@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : VGFR2_HUMAN: (2013-07-25 )
MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
Atome Classification :
(88 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.....-..840.......850.......860....--.....870......-.880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLG-KPLGRGAFGQVIEADAFGIDKTA--TCRT--VAVKMLKEGATHSE-HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
127
HHSearch
93.25
100%
-110
- C4 -
3VHE
1
A:
[1-359]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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G
-
K
P
L
G
R
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A
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G
Q
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I
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A
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A
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G
I
D
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T
A
--
T
C
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--
V
A
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E
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A
T
H
S
E
-
H
R
A
L
M
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E
L
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I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
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K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
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A
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M
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A
A
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N
I
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F
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A
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--
A
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C
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P
S
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R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.16
100%
-124
- C4 -
1Y6B
1
A:
[14-363]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
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P
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-
K
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--
G
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A
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A
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--
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--
V
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--
A
T
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S
E
-
H
R
A
L
M
S
E
L
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I
L
I
H
I
G
H
H
L
N
V
V
N
L
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G
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C
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K
P
G
G
P
L
M
V
I
V
E
F
C
K
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L
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T
Y
L
R
S
K
R
N
E
F
V
P
Y
------------------------------------------------------------
F
L
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L
E
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M
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A
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D
L
A
A
R
N
I
L
L
S
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K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
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E
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Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.80
99%
-105
- C4 -
3VHK
2
A:
[11-365]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
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L
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-
K
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L
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A
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E
A
D
A
F
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A
--
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--
V
A
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M
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S
E
-
H
R
A
L
M
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E
L
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I
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H
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N
L
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K
--------------------------------------------------------
Y
K
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I
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V
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--
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N
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A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.80
100%
-125
- C4 -
1Y6A
1
A:
[15-362]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
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-
K
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----
Q
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----
T
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-
H
R
A
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-----------------------------------------------------------
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M
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A
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D
Y
T
T
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G
E
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N
L
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Q
A
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
87.80
100%
-113
- C4 -
2XIR
1
A:
[11-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
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-
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---------------------------------------------------------
Y
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N
L
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A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
87.62
73%
-105
- C4 -
3HNG
1
A:
[5-360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
L
D
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Q
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-
P
Y
D
A
S
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W
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--
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Y
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A
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----------------------------------------------------------------
K
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N
N
V
V
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E
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L
G
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
86.64
85%
-112
- C4 -
3EWH
2
A:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
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W
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R
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K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-----
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.84
85%
-109
- C4 -
3U6J
1
A:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
--
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
85.77
84%
-114
- C4 -
3BE2
1
A:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-----
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.68
86%
-108
- C4 -
4ASD
1
A:
[39-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
E
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.53
84%
-118
- C4 -
2P2H
1
A:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
---------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
85.44
84%
-122
- C4 -
3B8R
2
VGFR2_HUMAN
A:
[4-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
85.35
84%
-123
- C4 -
3CPB
1
VGFR2_HUMAN
A:
[5-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
85.32
84%
-113
- C4 -
2RL5
1
A:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
--------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.26
86%
-108
- C4 -
3VNT
4
A:
[9-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
85.22
84%
-117
- C4 -
2P2I
1
VGFR2_HUMAN
A:
[3-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-----
T
C
R
T
--
V
A
V
K
M
L
----
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
85.20
84%
-118
- C4 -
3CP9
1
VGFR2_HUMAN
A:
[3-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
85.09
84%
-121
- C4 -
3CPC
1
VGFR2_HUMAN
A:
[6-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.07
86%
-111
- C4 -
3VO3
2
A:
[9-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
84.97
84%
-116
- C4 -
2QU5
1
A:
[2-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
-------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
84.94
84%
-117
- C4 -
3B8Q
1
VGFR2_HUMAN
A:
[4-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
84.92
84%
-112
- C4 -
3EFL
1
VGFR2_HUMAN
A:
[3-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
-----
T
C
R
T
--
V
A
V
K
M
L
K
E
--
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.90
84%
-113
- C4 -
3DTW
1
VGFR2_HUMAN
A:
[4-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
----
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.82
86%
-110
- C4 -
4AG8
1
A:
[11-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.60
84%
-128
- C4 -
2P2I
1
B:
[6-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
----
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
-----------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
84.35
84%
-124
- C4 -
3B8R
1
B:
[7-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
83.74
84%
-126
- C4 -
2QU6
1
B:
[8-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
-------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
83.63
84%
-119
- C4 -
3B8Q
1
B:
[6-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
83.31
84%
-121
- C4 -
3CP9
1
B:
[5-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
--------------------------------------------------------
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
82.87
84%
-123
- C4 -
3CPC
1
B:
[6-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
----------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.56
84%
-124
- C4 -
3EFL
1
B:
[7-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
-----------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
81.78
84%
-122
- C4 -
3CPB
1
B:
[6-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
C
R
T
--
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
---------------------------------------------------------
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
74.28
48%
-98
- C4 -
3RI1
1
?
A:
[13-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
------------------------------------------------------
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
74.20
50%
-101
- C4 -
4HVS
1
A:
[34-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
-
H
K
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
D
--
A
A
M
T
--
V
A
V
K
M
L
K
P
S
A
H
S
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
-------------------------------
D
S
F
H
S
S
D
T
S
P
A
S
----------
M
E
D
D
E
-------
N
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
73.66
48%
-100
- C4 -
3C4F
1
FGFR1_HUMAN
A:
[2-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
-------------
A
R
R
P
P
---------------------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
73.40
48%
-95
- C4 -
3RHX
5
FGFR1_HUMAN
A:
[6-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------------------------------------
E
E
Q
------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
73.39
48%
-99
- C4 -
3B2T
1
FGFR2_HUMAN
A:
[11-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
---PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-------------------------------------------------------
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
73.32
48%
-98
- C4 -
2PY3
1
FGFR2_HUMAN
A:
[24-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
73.30
48%
-99
- C4 -
3C4F
1
B:
[2-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
TK
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
-------------
A
R
R
P
P
---------------------------------------------
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.30
48%
-91
- C4 -
1FGI
1
FGFR1_HUMAN
A:
[10-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------------------------------------------
E
E
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
73.13
48%
-107
- C4 -
3GQL
1
C:
[17-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
-------------
A
R
R
P
P
----------------------------------------------
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
73.11
46%
-101
- C4 -
4HW7
1
A:
[36-338]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
L
P
Y
N
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
D
--
A
V
L
K
--
V
A
V
K
M
L
K
S
T
A
H
A
D
E
-
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
E
A
M
L
-----
G
P
S
---------------------------------------------
G
R
P
-------
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
----
S
F
L
Q
E
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
72.93
48%
-86
- C4 -
3JS2
1
B:
[17-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------------------------------------------
E
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
72.86
48%
-93
- C4 -
2PWL
1
FGFR2_HUMAN
B:
[24-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
-----------------------------------------------------
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
72.81
43%
-103
- C4 -
2IVS
5
RET_HUMAN
A:
[17-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
K
N
L
V
L
G
-
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
R
A
--
G
Y
T
T
--
V
A
V
K
M
L
K
E
N
A
S
P
S
E
-
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-------------
K
V
G
P
G
Y
L
-------------------------------------
R
A
--------
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
72.80
48%
-95
- C4 -
3RI1
1
FGFR2_HUMAN
B:
[13-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
---PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
------------------------------------------------------
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
72.79
48%
-99
- C4 -
3B2T
1
B:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
--
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-------------------------------------------------------
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.77
49%
-100
- C4 -
2PZP
1
FGFR2_HUMAN
A:
[24-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
E
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
72.70
49%
-96
- C4 -
2PZP
1
B:
[24-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
E
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
----------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
72.69
44%
-98
- C4 -
2I1M
1
A:
[30-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
T
Q
L
P
Y
N
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
D
--
A
V
L
K
--
V
A
V
K
M
L
K
S
T
A
H
A
D
E
-
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
-------------------------------
L
R
R
K
---------------------
S
R
V
L
E
T
D
-------
S
T
A
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
D
R
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
72.69
48%
-96
- C4 -
3GQL
1
FGFR1_HUMAN
A:
[17-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
-------------
A
R
R
P
P
----------------------------------------------
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
72.65
47%
-87
- C4 -
1T46
1
A:
[5-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
D
P
T
Q
L
P
Y
D
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
D
--
A
A
M
T
--
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
-------------------------------
R
K
R
D
S
F
--------------
L
A
L
D
L
E
D
L
L
S
-----------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
72.54
48%
-97
- C4 -
2PZ5
1
FGFR2_HUMAN
A:
[24-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
72.54
48%
-97
- C4 -
2PZ5
1
B:
[24-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
------------------------------------------------------
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
72.47
49%
-96
- C4 -
2Q0B
1
B:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-----------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
72.39
48%
-97
- C4 -
4F65
6
FGFR1_HUMAN
A:
[9-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
--
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-------------------------------------------
P
E
E
Q
------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
72.25
49%
-101
- C4 -
2PZR
1
FGFR2_HUMAN
A:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-----------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
72.19
49%
-101
- C4 -
2Q0B
1
FGFR2_HUMAN
A:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
72.13
48%
-97
- C4 -
1FGI
1
B:
[10-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------------------------------------
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
72.03
48%
-83
- C4 -
3JS2
1
FGFR1_HUMAN
A:
[17-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
---------------------------------
H
N
P
--------------
E
E
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
71.99
49%
-99
- C4 -
2PZR
1
B:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-----------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
71.94
44%
-99
- C4 -
2I0V
1
A:
[30-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
T
Q
L
P
Y
N
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
D
--
A
V
L
K
--
V
A
V
K
M
L
K
S
T
A
H
A
D
E
-
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
--------------------------------------------------
F
L
R
R
K
R
----------------
Q
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
71.91
50%
-105
- C4 -
2PVY
1
?
D:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
--------------------------------------------------
V
P
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
71.88
48%
-95
- C4 -
1AGW
1
FGFR1_HUMAN
A:
[10-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------------------------------------------
E
E
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
71.82
48%
-98
- C4 -
4F64
3
FGFR1_HUMAN
A:
[9-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------------------------------------
E
E
Q
------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
71.81
48%
-94
- C4 -
2PY3
1
B:
[24-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
----------------------------------------------------
E
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
71.63
48%
-97
- C4 -
3RHX
2
B:
[6-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------------------
Q
------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
71.47
48%
-95
- C4 -
4F65
4
B:
[9-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
-----
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-----------------------------------------------
Q
------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
71.27
48%
-96
- C4 -
4F63
3
FGFR1_HUMAN
A:
[9-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------------------------------------
E
E
Q
------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
71.24
48%
-100
- C4 -
3GQL
1
FGFR1_HUMAN
B:
[17-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
-------------
A
R
R
P
P
--------------------------------------------
P
E
E
Q
----
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
71.20
48%
-96
- C4 -
2FGI
1
FGFR1_HUMAN
A:
[10-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------------------------------------------
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-
D
I
H
H
I
D
Y
Y
K
K
T
-
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.10
48%
-95
- C4 -
3TT0
4
B:
[58-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------------------------------------
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
70.89
48%
-98
- C4 -
4F64
3
B:
[9-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
TK
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------------------
Q
------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
70.77
48%
-91
- C4 -
2PWL
1
FGFR2_HUMAN
A:
[24-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
PK
E
A
V
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------------------------------------------------
E
Q
---------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
70.73
48%
-97
- C4 -
1AGW
1
B:
[10-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------------------------------------
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
70.70
48%
-95
- C4 -
2FGI
1
B:
[10-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------------------------------------
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
70.66
48%
-99
- C4 -
4F63
3
B:
[9-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------------------
Q
------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
70.60
46%
-88
- C4 -
3G0F
1
KIT_HUMAN
A:
[28-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
D
P
T
Q
L
P
Y
D
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
D
--
A
A
M
T
--
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
-------------------------------
R
K
R
D
S
F
----------------
L
D
L
E
D
L
L
S
-----------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
69.73
46%
-87
- C4 -
3G0F
1
B:
[28-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
D
P
T
Q
L
P
Y
D
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
D
--
A
A
M
T
--
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
-------------------------------
R
K
R
D
S
F
----------------
L
D
L
E
D
L
L
S
-----------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
69.69
47%
-85
- C4 -
3G0E
1
A:
[28-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
D
P
T
Q
L
P
Y
D
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
D
--
A
A
M
T
--
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
-------------------------------
R
K
R
D
S
F
I
C
S
K
T
S
P
A
I
M
E
D
D
E
L
A
L
D
L
E
D
L
L
S
-----------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
69.58
40%
-104
- C4 -
4AOJ
1
NTRK1_HUMAN
A:
[33-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-----
K
M
L
--
V
A
V
K
A
L
K
E
-
A
S
E
S
A
-
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
--------------------------------------------------------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
69.50
48%
-76
- C4 -
3TT0
1
FGFR1_HUMAN
A:
[58-358]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
--------------------------
S
Y
N
P
S
H
N
P
--------------
E
E
Q
L
S
S
K
D
L
----------
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
66.01
37%
-99
- C4 -
4FYO
1
A:
[11-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
---
Q
M
K
K
--
V
V
K
T
--
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
------------------------------------------------------------------
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
64.16
31%
-86
- C4 -
3LVP
2
IGF1R_HUMAN
A:
[39-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
--
P
E
T
R
--
V
A
I
K
T
V
N
E
A
A
S
M
R
E
-
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
--------------------
T
R
G
---------------
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
--
P
V
--------------
L
A
P
P
S
L
S
K
-------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
62.54
35%
-86
- C4 -
3L8P
1
A:
[17-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
F
Q
-
D
V
I
G
E
G
N
F
G
Q
V
L
K
A
R
---
I
K
K
D
G
--
L
R
M
D
--
A
A
I
K
R
M
------------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
R
G
-
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
---------------------
V
L
E
T
D
-----
P
A
F
A
I
A
N
S
T
A
S
T
------------------------
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
---
Q
E
V
Y
V
K
K
-----
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
61.05
83%
-12
- C4 -
3CJG
1
A:
[11-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
N
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
--
T
-
R
T
--
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
------------------------------------------
F
V
P
Y
K
------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
--------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
59.62
34%
-81
- C4 -
2WQB
1
A:
[24-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
F
Q
-
D
V
I
G
E
G
--
G
Q
V
L
K
A
R
---
I
K
K
D
G
--
L
R
M
D
--
A
A
I
K
R
M
K
--------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
R
G
-
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
---------------------
V
L
E
T
D
-----
P
A
F
A
I
A
N
S
T
A
S
T
------------------------
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
---
Q
E
V
Y
V
K
K
T
-
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
59.53
35%
-84
- C4 -
2OSC
1
A:
[30-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
K
A
R
---
I
--------
M
D
--
A
A
I
K
R
M
K
----
K
D
D
-
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
-----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
---------------------
V
L
E
T
D
-----
P
A
F
A
I
A
N
S
T
A
S
T
------------------------
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
--------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Add PDB User Result:
(86 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
140
-
100%
-110
- C4 -
U140
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
-
100%
-110
- C4 -
U141
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
-
100%
-108
- C4 -
U142
1
A:
[810-1164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
L
D
E
H
C
E
R
-
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
----------------------------------------------------------------
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
-
100%
-110
- C4 -
U143
1
A:
[816-1168]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
-
100%
-110
- C4 -
U144
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
-
100%
-110
- C4 -
U145
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
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L
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L
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------------------------------------------------------
D
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
-
100%
-110
- C4 -
U146
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
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H
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L
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P
Y
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------------------------------------------------------
D
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
-
100%
-110
- C4 -
U147
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
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H
C
E
R
L
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V
P
Y
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------------------------------------------------------
D
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L
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
-
100%
-110
- C4 -
U148
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
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H
C
E
R
L
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------------------------------------------------------
D
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L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
-
100%
-110
- C4 -
U149
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
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H
C
E
R
L
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------------------------------------------------------
D
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
-
100%
-110
- C4 -
U150
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
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H
C
E
R
L
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P
Y
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------------------------------------------------------
D
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E
H
L
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N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
-
100%
-110
- C4 -
U151
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
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N
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F
V
P
Y
K
------------------------------------------------------
D
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E
H
L
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N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
-
100%
-110
- C4 -
U152
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
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Y
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N
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F
V
P
Y
K
------------------------------------------------------
D
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
-
100%
-110
- C4 -
U153
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
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H
C
E
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L
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N
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F
V
P
Y
K
------------------------------------------------------
D
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A
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E
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L
A
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A
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I
L
L
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K
N
V
V
K
I
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F
G
L
A
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I
Y
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D
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Y
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--
A
R
L
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L
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A
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I
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V
Y
T
I
Q
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V
W
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L
L
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L
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A
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Y
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K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
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D
Y
T
T
P
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M
Y
Q
T
M
L
D
C
W
H
G
E
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S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
-
100%
-110
- C4 -
U154
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
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L
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A
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A
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L
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I
L
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C
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F
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L
S
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Y
L
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
Y
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D
F
L
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L
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A
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--
A
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L
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L
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A
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R
L
K
E
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R
M
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A
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T
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M
Y
Q
T
M
L
D
C
W
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R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
-
100%
-110
- C4 -
U155
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
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A
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A
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L
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H
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A
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C
K
F
G
N
L
S
T
Y
L
R
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K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
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D
F
L
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L
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Y
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F
Q
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A
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--
A
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L
L
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R
L
K
E
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R
M
R
A
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M
Y
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M
L
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P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
-
100%
-110
- C4 -
U156
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
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C
K
F
G
N
L
S
T
Y
L
R
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K
R
N
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F
V
P
Y
K
------------------------------------------------------
D
L
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L
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L
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Y
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F
Q
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A
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A
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V
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--
A
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M
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T
M
L
D
C
W
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P
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R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
-
100%
-110
- C4 -
U157
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
P
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L
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K
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
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L
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A
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--
A
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M
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P
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F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
-
100%
-110
- C4 -
U158
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
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A
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A
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L
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
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L
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A
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--
A
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A
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M
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F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
-
100%
-110
- C4 -
U159
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
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A
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W
E
F
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L
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Y
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K
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
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L
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F
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A
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--
A
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F
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L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
-
100%
-110
- C4 -
U160
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
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R
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A
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Y
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
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A
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--
A
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
-
100%
-110
- C4 -
U161
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
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Y
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A
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W
E
F
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L
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L
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K
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
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--
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V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
-
100%
-120
- C4 -
U162
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
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----
Q
V
I
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A
D
A
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V
A
V
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M
L
K
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A
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V
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L
L
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A
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G
G
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V
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K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
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A
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L
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A
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N
I
L
L
S
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K
N
V
V
K
I
C
D
F
G
L
A
R
---------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
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L
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S
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Y
P
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K
I
D
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C
R
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L
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A
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Y
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M
L
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W
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S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
-
100%
-112
- C4 -
U163
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
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A
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A
F
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---
T
C
R
T
V
A
V
K
M
L
K
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A
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A
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L
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H
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L
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P
G
G
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V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
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A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
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N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
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----
D
P
D
Y
V
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-----
L
P
L
K
W
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A
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I
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D
R
V
Y
T
I
Q
S
D
V
W
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F
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L
L
W
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K
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C
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R
L
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G
T
R
M
R
A
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Y
T
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M
Y
Q
T
M
L
D
C
W
H
G
E
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R
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T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
-
100%
-110
- C4 -
U164
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
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A
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L
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A
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G
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L
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V
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C
K
F
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N
L
S
T
Y
L
R
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K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
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D
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L
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L
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Q
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A
K
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V
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--
A
R
L
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L
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A
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E
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A
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T
T
P
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M
Y
Q
T
M
L
D
C
W
H
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P
S
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R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
-
100%
-110
- C4 -
U165
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
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L
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L
G
K
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L
G
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G
A
F
G
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V
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A
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A
V
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A
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L
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L
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I
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H
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N
L
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A
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C
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F
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N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
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D
F
L
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L
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C
Y
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F
Q
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A
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--
A
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R
A
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Y
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T
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M
Y
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M
L
D
C
W
H
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R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
-
100%
-110
- C4 -
U166
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
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A
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H
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C
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F
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N
L
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Y
L
R
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K
R
N
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F
V
P
Y
K
------------------------------------------------------
D
L
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D
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L
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L
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Y
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A
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L
L
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V
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F
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D
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--
A
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A
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M
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M
L
D
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W
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P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
-
100%
-110
- C4 -
U167
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
P
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L
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L
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L
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C
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F
G
N
L
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T
Y
L
R
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K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
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D
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L
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L
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L
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Y
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F
Q
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A
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L
L
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V
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--
A
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M
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F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
-
100%
-110
- C4 -
U168
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
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Y
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A
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K
W
E
F
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C
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F
G
N
L
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T
Y
L
R
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K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
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D
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L
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L
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L
I
C
Y
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F
Q
V
A
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--
A
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
-
100%
-110
- C4 -
U169
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
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A
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K
W
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F
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L
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Y
L
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K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
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L
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L
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L
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C
Y
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A
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--
A
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
-
100%
-110
- C4 -
U170
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
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A
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W
E
F
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A
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H
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C
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F
G
N
L
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Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
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L
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A
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L
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
-
100%
-110
- C4 -
U171
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
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H
C
E
R
L
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Y
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------------------------------------------------------
D
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L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
-
100%
-110
- C4 -
U172
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
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L
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Y
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--
A
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L
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T
Y
L
R
S
K
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N
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F
V
P
Y
K
T
--------------------------------------------------
A
P
E
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L
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L
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L
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E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
-
100%
-110
- C4 -
U173
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
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A
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F
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N
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F
V
P
Y
K
------------------------------------------------------
D
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--
A
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S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
-
100%
-110
- C4 -
U174
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
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H
C
E
R
L
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A
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F
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P
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------------------------------------------------------
D
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--
A
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
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100%
-120
- C4 -
U175
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
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E
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L
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L
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T
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L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
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D
L
Y
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D
F
L
T
L
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H
L
I
C
Y
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F
Q
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L
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N
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V
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I
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D
F
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L
A
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---------------
L
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L
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H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
-
100%
-110
- C4 -
U176
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
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E
H
C
E
R
L
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F
V
P
Y
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------------------------------------------------------
D
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E
H
L
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N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
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100%
-110
- C4 -
U177
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
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H
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E
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L
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A
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F
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N
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F
V
P
Y
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------------------------------------------------------
D
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--
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
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100%
-115
- C4 -
U178
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
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Y
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A
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D
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---
T
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L
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T
Y
L
R
S
K
R
N
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F
V
P
Y
K
T
--------------------------------------------------
A
P
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D
L
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D
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L
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L
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H
L
I
C
Y
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F
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V
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-------------------
P
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L
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N
L
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N
A
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Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
-
100%
-110
- C4 -
U179
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
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P
Y
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------------------------------------------------------
D
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--
A
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
-
100%
-115
- C4 -
U180
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
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---
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N
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F
V
P
Y
K
T
--------------------------------------------------
A
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L
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-------------------
P
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E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
-
100%
-110
- C4 -
U181
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
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H
C
E
R
L
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Y
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V
P
Y
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------------------------------------------------------
D
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
-
100%
-110
- C4 -
U182
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
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Y
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A
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------------------------------------------------------
D
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A
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
-
100%
-110
- C4 -
U183
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
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K
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------------------------------------------------------
D
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E
H
L
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N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
-
100%
-110
- C4 -
U184
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
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H
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E
R
L
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------------------------------------------------------
D
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E
H
L
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N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
-
100%
-110
- C4 -
U185
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
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H
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E
R
L
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
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E
H
L
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N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
-
100%
-110
- C4 -
U186
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
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A
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------------------------------------------------------
D
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H
L
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L
L
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A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
-
100%
-110
- C4 -
U187
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
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H
C
E
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L
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------------------------------------------------------
D
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L
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N
V
V
K
I
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F
G
L
A
R
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I
Y
K
D
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Y
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--
A
R
L
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L
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A
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V
Y
T
I
Q
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W
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V
L
L
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I
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R
R
L
K
E
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M
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A
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M
L
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W
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R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
-
100%
-110
- C4 -
U188
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
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L
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V
P
Y
K
------------------------------------------------------
D
L
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--
A
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F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
-
100%
-110
- C4 -
U189
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
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L
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T
Y
L
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K
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
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L
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Y
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F
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--
A
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L
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P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
-
100%
-110
- C4 -
U190
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
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A
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L
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L
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T
Y
L
R
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K
R
N
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F
V
P
Y
K
------------------------------------------------------
D
L
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A
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--
A
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L
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L
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A
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P
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F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
-
100%
-112
- C4 -
U191
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
P
R
D
R
L
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---
T
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L
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L
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T
Y
L
R
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K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
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L
E
H
L
I
C
Y
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F
Q
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----
D
P
D
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V
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-----
L
P
L
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A
P
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L
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E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
-
99%
-109
- C4 -
U192
1
A:
[820-1171]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
-
K
W
E
F
P
R
D
R
L
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L
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K
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L
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-
G
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L
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T
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-------------
A
R
F
R
Q
-------------------------------------------------
E
D
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-
R
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E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
-
100%
-110
- C4 -
U193
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
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A
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L
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K
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N
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F
V
P
Y
K
------------------------------------------------------
D
L
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A
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--
A
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F
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E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
-
100%
-110
- C4 -
U194
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
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Y
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A
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K
W
E
F
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A
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L
L
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L
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K
R
N
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F
V
P
Y
K
------------------------------------------------------
D
L
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L
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Q
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A
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A
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
-
100%
-110
- C4 -
U195
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
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K
W
E
F
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R
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A
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H
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L
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Y
L
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K
R
N
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F
V
P
Y
K
------------------------------------------------------
D
L
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--
A
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E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
-
100%
-112
- C4 -
U196
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
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H
R
A
L
M
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L
K
I
L
I
H
I
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N
V
V
N
L
L
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K
P
G
G
P
L
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V
I
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K
F
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N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
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A
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L
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K
C
I
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L
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A
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I
L
L
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E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
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I
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L
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A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
-
100%
-110
- C4 -
U197
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
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L
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L
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G
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G
Q
V
I
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A
V
K
M
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A
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E
L
K
I
L
I
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H
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V
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N
L
L
G
A
C
T
K
P
G
G
P
L
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V
I
V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
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H
L
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C
Y
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F
Q
V
A
K
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M
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F
L
A
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C
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A
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I
L
L
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N
V
V
K
I
C
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F
G
L
A
R
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I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
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L
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W
M
A
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E
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I
F
D
R
V
Y
T
I
Q
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W
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L
L
W
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I
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L
G
A
S
P
Y
P
G
V
K
I
D
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F
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R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
-
100%
-112
- C4 -
U198
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
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---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
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H
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A
L
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I
L
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H
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N
L
L
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A
C
T
K
P
G
G
P
L
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V
I
V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
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N
I
L
L
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E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
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I
F
D
R
V
Y
T
I
Q
S
D
V
W
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L
L
W
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R
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L
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Y
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W
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E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
-
100%
-110
- C4 -
U199
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
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L
G
K
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L
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R
G
A
F
G
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V
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A
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A
F
G
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T
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A
V
K
M
L
K
E
G
A
T
H
S
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H
R
A
L
M
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E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
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V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
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H
L
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C
Y
S
F
Q
V
A
K
G
M
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F
L
A
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L
A
A
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I
L
L
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N
V
V
K
I
C
D
F
G
L
A
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D
I
Y
K
D
P
D
Y
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--
A
R
L
P
L
K
W
M
A
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I
F
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V
Y
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L
L
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A
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K
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A
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M
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P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
-
100%
-110
- C4 -
U200
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
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A
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A
F
G
I
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K
T
A
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R
T
V
A
V
K
M
L
K
E
G
A
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H
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A
L
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L
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I
L
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I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
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H
L
I
C
Y
S
F
Q
V
A
K
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L
A
A
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N
I
L
L
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V
K
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F
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L
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--
A
R
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L
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W
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A
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V
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L
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A
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Y
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M
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C
W
H
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P
S
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R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
-
100%
-123
- C4 -
U201
1
B:
[820-1165]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
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L
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I
L
I
H
I
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H
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V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
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I
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
---------------------------------------------------------
K
D
F
L
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L
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H
L
I
C
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F
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A
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G
M
E
F
L
A
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C
I
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D
L
A
A
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N
I
L
L
S
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K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
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T
I
F
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R
V
Y
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S
D
V
W
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L
L
W
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I
F
S
L
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A
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P
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P
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I
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R
R
L
K
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R
M
R
A
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Y
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Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
-
100%
-124
- C4 -
U202
1
A:
[819-1168]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
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M
L
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--
A
T
H
S
E
H
R
A
L
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L
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I
L
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I
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H
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L
L
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A
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G
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V
I
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
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F
L
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L
A
A
R
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I
L
L
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K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
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A
P
E
T
I
F
D
R
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Y
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L
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T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
-
100%
-110
- C4 -
U203
1
A:
[816-1168]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
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A
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A
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A
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A
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L
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A
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A
L
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L
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L
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H
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H
H
L
N
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V
N
L
L
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A
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P
G
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F
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F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
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L
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L
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A
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L
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A
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F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
-
100%
-110
- C4 -
U204
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
--
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
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L
K
I
L
I
H
I
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H
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N
L
L
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A
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G
G
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L
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V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
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A
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A
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A
A
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I
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A
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L
L
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P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
-
100%
-110
- C4 -
U205
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
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A
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A
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A
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T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
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D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
-
100%
-123
- C4 -
U206
1
B:
[820-1165]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
---------------------------------------------------------
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
-
100%
-110
- C4 -
U207
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
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H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
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K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
-
99%
-109
- C4 -
U208
1
A:
[820-1171]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
-
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
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R
T
V
A
V
K
M
L
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G
A
T
H
S
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H
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A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
-
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
-------------
A
R
F
R
Q
-------------------------------------------------
E
D
L
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
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I
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D
L
A
A
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N
I
L
L
S
E
K
N
V
V
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D
F
G
L
A
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D
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D
A
R
L
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L
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A
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Y
T
I
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S
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V
W
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F
G
V
L
L
W
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I
F
S
L
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A
S
P
Y
P
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V
K
I
D
E
E
F
-
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
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Y
Q
T
M
L
D
C
W
H
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E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
-
100%
-115
- C4 -
U209
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
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L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
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V
L
L
W
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I
F
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L
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A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
-
100%
-110
- C4 -
U210
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
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A
K
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E
F
L
A
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C
I
H
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D
L
A
A
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N
I
L
L
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E
K
N
V
V
K
I
C
D
F
G
L
A
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D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
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L
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W
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A
P
E
T
I
F
D
R
V
Y
T
I
Q
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D
V
W
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F
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V
L
L
W
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I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
-
100%
-112
- C4 -
U211
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
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F
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V
L
L
W
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I
F
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L
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A
S
P
Y
P
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V
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I
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F
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R
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L
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T
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R
A
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Y
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T
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Y
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T
M
L
D
C
W
H
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E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
-
100%
-110
- C4 -
U212
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
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A
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A
F
G
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T
A
T
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R
T
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A
V
K
M
L
K
E
G
A
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H
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H
R
A
L
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E
L
K
I
L
I
H
I
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H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
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H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
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C
I
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L
A
A
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N
I
L
L
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V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
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F
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L
L
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A
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I
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R
L
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E
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R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
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E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
-
100%
-110
- C4 -
U213
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
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H
R
A
L
M
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E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
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L
A
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L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
-
100%
-121
- C4 -
U214
1
B:
[819-1165]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
K
--------------------------------------------------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
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K
C
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L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
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T
I
F
D
R
V
Y
T
I
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S
D
V
W
S
F
G
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L
L
W
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I
F
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L
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A
S
P
Y
P
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V
K
I
D
E
E
F
C
R
R
L
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T
R
M
R
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Y
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T
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W
H
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P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
-
100%
-115
- C4 -
U215
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
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G
A
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A
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L
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V
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N
L
L
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P
G
G
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K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
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F
L
A
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K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
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F
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L
L
W
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S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
-
100%
-110
- C4 -
U216
1
A:
[811-1169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
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L
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F
G
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A
V
K
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L
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L
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H
H
L
N
V
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L
L
G
A
C
T
K
P
G
G
P
L
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V
I
V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
------------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
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A
K
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A
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A
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I
L
L
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K
N
V
V
K
I
C
D
F
G
L
A
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I
Y
K
D
P
D
Y
V
R
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--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
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D
V
W
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F
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V
L
L
W
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I
F
S
L
G
A
S
P
Y
P
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F
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R
R
L
K
E
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T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
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E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
-
100%
-112
- C4 -
U217
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
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H
R
A
L
M
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E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
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F
L
A
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K
C
I
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R
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L
A
A
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I
L
L
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K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
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T
I
F
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R
V
Y
T
I
Q
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D
V
W
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F
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L
L
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L
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A
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M
L
D
C
W
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F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
-
100%
-110
- C4 -
U218
1
A:
[816-1168]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
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L
G
R
G
A
F
G
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A
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A
F
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A
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A
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M
L
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E
G
A
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A
L
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L
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L
I
H
I
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H
H
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V
V
N
L
L
G
A
C
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P
G
G
P
L
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
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F
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A
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C
I
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L
A
A
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N
I
L
L
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K
N
V
V
K
I
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F
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L
A
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D
I
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D
P
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A
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A
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I
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D
R
V
Y
T
I
Q
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D
V
W
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F
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L
L
W
E
I
F
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L
G
A
S
P
Y
P
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V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
-
100%
-110
- C4 -
U219
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
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--
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
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H
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H
R
A
L
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L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
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A
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P
G
G
P
L
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V
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K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
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A
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L
A
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C
I
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L
A
A
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N
I
L
L
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K
N
V
V
K
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D
F
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A
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I
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K
D
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Y
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D
A
R
L
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L
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A
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L
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C
R
R
L
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M
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A
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Y
T
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M
L
D
C
W
H
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E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
-
100%
-115
- C4 -
U220
1
A:
[815-1171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
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L
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I
L
I
H
I
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H
H
L
N
V
V
N
L
L
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A
C
T
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P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
--------------------------------------------------
A
P
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
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F
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L
L
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R
R
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A
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E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
-
99%
-107
- C4 -
U221
1
A:
[808-1168]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
L
P
L
D
E
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
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A
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A
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A
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L
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A
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A
L
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L
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I
L
I
H
I
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H
H
L
N
V
V
N
L
L
G
A
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-
G
G
P
L
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I
V
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F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-----
G
A
R
---------------------------------------------
E
A
P
-------
L
T
L
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H
L
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F
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A
A
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L
L
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A
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A
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T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
N
----
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
-
99%
-107
- C4 -
U222
1
A:
[808-1168]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
L
P
L
D
E
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
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I
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A
D
A
F
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I
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A
T
C
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T
V
A
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L
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A
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A
L
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L
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I
L
I
H
I
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H
H
L
N
V
V
N
L
L
G
A
C
T
K
-
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-----
G
A
R
---------------------------------------------
E
A
P
-------
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
N
----
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
-
99%
-107
- C4 -
U223
1
A:
[808-1168]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
L
P
L
D
E
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
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I
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A
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A
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A
T
C
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T
V
A
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K
M
L
K
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G
A
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H
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H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
-
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-----
G
A
R
---------------------------------------------
E
A
P
-------
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
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F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
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D
F
G
L
A
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D
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K
D
P
D
Y
V
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K
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A
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L
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L
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A
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I
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Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
N
----
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
-
100%
-113
- C4 -
U224
1
A:
[816-1168]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
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L
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A
F
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A
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A
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L
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I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
---------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
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K
N
V
V
K
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F
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L
A
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K
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A
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P
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R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
-
100%
-121
- C4 -
U225
1
B:
[819-1165]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
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E
L
K
I
L
I
H
I
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H
H
L
N
V
V
N
L
L
G
A
C
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P
G
G
P
L
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V
I
V
E
F
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F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
T
K
--------------------------------------------------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
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L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
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T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
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L
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A
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P
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P
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P
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F
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E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------