123
- C4 -
3L8V
1
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.19
40%
-125
- C4 -
3CTH
1
A:
[7-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
72.12
40%
-137
- C4 -
3QTI
2
B:
[12-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
71.74
41%
-118
- C4 -
2FO0
3
ABL1_HUMAN
A:
[220-479]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.60
41%
-121
- C4 -
4GG7
1
A:
[37-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
131
HHSearch
71.46
42%
-132
- C4 -
3C1X
1
A:
[70-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
V
H
--
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
-----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
-------
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
----------------------------------------------------------------------------------------------
64
PsiBlast_CBE
71.13
38%
-106
- C4 -
3LW0
4
IGF1R_HUMAN
B:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P---------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
55
PsiBlast_CBE
70.95
40%
-130
- C4 -
3CE3
1
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
70.67
41%
-118
- C4 -
2Z60
1
ABL1_MOUSE
A:
[16-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
97
PsiBlast_CBE
70.17
41%
-108
- C4 -
1FPU
1
ABL1_MOUSE
B:
[21-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
70.02
38%
-104
- C4 -
3LW0
3
D:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P---------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
61
PsiBlast_CBE
69.93
38%
-104
- C4 -
3I81
1
A:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE-
E
N
N
P
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
83
PsiBlast_CBE
69.92
41%
-118
- C4 -
1OPK
3
ABL1_MOUSE
A:
[223-482]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
81
PsiBlast_CBE
69.90
41%
-116
- C4 -
3IK3
1
ABL1_MOUSE
A:
[16-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
63
PsiBlast_CBE
69.86
38%
-104
- C4 -
3LW0
4
IGF1R_HUMAN
C:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P---------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
86
PsiBlast_CBE
69.83
41%
-116
- C4 -
3MS9
2
ABL1_MOUSE
B:
[21-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.76
97%
-139
- C4 -
4FF8
1
A:
[80-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
D
H
P
H
V
A
K
L
V
-----------------
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
--
I
-------
P
--
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
---------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
--
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
----
T
C
L
R
M
E
L
E
N
I
L
----------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
69.75
41%
-119
- C4 -
1OPL
1
ABL1_HUMAN
B:
[262-518]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--
R
Q
E
----
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
69.66
40%
-129
- C4 -
3A4P
3
A:
[22-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
-----
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
------------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
69.58
41%
-112
- C4 -
3KFA
1
ABL1_MOUSE
B:
[16-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
94
PsiBlast_CBE
69.57
41%
-117
- C4 -
1M52
1
ABL1_MOUSE
A:
[21-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
65
PsiBlast_CBE
69.57
38%
-106
- C4 -
3LW0
3
IGF1R_HUMAN
A:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P---------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
80
PsiBlast_CBE
69.54
41%
-117
- C4 -
3IK3
1
ABL1_MOUSE
B:
[16-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
101
PsiBlast_CBE
69.49
41%
-120
- C4 -
1OPL
2
ABL1_HUMAN
A:
[262-521]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--
R
Q
E
----
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
93
PsiBlast_CBE
69.32
41%
-116
- C4 -
1M52
3
ABL1_MOUSE
B:
[21-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
91
PsiBlast_CBE
69.29
41%
-115
- C4 -
1OPJ
2
ABL1_MOUSE
B:
[21-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
84
PsiBlast_CBE
68.88
41%
-113
- C4 -
3OY3
1
ABL1_MOUSE
B:
[16-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.86
38%
-104
- C4 -
3NW6
1
A:
[7-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
E
N
N
P
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
68
PsiBlast_CBE
68.62
38%
-104
- C4 -
3NW7
1
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
E
N
N
P
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
92
PsiBlast_CBE
68.41
41%
-114
- C4 -
1OPJ
2
ABL1_MOUSE
A:
[21-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
85
PsiBlast_CBE
68.25
41%
-111
- C4 -
3OY3
1
ABL1_MOUSE
A:
[16-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
67
PsiBlast_CBE
67.96
38%
-107
- C4 -
1JQH
1
IGF1R_HUMAN
B:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P---------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
53
PsiBlast_CBE
67.96
40%
-127
- C4 -
3CTJ
1
A:
[7-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
--
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
R
N
E
T
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
67.87
41%
-112
- C4 -
3MS9
2
ABL1_MOUSE
A:
[21-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
67.82
41%
-112
- C4 -
1IEP
1
ABL1_MOUSE
A:
[21-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
67.63
38%
-102
- C4 -
3NW5
1
A:
[6-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
E
N
N
P
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
88
PsiBlast_CBE
67.59
41%
-115
- C4 -
3K5V
2
ABL1_MOUSE
B:
[21-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
---
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
89
PsiBlast_CBE
67.31
41%
-115
- C4 -
3K5V
2
ABL1_MOUSE
A:
[21-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
-
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
72
PsiBlast_CBE
67.26
38%
-100
- C4 -
3QQU
1
D:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
-----
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
95
PsiBlast_CBE
67.13
41%
-110
- C4 -
1IEP
1
ABL1_MOUSE
B:
[21-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
67.11
38%
-98
- C4 -
3QQU
1
IGF1R_HUMAN
B:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-----------PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
71
PsiBlast_CBE
66.84
38%
-101
- C4 -
2OJ9
1
A:
[6-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE--------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
98
PsiBlast_CBE
66.64
41%
-108
- C4 -
1FPU
1
ABL1_MOUSE
A:
[21-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
------
N
R
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
66.28
38%
-112
- C4 -
3LVP
2
IGF1R_HUMAN
A:
[39-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
WEVARE
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
E
--
P
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-----------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
73
PsiBlast_CBE
66.27
38%
-101
- C4 -
3QQU
1
IGF1R_HUMAN
C:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
----
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
78
PsiBlast_CBE
65.46
40%
-103
- C4 -
3EKN
1
A:
[15-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
--
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
E
N
N
P
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
65.28
38%
-100
- C4 -
3QQU
1
IGF1R_HUMAN
A:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
--
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
D
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
77
PsiBlast_CBE
65.25
40%
-110
- C4 -
1I44
1
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
--
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
E
N
N
P
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
--------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
65.23
40%
-115
- C4 -
3EKK
1
A:
[15-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
--
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
E
N
N
P
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
----------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
63.89
41%
-97
- C4 -
3ETA
1
INSR_HUMAN
A:
[13-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
--
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
E
N
N
P
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
61.71
41%
-96
- C4 -
3ETA
1
B:
[13-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
--
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
E
N
N
P
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
Add PDB User Result:
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
135
-
100%
-116
- C4 -
U135
1
A:
[512-801]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
E
Q
Q
F
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
G
S
F
V
K
V
A
V
K
M
L
K
A
D
I
I
A
S
S
D
I
E
-
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
R
A
------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
G
E
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
S
R
K
I
Y
S
G
D
Y
Y
R
Q
G
---
K
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
D
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
V
L
S
A
S
Q
D
-----------------------------------------------------------------------------------------
136
-
100%
-137
- C4 -
U136
1
A:
[495-793]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
L
G
I
S
D
E
L
K
E
K
L
E
D
V
L
I
P
E
Q
Q
F
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
----
S
F
V
K
V
A
V
K
M
L
K
A
-
I
I
A
S
S
D
I
E
E
F
L
R
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-------------------------------------------------------------------------------------------------
137
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-109
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U137
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[513-790]
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----------------------------------------------------------------------------------------------------
138
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-145
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U138
1
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[496-793]
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-------------------------------------------------------------------------------------------------
139
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-144
- C4 -
U139
1
A:
[495-793]
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-------------------------------------------------------------------------------------------------
140
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-134
- C4 -
U140
1
A:
[519-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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-----------------------------------------------------------------------------------------------
141
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- C4 -
U141
1
A:
[495-793]
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-------------------------------------------------------------------------------------------------
142
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U142
1
A:
[496-793]
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-------------------------------------------------------------------------------------------------
143
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-142
- C4 -
U143
1
A:
[497-793]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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-------------------------------------------------------------------------------------------------
144
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-135
- C4 -
U144
1
A:
[496-793]
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-------------------------------------------------------------------------------------------------
145
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-131
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U145
1
A:
[519-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
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M
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L
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N
I
L
G
Q
L
S
V
-----------------------------------------------------------------------------------------------
146
-
100%
-145
- C4 -
U146
1
B:
[496-793]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
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D
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L
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--------------------
P
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L
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N
I
L
G
Q
L
-------------------------------------------------------------------------------------------------
147
-
99%
-132
- C4 -
U147
1
A:
[495-793]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
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L
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---------
P
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S
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L
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N
I
L
G
Q
L
-------------------------------------------------------------------------------------------------
148
-
100%
-131
- C4 -
U148
1
A:
[519-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
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L
G
K
G
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F
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A
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L
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----
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L
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N
I
L
G
Q
L
S
V
-----------------------------------------------------------------------------------------------
149
-
100%
-125
- C4 -
U149
1
B:
[519-791]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
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M
L
G
K
G
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F
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R
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A
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L
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------
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A
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L
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----
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L
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N
I
L
G
---------------------------------------------------------------------------------------------------
150
-
100%
-126
- C4 -
U150
1
A:
[495-793]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
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L
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I
L
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Q
L
-------------------------------------------------------------------------------------------------
151
-
100%
-125
- C4 -
U151
1
B:
[519-791]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
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L
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N
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---------------------------------------------------------------------------------------------------
152
-
100%
-114
- C4 -
U152
1
C:
[513-801]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
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L
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A
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-----------------------------------------------------------------------------------------
153
-
100%
-125
- C4 -
U153
1
B:
[519-791]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
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---
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L
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N
I
L
G
---------------------------------------------------------------------------------------------------
154
-
100%
-133
- C4 -
U154
1
A:
[495-793]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
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N
I
L
G
Q
L
-------------------------------------------------------------------------------------------------
155
-
100%
-131
- C4 -
U155
1
A:
[519-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
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K
A
D
I
I
---
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
P
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
----
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
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N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
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D
M
T
V
C
V
A
D
F
G
L
S
R
-
I
Y
S
G
D
Y
Y
R
Q
G
C
A
S
K
L
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V
K
W
L
A
L
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S
L
A
D
N
L
Y
T
V
Q
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D
V
W
A
F
G
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T
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W
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T
R
G
Q
T
P
Y
A
G
I
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N
A
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I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
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C
M
E
D
V
Y
D
L
M
Y
Q
C
W
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A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
V
-----------------------------------------------------------------------------------------------
156
-
100%
-138
- C4 -
U156
1
A:
[495-793]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
L
G
I
S
D
E
L
K
E
K
L
E
D
V
L
I
P
E
Q
Q
F
T
L
G
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L
G
K
G
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V
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E
A
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L
K
Q
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V
A
V
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M
L
K
A
-
I
I
A
S
S
D
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F
L
R
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A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
R
A
K
-----
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
-----
I
G
E
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
-------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
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I
M
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G
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T
P
Y
A
G
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N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
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C
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D
V
Y
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A
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P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
-------------------------------------------------------------------------------------------------
157
-
99%
-132
- C4 -
U157
1
A:
[495-793]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
L
G
I
S
D
E
L
K
E
K
L
E
D
V
L
I
P
E
Q
Q
F
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
G
S
F
V
K
V
A
V
K
M
L
K
A
----
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
K
---------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
-----
I
G
E
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
S
R
K
--
S
G
D
Y
Y
-----
S
K
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
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C
M
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D
V
Y
D
L
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Y
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C
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A
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P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
-------------------------------------------------------------------------------------------------
158
-
100%
-135
- C4 -
U158
1
A:
[496-793]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
G
I
S
D
E
L
K
E
K
L
E
D
V
L
I
P
E
Q
Q
F
T
L
G
R
M
L
G
K
G
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F
G
S
V
R
E
A
Q
L
K
Q
E
D
G
S
F
V
K
V
A
V
K
M
L
K
A
-
I
I
A
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
R
A
K
-----
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
-----
I
G
E
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
------------
Q
G
C
A
S
K
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
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I
M
T
R
G
Q
T
P
Y
A
G
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N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
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C
M
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D
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
-------------------------------------------------------------------------------------------------
159
-
100%
-125
- C4 -
U159
1
B:
[519-791]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
---
V
K
V
A
V
K
M
L
K
A
D
I
I
---
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
P
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
----
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
S
R
-
I
Y
S
G
D
Y
Y
R
Q
G
C
A
S
K
L
P
V
K
W
L
A
L
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L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
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I
M
T
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G
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T
P
Y
A
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A
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Y
N
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L
I
G
G
N
R
L
K
Q
P
P
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M
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D
V
Y
D
L
M
Y
Q
C
W
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A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
---------------------------------------------------------------------------------------------------
160
-
99%
-139
- C4 -
U160
1
A:
[499-796]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
D
E
L
K
E
K
L
E
D
V
L
I
P
E
Q
Q
F
T
L
G
R
M
L
G
K
G
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F
G
S
V
R
E
A
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L
K
Q
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D
G
S
F
V
K
V
A
V
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M
L
K
A
-
I
I
A
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
R
A
-----
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
N
-----
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
-------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
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I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
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C
M
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D
V
Y
D
L
M
Y
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C
W
S
A
D
P
K
Q
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P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
V
L
----------------------------------------------------------------------------------------------
161
-
100%
-125
- C4 -
U161
1
B:
[519-791]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
---
V
K
V
A
V
K
M
L
K
A
D
I
I
---
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
P
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
----
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
S
R
-
I
Y
S
G
D
Y
Y
R
Q
G
C
A
S
K
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
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C
M
E
D
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
---------------------------------------------------------------------------------------------------
162
-
100%
-131
- C4 -
U162
1
A:
[519-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
---
V
K
V
A
V
K
M
L
K
A
D
I
I
---
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
P
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
----
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
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-
I
Y
S
G
D
Y
Y
R
Q
G
C
A
S
K
L
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V
K
W
L
A
L
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S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
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I
Y
N
Y
L
I
G
G
N
R
L
K
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P
P
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C
M
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D
V
Y
D
L
M
Y
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C
W
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A
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P
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R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
V
-----------------------------------------------------------------------------------------------
163
-
100%
-131
- C4 -
U163
1
A:
[519-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
---
V
K
V
A
V
K
M
L
K
A
D
I
I
---
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
P
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
----
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
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S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
S
R
-
I
Y
S
G
D
Y
Y
R
Q
G
C
A
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L
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V
K
W
L
A
L
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L
A
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N
L
Y
T
V
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D
V
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A
F
G
V
T
M
W
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I
M
T
R
G
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P
Y
A
G
I
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N
A
E
I
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N
Y
L
I
G
G
N
R
L
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P
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D
L
M
Y
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C
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A
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P
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P
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F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
V
-----------------------------------------------------------------------------------------------
164
-
100%
-131
- C4 -
U164
1
A:
[519-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
---
V
K
V
A
V
K
M
L
K
A
D
I
I
---
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
P
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
----
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
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D
M
T
V
C
V
A
D
F
G
L
S
R
-
I
Y
S
G
D
Y
Y
R
Q
G
C
A
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K
L
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V
K
W
L
A
L
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L
A
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L
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W
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T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
D
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
V
-----------------------------------------------------------------------------------------------
165
-
99%
-132
- C4 -
U165
1
A:
[495-793]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
L
G
I
S
D
E
L
K
E
K
L
E
D
V
L
I
P
E
Q
Q
F
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
G
S
F
V
K
V
A
V
K
M
L
K
A
----
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
K
---------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
-----
I
G
E
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
S
R
K
--
S
G
D
Y
Y
-----
S
K
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
D
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
-------------------------------------------------------------------------------------------------
166
-
100%
-131
- C4 -
U166
1
A:
[519-795]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
K
Q
E
D
---
V
K
V
A
V
K
M
L
K
A
D
I
I
---
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
P
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
----
N
P
F
N
L
P
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
S
R
-
I
Y
S
G
D
Y
Y
R
Q
G
C
A
S
K
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
Q
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
D
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
V
-----------------------------------------------------------------------------------------------