@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAPK2_HUMAN: (2015-10-02 )
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
Atome Classification :
(82 SA)
.........10........20........30........40.......----.50.....---...60........-.-70.-........80...--.----....90........100......----.----110........120.......130-.......140....---.---..---150-.----.---.---.--.....160---..-.-...---.-.170.......180.......190----.--.......200.......210.......----220...-.....--230.-..--.----.----.----...240.........250.....-----..------260........270-------........-.280-......-..290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEKQKHDG
R
V
K
I
G
H
Y
V
LGDTLGVG
T
F
G
K
V
K
IGEHQLT
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
---
V
V
G
K
-
I
K
R
E
I
Q
N
L
-
K
-
L
-F-RHP
H
I
I
K
L
Y
Q
V
IS--T----P
T
D
F
F
M
V
M
E
Y
VSG
G
E
L
F
D
Y
I
C
KH----G----
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
HRDLKPE
N
V
L
---
L
---DA---H---M----N---A---
K
--
I
A
D
F
G
L
S
----
N
M-M-SDG---
E
-
F
L
R
TSCGSPNYAA
P
E
VISGRLYA-----G--PE
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
CGTLPFDDE
H
V
----
P
-
T
L
F
K
-
K
IRG
G
--
V
--
F
-Y
I
--
P
----
E
----
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
QVDPL
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
---------D
L
P
S
YLFP-EDP--SYDANV-I
D
D
E
A
V
K
E
V
C
E
KFEC
T
E
S
E
V
M
N
S
L
YSGDP
Q
D
Q
L
A
V
A
Y
H
L
I
ID
N
R
R
I
M
N
Q
A
S
E
F
Y
LASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKS
L
A
V
K
K
A
K
W
H
LGIRSQSK
P
Y
D
I
M
A
E
V
Y
R
A
M
K
QLD
F
E
W
K
V
V
N
A
Y
H
L
R
V
R
RKNPVTG
N
Y
V
K
M
S
L
Q
L
Y
L
VDN
R
S
Y
L
L
D
FKSI
D
D
E
V
V
E
QRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSG
S
L
TGSLTGS
T
L
S
SVSPRLGS
H
T
M
D
F
F
E
M
C
A
S
L
I
T
T
LAR
7
PsiBlast_PDB
85.03
73%
-133
- C4 -
4QFS
2
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
---
V
V
G
K
-
I
R
R
E
I
Q
N
L
-
K
-
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
----
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
----
N
---
A
---
K
--
I
A
D
F
G
L
S
----
N
M
-
M
-
S
D
G
---
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
----
P
-
T
L
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
T
--
P
----
Q
----
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
---------
D
L
P
K
Y
L
F
-------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
6
PsiBlast_PDB
84.91
73%
-133
- C4 -
4QFR
2
?
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
---
V
V
G
K
-
I
R
R
E
I
Q
N
L
-
K
-
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
----
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
----
N
---
A
---
K
--
I
A
D
F
G
L
S
----
N
M
-
M
-
S
D
G
---
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
----
P
-
T
L
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
T
--
P
----
Q
----
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
---------
D
L
P
K
Y
L
F
-------------------------------------------------------------------------------------------------------------------------------
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
-----------------------------------------------------------
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
5
PsiBlast_PDB
83.47
73%
-132
- C4 -
4QFG
1
AAPK1_RAT
A:
[11-503]
--------
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
---
V
V
G
K
-
I
R
R
E
I
Q
N
L
-
K
-
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
----
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
----
N
---
A
---
K
--
I
A
D
F
G
L
S
----
N
M
-
M
-
S
D
G
---
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
----
P
-
T
L
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
T
--
P
----
Q
----
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
---------
D
L
P
K
Y
L
F
P
-------------------------------------------------------------------------------------------------------------------------------
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
-------------------------------------------------------
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
4
PsiBlast_PDB
82.09
74%
-126
- C4 -
4RER
3
AAPK1_HUMAN
A:
[1-540]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
---
V
V
G
K
-
I
R
R
E
I
Q
N
L
-
K
-
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
----
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
----
N
---
A
---
K
--
I
A
D
F
G
L
S
----
N
M
-
M
-
S
D
G
---
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
----
P
-
T
L
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
T
--
P
----
Q
----
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
---------
D
L
P
K
Y
L
F
P
-
E
D
P
--
S
Y
S
-----
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
-----
D
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
-------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
I
T
----------------------------------------------------
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
3
PsiBlast_PDB
76.34
74%
-115
- C4 -
4REW
2
AAPK1_HUMAN
A:
[1-540]
--------
G
S
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
---
V
V
G
K
-
I
R
R
E
I
Q
N
L
-
K
-
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
----
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
----
N
---
A
---
K
--
I
A
D
F
G
L
S
----
N
M
-
M
-
S
D
G
---
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
----
P
-
T
L
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
T
--
P
----
Q
----
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
---------
D
L
P
K
Y
L
F
P
-
E
---------------------------------------------------
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
------
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
--------------------
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
Y
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
G
------------------------------------------------------
P
R
P
G
S
H
T
I
E
F
F
E
M
C
A
N
L
I
K
I
L
A
Q
8
PsiBlast_PDB
75.45
80%
-127
- C4 -
4CFH
2
AAPK1_RAT
A:
[29-489]
---------
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
---
V
V
G
K
-
I
R
R
E
I
Q
N
L
-
K
-
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
----
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
----
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
----
N
---
A
---
K
--
I
A
D
F
G
L
S
----
N
M
-
M
-
S
D
G
---
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
----
P
-
T
L
F
K
-
K
I
C
D
G
--
I
--
F
-
Y
T
--
P
----
Q
----
Y
----
L
N
P
S
--
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
---------
D
L
P
K
Y
L
F
P
-
E
D
-------------------------------------------
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
-
S
F
L
D
D
H
H
L
-----
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
-------------------
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
I
----------------------------------------------------------------------------
12
PsiBlast_PDB
71.35
99%
-133
- C4 -
3AQV
1
AAPK2_HUMAN
A:
[4-276]
------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
---
V
V
G
K
-
I
K
R
E
I
Q
N
L
-
K
-
L
-
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
----
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
----
G
----
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
----
N
---
A
---
K
--
I
A
D
F
G
L
S
----
N
M
-
M
-
S
D
G
---
E
-
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
----
P
-
T
L
F
K
-
K
I
R
G
G
--
V
--
F
-
Y
I
--
P
----
E
----
Y
----
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
------
K
-
D
I
R
E
H
E
W
F
K
Q
---------
D
L
P
S
Y
L
F
P
-
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
58.85
43%
-111
- C4 -
4BKY
1
MELK_HUMAN
A:
[9-326]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-------
D
L
P
R
-
I
K
T
E
I
E
A
L
-
K
-
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
----
K
---
L
---
K
--
L
I
D
F
G
L
C
----
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
----
M
-
A
L
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
V
--
P
----
K
----
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
Q
---------
D
Y
N
Y
---
P
-
V
E
W
QS
K
N
P
F
I
H
-
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
-
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
56.50
44%
-108
- C4 -
4CZT
4
CIPKN_ARATH
D:
[4-290]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
---
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
-
L
-
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
----
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
----
A
---
L
---
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
-
E
D
G
-----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
----
T
-
S
L
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
C
--
P
----
P
----
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
------
A
-
E
V
I
E
N
E
W
F
K
K
------------
G
Y
K
A
P
-
K
F
E
--
N
A
D
V
S
L
-
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
56.12
47%
-121
- C4 -
4CQG
1
MELK_MOUSE
A:
[8-266]
------------
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
A
L
G
S
-----
D
L
P
R
-
V
K
T
E
I
D
A
L
-
K
-
S
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
N
---
H
----
K
---
L
---
K
--
L
I
D
F
G
L
C
----
A
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
------------
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
----
M
-
A
L
Y
K
-
K
I
M
R
G
--
K
--
Y
-
E
V
--
P
----
K
----
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
R
-
N
L
L
N
H
P
W
V
M
Q
---------
D
Y
S
C
P
V
E
W
-
Q
S
K
--
T
P
L
T
H
L
-
D
E
D
C
V
T
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
L
E
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
55.53
44%
-107
- C4 -
4CZT
3
CIPKN_ARATH
A:
[4-290]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
---
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
-
L
-
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
----
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
----
A
---
L
---
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
-
E
D
G
-----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
----
T
-
S
L
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
C
--
P
----
P
----
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
------
A
-
E
V
I
E
N
E
W
F
K
K
------------
G
Y
K
A
P
-
K
F
E
--
N
--
V
S
L
-
D
D
V
D
A
I
F
D
D
S
G
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
55.16
43%
-109
- C4 -
4CZU
3
CIPKN_ARATH
D:
[4-290]
------
H
S
G
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
---
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
-
L
-
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
----
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
----
A
---
L
---
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
-
E
D
G
-----
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
----
T
-
S
L
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
C
--
P
----
P
----
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
------
A
-
E
V
I
E
N
E
W
F
K
K
------------
G
Y
K
A
P
-
K
F
E
--
N
A
D
V
S
L
-
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
54.78
36%
-119
- C4 -
3IGO
8
?
A:
[30-295]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
----
T
-
S
T
-
I
L
R
E
V
E
L
L
-
K
-
K
-
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
--
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
----
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
---
K
EKD
C
----
D
---
I
---
K
--
I
I
D
F
G
L
S
----
T
C
-
F
-
Q
Q
N
---
T
--------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
----
Y
-
D
I
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
L
--
P
----
Q
----
W
R
T
--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
------
T
-
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
IS
D
L
P
S
L
E
S
A
-
M
T
N
--
I
R
Q
F
Q
A
-
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
N
S
L
I
Q
G
S
T
I
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
A
S
A
I
D
R
T
I
L
L
S
R
E
R
M
E
R
A
F
K
M
F
D
K
D
G
S
G
K
I
S
T
K
E
L
F
K
L
E
S
I
I
E
Q
V
D
N
N
K
D
G
E
V
D
F
N
E
F
V
E
M
L
Q
N
F
V
R
N
-------------------------------------------------------------------------------------------------------
128
HHSearch
54.73
38%
-122
- C4 -
4GV1
5
AKT1_HUMAN
A:
[3-270]
--------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
----
K
E
V
I
V
A
K
D
---
E
V
A
H
-
T
L
T
E
N
R
V
L
-
Q
-
N
-
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
--
T
----
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
----
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
---
D
K
---
D
---
G
----
H
---
I
---
K
--
I
T
D
F
G
L
C
----
K
E
G
I
-
K
D
G
---
A
-
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
------
G
--
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
----
E
-
K
L
F
E
-
L
I
L
M
E
--
E
--
I
-
R
F
--
P
----
R
----
T
----
L
G
P
E
--
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
------
K
-
E
I
M
Q
H
R
F
F
A
G
---------
I
V
W
Q
H
V
Y
E
-
K
K
L
--
S
P
P
F
K
P
-
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
54.68
44%
-113
- C4 -
4CZT
3
CIPKN_ARATH
C:
[10-290]
------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
----
K
E
K
V
L
K
N
K
---
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
-
L
-
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
----
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
----
A
---
L
---
K
--
V
S
D
F
G
L
S
ALPQ
Q
V
-
R
-
E
D
G
-----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
--
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
----
T
-
S
L
Y
K
-
K
I
F
K
A
--
E
--
F
-
T
C
--
P
----
P
----
W
----
F
S
A
S
--
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
------
A
-
E
V
I
E
N
E
W
F
K
K
------------
G
Y
K
A
P
-
K
F
E
--
N
A
D
V
S
L
-
D
D
V
D
A
I
F
D
D
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
54.43
38%
-133
- C4 -
2JC6
1
KCC1D_HUMAN
C:
[24-283]
---------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
-----------
S
-
I
E
N
E
I
A
V
L
-
R
-
K
-
I
-
K
H
E
N
I
V
A
L
E
D
I
Y
E
--
S
----
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
----
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
---
E
---
S
----
K
---
I
---
M
--
I
S
------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
----
S
-
K
L
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
F
DS
P
----
Y
----
W
DD--
I
S
D
S
--
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
------
E
-
Q
A
A
R
H
P
W
I
A
G
---------
D
T
A
L
N
K
N
I
-
H
E
S
--
V
S
A
Q
I
R
-
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
54.39
36%
-120
- C4 -
3NCG
1
?
A:
[30-295]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
---
T
-
S
T
-
I
L
R
E
V
E
L
L
-
K
-
K
-
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
--
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
----
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
---
K
EKD
C
----
D
---
I
---
K
--
I
I
D
F
G
L
S
----
T
C
-
F
-
Q
Q
N
---
T
------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
----
Y
-
D
I
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
L
--
P
----
Q
----
W
R
T
--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
------
T
-
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
IS
D
L
P
S
L
E
S
A
-
M
T
N
--
I
R
Q
F
Q
A
-
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
N
G
S
T
I
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
A
S
A
I
D
R
T
I
L
L
S
R
E
R
M
E
R
A
F
K
M
F
D
K
D
G
S
G
K
I
S
T
K
E
L
D
F
N
E
F
V
E
M
L
Q
N
---------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
54.07
38%
-133
- C4 -
4FG9
1
KCC1A_HUMAN
A:
[20-279]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
E
---------------
E
N
E
I
A
V
L
-
H
-
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
----
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
----
K
---
I
---
M
--
I
S
D
F
----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
----
A
-
K
L
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
F
DS
P
----
Y
----
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
------
E
-
Q
A
L
Q
H
P
W
I
A
G
---------
D
T
A
L
D
K
N
I
-
H
Q
S
--
V
S
E
Q
I
K
-
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
53.88
38%
-134
- C4 -
4FG8
1
KCC1A_HUMAN
A:
[20-279]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
E
----------------
N
E
I
A
V
L
-
H
-
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
----
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
----
K
---
I
---
M
--
I
S
D
F
---------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
----
A
-
K
L
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
F
DS
P
----
Y
----
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
------
E
-
Q
A
L
Q
H
P
W
I
A
G
---------
D
T
A
L
D
K
N
I
-
H
Q
S
--
V
S
E
Q
I
K
-
K
N
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
53.69
38%
-132
- C4 -
2JC6
1
KCC1D_HUMAN
A:
[24-283]
---------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
----------
S
S
-
I
E
N
E
I
A
V
L
-
R
-
K
-
I
-
K
H
E
N
I
V
A
L
E
D
I
Y
E
--
S
----
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
----
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
---
E
---
S
----
K
---
I
---
M
--
I
S
------------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
----
S
-
K
L
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
F
DS
P
----
Y
----
W
DD--
I
S
D
S
--
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
------
E
-
Q
A
A
R
H
P
W
I
A
G
---------
D
T
A
L
N
K
N
I
-
H
E
S
--
V
S
A
Q
I
R
-
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
53.69
46%
-113
- C4 -
4BKZ
1
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
--------
L
P
R
-
I
K
T
E
I
E
A
L
-
K
-
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
----
K
---
L
---
K
--
L
I
D
F
G
L
C
----
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
--
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
----
M
-
A
L
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
V
--
P
----
K
----
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
Q
---------
D
---
Y
N
Y
P
V
E
W
Q
--
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
53.20
36%
-116
- C4 -
3MWU
1
?
A:
[30-295]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
---
T
-
S
T
-
I
L
R
E
V
E
L
L
-
K
-
K
-
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
--
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
----
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
---
K
EKD
C
----
D
---
I
---
K
--
I
I
D
F
G
L
S
----
T
C
-
F
-
Q
Q
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
----
Y
-
D
I
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
L
--
P
----
Q
----
W
R
T
--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
------
T
-
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
IS
D
L
P
S
L
E
S
A
-
M
T
N
--
I
R
Q
F
Q
A
-
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
N
S
L
I
Q
N
E
G
S
T
I
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
A
S
A
I
D
R
T
I
L
L
S
R
E
R
M
E
R
A
F
K
M
F
D
K
D
G
S
G
K
I
S
T
K
E
L
E
Q
V
D
N
N
K
D
G
E
V
D
F
N
E
F
V
E
M
L
Q
N
F
V
R
-------------------------------------------------------------------------------------------------------------
133
HHSearch
52.91
31%
-117
- C4 -
4C2V
1
AUKBA_XENLA
A:
[12-282]
---------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
----
K
S
Q
L
E
K
E
G
---
V
E
H
Q
-
L
R
R
E
I
E
I
Q
-
S
-
H
-
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
--
D
----
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
----
G
----
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
----
E
---
L
---
K
--
I
A
D
F
G
W
S
----
V
H
-
A
-
P
S
----
L
-
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
------
D
--
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
----
T
-
E
T
H
R
-
R
I
V
N
V
--
D
--
L
-
K
F
--
P
----
P
----
F
----
L
S
D
G
--
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
------
K
-
G
V
M
E
H
P
W
V
K
A
---------
N
S
R
R
V
L
P
P
-
V
Y
Q
--
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
52.74
46%
-114
- C4 -
4BKY
1
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-------
D
L
P
R
-
I
K
T
E
I
E
A
L
-
K
-
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
----
K
---
L
---
K
--
L
I
D
F
G
L
C
----
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
----
M
-
A
L
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
V
--
P
----
K
----
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
Q
---------
D
---
Y
N
Y
P
V
E
W
Q
--
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
52.70
36%
-114
- C4 -
4Y5Q
1
?
A:
[30-295]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
---
T
-
S
T
-
I
L
R
E
V
E
L
L
-
K
-
K
-
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
--
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
----
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
---
K
EKD
C
----
D
---
I
---
K
--
I
I
D
F
G
L
S
----
T
C
-
F
-
Q
Q
N
---
T
----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
----
Y
-
D
I
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
L
--
P
----
Q
----
W
R
T
--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
------
T
-
Q
C
L
E
H
P
W
I
Q
K
Y
SS
E
T
P
T
IS
D
L
P
S
L
E
S
A
-
M
T
N
--
I
R
Q
F
Q
A
-
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
N
S
G
S
T
I
E
D
Q
I
D
S
L
M
P
L
L
D
M
D
G
S
G
S
I
E
Y
S
E
F
I
A
S
A
I
D
R
T
I
L
L
S
R
E
R
M
E
R
A
F
K
M
F
D
K
D
G
S
G
K
I
S
T
K
E
L
F
K
L
F
S
E
Q
V
D
N
N
K
D
G
E
V
D
F
N
E
F
V
E
M
L
Q
N
F
V
R
N
------------------------------------------------------------------------------------------------------------
143
HHSearch
52.50
34%
-108
- C4 -
1RDQ
3
KAPCA_MOUSE
E:
[35-298]
-------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
---
Q
I
E
H
-
T
L
N
E
K
R
I
L
-
Q
-
A
-
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
--
D
----
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
----
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
----
Y
---
I
---
Q
--
V
T
D
F
G
F
A
----
K
R
-
V
-
K
G
R
---
T
---
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
----
I
-
Q
I
Y
E
-
K
I
V
S
G
--
K
--
V
-
R
F
--
P
----
S
----
H
----
F
S
S
D
--
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
------
N
-
D
I
K
N
H
K
W
F
A
T
---------
T
D
W
I
A
I
Y
Q
-
R
K
V
--
E
A
P
F
I
P
-
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
52.21
38%
-117
- C4 -
3BHH
1
KCC2B_HUMAN
A:
[6-266]
---------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
---
H
-
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
-
L
-
K
H
S
N
I
V
R
L
H
D
S
I
S
--
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
C
----
K
---
G
A
A
V
K
--
L
A
D
F
G
L
A
I
---
E
V
-
Q
-
G
D
Q
---
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
--
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
----
H
-
K
L
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
F
--
P
SPEW
D
----
T
----
V
T
P
E
--
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
------
H
-
E
A
L
K
H
P
W
V
C
Q
---------
R
S
T
V
A
S
M
M
-
H
R
Q
--
E
T
V
E
C
L
-
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
52.15
36%
-111
- C4 -
3MA6
1
?
B:
[39-292]
--------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
-
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
52.06
36%
-113
- C4 -
3MA6
1
?
A:
[39-292]
--------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
-
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
52.00
46%
-113
- C4 -
4BL1
1
MELK_HUMAN
A:
[9-291]
------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
--------
L
P
R
-
I
K
T
E
I
E
A
L
-
K
-
N
-
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
--
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
----
K
---
L
---
K
--
L
I
D
F
G
L
C
----
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
----
M
-
A
L
Y
K
-
K
I
M
R
G
--
K
--
Y
-
D
V
--
P
----
K
----
W
----
L
S
P
S
--
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
------
K
-
N
L
L
N
H
P
W
I
M
Q
---------
D
---
Y
N
Y
P
V
E
W
Q
--
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
51.52
36%
-108
- C4 -
2WEI
1
?
A:
[30-282]
---------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
---
T
-
S
T
-
I
L
R
E
V
E
L
L
-
K
-
K
-
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
--
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
----
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
---
K
EKD
C
----
D
---
I
---
K
--
I
I
D
F
G
L
S
----
T
C
-
F
-
Q
Q
N
---
T
-
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
----
Y
-
D
I
L
K
-
R
V
E
T
G
KY
A
--
F
-
D
L
--
P
----
Q
----
W
RT--
I
S
D
D
--
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
------
T
-
Q
C
L
E
H
P
W
I
Q
K
---------
Y
S
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
51.33
38%
-117
- C4 -
3BHH
1
KCC2B_HUMAN
B:
[6-266]
---------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
---
H
-
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
-
L
-
K
H
S
N
I
V
R
L
H
D
S
I
S
--
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
C
----
K
---
G
AAV
K
--
L
A
D
F
G
L
A
I---
E
V
-
Q
-
G
D
Q
---
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
--
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
----
H
-
K
L
Y
Q
-
Q
I
K
A
G
--
A
--
Y
-
D
F
--
P
SPEW
D
----
T
----
V
T
P
E
--
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
------
H
-
E
A
L
K
H
P
W
V
C
Q
---------
R
S
T
V
A
S
M
M
-
H
R
Q
--
E
T
V
E
C
L
-
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
51.20
38%
-124
- C4 -
4FG8
1
KCC1A_HUMAN
B:
[20-279]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
-----------------
N
E
I
A
V
L
-
H
-
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
----
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
----
K
---
I
---
M
--
I
S
D
F
G
-------------
G
---
S
-
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
----
A
-
K
L
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
F
DS
P
----
Y
----
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
------
E
-
Q
A
L
Q
H
P
W
I
A
G
---------
D
T
A
L
D
K
N
I
-
H
Q
S
--
V
S
E
Q
I
K
-
K
N
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
50.11
36%
-132
- C4 -
4BDJ
1
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------------
N
-
V
E
T
E
I
E
I
L
-
K
-
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
----
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
S
---
Q
---
E
----
E
D
C
L
I
---
K
--
I
T
D
F
G
H
S
----
K
I
-
L
--
E
T
---
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
----
Q
-
V
S
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
I
--
P
----
E
----
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
Q
D
---------
E
D
M
K
R
K
F
Q
-
D
L
L
--
S
E
E
N
E
S
-
T
A
L
P
Q
V
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
49.78
36%
-127
- C4 -
4BDF
3
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------------
N
-
V
E
T
E
I
E
I
L
-
K
-
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
----
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
S
---
Q
---
E
----
E
D
C
L
I
---
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-
G
E
T
---
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
----
Q
-
V
S
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
I
--
P
----
E
----
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
Q
D
---------
E
D
M
K
R
K
F
Q
-
D
L
L
--
S
E
E
N
E
S
-
T
A
L
P
Q
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
49.57
32%
-113
- C4 -
2W5A
5
NEK2_HUMAN
A:
[4-273]
-----------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
----
Y
G
S
M
T
E
-
A
---
E
K
Q
M
-
L
V
S
E
V
N
L
L
-
R
-
E
-
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
----
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
----
Y
-
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
-
L
H
R
D
L
K
P
A
N
V
F
---
L
---
D
G
---
K
---
Q
----
N
---
V
---
K
--
L
G
D
F
G
L
A
----
R
I
-
L
---
T
---
S
-
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-
Y
------
N
--
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
----
K
-
E
L
A
G
-
K
I
R
E
G
--
K
--
F
R
R
I
--
P
----
Y
----
R
----
Y
S
D
E
--
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
------
E
-
E
I
L
E
N
P
L
I
L
E
---------
H
H
H
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
49.38
35%
-115
- C4 -
4MVF
2
CDPK2_PLAFK
A:
[51-315]
------
H
S
G
K
L
E
-
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
K
----
K
D
R
L
K
N
------
I
N
R
-
F
F
Q
E
I
E
I
M
-
K
-
K
-
L
-
D
H
P
N
I
V
K
L
Y
E
T
Y
E
--
N
----
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
N
----
G
----
S
-
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
-
L
N
I
V
H
R
D
L
K
P
E
N
F
L
---
F
---
Q
S
---
E
---
N
----
K
D
S
L
L
---
K
--
I
I
D
F
G
L
S
----
K
N
-
L
----------------------------
K
Y
-------
D
--
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
---------------------------
C
F
--
Y
----
E
----
N
DWGS
I
S
S
D
--
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
-----
T
I
------
E
-
E
A
L
N
H
P
W
I
T
Q
---------
M
T
K
S
H
V
E
L
-
S
S
T
--
L
L
K
N
L
K
-
N
F
K
K
E
N
E
L
K
K
I
A
L
T
I
I
A
K
H
L
C
D
V
E
I
N
N
L
R
N
I
F
I
A
L
D
V
D
N
S
G
T
L
S
S
Q
E
I
L
D
G
L
K
K
I
G
Y
Q
K
I
P
P
D
I
H
Q
V
L
R
D
I
D
S
N
A
S
G
Q
I
H
Y
T
D
F
L
A
A
T
I
D
K
Q
T
Y
L
K
K
E
V
C
L
I
P
F
K
F
F
D
I
D
G
N
G
K
I
S
V
E
E
L
K
R
I
F
G
P
L
I
D
K
A
I
D
S
L
L
Q
E
V
D
L
N
G
D
G
E
I
D
F
H
E
F
M
L
M
M
S
K
L
E
H
--------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
49.29
36%
-125
- C4 -
4BDG
2
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------------
N
-
V
E
T
E
I
E
I
L
-
K
-
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
----
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
S
---
Q
---
E
----
E
D
C
L
I
---
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-
G
E
T
---
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
----
Q
-
V
S
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
I
--
P
----
E
----
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
Q
D
---------
E
D
M
K
R
K
F
Q
-
D
L
L
--
S
E
E
N
E
S
-
T
A
L
P
Q
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
49.18
36%
-125
- C4 -
2YCR
1
CHK2_HUMAN
A:
[11-281]
--------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------------
N
-
V
E
T
E
I
E
I
L
-
K
-
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
----
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
S
---
Q
---
E
----
E
D
C
L
I
---
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-
G
E
T
---
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
----
Q
-
V
S
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
I
--
P
----
E
----
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
Q
D
---------
E
D
M
K
R
K
F
Q
-
D
L
L
--
S
E
E
N
E
S
-
T
A
K
P
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
49.16
35%
-112
- C4 -
3C0I
1
CSKP_HUMAN
A:
[24-293]
-------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
----
V
A
K
F
T
S
S
P
GL-
S
T
E
D
-
L
K
R
E
A
S
I
C
-
H
-
M
-
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
--
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
----
A
D
A
G
F
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
---
L
---
A
S
---
K
---
E
----
N
S
A
P
V
---
K
--
L
G
G
F
G
V
A
----
I
Q
-
L
-
G
E
S
---
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
------
G
--
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-----
E
-
R
L
F
E
-
G
I
I
K
G
--
K
--
Y
-
K
M
N
-
P
----
R
QWS-
H
----
I
S
E
S
--
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
------
Y
-
E
A
L
N
H
P
W
L
K
E
---------
R
D
R
Y
A
Y
K
I
-
H
L
P
--
E
T
V
E
Q
L
-
R
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
48.83
36%
-130
- C4 -
4BDE
5
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-----------
A
L
N
-
V
E
T
E
I
E
I
L
-
K
-
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
----
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
S
---
Q
---
E
----
E
D
C
L
I
---
K
--
I
T
D
F
G
H
S
----
K
I
-
L
---
T
---
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
----
Q
-
V
S
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
I
--
P
----
E
----
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
Q
D
---------
E
D
M
K
R
K
F
Q
-
D
L
L
--
S
E
E
N
E
S
-
T
A
L
P
Q
V
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
48.79
36%
-122
- C4 -
4BDK
4
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-----------
A
L
N
-
V
E
T
E
I
E
I
L
-
K
-
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
----
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
S
---
Q
---
E
----
E
D
C
L
I
---
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-
G
E
T
---
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
----
Q
-
V
S
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
I
--
P
----
E
----
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
Q
D
---------
E
D
M
K
R
K
F
Q
-
D
L
L
--
S
E
E
N
E
S
-
T
A
L
P
Q
V
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
48.78
38%
-126
- C4 -
4FG7
1
KCC1A_HUMAN
A:
[20-277]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
------------------
S
-
M
E
N
E
I
A
V
L
-
H
-
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
----
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
----
K
---
I
---
M
--
I
S
D
F
G
L
S
----
K
M
-
E
-
D
P
G
------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
----
A
-
K
L
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
F
DS
P
----
Y
----
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
------
E
-
Q
A
L
Q
H
P
W
I
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
48.68
36%
-133
- C4 -
4BDH
4
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------------
N
-
V
E
T
E
I
E
I
L
-
K
-
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
----
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
S
---
Q
---
E
----
E
D
C
L
I
---
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-
G
E
T
---
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
----
Q
-
V
S
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
I
--
P
----
E
----
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
Q
D
---------
E
D
M
K
R
K
F
Q
-
D
L
L
--
S
E
E
N
E
S
-
T
A
L
P
Q
V
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
48.26
34%
-109
- C4 -
2Y0A
1
DAPK1_HUMAN
A:
[11-277]
-------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
----
K
R
R
T
K
S
S
R
RGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
-
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
D
---
R
---
N
VP
K
P
R
---
I
---
K
--
I
I
D
F
G
L
A
----
H
K
-
I
-
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
------
G
--
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
----
Q
-
E
T
L
A
-
N
V
S
A
V
--
N
--
Y
-
E
F
--
E
D---
E
YFS-
N
----
T
S
A
L
--
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
------
Q
-
D
S
L
Q
H
P
W
I
K
P
---------
K
D
T
Q
Q
A
L
S
-
R
K
A
--
S
A
V
N
M
E
-
K
F
K
K
F
A
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
48.23
38%
-127
- C4 -
4FG9
1
KCC1A_HUMAN
B:
[20-279]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
------------------
E
I
A
V
L
-
H
-
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
--
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
----
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
----
K
---
I
---
M
--
I
S
D
F
--------------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
----
A
-
K
L
F
E
-
Q
I
L
K
A
--
E
--
Y
-
E
F
DS
P
----
Y
----
W
DD--
I
S
D
S
--
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
------
E
-
Q
A
L
Q
H
P
W
I
A
G
---------
D
T
A
L
D
K
N
I
-
H
Q
S
--
V
S
E
Q
I
K
-
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
47.98
37%
-113
- C4 -
2Y7J
1
PHKG2_HUMAN
D:
[100-365]
-------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V---
R
L
S
P
E
Q
L
E
---
E
V
R
E
A
T
R
R
E
T
H
I
L
-
R
Q
V
-
A
-
G
H
P
H
I
I
T
L
I
D
S
Y
E
--
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
N
---
M
----
Q
---
I
---
R
--
L
S
D
F
G
F
S
----
C
H
-
L
-
E
P
G
---
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
----
I
-
L
M
L
R
-
M
I
M
E
G
QY
Q
--
F
-
S
S
--
P
----
E
----
W
----
D
D
R
S
ST
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
------
E
-
Q
A
L
Q
H
P
F
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
47.96
39%
-113
- C4 -
3F3Z
5
?
A:
[9-271]
-------------
Q
Y
Y
T
L
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
----
K
Y
F
V
E
D
------
V
D
R
-
F
K
Q
E
I
E
I
M
-
K
-
S
-
L
-
D
H
P
N
I
I
R
L
Y
E
T
F
E
--
D
----
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
----
R
----
V
-
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
-
L
N
V
A
H
R
D
L
K
P
E
N
F
L
---
F
LTD
S
P
---
D
---
S
----
P
---
L
---
K
--
L
I
D
F
G
L
A
----
A
R
-
F
-
K
P
G
---
K
-
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
L
--
Y
-----
G
--
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
D
----
S
-
E
V
M
L
-
K
I
R
E
G
--
T
--
F
-
T
F
--
P
----
E
KDWL
N
----
V
S
P
Q
--
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
-----
T
S
------
L
-
Q
A
L
E
H
E
W
F
E
K
---------
Q
L
S
S
S
P
R
N
-
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
47.93
34%
-111
- C4 -
1XJD
1
A:
[16-275]
------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
----
K
D
V
V
L
M
D
D
---
D
V
E
C
-
T
M
V
E
K
R
V
L
-
S
-
L
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
--
T
----
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
----
H
----
K
-
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
---
L
---
D
K
---
D
---
G
----
H
---
I
---
K
--
I
A
D
F
G
M
C
----
K
E
-
N
-
M
L
G
D--
A
-
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
------
N
--
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
----
E
-
E
L
F
H
-
S
I
R
M
D
--
N
--
P
-
F
Y
--
P
----
R
----
W
----
L
E
K
E
--
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
V
------
R
G
D
I
R
Q
H
P
L
F
R
E
---------
I
N
W
E
E
L
E
R
-
K
E
I
--
D
P
Q
N
M
F
-
R
N
F
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
47.93
37%
-115
- C4 -
3TXO
1
A:
[23-286]
-------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
T
G
D
L
Y
A
V
K
V
L
K
----
K
D
V
I
L
Q
D
D
---
D
V
E
C
-
T
M
T
E
K
R
I
L
-
S
-
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
--
T
----
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
----
R
----
R
-
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
---
L
---
D
H
---
E
---
G
----
H
---
C
---
K
--
L
A
D
F
G
M
C
----
K
E
-
G
I
C
-------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
------
G
--
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
----
D
-
D
L
F
E
-
A
I
L
N
D
--
E
--
V
-
V
Y
--
P
----
T
----
W
----
L
H
E
D
--
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
K
E
---------
I
D
W
A
Q
L
N
H
-
R
Q
I
--
E
P
P
F
R
P
-
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
47.81
36%
-125
- C4 -
4BDI
6
CHK2_HUMAN
A:
[17-287]
--------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-----------
A
L
N
-
V
E
T
E
I
E
I
L
-
K
-
K
-
L
-
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
-----
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
----
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
S
---
Q
---
E
----
E
D
C
L
I
---
K
--
I
T
D
F
G
H
S
----
K
I
-
L
-
G
E
T
---
S
-
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
----
Q
-
V
S
L
K
D
Q
I
T
S
G
--
K
--
Y
N
F
I
--
P
----
E
----
V
WAE-
V
S
E
K
--
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
------
E
-
E
A
L
R
H
P
W
L
Q
D
---------
E
D
M
K
R
K
F
Q
-
D
L
L
--
S
E
E
N
E
S
-
T
A
L
P
Q
V
L
A
Q
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
47.57
37%
-114
- C4 -
2Y7J
1
PHKG2_HUMAN
C:
[100-365]
-------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTAE
R
L
S
P
E
Q
L
E
---
E
V
R
E
A
T
R
R
E
T
H
I
L
-
R
Q
V
-
A
-
G
H
P
H
I
I
T
L
I
D
S
Y
E
--
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
N
---
M
----
Q
---
I
---
R
--
L
S
D
F
G
F
S
----
C
H
-
L
-
E
P
G
---
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
----
I
-
L
M
L
R
-
M
I
M
E
G
QY
Q
--
F
-
S
S
--
P
----
E
----
W
----
D
D
R
S
ST
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
------
E
-
Q
A
L
Q
H
P
F
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
47.30
36%
-122
- C4 -
4QOX
1
CDPK4_PLAF7
A:
[85-338]
---------------------
L
G
K
G
S
F
G
E
V
I
L
S
R
D
K
H
T
G
H
E
Y
A
I
K
V
I
S
----
K
K
H
V
K
R
K
T
---
D
K
E
S
-
L
L
R
E
V
E
L
L
-
K
-
M
-
L
-
D
H
I
N
I
M
K
L
Y
E
F
F
E
--
D
----
N
N
Y
Y
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
-
N
N
V
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
T
---
K
NED
M
----
I
---
I
---
K
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
Y
S
---------
K
I
G
T
A
Y
Y
I
A
P
D
V
L
H
G
T
Y
-------
D
--
E
K
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
S
N
E
----
Y
-
D
I
L
K
-
K
V
E
A
G
KY
T
--
F
-
D
L
--
P
----
Q
----
F
KK--
I
S
D
K
--
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
I
-----
S
A
------
R
-
D
A
L
E
H
E
W
I
K
M
---------
M
T
S
K
L
E
L
S
-
I
A
N
--
I
R
Q
F
Q
S
-
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
T
I
D
E
T
K
E
L
T
K
I
F
K
K
M
D
K
N
G
D
G
Q
L
D
R
N
E
L
I
I
G
Y
K
E
L
L
K
L
K
G
E
T
S
D
L
D
N
A
A
I
E
Y
E
V
D
Q
I
L
N
S
I
D
L
D
Q
N
G
Y
I
E
Y
S
E
F
L
T
V
S
I
D
R
K
L
L
L
S
T
E
R
L
E
K
A
F
K
L
F
D
K
D
G
S
G
K
I
S
A
N
E
L
A
Q
L
F
G
L
S
D
V
S
S
E
C
W
K
T
V
L
K
E
V
D
Q
N
N
D
G
E
I
D
F
K
E
F
R
D
M
L
V
K
L
C
N
Y
----------------------------------------------------------------------------------------------
103
PsiBlast_CBE
46.99
37%
-115
- C4 -
2Y7J
1
PHKG2_HUMAN
A:
[100-365]
-------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
VTA
E
R
L
S
P
E
Q
L
E
---
E
V
R
E
A
T
R
R
E
T
H
I
L
-
R
Q
V
-
A
-
G
H
P
H
I
I
T
L
I
D
S
Y
E
--
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
N
---
M
----
Q
---
I
---
R
--
L
S
D
F
G
F
S
----
C
H
-
L
-
E
P
G
---
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
----
I
-
L
M
L
R
-
M
I
M
E
G
QY
Q
--
F
-
S
S
--
P
----
E
----
W
----
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
------
E
-
Q
A
L
Q
H
P
F
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
46.69
39%
-118
- C4 -
2JAM
3
KCC1G_HUMAN
A:
[11-264]
---------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
----
K
S
------------
S
-
L
E
N
E
I
A
V
L
-
K
-
K
-
I
-
K
H
E
N
I
V
T
L
E
D
I
Y
E
--
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
----
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y--
L
---
T
P
---
E
---
E
----
N
---
S
---
K
I
M
I
T
D
F
G
L
S
----
K
M
-
E
-
Q
N
G
-----
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
----
S
-
K
L
F
E
-
K
I
K
E
G
--
Y
YE
F
-
E
S
--
P
----
F
----
W
DD--
I
S
E
S
--
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
------
E
-
K
A
L
S
H
P
W
I
D
G
---------
N
T
A
L
H
R
D
I
-
Y
P
S
--
V
S
L
Q
I
Q
-
K
N
F
A
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
45.77
39%
-120
- C4 -
2JAM
3
KCC1G_HUMAN
B:
[11-264]
---------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
----
K
S
------------
S
-
L
E
N
E
I
A
V
L
-
K
-
K
-
I
-
K
H
E
N
I
V
T
L
E
D
I
Y
E
--
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
----
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y--
L
---
T
P
---
E
---
E
----
N
---
S
---
K
I
M
I
T
D
F
G
L
S
----
K
M
-
E
-
Q
N
G
-----
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
----
S
-
K
L
F
E
-
K
I
K
E
G
--
Y
YE
F
-
E
S
--
P
----
F
----
W
DD--
I
S
E
S
--
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
------
E
-
K
A
L
S
H
P
W
I
D
G
---------
N
T
A
L
H
R
D
I
-
Y
P
S
--
V
S
L
Q
I
Q
-
K
N
F
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
45.21
32%
-89
- C4 -
4MX9
1
?
A:
[34-348]
--------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
K
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
S
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
N
V
L
A
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------------
54
PsiBlast_CBE
45.21
32%
-93
- C4 -
4IFG
1
?
A:
[57-370]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
--------------------------------------------------------------------------------------------
79
PsiBlast_CBE
45.08
32%
-87
- C4 -
4MXA
1
?
A:
[34-348]
--------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
K
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
S
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
N
V
L
A
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------------
53
PsiBlast_CBE
45.01
32%
-91
- C4 -
4IHP
1
?
A:
[57-370]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
---
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
---------------------------------------------------------------------------------------------
72
PsiBlast_CBE
44.89
32%
-91
- C4 -
3T3V
2
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
------------------------------------------------------------------------------------------
52
PsiBlast_CBE
44.55
32%
-109
- C4 -
3HX4
3
?
A:
[58-371]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
----------
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
-----------------------------------------------------------------------------------------
130
HHSearch
44.48
35%
-104
- C4 -
2YEX
8
CHK1_HUMAN
A:
[6-270]
------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
----
M
K
R
A
--
V
D
---
C
P
E
N
-
I
K
K
E
I
C
I
N
-
K
-
M
-
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
--
E
----
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
----
I
----
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
----
N
---
L
---
K
--
I
S
D
F
G
L
A
----
T
V
-
F
-
R
Y
N
N
R
E
R
-
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
--
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
----
S
C
Q
E
Y
S
-
D
W
K
E
K
--
K
--
T
-
Y
L
--
N
PW--
K
----
K
----
I
D
S
A
--
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
------
P
-
D
I
K
K
D
R
W
Y
N
K
---------
P
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
44.28
32%
-91
- C4 -
4TZR
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------
55
PsiBlast_CBE
43.82
32%
-93
- C4 -
3KU2
1
?
A:
[57-370]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
--------------------------------------------------------------------------------------------
69
PsiBlast_CBE
43.67
32%
-92
- C4 -
3V51
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
--------------------------------------------------------------------------------------
71
PsiBlast_CBE
43.66
32%
-90
- C4 -
3UPX
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
-------
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
--------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
43.30
32%
-94
- C4 -
3SX9
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-----------------------------------------------------------------------------------------
142
HHSearch
43.24
35%
-110
- C4 -
1NXK
1
MAPK2_HUMAN
A:
[62-330]
-------------
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
----
D
C
-----------
P
K
-
A
R
R
E
V
E
L
H
W
R
-
A
-
S
-
Q
C
P
H
I
V
R
I
V
D
V
Y
E
--
N
LYAG
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
----------A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
---
Y
---
T
S
KRP
N
---
A
----
I
---
L
---
K
--
L
T
D
F
G
F
A
----
K
E
-
T
-
T
---------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
------
D
--
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
LAIS
P
-
G
M
K
T
-
R
I
R
M
G
--
Q
--
Y
-
E
F
--
P
----
N
PEWS
E
----
V
S
E
E
--
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
------
T
-
E
F
M
N
H
P
W
I
M
Q
---------
S
T
K
V
P
Q
T
P
-
L
H
T
--
S
R
V
L
K
E
-
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
43.18
32%
-94
- C4 -
3UPZ
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
-------
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------
68
PsiBlast_CBE
43.15
32%
-92
- C4 -
3V5P
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
-------
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
----------------------------------------------------------------------------------------------
66
PsiBlast_CBE
42.82
32%
-90
- C4 -
4JBV
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------
73
PsiBlast_CBE
42.78
32%
-93
- C4 -
3T3U
5
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
42.56
32%
-90
- C4 -
4M84
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------
67
PsiBlast_CBE
42.49
32%
-92
- C4 -
3V5T
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------
74
PsiBlast_CBE
42.47
32%
-90
- C4 -
3SXF
3
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
42.46
32%
-90
- C4 -
4WG3
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------
61
PsiBlast_CBE
42.24
32%
-90
- C4 -
4WG4
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
------
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------------
77
PsiBlast_CBE
41.94
32%
-93
- C4 -
3I7B
4
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
----------------------------------------------------------------------------------------
60
PsiBlast_CBE
41.69
32%
-90
- C4 -
4WG5
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------
64
PsiBlast_CBE
41.55
32%
-88
- C4 -
4ONA
1
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
K
K
--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
R
M
K
G
Q
D
A
S
M
L
D
A
S
A
V
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
-------------------------------------------------------------------------------------
76
PsiBlast_CBE
41.43
32%
-91
- C4 -
3N51
3
?
A:
[34-347]
---------------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
---
D
K
E
S
-
L
L
R
E
V
Q
L
L
-
K
-
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
----
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
---
K
SKD
A
----
N
---
I
---
R
--
I
I
D
F
G
L
S
----
T
H
-
F
-
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
----
Y
-
D
I
L
K
-
K
V
E
K
G
KY
T
--
F
-
E
L
--
P
----
Q
----
W
KK--
V
S
E
S
--
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
------
R
-
D
A
L
D
H
E
W
I
Q
T
---------
Y
T
K
E
Q
I
S
V
-
D
V
P
--
S
L
D
N
A
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
Y
K
E
L
M
E
H
E
V
D
Q
V
L
D
A
V
D
F
D
K
N
G
Y
I
E
Y
S
E
F
V
T
V
A
M
D
R
K
T
L
L
S
R
E
R
L
E
R
A
F
R
M
F
D
S
D
N
S
G
K
I
S
S
T
E
L
A
T
I
F
G
V
S
D
V
D
S
E
T
W
K
S
V
L
S
E
V
D
K
N
N
D
G
E
V
D
F
D
E
F
Q
Q
M
L
L
K
L
C
G
N
----------------------------------------------------------------------------------------------------