@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UFO_HUMAN: (2013-07-25 )
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Atome Classification :
(98 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530....--..--.540.......550..-.-.---.---..-560.......570.......580.......590.......600...--....610.......620.......630--....-.-..640....-..--.650..-.....660.......670.......680.......690.......700--.--......710.......720.......730.......740.......750.......760.......770.......780.......790......----.800.......810.....-..820.......830.......840.......850.......860.......870.......880.......890..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKV--AL--GKTLGEGEFGAVMEGQ-L-N---Q---DD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCF--QGSERESFPAPVVILPFMKHGDLHSFL--LYSR-L-GDQPVYLPT-QM--LVKFMA-DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDY--Y--RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTE----LREDLENTLKALPPAQEPD-EILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
25
PsiBlast_CBE
95.40
69%
-129
- C5 -
2P0C
1
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
--
I
L
--
G
K
I
L
G
E
G
---
S
V
M
E
G
N
-
L
-
K
---
Q
---
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
----------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
-
E
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.19
69%
-126
- C5 -
2P0C
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
--
I
L
--
G
K
I
L
G
--
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
---
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
----------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
-
E
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.14
69%
-124
- C5 -
3BPR
1
MERTK_HUMAN
A:
[24-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
--
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
---
E
D
G
T
S
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
-
E
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
23
PsiBlast_CBE
93.98
69%
-123
- C5 -
3BPR
1
D:
[24-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
--
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
---
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
-
E
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
24
PsiBlast_CBE
93.66
69%
-127
- C5 -
3BPR
1
MERTK_HUMAN
B:
[25-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
--
I
L
--
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
---
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
--------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
-
E
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.61
69%
-127
- C5 -
3TCP
1
MERTK_HUMAN
A:
[26-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
--
I
L
--
G
K
I
L
G
-----
S
V
M
E
G
N
-
L
-
K
---
Q
---
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
-
E
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.57
69%
-121
- C5 -
3BRB
2
B:
[24-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
--
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
---
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
-
E
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
21
PsiBlast_CBE
90.13
69%
-118
- C5 -
3TCP
1
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
--
I
L
--
G
K
I
L
G
E
G
---
S
V
M
E
G
N
-
L
-
K
---
Q
---
E
D
G
T
S
L
K
V
A
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
-
E
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
-----------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.16
61%
-128
- C5 -
3QUP
1
A:
[16-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---
F
--
T
L
--
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
-
L
--------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
--
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-
I
----
P
F
N
L
P
L
-
Q
T
--
L
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
---------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.59
61%
-122
- C5 -
4FEQ
1
A:
[22-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
--
T
L
--
G
R
M
L
G
K
G
---
S
V
R
E
A
Q
-
L
-
K
--------
D
G
S
F
V
K
V
A
V
K
M
L
------------
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
-------------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-
I
--------
P
L
-
Q
T
--
L
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
G
H
L
-------------------------------------------------------------------------------------
134
HHSearch
79.91
43%
-117
- C5 -
3C1X
1
A:
[70-359]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
-
L
---
D
N--
D
G
-
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
S
E
-----
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
--
R
N
-------
E
T
H
N
P
T
V
-
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
74
PsiBlast_CBE
79.91
40%
-110
- C5 -
3PLS
1
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
R
V
--
V
T
HS
D
R
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
I
-
D
---
Q
---
A
Q
-
N
R
I
Q
C
A
I
K
S
L
S
-
R
I
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
N
H
P
N
V
L
A
L
I
G
I
M
L
P
P
E
G
-------
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
----------
R
S
P
Q
R
N
P
T
V
K
D
--
L
I
S
F
G
L
-
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
E
Y
--
Y
SV
Q
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
----
L
V
G
E
V
E
Q
I
V
S
A
L
-------------------------------------------------------------------------------------
102
PsiBlast_CBE
76.67
42%
-102
- C5 -
1OPL
1
ABL1_HUMAN
B:
[256-518]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
N
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
100
PsiBlast_CBE
76.15
42%
-105
- C5 -
2QOH
1
ABL1_MOUSE
A:
[10-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------
126
HHSearch
76.10
45%
-103
- C5 -
1OPK
3
ABL1_MOUSE
A:
[214-479]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
---
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
--
R
------
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
--
R
E
C
------
N
R
Q
E
V
S
A
-
V
V
--
L
L
Y
M
A
T
-
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
51
PsiBlast_CBE
76.05
41%
-98
- C5 -
3LW0
2
IGF1R_HUMAN
A:
[12-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P---------
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
114
HHSearch
76.01
38%
-107
* C5 *
4AOJ
1
NTRK1_HUMAN
A:
[37-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
--
V
L
--
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
-
H
---
N
LLP----
K
M
L
V
A
V
K
A
L
K
E
A
--
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
------
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
-
P
D---
P
G
P
L
G
L
-
G
Q
--
L
L
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
--------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
----
V
H
A
R
L
Q
A
L
A
Q
A
P
P
------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.89
45%
-113
- C5 -
3U6I
1
A:
[31-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
75.86
41%
-96
- C5 -
3LW0
2
D:
[12-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P---------
P
P
-
S
L
SK
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
50
PsiBlast_CBE
75.80
41%
-97
- C5 -
3LW0
3
IGF1R_HUMAN
B:
[12-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P---------
P
P
-
S
L
SK
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
97
PsiBlast_CBE
75.49
42%
-103
- C5 -
3KF4
1
ABL1_MOUSE
B:
[10-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------
99
PsiBlast_CBE
75.46
42%
-97
- C5 -
2QOH
1
ABL1_MOUSE
B:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
---
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
49
PsiBlast_CBE
75.29
41%
-96
- C5 -
3LW0
3
IGF1R_HUMAN
C:
[12-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P---------
P
P
-
S
L
SK
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
98
PsiBlast_CBE
75.23
42%
-97
- C5 -
3KF4
1
ABL1_MOUSE
A:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
65
PsiBlast_CBE
75.18
41%
-98
- C5 -
3NW5
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
-
E
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
89
PsiBlast_CBE
74.65
42%
-102
- C5 -
1M52
3
ABL1_MOUSE
B:
[15-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
16
PsiBlast_PDB
74.52
45%
-113
- C5 -
3U6H
1
A:
[31-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
74.46
45%
-117
- C5 -
3EFK
1
B:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
74.43
45%
-114
- C5 -
3EFK
1
MET_HUMAN
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
74.13
44%
-99
- C5 -
3QRJ
1
ABL1_HUMAN
B:
[15-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
N
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
77
PsiBlast_CBE
73.94
42%
-96
- C5 -
2Z60
1
ABL1_MOUSE
A:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
38
PsiBlast_CBE
73.91
45%
-119
- C5 -
2RFN
1
MET_HUMAN
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
----
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.90
42%
-98
- C5 -
3IK3
1
ABL1_MOUSE
B:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
12
PsiBlast_PDB
73.90
45%
-119
- C5 -
4EEV
1
A:
[49-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.67
42%
-101
- C5 -
3DKF
1
A:
[33-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
---------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
--------------------------------------------------------------------
63
PsiBlast_CBE
73.60
41%
-98
- C5 -
3NW7
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
-
E
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
64
PsiBlast_CBE
73.52
41%
-95
- C5 -
3NW6
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
-
E
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.36
45%
-109
- C5 -
2WD1
3
A:
[24-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
73.27
41%
-101
- C5 -
1JQH
1
IGF1R_HUMAN
B:
[16-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
84
PsiBlast_CBE
73.25
42%
-90
- C5 -
3K5V
2
ABL1_MOUSE
B:
[15-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
---
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
90
PsiBlast_CBE
73.17
42%
-102
- C5 -
1M52
1
ABL1_MOUSE
A:
[15-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
33
PsiBlast_CBE
73.13
45%
-112
- C5 -
3EFJ
1
MET_HUMAN
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
73.10
42%
-100
- C5 -
3I81
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---
E
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
76
PsiBlast_CBE
73.08
42%
-99
- C5 -
3IK3
1
ABL1_MOUSE
A:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
29
PsiBlast_CBE
73.03
45%
-109
- C5 -
3F66
4
MET_HUMAN
A:
[27-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
72.86
42%
-93
- C5 -
3KFA
1
ABL1_MOUSE
A:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
79
PsiBlast_CBE
72.84
42%
-95
- C5 -
3OY3
1
ABL1_MOUSE
A:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
37
PsiBlast_CBE
72.83
45%
-118
- C5 -
2RFN
1
B:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
----
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
72.78
41%
-96
- C5 -
2OJ9
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
----------
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
32
PsiBlast_CBE
72.78
45%
-114
- C5 -
3EFJ
1
B:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.77
45%
-110
- C5 -
4DEH
1
A:
[31-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
-------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-------
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.75
45%
-106
- C5 -
3RHK
1
MET_HUMAN
A:
[50-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
72.65
42%
-96
- C5 -
3QQU
1
IGF1R_HUMAN
B:
[9-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-------------
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
45
PsiBlast_CBE
72.54
45%
-110
- C5 -
2WGJ
1
A:
[29-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-----------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
72.44
44%
-114
- C5 -
3QTI
1
MET_HUMAN
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
-----------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
---
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.34
45%
-112
- C5 -
3CD8
1
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
-------------
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
------------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
72.31
45%
-113
- C5 -
3CCN
1
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
-------------
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
72.26
42%
-93
- C5 -
3KFA
1
ABL1_MOUSE
B:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
82
PsiBlast_CBE
72.23
42%
-101
- C5 -
3MS9
2
ABL1_MOUSE
B:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.13
44%
-116
- C5 -
3QTI
1
B:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-----------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
72.09
44%
-112
- C5 -
3F82
1
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L------------
K
I
H
C
A
V
K
S
L
N
-
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
71.99
42%
-90
- C5 -
2FO0
3
ABL1_HUMAN
A:
[214-487]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
N
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
67
PsiBlast_CBE
71.98
42%
-96
- C5 -
3QQU
1
D:
[9-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
------
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
39
PsiBlast_CBE
71.97
45%
-104
- C5 -
3LQ8
1
A:
[30-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
-----------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
--
D
K
E
Y
--
Y
S------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
71.93
42%
-97
- C5 -
3MS9
2
ABL1_MOUSE
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
87
PsiBlast_CBE
71.86
42%
-93
- C5 -
1OPJ
2
ABL1_MOUSE
B:
[15-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
70
PsiBlast_CBE
71.86
42%
-99
- C5 -
3QQU
1
IGF1R_HUMAN
A:
[9-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
------------
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
92
PsiBlast_CBE
71.85
42%
-97
- C5 -
1IEP
1
ABL1_MOUSE
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
93
PsiBlast_CBE
71.81
42%
-95
- C5 -
1FPU
1
ABL1_MOUSE
B:
[15-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
73
PsiBlast_CBE
71.79
42%
-112
- C5 -
3LVP
2
IGF1R_HUMAN
A:
[44-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
-
E
--
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-----------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
27
PsiBlast_CBE
71.67
45%
-107
- C5 -
3RHK
1
B:
[50-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.62
42%
-94
- C5 -
3OY3
1
ABL1_MOUSE
B:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
72
PsiBlast_CBE
71.62
44%
-114
- C5 -
1R0P
1
A:
[30-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
-----------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
DS
V
--
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
71.59
42%
-94
- C5 -
3K5V
2
ABL1_MOUSE
A:
[15-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
-
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
18
PsiBlast_PDB
71.47
45%
-112
- C5 -
4DEG
1
A:
[31-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
-------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
71.43
45%
-107
- C5 -
3ZXZ
1
A:
[29-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-----------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
71.40
42%
-90
- C5 -
3DKC
1
A:
[33-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
D
S
V
--
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
G
-------------------------------------------------------------------
15
PsiBlast_PDB
71.40
45%
-112
- C5 -
3I5N
1
A:
[31-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-----
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.37
45%
-104
- C5 -
3ZZE
1
A:
[29-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
71.13
45%
-107
- C5 -
4AOI
1
A:
[29-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-----------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
71.01
45%
-105
- C5 -
2WKM
1
A:
[29-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
128
HHSearch
70.98
38%
-99
- C5 -
1QCF
1
HCK_HUMAN
A:
[181-445]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
--
K
L
--
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
-
Y
-
N
---
K
-------
H
T
K
V
A
V
K
T
M
K
P
G
S
---
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
---------
K
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
--
K
S
D
E
------
G
S
K
Q
P
L
-
P
K
--
L
I
D
F
S
A
-
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
-----
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
E
------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.96
45%
-111
- C5 -
4DEI
1
A:
[31-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
-----------
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
70.85
44%
-111
- C5 -
3A4P
3
A:
[37-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
----------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
------------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
70.84
44%
-111
- C5 -
3L8V
1
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
70.80
42%
-87
- C5 -
1OPJ
2
ABL1_MOUSE
A:
[15-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
36
PsiBlast_CBE
70.75
45%
-110
- C5 -
2RFS
1
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
-------------
K
I
H
C
A
V
K
S
L
N
-----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
-----------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
70.67
45%
-107
- C5 -
4AP7
1
A:
[29-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-----------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
70.47
42%
-96
- C5 -
3QQU
1
IGF1R_HUMAN
C:
[9-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
K
I
--
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
---
D
E
-
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
-----
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
28
PsiBlast_CBE
70.46
45%
-111
- C5 -
3F66
3
B:
[27-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-----------
K
K
I
H
C
A
V
K
S
L
N
-------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
70.45
44%
-115
- C5 -
3CE3
1
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
70.43
42%
-97
- C5 -
1IEP
1
ABL1_MOUSE
B:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
59
PsiBlast_CBE
70.25
44%
-115
- C5 -
3CTH
1
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
70.21
42%
-95
- C5 -
1FPU
1
ABL1_MOUSE
A:
[15-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
--
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
---
Y
S
---
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
-
N
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.23
61%
-108
- C5 -
4FF8
1
A:
[80-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
D
H
P
H
V
A
K
L
V
-------------------
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-
I
--------
P
L
-
Q
T
--
L
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
---------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
--
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
----------------------------------------------------------------------------------------
58
PsiBlast_CBE
68.72
44%
-118
- C5 -
3CTJ
1
A:
[32-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.24
45%
-104
- C5 -
4GG7
1
A:
[51-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.39
45%
-105
- C5 -
4GG5
1
A:
[51-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
---
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
----
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
----------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
Add PDB User Result:
(49 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
135
-
100%
-105
- C5 -
U135
1
A:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
--
L
K
V
A
V
K
T
M
K
I
------
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
----
E
R
E
--
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
S
R
L
G
D
Q
P
V
---
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
L
S
-
K
I
Y
N
G
D
Y
Y
R
Q
G
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
136
-
100%
-105
- C5 -
U136
1
A:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
--
L
K
V
A
V
K
T
M
K
I
------
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
----
E
R
E
--
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
S
R
L
G
D
Q
P
V
---
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
L
S
-
K
I
Y
N
G
D
Y
Y
R
Q
G
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
137
-
99%
-112
- C5 -
U137
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
----
A
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
---------
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
L
S
K
K
--
N
G
D
Y
Y
-----
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
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E
I
Y
D
Y
L
R
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R
L
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A
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L
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A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
138
-
100%
-122
- C5 -
U138
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
-
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
139
-
100%
-121
- C5 -
U139
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
-
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
140
-
100%
-122
- C5 -
U140
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
-
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
141
-
99%
-120
- C5 -
U141
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
-----
I
L
K
V
A
V
K
T
M
K
-----
A
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
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V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
-----------------
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
142
-
99%
-112
- C5 -
U142
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
----
A
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
---------
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
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Y
L
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I
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L
A
A
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C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
L
S
K
K
--
N
G
D
Y
Y
-----
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
143
-
100%
-119
- C5 -
U143
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
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I
L
K
V
A
V
K
T
M
K
-
A
I
C
T
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E
L
E
D
F
L
S
E
A
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M
K
E
F
D
H
P
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V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
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Q
M
L
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F
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A
D
I
A
S
G
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F
I
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D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
------------
Q
G
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
144
-
100%
-121
- C5 -
U144
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
-
A
I
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T
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S
E
L
E
D
F
L
S
E
A
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C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
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V
Y
L
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T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
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T
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I
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D
L
A
A
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N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
------------------
M
P
V
K
W
I
A
I
E
S
L
A
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R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
145
-
99%
-120
- C5 -
U145
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
-----
I
L
K
V
A
V
K
T
M
K
-----
A
S
E
L
E
D
F
L
S
E
A
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C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
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F
L
------
D
Q
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Y
L
P
T
Q
M
L
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A
D
I
A
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D
L
A
A
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L
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N
M
S
V
C
V
A
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F
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-----------------
K
M
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W
I
A
I
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S
L
A
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K
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W
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Y
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E
I
Y
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Y
L
R
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G
N
R
L
K
Q
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A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
146
-
100%
-101
- C5 -
U146
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
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N
Q
D
D
--
L
K
V
A
V
K
T
M
K
I
A
I
C
---
E
L
E
D
F
L
S
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A
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C
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V
M
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I
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----
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E
--
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A
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V
I
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--
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L
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---
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-
K
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L
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R
E
D
L
E
N
T
L
K
A
L
P
P
A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
147
-
100%
-121
- C5 -
U147
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
-----
I
L
K
V
A
V
K
T
M
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-----
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
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F
D
H
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V
M
R
L
I
G
V
C
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---------
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
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Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
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G
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L
A
A
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N
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M
L
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M
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V
C
V
A
D
F
G
L
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K
K
I
Y
N
G
D
Y
Y
R
--
R
I
A
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P
V
K
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I
A
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A
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Y
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W
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S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
148
-
99%
-119
- C5 -
U148
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
-----
I
L
K
V
A
V
K
T
M
K
----
A
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S
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L
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D
F
L
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V
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M
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N
V
M
R
L
I
G
V
C
----------
A
P
V
V
I
L
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F
M
K
H
G
D
L
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F
L
------
D
Q
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L
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F
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A
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A
A
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N
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M
L
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K
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Y
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R
-
G
R
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Y
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A
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S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
149
-
99%
-120
- C5 -
U149
1
A:
[528-809]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
M
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
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M
E
G
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L
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Q
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--
I
L
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A
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M
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I
A
I
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---
E
L
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L
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A
V
C
M
K
E
F
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M
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L
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------
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V
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L
H
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F
L
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----
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M
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V
C
V
A
D
F
G
L
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K
K
I
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-
G
D
Y
Y
R
Q
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L
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L
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P
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F
T
E
L
R
E
D
L
E
N
T
L
K
A
-------------------------------------------------------------------------------------
150
-
100%
-106
- C5 -
U150
1
A:
[531-808]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
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L
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V
A
V
K
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A
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T
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L
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-
F
L
S
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A
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C
M
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V
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G
V
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F
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------
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V
I
L
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L
H
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F
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L
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A
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L
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M
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V
C
V
A
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G
L
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K
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D
Y
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D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
--------------------------------------------------------------------------------------
151
-
100%
-106
- C5 -
U151
1
A:
[531-808]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
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L
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V
A
V
K
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A
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T
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-
F
L
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A
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C
M
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V
M
R
L
I
G
V
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F
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------
A
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V
I
L
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H
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L
H
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F
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A
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V
C
V
A
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F
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L
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K
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N
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D
Y
Y
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---
K
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K
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A
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R
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F
T
E
L
R
E
D
L
E
N
T
L
K
--------------------------------------------------------------------------------------
152
-
100%
-123
- C5 -
U152
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
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-
I
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V
M
R
L
I
G
V
C
F
Q
G
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-----
P
A
P
V
V
I
L
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F
M
K
H
G
D
L
H
S
F
L
L
Y
-----
Q
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Y
L
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T
Q
M
L
V
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F
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A
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A
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A
A
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N
C
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L
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N
M
S
V
C
V
A
D
F
-------------------
M
P
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K
W
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A
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L
A
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L
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D
L
E
N
T
L
K
A
L
P
P
----------------------------------------------------------------------------------
153
-
100%
-123
- C5 -
U153
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
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V
M
V
D
R
H
K
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C
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-----
P
A
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V
V
I
L
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L
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F
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-----
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A
A
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L
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V
C
V
A
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-------------------
M
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N
T
L
K
A
L
P
P
----------------------------------------------------------------------------------
154
-
100%
-106
- C5 -
U154
1
A:
[531-808]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
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G
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F
G
A
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-
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V
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R
L
I
G
V
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F
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------
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---
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L
E
N
T
L
K
--------------------------------------------------------------------------------------
155
-
100%
-123
- C5 -
U155
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
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V
M
V
D
R
H
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-----
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L
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-----
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-------------------
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A
L
P
P
----------------------------------------------------------------------------------
156
-
100%
-101
- C5 -
U156
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
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V
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L
G
K
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A
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---
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----
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Q
E
P
D
E
I
L
--------------------------------------------------------------------------
157
-
99%
-120
- C5 -
U157
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
-----
I
L
K
V
A
V
K
T
M
K
-----
A
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
-----------------
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
158
-
100%
-101
- C5 -
U158
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
--
L
K
V
A
V
K
T
M
K
I
A
I
C
---
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
----
E
R
E
--
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
S
R
L
G
D
Q
P
V
---
T
Q
M
L
V
K
F
M
A
D
I
A
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G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
L
S
-
K
I
Y
N
G
D
Y
Y
R
Q
G
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
159
-
99%
-112
- C5 -
U159
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
----
A
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
---------
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
L
S
K
K
--
N
G
D
Y
Y
-----
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
160
-
100%
-101
- C5 -
U160
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
--
L
K
V
A
V
K
T
M
K
I
A
I
C
---
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
----
E
R
E
--
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
S
R
L
G
D
Q
P
V
---
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
L
S
-
K
I
Y
N
G
D
Y
Y
R
Q
G
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
161
-
100%
-123
- C5 -
U161
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
I
-
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
G
S
-----
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
-----
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
-------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
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W
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F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
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E
I
Y
D
Y
L
R
Q
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N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
----------------------------------------------------------------------------------
162
-
100%
-101
- C5 -
U162
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
--
L
K
V
A
V
K
T
M
K
I
A
I
C
---
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
----
E
R
E
--
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
S
R
L
G
D
Q
P
V
---
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
L
S
-
K
I
Y
N
G
D
Y
Y
R
Q
G
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
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F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
163
-
99%
-120
- C5 -
U163
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
-----
I
L
K
V
A
V
K
T
M
K
-----
A
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
-----
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
------
D
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
G
-----------------
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
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F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
164
-
100%
-123
- C5 -
U164
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
I
-
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
G
S
-----
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
-----
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
-------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
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L
D
G
L
Y
A
L
M
S
R
C
W
E
L
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P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
----------------------------------------------------------------------------------
165
-
100%
-123
- C5 -
U165
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
S
I
L
K
V
A
V
K
T
M
K
I
-
I
C
T
R
S
E
L
E
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F
L
S
E
A
V
C
M
K
E
F
D
H
P
N
V
M
R
L
I
G
V
C
F
Q
G
S
-----
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
-----
Q
P
V
Y
L
P
T
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
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L
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T
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F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
M
S
V
C
V
A
D
F
-------------------
M
P
V
K
W
I
A
I
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S
L
A
D
R
V
Y
T
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K
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F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
----------------------------------------------------------------------------------
166
-
100%
-101
- C5 -
U166
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
N
Q
D
D
--
L
K
V
A
V
K
T
M
K
I
A
I
C
---
E
L
E
D
F
L
S
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A
V
C
M
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F
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V
M
R
L
I
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----
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E
--
P
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V
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L
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M
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F
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--
S
R
L
G
D
Q
P
V
---
T
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M
L
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F
M
A
D
I
A
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G
M
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Y
L
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H
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L
A
A
R
N
C
M
L
N
E
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M
S
V
C
V
A
D
F
G
L
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-
K
I
Y
N
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Y
R
Q
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A
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V
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Y
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Y
L
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L
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L
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E
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L
E
N
T
L
K
A
L
P
P
A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
167
-
100%
-123
- C5 -
U167
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
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A
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-
I
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V
M
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L
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-----
P
A
P
V
V
I
L
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F
M
K
H
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D
L
H
S
F
L
L
Y
-----
Q
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Y
L
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Q
M
L
V
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F
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A
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I
A
S
G
M
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L
A
A
R
N
C
M
L
N
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M
S
V
C
V
A
D
F
-------------------
M
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F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
----------------------------------------------------------------------------------
168
-
100%
-123
- C5 -
U168
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
V
A
L
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L
I
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V
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F
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-----
P
A
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V
V
I
L
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F
M
K
H
G
D
L
H
S
F
L
L
Y
-----
Q
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Y
L
P
T
Q
M
L
V
K
F
M
A
D
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A
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L
A
A
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C
M
L
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M
S
V
C
V
A
D
F
-------------------
M
P
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K
W
I
A
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L
A
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L
E
N
T
L
K
A
L
P
P
----------------------------------------------------------------------------------
169
-
99%
-120
- C5 -
U169
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
-----
I
L
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M
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-----
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L
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A
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L
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V
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-----
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F
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A
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V
V
I
L
P
F
M
K
H
G
D
L
H
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F
L
------
D
Q
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Y
L
P
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Q
M
L
V
K
F
M
A
D
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V
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A
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F
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-----------------
K
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A
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S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
170
-
100%
-101
- C5 -
U170
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
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D
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--
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---
E
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----
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---
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L
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A
L
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A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
171
-
99%
-120
- C5 -
U171
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
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M
E
G
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-----
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-----
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-----
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------
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-----------------
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P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
172
-
100%
-119
- C5 -
U172
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
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F
G
A
V
M
E
G
Q
L
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-----
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------
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------------
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P
Q
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P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
173
-
100%
-122
- C5 -
U173
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
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K
T
L
G
E
G
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F
G
A
V
M
E
G
Q
L
N
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-----
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------
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A
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A
A
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M
L
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N
M
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V
C
V
A
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F
--------------------
P
V
K
W
I
A
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F
T
E
L
-----------------------------------------------------------------------------------------------
174
-
100%
-123
- C5 -
U174
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
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E
L
K
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K
L
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V
M
V
D
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H
K
V
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-----
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L
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L
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-----
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L
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S
V
C
V
A
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-------------------
M
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T
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L
R
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D
L
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T
L
K
A
L
P
P
----------------------------------------------------------------------------------
175
-
100%
-101
- C5 -
U175
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
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V
A
L
G
K
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L
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G
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G
A
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--
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---
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N
T
L
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A
L
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P
A
Q
E
P
D
E
I
L
--------------------------------------------------------------------------
176
-
99%
-120
- C5 -
U176
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
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Q
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-----
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-----
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-----
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------
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-----------------
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N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
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A
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C
L
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G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
177
-
99%
-116
- C5 -
U177
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
L
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----
I
L
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-
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L
I
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-----
S
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A
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V
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------
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A
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F
T
E
L
-----------------------------------------------------------------------------------------------
178
-
100%
-101
- C5 -
U178
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
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V
A
L
G
K
T
L
G
E
G
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F
G
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M
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D
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--
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---
E
L
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---
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A
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A
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P
D
E
I
L
--------------------------------------------------------------------------
179
-
100%
-125
- C5 -
U179
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
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F
G
A
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M
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G
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-----
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------
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P
S
F
T
E
L
-----------------------------------------------------------------------------------------------
180
-
99%
-116
- C5 -
U180
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
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F
G
A
V
M
E
G
Q
L
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----
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A
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-
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-----
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------
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F
T
E
L
-----------------------------------------------------------------------------------------------
181
-
100%
-123
- C5 -
U181
1
A:
[517-812]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
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L
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V
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-----
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L
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F
L
L
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-----
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V
C
V
A
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-------------------
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A
L
P
P
----------------------------------------------------------------------------------
182
-
100%
-101
- C5 -
U182
1
B:
[531-820]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
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V
A
L
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K
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G
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G
A
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D
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--
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---
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----
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A
L
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P
A
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E
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D
E
I
L
--------------------------------------------------------------------------
183
-
100%
-125
- C5 -
U183
1
A:
[536-799]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
G
K
T
L
G
E
G
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F
G
A
V
M
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G
Q
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-----
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A
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V
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------
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V
C
V
A
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-------------------
M
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F
T
E
L
-----------------------------------------------------------------------------------------------