@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : VGFR3_HUMAN: (2013-07-25 )
MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRRRPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY
Atome Classification :
(95 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840......-.850.......860.......870....--.....880.......-890.......900.......910.......920.......930.......940...-....950.......960.......970.......980.......990.......1000......1010......1020......1030......-1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLG-RVLGYGAFGKVVEASAFGIHKG--SSCD--TVAVKMLKEGATASE-HRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDA-FSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLA-ARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRRRPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY
7
PsiBlast_PDB
92.35
68%
-110
- C5 -
3VHK
2
A:
[11-365]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
K
------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
92.11
69%
-115
- C5 -
3VHE
1
A:
[1-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
K
----------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.94
68%
-125
- C5 -
1Y6B
1
A:
[14-363]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
--
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
----------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.79
66%
-107
- C5 -
3HNG
1
A:
[5-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
L
D
E
Q
C
E
R
-
P
Y
D
A
S
K
W
E
F
A
R
E
R
L
K
L
G
-
K
S
L
G
R
G
A
F
G
K
V
V
Q
A
S
A
F
G
I
K
K
S
--
P
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
-
Y
K
A
L
M
T
E
L
K
I
L
T
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
Q
G
G
P
L
M
V
I
V
E
Y
C
K
Y
G
N
L
S
N
Y
L
K
S
K
R
---------------------------------------------------------------
K
E
P
I
T
M
E
D
L
I
S
Y
S
F
Q
V
A
R
G
M
E
F
L
S
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
N
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
N
P
D
Y
V
R
K
--
T
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
I
Y
S
T
K
S
D
V
W
S
Y
G
V
L
L
W
E
I
F
S
L
G
G
S
P
Y
P
G
V
Q
M
D
E
D
F
C
S
R
L
R
E
G
M
R
M
R
A
P
E
Y
S
T
P
E
I
Y
Q
I
M
L
D
C
W
H
R
D
P
K
E
R
P
R
F
A
E
L
V
E
K
L
G
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.41
68%
-128
- C5 -
1Y6A
1
A:
[15-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
----
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
---------------------------------------------------------
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
88.79
77%
-115
- C5 -
2XIR
1
A:
[11-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
-------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.03
65%
-110
- C5 -
4ASD
1
A:
[39-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
E
L
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
-----------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
86.48
65%
-130
- C5 -
2QU6
1
B:
[8-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
-----------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.29
66%
-113
- C5 -
3VO3
2
A:
[9-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
K
----------------------------------------------------
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.24
66%
-111
- C5 -
3VNT
4
A:
[9-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
K
------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
86.22
66%
-108
- C5 -
3U6J
1
A:
[1-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
----
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
86.08
65%
-122
- C5 -
3CPC
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
85.91
65%
-121
- C5 -
3B8R
2
VGFR2_HUMAN
A:
[4-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
85.69
65%
-116
- C5 -
2QU5
1
A:
[2-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
-------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.62
66%
-110
- C5 -
4AG8
1
A:
[11-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
-----------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
85.51
65%
-122
- C5 -
3CPB
1
VGFR2_HUMAN
A:
[5-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
85.33
65%
-116
- C5 -
2P2H
1
A:
[1-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
---------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.33
65%
-127
- C5 -
2P2I
1
B:
[6-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
----
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
-------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
85.32
65%
-111
- C5 -
3EWH
2
A:
[1-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-----
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
85.15
65%
-123
- C5 -
3B8R
1
B:
[7-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
----------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.14
66%
-122
- C5 -
3CJG
1
A:
[11-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
N
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
----------------------------------------------------
Y
K
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
--------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
85.13
65%
-114
- C5 -
3BE2
1
A:
[1-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-----
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.12
65%
-123
- C5 -
3EFL
1
B:
[7-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
-------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.12
65%
-114
- C5 -
2P2I
1
VGFR2_HUMAN
A:
[3-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
-----
T
C
R
--
T
V
A
V
K
M
L
----
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
85.07
65%
-117
- C5 -
3CP9
1
VGFR2_HUMAN
A:
[3-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.95
65%
-112
- C5 -
3EFL
1
VGFR2_HUMAN
A:
[3-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
-----
T
C
R
--
T
V
A
V
K
M
L
K
E
--
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
84.88
65%
-116
- C5 -
3B8Q
1
VGFR2_HUMAN
A:
[4-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
84.64
65%
-113
- C5 -
2RL5
1
A:
[1-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
A
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
--------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
84.49
65%
-122
- C5 -
3CP9
1
B:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
----------
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.39
65%
-113
- C5 -
3DTW
1
VGFR2_HUMAN
A:
[4-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
----
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
V
A
P
----
E
D
L
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
84.23
65%
-116
- C5 -
3B8Q
1
B:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
----------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.98
65%
-125
- C5 -
3CPC
1
B:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.56
65%
-120
- C5 -
3CPB
1
B:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
-
K
P
L
G
-----
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
---
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
--------------------------------------------
Y
K
-----------
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.01
65%
-120
- C5 -
3CJF
1
A:
[12-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
N
L
G
-
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
--
A
T
C
R
--
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
-
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
-
F
V
P
Y
----------------------------------------------------
K
---
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
-
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
--
L
A
R
D
I
Y
K
------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
79.04
47%
-107
- C5 -
2I0V
1
A:
[29-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
D
P
T
Q
L
P
Y
N
E
K
----------
W
E
F
P
R
N
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
--
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
-
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
-------------------------------
R
K
R
----------------------------------
Q
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
-
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
78.85
44%
-107
- C5 -
1FGI
1
B:
[7-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
78.57
47%
-105
- C5 -
4HW7
1
A:
[36-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
L
P
Y
N
E
K
----------
W
E
F
P
R
N
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
--
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
-
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
E
A
M
L
G
P
S
---------------------
G
R
-----------------------------------
P
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
-
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
E
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
78.42
44%
-101
- C5 -
1FGI
1
FGFR1_HUMAN
A:
[9-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
-----------------------------------------------------
E
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
78.21
44%
-105
- C5 -
1AGW
1
FGFR1_HUMAN
A:
[9-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
-----------------------------------------------------
E
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
78.18
44%
-97
- C5 -
3JS2
1
B:
[14-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
------------------------------------------------------
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
78.13
45%
-106
- C5 -
3RI1
1
?
A:
[13-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
------------------------
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
77.95
44%
-106
- C5 -
3RHX
3
B:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
77.94
44%
-106
- C5 -
4F64
3
FGFR1_HUMAN
A:
[8-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
-----------------------------------------------------
E
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
77.88
45%
-103
- C5 -
3C4F
1
FGFR1_HUMAN
A:
[7-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------------------------------
R
R
P
P
-----------------------
E
E
Q
--------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
77.87
44%
-108
- C5 -
1AGW
1
B:
[7-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
77.82
45%
-105
- C5 -
2PZR
1
B:
[23-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
-----------------------
P
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
77.80
44%
-106
- C5 -
2FGI
1
B:
[7-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
77.78
44%
-103
- C5 -
4F65
6
FGFR1_HUMAN
A:
[8-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
--KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
----------------------------------------------------
P
E
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
77.78
47%
-105
- C5 -
2I1M
1
A:
[29-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
D
P
T
Q
L
P
Y
N
E
K
----------
W
E
F
P
R
N
N
L
Q
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
--
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
-
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-----
S
R
V
L
E
T
D
---------------------------------
S
T
A
--------------------
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
-
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
77.69
44%
-96
- C5 -
3JS2
1
FGFR1_HUMAN
A:
[16-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
G
L
------------------------------------------------
H
N
P
E
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
77.69
44%
-106
- C5 -
4F63
3
B:
[6-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
77.68
44%
-105
- C5 -
3B2T
1
FGFR2_HUMAN
A:
[8-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
-----
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
-------------------------
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
77.68
45%
-105
- C5 -
2PWL
1
FGFR2_HUMAN
B:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
G
-----------------------
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
77.64
45%
-107
- C5 -
2PY3
1
FGFR2_HUMAN
A:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
------------------------
P
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
77.59
44%
-102
- C5 -
3RHX
5
FGFR1_HUMAN
A:
[5-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
-----------------------------------------------------
E
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
77.56
44%
-108
- C5 -
3B2T
1
B:
[8-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
----
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
-------------------------
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
77.48
44%
-103
- C5 -
4F63
3
FGFR1_HUMAN
A:
[8-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
-----------------------------------------------------
E
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
77.46
44%
-107
- C5 -
3GQL
1
C:
[15-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------------------------------
R
R
P
P
------------------------
E
Q
--------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
77.46
45%
-108
- C5 -
2PZR
1
FGFR2_HUMAN
A:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
AV
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
-----------------------
P
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
77.38
49%
-99
- C5 -
4HVS
1
A:
[30-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
T
Q
L
P
Y
D
H
K
----------
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
--
T
V
A
V
K
M
L
K
P
S
A
H
S
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
-
F
H
----------------------------
S
S
D
----------------
T
S
P
A
S
M
E
D
D
E
--
N
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
-
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
77.37
45%
-106
- C5 -
2PZ5
1
FGFR2_HUMAN
A:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
------------------------
P
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
77.31
44%
-106
- C5 -
2FGI
1
FGFR1_HUMAN
A:
[9-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
-----------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-
D
I
H
H
I
D
Y
Y
K
K
T
-
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
77.25
45%
-105
- C5 -
3RI1
1
FGFR2_HUMAN
B:
[13-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
-----
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
------------------------
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
77.22
44%
-107
- C5 -
4F64
3
B:
[6-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
77.20
44%
-106
- C5 -
3TT0
4
B:
[55-356]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
77.19
45%
-107
- C5 -
2Q0B
1
FGFR2_HUMAN
A:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
------------------------
P
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
77.16
45%
-102
- C5 -
3C4F
1
B:
[7-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------------------------------
R
R
P
P
-----------------------
E
E
Q
--------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
77.09
42%
-105
- C5 -
2IVS
5
RET_HUMAN
A:
[17-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
K
N
L
V
L
G
-
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
R
--
A
G
Y
T
--
T
V
A
V
K
M
L
K
E
N
A
S
P
S
E
-
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
----------------------------
G
P
G
------
Y
L
----------------
R
A
-------
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
-
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
77.09
44%
-102
- C5 -
3GQL
1
FGFR1_HUMAN
B:
[15-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------------------------------
R
R
P
P
----------------------
P
E
E
Q
--------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
77.08
45%
-111
- C5 -
2PVY
1
?
D:
[23-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
G
---------
V
-----------
P
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
77.06
45%
-105
- C5 -
2PZ5
1
B:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
AV
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
------------------------
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
76.99
45%
-107
- C5 -
2PZP
1
FGFR2_HUMAN
A:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
E
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
------------------------
P
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
76.96
45%
-105
- C5 -
2PZP
1
B:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
E
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
G
----------------------
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
76.56
45%
-102
- C5 -
2PY3
1
B:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
P
G
----------------------
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
76.55
45%
-103
- C5 -
2Q0B
1
B:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
-----------------------
P
E
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
76.52
45%
-101
- C5 -
2PWL
1
FGFR2_HUMAN
A:
[23-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
--
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
P
-------------------------
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
76.46
44%
-100
- C5 -
4F65
4
B:
[6-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
--P-
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
------------------------------------------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
75.68
44%
-94
- C5 -
3GQL
1
FGFR1_HUMAN
A:
[15-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
------------------------------
R
R
P
P
------------------------
E
Q
--------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
L
D
L
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
75.37
44%
-85
- C5 -
3TT0
1
FGFR1_HUMAN
A:
[55-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
R
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
KP
N
R
V
T
--
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
-
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----
P
P
G
L
E
Y
S
-----------------------------------------
Y
N
P
S
H
N
P
E
E
----
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.21
45%
-103
- C5 -
1OEC
1
A:
[15-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-----
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
-
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
------------------------------
R
R
--------------------------
E
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
-
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
74.56
39%
-110
- C5 -
4AOJ
1
NTRK1_HUMAN
A:
[33-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-----
K
M
--
L
V
A
V
K
A
L
K
E
-
A
S
E
S
A
-
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
-------------------------------------------------------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
-
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
74.31
34%
-101
- C5 -
3EKK
1
A:
[8-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
--
E
A
E
T
--
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
-
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
-
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
-----
P
E
A
E
N
N
P
---
G
R
-----------------------------------------------
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
-
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
73.82
35%
-98
- C5 -
1I44
1
A:
[11-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
--
E
A
E
T
--
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
-
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
-
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
-----
P
E
A
E
N
N
P
---
G
R
-----------------------------------------------
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
-
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
73.00
34%
-91
- C5 -
3EKN
1
A:
[8-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
--
E
A
E
T
--
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
-
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
-
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
-----
P
E
A
E
N
N
P
---
G
R
-----------------------------------------------
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
-
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
71.02
37%
-104
- C5 -
4FYO
1
A:
[11-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
---
Q
M
K
--
K
V
V
K
--
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
-----------------------------------------------------------------
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
-
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
70.67
32%
-89
- C5 -
3I81
1
A:
[8-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
--
E
P
E
T
--
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
-
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
-
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-----
P
E
-
E
N
N
P
--------------------------------------------------
V
L
A
P
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
-
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
70.02
32%
-89
- C5 -
3NW7
1
A:
[8-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
--
E
P
E
T
--
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
-
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
-
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-----
P
E
M
E
N
N
P
V
--------------------------------------------------
L
A
P
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
-
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
68.50
31%
-99
- C5 -
3LVP
2
IGF1R_HUMAN
A:
[39-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
--
E
P
E
T
--
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
-
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
-
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-----
P
E
M
E
--
P
--------------------------------------------------
V
L
A
P
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
-
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
67.13
36%
-88
- C5 -
3L8P
1
A:
[22-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
E
G
N
F
G
Q
V
L
K
A
R
---
I
K
K
D
--
G
L
R
M
--
D
A
A
I
K
R
M
------------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
------
V
L
E
T
D
P
A
--------------------------
F
A
I
A
N
S
T
A
-----------------
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
-
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
---
Q
E
V
Y
V
K
K
-----
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
66.91
36%
-84
- C5 -
2OSC
1
A:
[30-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
K
A
R
---
I
--------
M
--
D
A
A
I
K
R
M
K
----
K
D
D
-
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
------
V
L
E
T
D
P
A
--------------------------
F
A
I
A
N
S
T
A
-----------------
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
-
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
--------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
66.20
41%
-58
- C5 -
3G0E
1
A:
[28-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
D
P
T
Q
L
P
---------
Y
D
-
H
K
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
--
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
-
F
I
-
C
S
K
T
S
P
A
------
I
M
E
D
D
E
L
A
L
D
L
E
D
L
L
S
-----
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
----------------
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
----
G
N
A
R
---------------
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
65.98
36%
-81
- C5 -
2WQB
1
A:
[29-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
E
G
--
G
Q
V
L
K
A
R
---
I
K
K
D
--
G
L
R
M
--
D
A
A
I
K
R
M
K
--------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
------
V
L
E
T
D
P
A
--------------------------
F
A
I
A
N
S
T
A
-----------------
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
-
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
---
Q
E
V
Y
V
K
K
T
-
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
65.95
40%
-51
- C5 -
1T46
1
A:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
D
P
T
Q
L
P
Y
D
H
K
----------
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
--
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
-
F
---------------------
L
A
L
D
L
E
D
L
L
S
-----
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
----------------
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
----
G
N
A
R
---------------
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
65.73
41%
-56
- C5 -
3G0F
1
KIT_HUMAN
A:
[28-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
D
P
T
Q
L
P
---------
Y
D
-
H
K
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
--
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
-
F
-----------------------
L
D
L
E
D
L
L
S
-----
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
----------------
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
----
G
N
A
R
---------------
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
65.44
41%
-56
- C5 -
3G0F
1
B:
[28-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
D
P
T
Q
L
P
---------
Y
D
-
H
K
W
E
F
P
R
N
R
L
S
F
G
-
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
--
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
-
F
-----------------------
L
D
L
E
D
L
L
S
-----
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
----------------
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
----
G
N
A
R
---------------
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Add PDB User Result:
(65 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRRRPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTFFTDNSY
139
-
100%
-111
- C5 -
U139
1
A:
[821-1173]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
L
E
E
Q
C
E
Y
-
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
--------------------------------------------------------------
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
-
100%
-119
- C5 -
U140
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
-
100%
-119
- C5 -
U141
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
-
99%
-115
- C5 -
U142
1
A:
[827-1177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
R
-------------------------------------------------------
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
S
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
-
100%
-119
- C5 -
U143
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
-
100%
-119
- C5 -
U144
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
-
100%
-119
- C5 -
U145
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
-
100%
-119
- C5 -
U146
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
-
100%
-119
- C5 -
U147
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
-
100%
-119
- C5 -
U148
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
-
100%
-119
- C5 -
U149
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
-
100%
-119
- C5 -
U150
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
-
100%
-119
- C5 -
U151
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
-
100%
-119
- C5 -
U152
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
-
100%
-119
- C5 -
U153
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
-
100%
-119
- C5 -
U154
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
-
100%
-119
- C5 -
U155
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
-
100%
-119
- C5 -
U156
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
-
100%
-119
- C5 -
U157
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
-
100%
-119
- C5 -
U158
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
-
100%
-116
- C5 -
U159
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
-
100%
-119
- C5 -
U160
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
-
100%
-119
- C5 -
U161
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
-
100%
-119
- C5 -
U162
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
-
100%
-119
- C5 -
U163
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
-
100%
-119
- C5 -
U164
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
-
100%
-119
- C5 -
U165
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
-
100%
-119
- C5 -
U166
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
-
100%
-119
- C5 -
U167
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
-
100%
-119
- C5 -
U168
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
-
100%
-119
- C5 -
U169
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
-
100%
-119
- C5 -
U170
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
-
100%
-119
- C5 -
U171
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
-
100%
-119
- C5 -
U172
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
-
100%
-119
- C5 -
U173
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
-
100%
-119
- C5 -
U174
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
-
100%
-119
- C5 -
U175
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
-
100%
-119
- C5 -
U176
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
-
100%
-120
- C5 -
U177
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
-
100%
-119
- C5 -
U178
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
-
100%
-119
- C5 -
U179
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
-
100%
-119
- C5 -
U180
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
-
100%
-112
- C5 -
U181
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
--
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
S
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
-
100%
-119
- C5 -
U182
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
-
100%
-120
- C5 -
U183
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
-
100%
-119
- C5 -
U184
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
-
100%
-120
- C5 -
U185
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
-
100%
-120
- C5 -
U186
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
-
100%
-118
- C5 -
U187
1
A:
[827-1177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
-------------------------------------------------------
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
S
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
-
100%
-119
- C5 -
U188
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
-
100%
-119
- C5 -
U189
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
-
100%
-128
- C5 -
U190
1
B:
[831-1174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
-----
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
---
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------------------
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
-
100%
-118
- C5 -
U191
1
A:
[827-1177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
-------------------------------------------------------
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
S
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
-
100%
-119
- C5 -
U192
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
-
100%
-120
- C5 -
U193
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
-
100%
-116
- C5 -
U194
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
-
100%
-123
- C5 -
U195
1
B:
[831-1174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
-----
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
---
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
----------------------
R
R
---------------------------------
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
-
100%
-119
- C5 -
U196
1
A:
[822-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
E
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
A
----------------------------------------------------
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
-
100%
-116
- C5 -
U197
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
-
100%
-120
- C5 -
U198
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
-
100%
-116
- C5 -
U199
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
-
99%
-114
- C5 -
U200
1
A:
[819-1173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
V
P
L
E
E
Q
----------
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
K
G
S
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
-
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
C
R
R
--------------------------------------------------------
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
S
A
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
-
100%
-116
- C5 -
U201
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
-
100%
-116
- C5 -
U202
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
-
100%
-116
- C5 -
U203
1
A:
[826-1180]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
C
E
Y
L
S
Y
D
A
S
Q
W
E
F
P
R
E
R
L
H
L
G
R
V
L
G
Y
G
A
F
G
K
V
V
E
A
S
A
F
G
I
H
---
S
C
D
T
V
A
V
K
M
L
K
E
G
A
T
A
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
N
H
L
N
V
V
N
L
L
G
A
C
T
K
P
Q
G
P
L
M
V
I
V
E
F
C
K
Y
G
N
L
S
N
F
L
R
A
K
R
D
A
F
S
P
--------------------------------------------
R
R
A
S
P
----
E
D
L
W
L
S
P
L
T
M
E
D
L
V
C
Y
S
F
Q
V
A
R
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
S
D
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
S
I
F
D
K
V
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
Q
I
N
E
E
F
C
Q
R
L
R
D
G
T
R
M
R
A
P
E
L
A
T
P
A
I
R
R
I
M
L
N
C
W
S
G
D
P
K
A
R
P
A
F
S
E
L
V
E
I
L
G
D
L
L
Q
G
R
G
L
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------