@TOME V2.3
(Nov 2016)

Ref. - - Doc.
Global output mode :
Sort entries by :
Sequence Color type :

Show alignment :
Column output:
Score:

Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : AAPK2_HUMAN: (2015-10-02 )
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR

Atome Classification :

(82 SA) .........10........20........30........40.......----.50.....---...60........-.-70.-........80...--.----....90........100......----.----110........120.......130-.......140....---.---..---150-.----.---.---.--.....160---..-.-...---.-.170.......180.......190----.--.......200.......210.......----220...-.....--230.-..--.----.----.----...240.........250.....-----..------260........270-------........-.280-......-..290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN----RQKIRSLD---VVGK-IKREIQNL-K-L-F-RHPHIIKLYQVIS--T----PTDFFMVMEYVSGGELFDYICKH----G----R-VEEMEARRLFQQILSAVDYCHR-HMVVHRDLKPENVL---L---DA---H---M----N---A---K--IADFGLS----NM-M-SDG---E-FLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSCGVILYALLCGTLPFDDEHV----P-TLFK-KIRGG--V--F-YI--P----E----Y----LNRS--VATLLMHMLQVDPLKRA-----TI------K-DIREHEWFKQ---------DLPSYLFP-EDP--SYDANV-IDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
7 PsiBlast_PDB 85.0373%-133 - C4 -4QFS AAPK1_RAT A:[11-503] --------GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN----RQKIRSLD---VVGK-IRREIQNL-K-L-F-RHPHIIKLYQVIS--T----PSDIFMVMEYVSGGELFDYICKN----G----R-LDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVL---L---DA---H---M----N---A---K--IADFGLS----NM-M-SDG---E-FLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHV----P-TLFK-KICDG--I--F-YT--P----Q----Y----LNPS--VISLLKHMLQVDPMKRA-----TI------K-DIREHEWFKQ---------DLPKYLF-------------------------------------------------------------------------------------------------------------------------------KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDD-----------------------------------------------------------SHTIEFFEMCANLIKILAQ
6 PsiBlast_PDB 84.9173%-133 - C4 -4QFR ? A:[11-503] --------GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN----RQKIRSLD---VVGK-IRREIQNL-K-L-F-RHPHIIKLYQVIS--T----PSDIFMVMEYVSGGELFDYICKN----G----R-LDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVL---L---DA---H---M----N---A---K--IADFGLS----NM-M-SDG---E-FLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHV----P-TLFK-KICDG--I--F-YT--P----Q----Y----LNPS--VISLLKHMLQVDPMKRA-----TI------K-DIREHEWFKQ---------DLPKYLF-------------------------------------------------------------------------------------------------------------------------------KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDD-----------------------------------------------------------SHTIEFFEMCANLIKILAQ
5 PsiBlast_PDB 83.4773%-132 - C4 -4QFG AAPK1_RAT A:[11-503] --------GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN----RQKIRSLD---VVGK-IRREIQNL-K-L-F-RHPHIIKLYQVIS--T----PSDIFMVMEYVSGGELFDYICKN----G----R-LDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVL---L---DA---H---M----N---A---K--IADFGLS----NM-M-SDG---E-FLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHV----P-TLFK-KICDG--I--F-YT--P----Q----Y----LNPS--VISLLKHMLQVDPMKRA-----TI------K-DIREHEWFKQ---------DLPKYLFP-------------------------------------------------------------------------------------------------------------------------------WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDE-------------------------------------------------------RPGSHTIEFFEMCANLIKILAQ
4 PsiBlast_PDB 82.0974%-126 - C4 -4RER AAPK1_HUMAN A:[1-540] --------GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN----RQKIRSLD---VVGK-IRREIQNL-K-L-F-RHPHIIKLYQVIS--T----PSDIFMVMEYVSGGELFDYICKN----G----R-LDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVL---L---DA---H---M----N---A---K--IADFGLS----NM-M-SDG---E-FLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHV----P-TLFK-KICDG--I--F-YT--P----Q----Y----LNPS--VISLLKHMLQVDPMKRA-----SI------K-DIREHEWFKQ---------DLPKYLFP-EDP--SYS-----DDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-----DHHL-----TRPHPERVPFLVAETP-------------------RKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDGIT----------------------------------------------------PRPGSHTIEFFEMCANLIKILAQ
3 PsiBlast_PDB 76.3474%-115 - C4 -4REW AAPK1_HUMAN A:[1-540] --------GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN----RQKIRSLD---VVGK-IRREIQNL-K-L-F-RHPHIIKLYQVIS--T----PSDIFMVMEYVSGGELFDYICKN----G----R-LDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVL---L---DA---H---M----N---A---K--IADFGLS----NM-M-SDG---E-FLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHV----P-TLFK-KICDG--I--F-YT--P----Q----Y----LNPS--VISLLKHMLQVDPMKRA-----SI------K-DIREHEWFKQ---------DLPKYLFP-E---------------------------------------------------IDNRRIMNEAKDFYLATSPPD------HHL-----TRPHPERVPFLVAET--------------------RKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDG------------------------------------------------------PRPGSHTIEFFEMCANLIKILAQ
8 PsiBlast_PDB 75.4580%-127 - C4 -4CFH AAPK1_RAT A:[29-489] ---------RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN----RQKIRSLD---VVGK-IRREIQNL-K-L-F-RHPHIIKLYQVIS--T----PSDIFMVMEYVSGGELFDYICKN----G----R-LDEKESRRLFQQILSGVDYCHR-HMVVHRDLKPENVL---L---DA---H---M----N---A---K--IADFGLS----NM-M-SDG---E-FLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHV----P-TLFK-KICDG--I--F-YT--P----Q----Y----LNPS--VISLLKHMLQVDPMKRA-----TI------K-DIREHEWFKQ---------DLPKYLFP-ED-------------------------------------------AVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDHHL-----TRPHPERVPFLVAETPRA-------------------AKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEI----------------------------------------------------------------------------
12 PsiBlast_PDB 71.3599%-133 - C4 -3AQV AAPK2_HUMAN A:[4-276] ------HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN----RQKIRSLD---VVGK-IKREIQNL-K-L-F-RHPHIIKLYQVIS--T----PTDFFMVMEYVSGGELFDYICKH----G----R-VEEMEARRLFQQILSAVDYCHR-HMVVHRDLKPENVL---L---DA---H---M----N---A---K--IADFGLS----NM-M-SDG---E-FL------PNYAAPEVISGRLYA-----G--PEVDIWSCGVILYALLCGTLPFDDEHV----P-TLFK-KIRGG--V--F-YI--P----E----Y----LNRS--VATLLMHMLQVDPLKRA-----TI------K-DIREHEWFKQ---------DLPSYLFP-E------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125 HHSearch 58.8543%-111 - C4 -4BKY MELK_HUMAN A:[9-326] ------------LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMD----KNTL-------DLPR-IKTEIEAL-K-N-L-RHQHICQLYHVLE--T----ANKIFMVLEYCPGGELFDYIISQ----D----R-LSEEETRVVFRQIVSAVAYVHS-QGYAHRDLKPENLL---F---DE---Y---H----K---L---K--LIDFGLC----A-------------------SLAYAAPELIQGK--------G--SEADVWSMGILLYVLMCGFLPFDDDNV----M-ALYK-KIMRG--K--Y-DV--P----K----W----LSPS--SILLLQQMLQVDPKKRI-----SM------K-NLLNHPWIMQ---------DYNY---P-VEWQSKNPFIH-LDDDCVTELSVHHRNNRQTMEDL-ISLWQYDHLTATYLLLLAKKARGKPVRLR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23 PsiBlast_CBE 56.5044%-108 - C4 -4CZT CIPKN_ARATH D:[4-290] ------HSGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVID----KEKVLKNK---MIAQ-IKREISTM-K-L-I-KHPNVIRMFEVMA--S----KTKIYFVLEFVTGGELFDKISSN----G----R-LKEDEARKYFQQLINAVDYCHS-RGVYHRDLKPENLL---L---DA---N---G----A---L---K--VSDFGLSALPQQV-R-EDG-----LLHTTCGTPNYVAPEVINNKGYD-----G--AKADLWSCGVILFVLMAGYLPFEDSNL----T-SLYK-KIFKA--E--F-TC--P----P----W----FSAS--AKKLIKRILDPNPATRI-----TF------A-EVIENEWFKK------------GYKAP-KFE--NADVSL-DDVDAIFDDSNLVVERRE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33 PsiBlast_CBE 56.1247%-121 - C4 -4CQG MELK_MOUSE A:[8-266] ------------LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMD----KNALGS-----DLPR-VKTEIDAL-K-S-L-RHQHICQLYHVLE--T----KNKIFMVLEYCPGGELFDYIISQ----D----R-LSEEETRVVFRQILSAVAYVHS-QGYAHRDLKPENLL---F---DE---N---H----K---L---K--LIDFGLC----AK----------------CGSLAYAAPELIQG------------SEADVWSMGILLYVLMCGFLPFDDDNV----M-ALYK-KIMRG--K--Y-EV--P----K----W----LSPS--SILLLQQMLQVDPKKRI-----SM------R-NLLNHPWVMQ---------DYSCPVEW-QSK--TPLTHL-DEDCVTELSVHHRSSRQTMEDLISSWQYDHLTATYLLLLAKKARLEHHH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16 PsiBlast_PDB 55.5344%-107 - C4 -4CZT CIPKN_ARATH A:[4-290] ------HSGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVID----KEKVLKNK---MIAQ-IKREISTM-K-L-I-KHPNVIRMFEVMA--S----KTKIYFVLEFVTGGELFDKISSN----G----R-LKEDEARKYFQQLINAVDYCHS-RGVYHRDLKPENLL---L---DA---N---G----A---L---K--VSDFGLSALPQQV-R-EDG-----LLHTTCGTPNYVAPEVINNKGYD-----G--AKADLWSCGVILFVLMAGYLPFEDSNL----T-SLYK-KIFKA--E--F-TC--P----P----W----FSAS--AKKLIKRILDPNPATRI-----TF------A-EVIENEWFKK------------GYKAP-KFE--N--VSL-DDVDAIFDDSGES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25 PsiBlast_CBE 55.1643%-109 - C4 -4CZU CIPKN_ARATH D:[4-290] ------HSGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVID----KEKVLKNK---MIAQ-IKREISTM-K-L-I-KHPNVIRMFEVMA--S----KTKIYFVLEFVTGGELFDKISSN----G----R-LKEDEARKYFQQLINAVDYCHS-RGVYHRDLKPENLL---L---DA---N---G----A---L---K--VSDFGLSALPQQV-R-EDG-----LLHDTCGTPNYVAPEVINNKGYD-----G--AKADLWSCGVILFVLMAGYLPFEDSNL----T-SLYK-KIFKA--E--F-TC--P----P----W----FSAS--AKKLIKRILDPNPATRI-----TF------A-EVIENEWFKK------------GYKAP-KFE--NADVSL-DDVDAIFDDSNLVVERRE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94 PsiBlast_CBE 54.7836%-119 - C4 -3IGO ? A:[30-295] ---------------------LGKGSFGEVLKCKDRITQQEYAVKVIN----KASAKNK----T-ST-ILREVELL-K-K-L-DHPNIMKLFEILE--D----SSSFYIVGELYTGGELFDEIIKR----K----R-FSEHDAARIIKQVFSGITYMHK-HNIVHRDLKPENIL---L---ES---KEKDC----D---I---K--IIDFGLS----TC-F-QQN---T--------TAYYIAPEVLRGTY-------D--EKCDVWSAGVILYILLSGTPPFYGKNE----Y-DILK-RVETGKYA--F-DL--P----Q----WRT--ISDD--AKDLIRKMLTFHPSLRI-----TA------T-QCLEHPWIQKYSSETPTISDLPSLESA-MTN--IRQFQA-EKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNSLIQGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELFKLESIIEQVDNNKDGEVDFNEFVEMLQNFVRN-------------------------------------------------------------------------------------------------------
128 HHSearch 54.7338%-122 - C4 -4GV1 AKT1_HUMAN A:[3-270] --------SRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK----KEVIVAKD---EVAH-TLTENRVL-Q-N-S-RHPFLTALKYSFQ--T----HDRLCFVMEYANGGELFFHLSRE----R----V-FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLM---L---DK---D---G----H---I---K--ITDFGLC----KEGI-KDG---A-TMKTFCGTPEYLAPEVLEDNDY------G--RAVDWWGLGVVMYEMMCGRLPFYNQDH----E-KLFE-LILME--E--I-RF--P----R----T----LGPE--AKSLLSGLLKKDPKQRLGGGSEDA------K-EIMQHRFFAG---------IVWQHVYE-KKL--SPPFKP-QVTSETDTRYFDEEFTAQMITITPSMECVDSERRPHFPQFDYSAS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24 PsiBlast_CBE 54.6844%-113 - C4 -4CZT CIPKN_ARATH C:[10-290] ------------VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVID----KEKVLKNK---MIAQ-IKREISTM-K-L-I-KHPNVIRMFEVMA--S----KTKIYFVLEFVTGGELFDKISSN----G----R-LKEDEARKYFQQLINAVDYCHS-RGVYHRDLKPENLL---L---DA---N---G----A---L---K--VSDFGLSALPQQV-R-EDG-----LLHTTCGTPNYVAPEVINNKGYD-----G--AKADLWSCGVILFVLMAGYLPFEDSNL----T-SLYK-KIFKA--E--F-TC--P----P----W----FSAS--AKKLIKRILDPNPATRI-----TF------A-EVIENEWFKK------------GYKAP-KFE--NADVSL-DDVDAIFDDSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50 PsiBlast_CBE 54.4338%-133 - C4 -2JC6 KCC1D_HUMAN C:[24-283] ---------------FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIP----KKA-----------S-IENEIAVL-R-K-I-KHENIVALEDIYE--S----PNHLYLVMQLVSGGELFDRIVEK----G----F-YTEKDASTLIRQVLDAVYYLHR-MGIVHRDLKPENLL---YYSQDE---E---S----K---I---M--IS------------------------------PGYVAPEVLAQKPYS-----K--A-VDCWSIGVIAYILLCGYPPFYDEND----S-KLFE-QILKA--E--Y-EFDSP----Y----WDD--ISDS--AKDFIRNLMEKDPNKRY-----TC------E-QAARHPWIAG---------DTALNKNI-HES--VSAQIR-KNFAKSKWRQAFNAT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92 PsiBlast_CBE 54.3936%-120 - C4 -3NCG ? A:[30-295] ---------------------LGKGSFGEVLKCKDRITQQEYAVKVIN----KASAKNKD---T-ST-ILREVELL-K-K-L-DHPNIMKLFEILE--D----SSSFYIVGELYTGGELFDEIIKR----K----R-FSEHDAARIIKQVFSGITYMHK-HNIVHRDLKPENIL---L---ES---KEKDC----D---I---K--IIDFGLS----TC-F-QQN---T------IGTAYYIAPEVLRGTY-------D--EKCDVWSAGVILYILLSGTPPFYGKNE----Y-DILK-RVETGKYA--F-DL--P----Q----WRT--ISDD--AKDLIRKMLTFHPSLRI-----TA------T-QCLEHPWIQKYSSETPTISDLPSLESA-MTN--IRQFQA-EKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELDFNEFVEMLQN---------------------------------------------------------------------------------------------------------------------------------
82 PsiBlast_CBE 54.0738%-133 - C4 -4FG9 KCC1A_HUMAN A:[20-279] ---------------YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIA----KE---------------ENEIAVL-H-K-I-KHPNIVALDDIYE--S----GGHLYLIMQLVSGGELFDRIVEK----G----F-YTERDASRLIFQVLDAVKYLHD-LGIVHRDLKPENLLYYSL---DE---D---S----K---I---M--ISDF----------------------------PGYVAPEVLAQKPYS-----K--A-VDCWSIGVIAYILLCGYPPFYDEND----A-KLFE-QILKA--E--Y-EFDSP----Y----WDD--ISDS--AKDFIRHLMEKDPEKRF-----TC------E-QALQHPWIAG---------DTALDKNI-HQS--VSEQIK-KNFAKSKWKQAFNATAVVR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84 PsiBlast_CBE 53.8838%-134 - C4 -4FG8 KCC1A_HUMAN A:[20-279] ---------------YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIA----KE----------------NEIAVL-H-K-I-KHPNIVALDDIYE--S----GGHLYLIMQLVSGGELFDRIVEK----G----F-YTERDASRLIFQVLDAVKYLHD-LGIVHRDLKPENLLYYSL---DE---D---S----K---I---M--ISDF---------------------------TPGYVAPEVLAQKPYS-----K--A-VDCWSIGVIAYILLCGYPPFYDEND----A-KLFE-QILKA--E--Y-EFDSP----Y----WDD--ISDS--AKDFIRHLMEKDPEKRF-----TC------E-QALQHPWIAG---------DTALDKNI-HQS--VSEQIK-KNFA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51 PsiBlast_CBE 53.6938%-132 - C4 -2JC6 KCC1D_HUMAN A:[24-283] ---------------FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIP----KKA----------SS-IENEIAVL-R-K-I-KHENIVALEDIYE--S----PNHLYLVMQLVSGGELFDRIVEK----G----F-YTEKDASTLIRQVLDAVYYLHR-MGIVHRDLKPENLL---YYSQDE---E---S----K---I---M--IS------------------------------PGYVAPEVLAQKPYS-----K--A-VDCWSIGVIAYILLCGYPPFYDEND----S-KLFE-QILKA--E--Y-EFDSP----Y----WDD--ISDS--AKDFIRNLMEKDPNKRY-----TC------E-QAARHPWIAG---------DTALNKNI-HES--VSAQIR-KNFAKSKWRQAFNAT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31 PsiBlast_CBE 53.6946%-113 - C4 -4BKZ MELK_HUMAN A:[9-291] ------------LKYYELHETIGTG--AKVKLACHILTGEMVAIKIMD----KNTL--------LPR-IKTEIEAL-K-N-L-RHQHICQLYHVLE--T----ANKIFMVLEYCPGGELFDYIISQ----D----R-LSEEETRVVFRQIVSAVAYVHS-QGYAHRDLKPENLL---F---DE---Y---H----K---L---K--LIDFGLC----A-------------------SLAYAAPELIQG---------G--SEADVWSMGILLYVLMCGFLPFDDDNV----M-ALYK-KIMRG--K--Y-DV--P----K----W----LSPS--SILLLQQMLQVDPKKRI-----SM------K-NLLNHPWIMQ---------D---YNYPVEWQ--SKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93 PsiBlast_CBE 53.2036%-116 - C4 -3MWU ? A:[30-295] ---------------------LGKGSFGEVLKCKDRITQQEYAVKVIN----KASAKNKD---T-ST-ILREVELL-K-K-L-DHPNIMKLFEILE--D----SSSFYIVGELYTGGELFDEIIKR----K----R-FSEHDAARIIKQVFSGITYMHK-HNIVHRDLKPENIL---L---ES---KEKDC----D---I---K--IIDFGLS----TC-F-QQN--------DRIGTAYYIAPEVLRGTY-------D--EKCDVWSAGVILYILLSGTPPFYGKNE----Y-DILK-RVETGKYA--F-DL--P----Q----WRT--ISDD--AKDLIRKMLTFHPSLRI-----TA------T-QCLEHPWIQKYSSETPTISDLPSLESA-MTN--IRQFQA-EKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNSLIQNEGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELEQVDNNKDGEVDFNEFVEMLQNFVR-------------------------------------------------------------------------------------------------------------
133 HHSearch 52.9131%-117 - C4 -4C2V AUKBA_XENLA A:[12-282] ---------KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLF----KSQLEKEG---VEHQ-LRREIEIQ-S-H-L-RHPNILRMYNYFH--D----RKRIYLMLEFAPRGELYKELQKH----G----R-FDEQRSATFMEELADALHYCHE-RKVIHRDIKPENLL---M---GY---K---G----E---L---K--IADFGWS----VH-A-PS----L-RRRTMCGTLDYLPPEMIEGKTH------D--EKVDLWCAGVLCYEFLVGMPPFDSPSH----T-ETHR-RIVNV--D--L-KF--P----P----F----LSDG--SKDLISKLLRYHPPQRL-----PL------K-GVMEHPWVKA---------NSRRVLPP-VYQ--S-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32 PsiBlast_CBE 52.7446%-114 - C4 -4BKY MELK_HUMAN A:[9-291] ------------LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMD----KNTL-------DLPR-IKTEIEAL-K-N-L-RHQHICQLYHVLE--T----ANKIFMVLEYCPGGELFDYIISQ----D----R-LSEEETRVVFRQIVSAVAYVHS-QGYAHRDLKPENLL---F---DE---Y---H----K---L---K--LIDFGLC----A-------------------SLAYAAPELIQGK--------G--SEADVWSMGILLYVLMCGFLPFDDDNV----M-ALYK-KIMRG--K--Y-DV--P----K----W----LSPS--SILLLQQMLQVDPKKRI-----SM------K-NLLNHPWIMQ---------D---YNYPVEWQ--SKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91 PsiBlast_CBE 52.7036%-114 - C4 -4Y5Q ? A:[30-295] ---------------------LGKGSFGEVLKCKDRITQQEYAVKVIN----KASAKNKD---T-ST-ILREVELL-K-K-L-DHPNIMKLFEILE--D----SSSFYIVGELYTGGELFDEIIKR----K----R-FSEHDAARIIKQVFSGITYMHK-HNIVHRDLKPENIL---L---ES---KEKDC----D---I---K--IIDFGLS----TC-F-QQN---T----DRIGTAYYIAPEVLRGTY-------D--EKCDVWSAGVILYILLSGTPPFYGKNE----Y-DILK-RVETGKYA--F-DL--P----Q----WRT--ISDD--AKDLIRKMLTFHPSLRI-----TA------T-QCLEHPWIQKYSSETPTISDLPSLESA-MTN--IRQFQA-EKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDSNSGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDKDGSGKISTKELFKLFSEQVDNNKDGEVDFNEFVEMLQNFVRN------------------------------------------------------------------------------------------------------------
143 HHSearch 52.5034%-108 - C4 -1RDQ KAPCA_MOUSE E:[35-298] -------QNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILD----KQKVVKLK---QIEH-TLNEKRIL-Q-A-V-NFPFLVKLEFSFK--D----NSNLYMVMEYVAGGEMFSHLRRI----G----R-FSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLL---I---DQ---Q---G----Y---I---Q--VTDFGFA----KR-V-KGR---T---WTLCGTPEALAPEIILSKGY------N--KAVDWWALGVLIYEMAAGYPPFFADQP----I-QIYE-KIVSG--K--V-RF--P----S----H----FSSD--LKDLLRNLLQVDLTKRFGNLKNGV------N-DIKNHKWFAT---------TDWIAIYQ-RKV--EAPFIP-KFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98 PsiBlast_CBE 52.2138%-117 - C4 -3BHH KCC2B_HUMAN A:[6-266] ---------------YQLYEDIG----SVVRRCVKLCTGHEYAAKIIN----TKKLSARD---H-QK-LEREARIC-R-L-L-KHSNIVRLHDSIS--E----EGFHYLVFDLVTGGELFEDIVAR----E----Y-YSEADASHCIQQILEAVLHCHQ-MGVVHRDLKPENLL---L---AS---K---C----K---GAAVK--LADFGLAI---EV-Q-GDQ---Q-AWFGFAGTPGYLSPEVLRKEAYG-----K--P-VDIWACGVILYILLVGYPPFWDEDQ----H-KLYQ-QIKAG--A--Y-DF--PSPEWD----T----VTPE--AKNLINQMLTINPAKRI-----TA------H-EALKHPWVCQ---------RSTVASMM-HRQ--ETVECL-KKFNARRKLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86 PsiBlast_CBE 52.1536%-111 - C4 -3MA6 ? B:[39-292] --------------------VLGKGSFGEVILCKDKITGQECAVKVIS----KRQVKQ-T---DKES-LLREVQLL-K-Q-L-DHPNIMKLYEFFE--D----KGYFYLVGEVYTGGELFDEIISR----K----R-FSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---L---ES---KSKDA----N---I---R--IIDFGLS----TH-F-EAS---K-KMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANE----Y-DILK-KVEKGKYT--F-EL--P----Q----WKK--VSES--AKDLIRKMLTYVPSMRI-----SA------R-DALDHEWIQT---------YT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87 PsiBlast_CBE 52.0636%-113 - C4 -3MA6 ? A:[39-292] --------------------VLGKGSFGEVILCKDKITGQECAVKVIS----KRQVKQKT---DKES-LLREVQLL-K-Q-L-DHPNIMKLYEFFE--D----KGYFYLVGEVYTGGELFDEIISR----K----R-FSEVDAARIIRQVLSGITYMHK-NKIVHRDLKPENLL---L---ES---KSKDA----N---I---R--IIDFGLS----TH-F-E-S---K-KMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANE----Y-DILK-KVEKGKYT--F-EL--P----Q----WKK--VSES--AKDLIRKMLTYVPSMRI-----SA------R-DALDHEWIQT---------YTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30 PsiBlast_CBE 52.0046%-113 - C4 -4BL1 MELK_HUMAN A:[9-291] ------------LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMD----KNTL--------LPR-IKTEIEAL-K-N-L-RHQHICQLYHVLE--T----ANKIFMVLEYCPGGELFDYIISQ----D----R-LSEEETRVVFRQIVSAVAYVHS-QGYAHRDLKPENLL---F---DE---Y---H----K---L---K--LIDFGLC----AK------------------SLAYAAPELIQGK--------G--SEADVWSMGILLYVLMCGFLPFDDDNV----M-ALYK-KIMRG--K--Y-DV--P----K----W----LSPS--SILLLQQMLQVDPKKRI-----SM------K-NLLNHPWIMQ---------D---YNYPVEWQ--SKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96 PsiBlast_CBE 51.5236%-108 - C4 -2WEI ? A:[30-282] ---------------------LGKGSFGEVLKCKDRITQQEYAVKVIN----KASAKNKD---T-ST-ILREVELL-K-K-L-DHPNIMKLFEILE--D----SSSFYIVGELYTGGELFDEIIKR----K----R-FSEHDAARIIKQVFSGITYMHK-HNIVHRDLKPENIL---L---ES---KEKDC----D---I---K--IIDFGLS----TC-F-QQN---T-KMKDRIGTAYYIAPEVLRGTY-------D--EKCDVWSAGVILYILLSGTPPFYGKNE----Y-DILK-RVETGKYA--F-DL--P----Q----WRT--ISDD--AKDLIRKMLTFHPSLRI-----TA------T-QCLEHPWIQK---------YSSE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97 PsiBlast_CBE 51.3338%-117 - C4 -3BHH KCC2B_HUMAN B:[6-266] ---------------YQLYEDIGK---SVVRRCVKLCTGHEYAAKIIN----TKKLSARD---H-QK-LEREARIC-R-L-L-KHSNIVRLHDSIS--E----EGFHYLVFDLVTGGELFEDIVAR----E----Y-YSEADASHCIQQILEAVLHCHQ-MGVVHRDLKPENLL---L---AS---K---C----K---GAAVK--LADFGLAI---EV-Q-GDQ---Q-AWFGFAGTPGYLSPEVLRKEAYG-----K--P-VDIWACGVILYILLVGYPPFWDEDQ----H-KLYQ-QIKAG--A--Y-DF--PSPEWD----T----VTPE--AKNLINQMLTINPAKRI-----TA------H-EALKHPWVCQ---------RSTVASMM-HRQ--ETVECL-KKFNARRKLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83 PsiBlast_CBE 51.2038%-124 - C4 -4FG8 KCC1A_HUMAN B:[20-279] ---------------YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIA----K-----------------NEIAVL-H-K-I-KHPNIVALDDIYE--S----GGHLYLIMQLVSGGELFDRIVEK----G----F-YTERDASRLIFQVLDAVKYLHD-LGIVHRDLKPENLLYYSL---DE---D---S----K---I---M--ISDFG-------------G---S-VLSTACGTPGYVAPEVLAQKPYS-----K--A-VDCWSIGVIAYILLCGYPPFYDEND----A-KLFE-QILKA--E--Y-EFDSP----Y----WDD--ISDS--AKDFIRHLMEKDPEKRF-----TC------E-QALQHPWIAG---------DTALDKNI-HQS--VSEQIK-KNFA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106 PsiBlast_CBE 50.1136%-132 - C4 -4BDJ CHK2_HUMAN A:[17-287] --------------EYIMSKTLG-----EVKLAFERKTCKKVAIKIIS----K-------------N-VETEIEIL-K-K-L-NHPCIIKIKNFFD--A-----EDYYIVLELMEGGELFDKVVGN----K----R-LKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVL---L---SS---Q---E----EDCLI---K--ITDFGHS----KI-L--ET---S-LMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRT----Q-VSLKDQITSG--K--YNFI--P----E----VWAE-VSEK--ALDLVKKLLVVDPKARF-----TT------E-EALRHPWLQD---------EDMKRKFQ-DLL--SEENES-TALPQVLA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110 PsiBlast_CBE 49.7836%-127 - C4 -4BDF CHK2_HUMAN A:[17-287] --------------EYIMSKTLG----GEVKLAFERKTCKKVAIKIIS----K-------------N-VETEIEIL-K-K-L-NHPCIIKIKNFFD--A-----EDYYIVLELMEGGELFDKVVGN----K----R-LKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVL---L---SS---Q---E----EDCLI---K--ITDFGHS----KI-L-GET---S-LMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRT----Q-VSLKDQITSG--K--YNFI--P----E----VWAE-VSEK--ALDLVKKLLVVDPKARF-----TT------E-EALRHPWLQD---------EDMKRKFQ-DLL--SEENES-TALPQVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144 HHSearch 49.5732%-113 - C4 -2W5A NEK2_HUMAN A:[4-273]